ライフサイエンスコーパス: protection from

1 agment (Fc) domain of VRC01 increased median protection from 8 to 14.5 weeks.

2 l response in immunized mice does not impair protection from a homologous challenge; however, it does

3 oncentration of pyocin S5 required to afford protection from a lethal infection at least 100-fold low

4 ntravenous challenge but may be suitable for protection from a mucosal challenge that better approxim

5 n can augment antibody responses and enhance protection from a SHIV challenge in rhesus macaques.

6 Subsequent infants obtained limited protection from a single antenatal dose, but revaccinati

7 TLR2-deficient eosinophils is sufficient for protection from a strain producing CDT.

8 ined whether HAI titers were associated with protection from A(H1N1)pdm09 infection.

9 /rs2899292 haplotype GG, in association with protection from A(H7N9) infection (OR = 0.26, P = 5.92 x

10 ic inhibition of RIG-I and TLR4 will provide protection from aberrant endothelial responses associate

11 moral immunity is acquired or correlate with protection from acute disease.

12 ietin (EPO) levels have been associated with protection from acute neurologic deficits in Kenyan chil

13 and IL-33 to enhance Treg- and ILC2-mediated protection from AKI, bears strong therapeutic potential.

14 By contrast, we observe protection from all symptomatic dengue disease at high a

15 finitive host helminth infections may confer protection from allergies.

16 Mechanistic studies further indicated that protection from allergy could be explained by a Treg-dep

17 sion, decreased gut neutrophils, and blocked protection from ameba infection.

18 D88 signaling is required for proliferation, protection from apoptosis and expression of activation/m

19 and these cells do not depend upon CHK1 for protection from apoptosis during replication stress.

20 were dependent on PIM1 for proliferation and protection from apoptosis.

21 Females were predicted to have protection from arrhythmia induction when progesterone i

22 stem of the neonate, which can contribute to protection from asthma-related, including infectious, ou

23 The protection from atherosclerosis appears to be due to dec

24 ression and activity, which is necessary for protection from ATII-induced dysfunction as mice either

25 provements in cognitive functioning and some protection from autism-spectrum traits.

26 60 autoantibody-negative relatives suggested protection from autoantibody development.

27 The persistent protection from autoimmune destruction was paralleled by

28 recruited to the pancreas and contributed to protection from autoimmune diabetes.

29 Thus, protection from autoimmunity afforded by particular MHC/

30 This newly defined mechanism confers protection from autoimmunity during pregnancy and repres

31 nsplants and are required for CCL22-mediated protection from autoimmunity.

32 c T cells during thymic development provides protection from autoimmunity.

33 otective encapsulation or with only targeted protection from autoimmunity.

34 g breathability and provide a high degree of protection from biological threats by size exclusion.

35 thability while maintaining a high degree of protection from biothreats by size exclusion.

36 portant role for IFN-gamma in TcREG-mediated protection from bone loss.

37 arbour high biodiversity and provide natural protection from bottom-trawling activities.

38 Global BK deficiency afforded protection from BW gain and excessive fat accumulation i

39 y, epithelial deficiency of Cyba resulted in protection from C. rodentium and L. monocytogenes infect

40 ANGPTL3 deficiency is associated with protection from CAD.

41 ed-end growth while simultaneously enhancing protection from capping proteins.

42 This protection from cardiac fibrosis in female rats can be a

43 There were no associations between protection from carriage and baseline levels of 6BPS IgG

44 Protection from carriage was associated with a high numb

45 I and provides infected cells some degree of protection from CD8(+) T cell-mediated effector function

46 Protection from cell death during oxidative stress will

47 inflammation, the molecular mechanisms of EC protection from cell-extrinsic, proapoptotic stimuli hav

48 or RNA stability, efficient translation, and protection from cell-intrinsic defenses.

49 m of nonischemic HF patients, as well as the protection from CF and HF in TCR-alpha(-/-) mice.

