ライフサイエンスコーパス: protective

1 lockade of dectin 1 downstream signaling was protective.

2 sk, while emotional undereating (EUE) may be protective.

3 amage, and exogenous application of hBD2 was protective.

4 accine that elicits such antibodies would be protective.

5 cutaneous white adipose tissue (WAT) appears protective.

6 ous T cell-dependent humoral response can be protective.

7 disease (AD), ApoE3 is neutral, and ApoE2 is protective.

8 Thus, failure to establish long-term protective Ab titers against S. aureus was not a consequ

9 nfected hepatoma cells.IMPORTANCE Due to the protective ability of HCV-specific T cells and the hepat

10 te antigens, accelerating the development of protective acquired immunity, which would take many year

11 hosts, one can expect that the efficiency of protective action of CRISPR-Cas systems against differen

12 idence for the role of RvTs in mediating the protective actions of atorvastatin and pravastatin in re

13 ting enzyme in the RvT pathway, reversed the protective actions of these statins on both joint and sy

14 thways, discussing their role in the in vivo protective activity of anti-HIV-1 antibodies.

15 r plants in the nightshade family synthesize protective acylated sugars in the tip cells of glandular

16 ivation of disease pathology, overriding the protective adaptive immune response.

17 pathogenic information to generate tailored protective adaptive immune responses.

18 t studies have identified SseB as a modestly protective Ag in susceptible C57BL/6 mice, but the mecha

19 pastoris We found that recombinant I62-CFH (protective against age-related macular degeneration) and

20 zymatic disorder in humans and appears to be protective against falciparum severe malaria.

21 e in a range of cellular assays, were poorly protective against HIV-1 infection of mucosal tissues.

22 est that non-genotype 3 HCV infection may be protective against HS.

23 naturally occurring immunity to HSV-2 may be protective against infection with a second strain.

24 nduced antibodies to HIV that were partially protective against infection, as well as antibodies to H

25 The extent to which breastfeeding is protective against later-life obesity is controversial.

26 2 signaling reduces neuroinflammation and is protective against neurodegeneration in the setting of p

27 tration improves endothelial function and is protective against oscillatory shear stress-induced endo

28 ologic evidence that dietary fiber intake is protective against overweight and obesity; however, resu

29 accine that has been reported to be safe and protective against P falciparum controlled human malaria

30 of warning received showed evidence of being protective against symptoms of the three mental illnesse

31 nt evidence for the primary use of mTORis as protective agents against most other cancer types.

32 in total energy intake from LC n-3 PUFAs in protective-allele (C-allele) carriers, whereas the corre

33 Greenness associations were more protective among men than women (HR 0.880, 95% CI 0.868-

34 ene fatty acids are formed in vivo and exert protective and anti-inflammatory effects via reversible

35 rogramming in a bidirectional manner between protective and pathogenic effector states.

36 2 and varepsilon4 alleles of APOE harbouring protective and risk increasing effects, respectively, in

37 age-specific and long-lived pre-erythrocytic protective anti-malarial immunity, mediated primarily by

38 accine induced higher-magnitude, potentially protective anti-V1V2 IgG responses than in adult vaccine

39 haracterization of the epitope recognized by protective antibodies may facilitate design of peptidomi

40 plasma cells (PCs) that can rapidly secrete protective antibodies within days of vaccination.

41 ferent emm types, is immunogenic and elicits protective antibodies.

42 apies is hampered by the gap in knowledge of protective antibody epitopes on the HAstV capsid surface

43 une responses have the potential to maintain protective antibody levels for years due to the immunogl

44 PC that are recognized by these potentially protective antibody responses are only poorly defined.

45 e tolerance mechanisms and may contribute to protective anticancer immunity.

46 hem, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a crucial component of a

47 xpresses a variety of structurally conserved protective antigens that include cell surface polysaccha

48 Carriers of protective APP A673T variant had, on average, 28% lower

49 eta TCR but lacking CD4/CD8 coreceptors play protective as well as pathogenic roles.

50 IgE production plays a crucial role in protective as well as pathogenic type 2 immune responses

51 Here we report protective association of a functional polymorphism in t

52 ser risk of acute pancreatitis, and that the protective association was significant among cases of bo

53 Although the evidence shows a protective association with HIV, it was categorised as l

54 rvoir layer, a mucoadhesive film layer and a protective backing layer.

55 s (T1D), we found that CRIg(+) TRMs formed a protective barrier surrounding pancreatic islets.

56 array of mimetic relationships that provide protective (Batesian mimicry) and predatory (aggressive

57 Sun-protective behavior affects skin cancer prevention.

58 ut sun safety behavior, which would make sun protective behavior more likely, could be promoted and s

59 itivity from infections may discourage these protective behaviors, even at temperatures below critica

60 to environmental decoherence because of the protective beta-barrel structure that encapsulates the f

61 ifications may be made to eventually achieve protective bNAb responses.

62 s that recognize influenza A virus HA can be protective, but the mechanism is not completely understo

63 Spending time outdoors is protective, but the mechanism underlying this associatio

64 in G-protein signaling or simply serve as a protective cap for the activating "Stachel" sequence.

65 ng in vitro cold hypoxic injury improved the protective capacity of H2 S >1000-fold compared to simil

66 e overload, an increase in leptin levels has protective cardiac effects with respect to rescuing the

67 tuberculosis (TB) is that the attributes of protective CD4(+) T cell responses are still elusive for

68 were more likely to report never/rare use of protective clothing (adjusted prevalence ratio [aPR], 1.

69 This commentary uses the dynamic of identity-protective cognition to pose a friendly challenge to Jus

70 r antecedent hypoglycemia causes blunting of protective counterregulatory responses, known as hypogly

71 study, we report the development of a highly protective CSP-based P. vivax vaccine, a virus-like part

72 associated lymphoid tissue and aim to elicit protective CTL-mediated immunity.

73 iterpenoid and triterpenoid biosynthesis for protective cuticle and wax.

74 and 161.6 mumol L(-1) and deformation of the protective cuticle.

75 was characterized by increased production of protective cytokines IFN-gamma, TNF-alpha, and IL-12, as

76 esponses, we found persistent degradation of protective ECM structures called perineuronal nets (PNNs

77 to steroid treatment shows a trend toward a protective effect (odds ratio, 0.16; 95% CI, 0.0-1.3; P

78 diet-induced liver injury and abolished the protective effect against cholesterol lipotoxicity in So

79 tes by transgenic overexpression of sEH, the protective effect against CNV was lost.

80 There was no additional protective effect associated with taking the highest dos

81 ponses in children and may have a clinically protective effect at the population level.

82 This protective effect is restricted to the molecular interac

83 Demethylation of DNA abrogated the protective effect of AC whereas remethylation of AC DNA

84 is study adds to the limited evidence of the protective effect of adherence to a Mediterranean dietar

85 ar endothelial growth factor strengthens the protective effect of amniotic fluid stem cells in a rena

86 y active Nlrp3(A350V) mutation abolished the protective effect of aPC, demonstrating that Nlrp3 suppr

87 In this report, we investigated the retina-protective effect of chrysophanol, an active component o

88 Results showed a protective effect of EBOTAb given post-exposurally, with

89 This study assesses how the protective effect of education changes under IMF program

90 Notably, the protective effect of etifoxine was abolished in mice dep

91 atic review and meta-analysis quantified the protective effect of facemasks and respirators against r

92 Most of the immunologic assays confirmed a protective effect of H. pylori.

93 The protective effect of Hdac1 ablation was detected also in

94 ovide a mechanistic basis for the dominantly protective effect of HLA in autoimmune disease, whereby

95 observational studies provided evidence of a protective effect of masks (OR = 0.13; 95% CI: 0.03-0.62

96 terial from an untreated mouse abolished the protective effect of microbiota depletion upon renal I/R