50 Biofilms confer many advantages, including protection from chemicals (including antibiotics), entra

51 highly conserved regions IV-V predict strong protection from clinical malaria.

52 re included to determine factors that confer protection from clinical symptoms.

53 on was used to create a predictive model for protection from CMV reactivation.

54 Smooth muscle tropomyosin offers little protection from cofilin cleavage, unlike its effect on W

55 rly disease-specific pathology, resulting in protection from cognitive deficits and depressive-like b

56 Our data suggest that protection from colitis following adoptive transfer of C

57 vate a noncanonical autophagy pathway during protection from colitis.

58 IRAK1 in recipient mice provided additional protection from colitis.

59 Colonoscopy provides incomplete protection from colorectal cancer (CRC), but determinant

60 gmoidoscopy continues to provide substantial protection from colorectal cancer diagnosis and death, w

61 ement regulators to their surfaces to afford protection from complement activation.

62 ces and hijack their regulatory function for protection from complement activation.

63 zation of the respiratory tract, and confers protection from complement-mediated killing.

64 ute to disease severity, and did not mediate protection from complement-mediated killing.

65 tment of FH affords P. falciparum merozoites protection from complement-mediated lysis.

66 ow-volume i.n. inoculation afforded complete protection from contact transmission and protection from

67 of-function variant that was associated with protection from coronary artery disease (p.S447*; minor-

68 s; these mutations were also associated with protection from coronary artery disease.

69 of Anaplastic Lyphoma Kinase) is linked to a protection from coronary artery disease.

70 ce, including non-redundant contributions to protection from cutaneous carcinogens.

71 itive to poly(A) 3'-termini, consistent with protection from deadenylation.

72 However, neutrophil depletion abrogated protection from death in Nlrp3(-/-) mice in response to

73 Our results showed protection from death in NLRP3-deficient (Nlrp3(-/-)) an

74 NF-kappaB signaling provided protection from death mediated by the cytokine TNF and w

75 one to delirium should validate their use in protection from delirium.

76 INTERPRETATION: Economic opportunities and protection from deportation for undocumented immigrants,

77 od Arrivals (DACA) program granted temporary protection from deportation to more than 780,000 unautho

78 nclosed reproductive propagules and provided protection from desiccation and UV-B radiation.

79 ite adipose tissue, as well as near-complete protection from development of fatty liver disease and g

80 ogenic Treg to conventional T cell ratio and protection from diabetes.

81 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of mode

82 tic steatosis and insulin resistance despite protection from diet-induced obesity.

83 enged multiple times by different routes, so protection from different challenge routes cannot be mea

84 proteins that play an important role in cell protection from different damaging factors including UVB

85 We were able to achieve protection from disease as early as 2 weeks after vaccin

86 ed, the association of these antibodies with protection from disease progression is poorly understood

87 ritoneal cells from EPS-treated mice confers protection from disease to recipient mice.

88 response generates the primary correlate of protection from disease, robust T cell responses could e

89 al family Lachnospiraceae as a correlate for protection from disease.

90 epresents a potential therapeutic target for protection from disseminated candidiasis.

91 e that ambrisentan treatment provides robust protection from diverse renal pathologies in SCD mice, a

92 eased in diabetic Chop(-/-) mice that showed protection from DN.

93 erefore, MSM hepatocytes are predisposed for protection from DR-mediated cell death.

94 nd essential turmeric oils provides superior protection from DSS-induced colitis than curcumin alone,

95 ecific immunomodifying therapy that provides protection from early allograft rejection in the absence

96 risk alleles were previously associated with protection from early-onset alopecia, another sexually d

97 % in RANTES(-/-)), which was associated with protection from endothelial dysfunction induced by Ang I

98 ophil-derived MPO contributes importantly to protection from endotoxemia.

99 ial dynamics through TMEM135 is critical for protection from environmental stress and controlling the

100 l expansion, particularly by providing early protection from excessive necrosis.

101 nd show that loss of IL-1R signaling confers protection from experimental autoimmune uveitis.

102 ling in these subjects, which drives reduced protection from Fas-mediated apoptosis, was also associa

103 easing GVHD through two opposing mechanisms: protection from fatal immunity by amphiregulin expressio

104 ns of the same antigens were associated with protection from febrile malaria.

105 uterine artery (UtA) blood flow and relative protection from fetal growth restriction seen in altitud

106 The computed barrier protection from fractional subdiffusion is some orders o

107 une system is essential to maintain adequate protection from fungal infections.

108 ransfer of allospecific Tregs offers greater protection from graft rejection compared to polyclonal T

109 compelling evidence that the virome provides protection from gut inflammatory conditions.

110 The protection from GVHD afforded by IL-17A required secreti

111 Moreover, protection from GVHD was attributable to augmented globa

112 Evidence for potential protection from harmful effects by cannabidiol continues

113 young) with serological evidence of vaccine protection from HBV infection rose from 57.8 (95% CI: 55

114 s to HBV-endemic regions; and adults seeking protection from HBV infection.

115 critical role in allergic reactions and host protection from helminth infection.

116 AEG-1 small interfering RNA provided marked protection from HFD-induced NASH in WT mice.

117 (iii) consequent immune responses, and (iv) protection from high-dose, high-volume lethal challenge

118 tly decreased tumor multiplicity and burden, protection from high-grade dysplasia and significantly r

119 g3 variant (Ile81Met) segregates with tissue protection from hind-limb ischemia.

120 NAb response can help clarify correlates of protection from HIV exposures and better delineate pathw

121 selective stabilization of host proteins and protection from host defense.

122 with intercellular communication pathways in protection from host defenses.

123 ate the transcriptional changes required for protection from HS In tomato (Solanum lycopersicum), Hsf

124 ts elucidate the importance of STING in host protection from HSV-1 and demonstrate the redundancy of

125 une response has a critical role not only in protection from human leishmaniasis but also in promotin

126 mechanism by which BSJYD provides myocardial protection from hypertension.

127 ved in evasion of antitumor immune response, protection from hypoxia, angiogenesis, DNA repair, cell

128 and macrophage infiltration with significant protection from I/R-induced acute renal failure and tubu

129 induced expression of UCP2 and sirtuin 3 and protection from I/R.

130 (10 mg/kg), providing additional evidence of protection from immune attack in the treated groups.

131 g TCD8 impairment in vivo and contributes to protection from immunopathology during viral clearance.

132 te cells, revealing a novel strategy of host protection from immunopathology.

133 regulatory T (Treg) cells provides essential protection from inappropriate immune responses.

134 on cell behavior, including cell activation, protection from/induction of apoptosis, release of infla

135 The vaccine alone provided no protection from infection following 12 consecutive low-d

136 rotein A (OspA) were shown to correlate with protection from infection with Borrelia burgdorferi, the

137 uced an Fc-mediated activity associated with protection from infection with HIV, SIV, and SHIV.

138 s, an activity that has been associated with protection from infection with HIV, SIV, and SHIV.

139 icit diverse antibodies that provide broader protection from infection.

140 eas with an antibody profile associated with protection from infection.

141 previously unrecognized mechanism of innate protection from infection.

142 major in vivo mechanism of antibody-mediated protection from infection.

143 clonal vaccine-induced antibody responses in protection from infection.

144 ute to tissue homeostasis and provide innate protection from infection.

145 f IVIg and disentangle mechanisms, including protection from infections, acute cellular and humoral r

146 r IFNs in reproductive tract homeostasis and protection from infections, but its intrinsic activities

147 in helminthic parasite infections, providing protection from inflammation.

148 ariants associated with increased risk of or protection from inflammatory bowel disease (IBD).

149 (H5N1) virus elicits robust, cross-reactive protection from influenza virus infection in two animal

150 ellular cytotoxicity (ADCC) may provide some protection from influenza virus infection.

151 , which is to unite digestive functions with protection from ingested environmental threats.