97 We also show the marked protective effect of PD-L1 expression on HCV-infected he

98 quired to confirm and further characterize a protective effect of physical activity on the onset and/

99 Ifng (Sphk2(-/-)Ifng(-/-) mice) blocked the protective effect of SphK2 deficiency in fibrosis.

100 To assess whether the protective effect of statins on the risk of glaucoma var

101 pathway of CYP142A1, while CIU revealed the protective effect of the heme group on the structure of

102 The protective effect of TPO against the primary oxidation o

103 as 2 mo, suggesting that GRP78 could exert a protective effect on acinar cells under stress, as durin

104 Autophagy has a protective effect on acute liver injury.

105 A protective effect on increased suicidal risk was found f

106 ropose a mechanism by which Psb28 exerts its protective effect on the RC47 intermediate.

107 Statins have been suggested to have a protective effect on venous thromboembolism (which inclu

108 APOE epsilon2/epsilon3 genotype conferred a protective effect on women (OR, 0.51; 95% CI, 0.43-0.61)

109 The protective effect persisted after 12 months of avoiding

110 of T6SS effector proteins that mediate this protective effect remain poorly defined.

111 The protective effect was more pronounced for PB than LC-DG

112 Furthermore, this protective effect was suppressed when antioxidant defens

113 in the extract were identified to exert cyto-protective effect.

114 parum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD

115 Bacterial taxa with protective effects against development of CDI were ident

116 like macrophages in fibrotic liver exert the protective effects against lethal insults through confer

117 tivity in APP mice; and that SS31 may confer protective effects against mitochondrial and synaptic to

118 IL-27 exerts protective effects in autoimmune diseases like experimen

119 ies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflamma

120 ng the abrogation of AdipoR1 in vitro, these protective effects of adiponectin were abolished.

121 These findings indicated that the protective effects of BAY against Abeta-induced memory d

122 in-3 protein, plays an important role in the protective effects of calpain inhibition for the treatme

123 ated from CpG-treated mice recapitulated the protective effects of CpG when administered before aller

124 ese data provide a mechanistic basis for the protective effects of the antibody in vitro and in vivo,

125 Protective effects of UV-B radiation against nonmelanoma

126 ton, a 5-LOX inhibitor with VPC reversed the protective effects of VPC against neuroinflammation.

127 Studies suggest that NGB exerts protective effects to neuronal cells and is implicated i

128 BK seems to permit the protective effects triggered by cinaciguat, riociguat, a

129 at Ape1 is indispensable for GAPDH-dependent protective effects.

130 hich is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus s

131 V glycoproteins for their immunogenicity and protective efficacy in cotton rats and African green mon

132 ests that the bivalent HPV-16/18 vaccine has protective efficacy in men.

133 This trial compared the protective efficacy in older adults of a quadrivalent, r

134 ing whether there may, or may not, have been protective efficacy in the RV144 vaccine trial have impo

135 ompared in vitro and in vivo the potency and protective efficacy of 5C4 and the murine precursor of p

136 Protective efficacy of 63% (P = .03) and 88% (P = .002)

137 current study, we examined the long-lasting protective efficacy of chimeric VLPs (cVLPs) containing

138 To test this assumption, changes in the protective efficacy of the immune response to B. burgdor

139 Compared with alum, the protective efficacy of the pandemic H1N1 influenza (pH1N

140 ruses influenced HAI-specific antibodies and protective efficacy using a broadly protective vaccine c

141 bining R21 with TRAP-based viral vectors and protective efficacy was significantly enhanced.

142 Several of our antibodies showed protective efficacy when tested in a novel murine challe

143 Protective efficiency was found to be 76 +/- 6% and 85 +

144 Telomeres, the protective ends of linear chromosomes, shorten throughou

145 ograms macrophages and tubules to generate a protective environment, in which tissue health is preser

146 an immunogenicity breakthrough to conserved protective epitopes.

147 eptidomimetics to focus vaccine responses on protective epitopes.