152 e design by providing testable correlates of protection from initial HIV infection.

153 Further, protection from injury is achieved by pharmacologic bloc

154 pleted C57BL/6 mice demonstrated significant protection from injury, which was not seen in CD4(-/-) m

155 ta5 antibody 8 hours after IRI also provided protection from injury.

156 One of the main mechanisms for protection from intense illumination is the dissipation

157 uated SIV in an individual animal can confer protection from intrarectal challenge while remaining in

158 an individual animal may be insufficient for protection from intravenous challenge but may be suitabl

159 l challenge while remaining insufficient for protection from intravenous challenge.

160 mune system CRISPR-Cas provides RNA-mediated protection from invading genetic elements.

161 -equitable ideas were connected and conveyed protection from IPV.

162 Protection from IRI in neutrophil-depleted WT recipients

163 by cells at the injury site is critical for protection from IRI through bone marrow-derived adenosin

164 rp3 suppression is required for aPC-mediated protection from IRI.

165 ketamine may have therapeutic potential for protection from ischaemic renal damage.

166 njuries and may have clinical application in protection from ischemic-induced renal injury.

167 Our data suggest that Idd4.1-dependent protection from islet autoimmunity is mediated by differ

168 other cytoprotective mechanisms important in protection from kidney disease.

169 the autophagic degradation and thus provides protection from lethal endotoxemia and sepsis.

170 Moreover, vaccinated mice gained significant protection from lethal fentanyl doses.

171 oproteins also provided durable, single-dose protection from lethal VEEV and EEEV challenges, demonst

172 hway, in hematopoietic cells is critical for protection from lethal WNV infection.

173 Protection from lethality by postchallenge administratio

174 wer vaccination coverage and shorter vaccine protection (from lifetime to 20 years).

175 of Pet10p and other perilipins extend beyond protection from lipases and include the preservation of

176 ave been shown to play a significant role in protection from liver-stage malaria.

177 , amelioration of behavioral aberrations and protection from loss of striatal dopaminergic markers.

178 ssing this protein did not exhibit effective protection from Lygus feeding damage.

179 ay result in increased malaria infection but protection from malaria disease.

180 te-opsonizing antibodies are associated with protection from malaria in a strain-specific or strain-t

181 ssociation between high levels of Ang II and protection from malaria pathogenesis can provide a likel

182 inhibit parasite activity and correlate with protection from malaria.

183 igh antibody levels were not associated with protection from malaria; in contrast, they were typicall

184 In order to obtain full protection from many vaccines, an individual needs to re

185 accounting for vaccine effectiveness, infant protection from maternal antibodies, and loss of immunit

186 Additional protection from maternal immunization is retained in inf

187 There is no longer evidence of additional protection from maternal vaccination after the third inf

188 rocytes: CNS coculture caused quiescence and protection from methotrexate toxicity in Mer(high) ALL c

189 ete protection from contact transmission and protection from morbidity, mortality, and viral growth d

190 f STIM2 results in lower cytokine levels and protection from mortality in a mouse model of systemic i

191 A of reprogramming transcription factors and protection from mRNA degradation by RNase.

192 n Th1 and Th17 immunity and confers dramatic protection from mucosal bacterial infections.

193 nation or preventative approaches to enhance protection from mucosal infection by improving immune de

194 papaverine and zolpidem provided significant protection from multiple pathophysiological features, an

195 in the mdx genetic background, resulting in protection from muscular dystrophy pathogenesis that inc

196 ROS-rich environments and require reductive protection from NRX1 for optimal activity.

197 A mice had higher liver lipid content and no protection from obesity but retained exquisite hepatic i

198 However, we also observed that the protection from obesity, adipose tissue inflammation, st

199 tissue to expend excess energy could improve protection from obesity.

200 phenotypic advantages over fII(WT) animals: protection from occlusive thrombosis after arterial inju

201 mice that induces gammadeltaT cell-mediated protection from opportunistic infection.

202 these studies are truly the genes conferring protection from or risk of disease but also to define th

203 Plants can also recruit protection from other species.

204 n; however, the mechanisms underlying tissue protection from oxidation products are poorly understood

205 pped with hexagonal boron nitride to provide protection from oxidation.

206 in and nucleic acid synthesis and structure, protection from oxidative damage, activity of ion channe

207 Genetic ablation of TRIM21 in mice confers protection from oxidative damages caused by arsenic-indu

208 sary for the regulation of light harvesting, protection from oxidative stress and adaptation to diffe

209 tracts (13.9microg/ml) provided complete DNA protection, from oxidative stress induced by AAPH (3.5mM

210 ovecii protease kexin (KEX1) correlates with protection from P. jirovecii colonization and pneumonia.

211 od-stage Plasmodium chabaudi offers the best protection from parasitemia and pathology in reinfection

212 e produced in the colon and are critical for protection from parasites, but can also be pathogenic in

213 e-surveillance system that not only provides protection from pathogen invasion but has also evolved t

214 s an effective immune response that provides protection from pathogens while limiting injury to host

215 plays vital functions in nutrient supply and protection from pathogens, yet characterization of the m

216 , and possibly related to food digestion and protection from pathogens.

217 Protection from pathological weight gain in the absence

218 te serum resistance, capsule production, and protection from phagocytosis by host immune cells.

219 zed relative to Rp, providing stereochemical protection from pharmacologic inactivation of the drug.

220 ynGAP1 levels in tau(-/-) mice abolished the protection from pharmacologically induced excitotoxicity

221 binding to the substrate sites resulting in protection from phosphorylation in the presence of Ca(2+

222 he Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria, as reflec

223 This result suggests that protection from postexposure vaccination may be antigen

224 in the various functions of skin, especially protection from predatorial attack.

225 hiolin and calcium carbonate, which provides protection from predators and extreme environmental cond

226 al members, including locomotory economy and protection from predators that prey on individuals, but

227 A similar effect with protection from preterm birth and perinatal death, and p

228 n promoting expression, cellular attachment, protection from proteases, and antibody evasion.

229 Polar recognition, protection from proteolysis, and stimulation of phosphat

230 les of which have been broadly attributed to protection from proteolysis, as the extracellular milieu

231 results in decreased thrombin generation and protection from pulmonary embolism, leading to prolonged

232 nduced anti-proliferative effects may confer protection from radiotherapy- and chemotherapy-induced g

233 nd expanded B-cell follicles correlated with protection from reactivation.

234 orbidities given that the use of mesh offers protection from recurrence without major morbidity.

235 te sustained depression of viral shedding or protection from recurrences.

236 , where FoxO tumor suppressors could provide protection from redox stress.

237 nfection treatment with RvD1 and RvD5 led to protection from reinfection associated with C. rodentium

238 ure primary infection, immune responses, and protection from reinfection by either a lethal challenge

239 ponses correlated with primary infection and protection from reinfection in the lungs.

240 als during previous infection correlate with protection from reinfection, suggesting that an effectiv

241 lectin immunoglobulin A was associated with protection from reinfection, while a high parasite burde

242 nts expressing AfIP-1A/1B demonstrate strong protection from rootworm injury.

243 did not alter IgA responses associated with protection from rotavirus disease.

244 g countries, and evaluations indicate waning protection from rotavirus immunization in the second yea

245 We suggest that protection from RSV infection is a function of a complex

246 fic components of the human immune system in protection from S. aureus infection.

247 B-1a cells provide immediate and essential protection from S. pneumoniae through production of natu

248 tralizing antibodies fail to provide lasting protection from seasonal epidemics.

249 to enhance immunogenicity to provide better protection from seasonal influenza virus infection and i

250 s and cell populations that are critical for protection from severe lung disease.

251 ithout G6PD deficiency, we found significant protection from severe malaria (odds ratio [OR] 0.82, 95

252 y of these diseases are also associated with protection from severe malaria, suggesting a role for ac

253 ponectin showed selective dWAT expansion and protection from skin and peritoneal fibrosis.