148 moderate-to-high myopia, and none were using protective eyewear when they sustained the eye trauma.

149 analysis showed that LMWH was an independent protective factor against mortality and thromboembolic c

150 suggesting that low SES in Choco serves as a protective factor against T2D.

151 eports as to whether it is a contributory or protective factor.

152 of suicide in OCD and identify the risk and protective factors associated with suicidal behavior in

153 ially captures environmental risk factors or protective factors has direct implications for risk pred

154 exposure to tobacco smoke, and prematurity; protective factors include breastfeeding, pacifier use,

155 Protective factors included vigorous physical activity,

156 and having a comorbid anxiety disorder were protective factors.

157 n, notably a necrotic core and thinning of a protective fibrous cap that overlies the core.

158 instead have a "settler" phenotype, forming protective flocs and tending to remain in their current

159 lammatory (M1) macrophage activation and was protective for multiple CNS cell types, indicating its p

160 In filamentous fungi, the protective function of RNAi in the maintenance of genome

161 ty of the cells to perform another important protective function, namely absorption of stray light.

162 ated activities and contribute to the skin's protective function.

163 Pain serves vital protective functions.

164 cohols, whereas ortho-derivatives are better protective groups for carboxylic acids.

165 ocols have been developed to remove benzyl O-protective groups from oxyarene N-heterocycles at positi

166 led to a less-diverse microbiome and loss of protective gut commensal strains (of the family Lachnosp

167 f indoor dust is associated with adverse and protective health effects.

168 Protective high-affinity antibody responses depend on co

169 ncated or produced in CHO cells.IMPORTANCE A protective HIV-1 vaccine will likely include a recombina

170 ctor cells in vitro Among persons expressing protective HLA class I alleles, carriage of Nef codon 9

171 nfers a markedly increased disease risk, the protective HLA-DR1 allele is dominantly protective in tr

172 Cretotrichopsenius display the protective horseshoe-crab-shaped body form typical of ma

173 higher late energy intake was significantly protective (HR: 0.91, 95% CI: 0.83, 1.0).

174 00% (n=48/48) of vaccine recipients achieved protective hSBA titres equal to or greater than the lowe

175 Disease-protective IFN-gamma could be derived from any lymphocyt

176 importance of IL-17A in the development of a protective immune response against Giardia.

177 Tools that enable the rapid evaluation of protective immune responses are essential to vaccine dev

178 n-specific immunotherapy is the induction of protective immune responses in the absence of anaphylact

179 ines have been shown to provide better cross-protective immune responses than inactivated vaccines by

180 erior humoral immune responses and conferred protective immunity against a lethal challenge dose of h

181 nstrate that CD8(+) T cells are required for protective immunity against a naturally occurring murine

182 promising candidates to examine induction of protective immunity against heterologous pathogens.

183 CD4 TEMRA cells have been implicated in protective immunity against pathogens such as dengue vir

184 cination with the batA mutant strain elicits protective immunity against subsequent infection with wi

185 mechanism has likely evolved to both sustain protective immunity and avoid autoantibody production.

186 r and describe how macrophages change during protective immunity and inflammation.

187 -modified mRNA-LNP elicits rapid and durable protective immunity and therefore represents a new and p

188 ogens, we validate that the prime targets of protective immunity are conformational epitopes at the d

189 ll responses.IgE is an important mediator of protective immunity as well as allergic reaction, but ho

190 ne/threonine kinase Akt in the generation of protective immunity by CD8(+) T cells.

191 ion by Toxoplasma gondii triggers a lifelong protective immunity due to the persistence of parasitic

192 studies typically examined the biomarkers of protective immunity however the biomarkers of attenuatio

193 ported to be associated with vaccine-induced protective immunity in challenge studies involving nonhu

194 ng the high-avidity epitope SSIEFARL induced protective immunity irrespective of gene expression cont

195 juvant properties that improve SseB-mediated protective immunity provided by circulating memory.

196 sceptible C57BL/6 mice, but the mechanism of protective immunity remains undefined.