254 NOD-Idd22 mice exhibit almost complete protection from spontaneous T1D and a significant reduct

255 and target gene expression, and unexpectedly protection from steatohepatitis and death.

256 alpha (P = .003), which were associated with protection from subsequent clinical malaria and parasite

257 tional T-cell subsets to pp65 that predicted protection from subsequent CMV viremia (concordance inde

258 pecific immunologic signature that predicted protection from subsequent CMV.

259 ation and their role as immune correlates of protection from subsequent DENV infections.

260 tory cytokine production was associated with protection from subsequent Pf infection, but also with a

261 nd associations between antibody levels with protection from symptomatic malaria in a treatment-reinf

262 worth and, as a result, equally deserving of protection from syndemic vulnerability.

263 l administration of AEA to NOD mice provides protection from T1D.

264 t factor Kap104, facilitating its continuous protection from the cellular degradation machinery.

265 DQA1*01:02-DQB1*06:02 haplotype is linked to protection from the development of type 1 diabetes (T1D)

266 skeletal muscle, putatively contributing to protection from the diet-induced obesity phenotype.

267 ation, modulating MC signal transduction and protection from the effects of MC mediators.

268 ession of gene patterns that facilitate host protection from the invading agent.

269 ic Cys529 variant apparently confers partial protection from the severest virus-induced asthma episod

270 Not accounting for protection from the use of ITNs during pregnancy, expand

271 esulted in altered immune responsiveness and protection from thermoneutral-housing-driven NAFLD ampli

272 Protection from these ADP factors may be important for a

273 to intrinsic contractile instabilities, and protection from these instabilities and organizational h

274 ng polyphosphate does not provide additional protection from thrombosis in factor XII-deficient anima

275 7BL/6 (BL6) mouse background segregates with protection from tissue necrosis in a shorter congenic fr

276 ning; (2) healthy brain development requires protection from toxic stress, not just enrichment; (3) a

277 and this decrease correlated with a complete protection from TT/Alum/IL-36beta-induced mortality.

278 Nitric oxide contributes to protection from tuberculosis.

279 trong CD4 T cell responses provide only weak protection from tuberculosis.

280 ) blood vessels, which likely contributed to protection from tumorigenesis.

281 Natural Killer (NK) cells confer protection from tumors and infections by releasing cytot

282 We investigated MHC-II-mediated protection from type 1 diabetes using a previously repor

283 arasitic exploitation, thermoregulation, and protection from ultraviolet light, microbes, and abrasio

284 mic differences in urogenital anatomy confer protection from UTI in males; however, as clinically obs

285 ematically the literature on "herd"/indirect protection from vaccinating children aged 6 months to 17

286 are required to better quantify the indirect protection from vaccinating children for different setti

287 Protection from vaccination was sustained after the firs

288 One such prechallenge correlate of protection from vaginal challenge has recently been iden

289 red for infection of neurons provides better protection from vaginal challenge with HSV-2 than that o

290 This novel mechanism contributes to protection from vasculopathy in transplanted organs trea

291 sion, deficiency of PCSK9 is associated with protection from venous thrombosis.

292 CRISPR-mediated adaptive immune systems for protection from viral infection, and viruses have evolve

293 V-5 mediates liver transduction and provides protection from virion neutralization in mice.

294 izing antibodies and conferred complete lung protection from virus challenge, with no ERD signs in th

295 ng activity, Th1 bias-inducing adjuvant, and protection from virus replication in the lower respirato

296 unity correlated with virologic response and protection from virus-related mortality.

297 Although T cells play a critical role in protection from viruses, bacteria, and tumors, they also

298 insecticidal activity and significant plant protection from WCR damage.

299 nsgenic corn plants expressing IPD072Aa show protection from WCR insect injury under field conditions

300 luate the role of SnTox1 in infection and in protection from wheat chitinases.