197 1 and Th17 cells have an established role in protective immunity to Bordetella pertussis, but this ev

198 her delineate mechanisms whereby HIV impairs protective immunity to M. tuberculosis, we evaluated the

199 l tumor-associated stroma (TAS) to configure protective immunity within the tumor microenvironment.

200 ovirus is an avirulent pathogen that elicits protective immunity, but we discovered that it can nonet

201 However, T cells are also critical in protective immunity, especially in immune-compromised pa

202 , indicating the generation of CT26-specific protective immunity.

203 phagocytosis (ADCP) activity, implicated in protective immunity.

204 inflammation while preserving and enhancing protective immunity.

205 eting distinct epitopes may be necessary for protective immunity.

206 inform ZIKV vaccine strategies for inducing protective immunity.

207 tabolism to persist in tissue and to mediate protective immunity.

208 and that antineuraminidase antibodies offer protective immunity.

209 dermal model of infection yet still elicited protective immunity.IMPORTANCE The vaccinia virus (VACV)

210 ed as wide-spectrum, stress response factors protective in amyloid disease models.

211 Bacterial cowshed isolates are allergy protective in mice; however, the underlying mechanisms a

212 Whether STN DBS can be protective in other models of synucleinopathy is unknown

213 tment with NKH-477, a compound discovered as protective in our previous studies on Krabbe disease, wh

214 infection in which antimicrobial immunity is protective in the vast majority of infected individuals

215 the protective HLA-DR1 allele is dominantly protective in trans with HLA-DR15 (ref.

216 SCFA are protective in various animal models of inflammatory dise

217 tivation and cytokine release, which mediate protective innate immune response.

218 Individuals expressing more protective isoform accumulate less brain beta-amyloid an

219 eexisting condition, even in the presence of protective laws in the United States.

220 The TiO2 protective layer on the PAN polymeric nanofibers was pre

221 ored to plasmonic nanostructures serves as a protective layer to preserve the biorecognition ability

222 ed C,H insertion reactions and consists of a protective layer, which shields the contacting solution

223 modest defects in the assembly of the spore protective layers that are exacerbated in the presence o

224 ring repeated malaria exposures would induce protective long-lived sterile immunity targeting pre-ery

225 eported inter-person contact with suboptimal protective mask usage.

226 In the latter case, the protective mechanism derives from FcRn binding to IgG in

227 Failure of this protective mechanism may contribute to diabetes in state

228 idence that the innate immune system employs protective mechanisms aimed at mitigating the risk of po

229 Starvation arouses evolved protective mechanisms including binge eating and increas

230 hat must rely mainly or exclusively on other protective mechanisms, although non-human primate (NHP)

231 Defining the role of beneficial allergy-protective members of the microbiota in the regulation o

232 hematologic and solid tumor cells) and their protective microenvironment.

233 Our studies suggest that mitochondrial protective miR-210 inhibition should be delayed until af

234 We observe that EMT silences protective mucosal interferon (IFN)-I and III production

235 ppropriate Vt is an essential part of a lung-protective MV strategy.

236 Protective NCD layers may prolong the lifetime of nuclea

237 ventional therapies are thought to reside in protective niches.

238 ve sensory input, the neural signals trigger protective (nocifensive) behaviors, and the sensory stim

239 sess whether neutrophils exert predominantly protective or deleterious effects on loss of B cell self

240 whether the high level of LCN2 in the CNS is protective or deleterious, we challenged Lcn2(-/-) mice

241 matory and infectious diseases, and may have protective or pathogenic effects, depending on the tissu

242 is not yet clear whether NK cells behave as protective or proatherogenic effectors.

243 ion of ceramic result in much slower loss of protective oxide layers formed during ablation than othe

244 Thus, paternal drug exposure induces a protective phenotype in offspring by enhancing metabolic

245 The protective phenotype involved the clustering of macropha

246 hin during AirR overproduction abolished the protective phenotype of increased staphyloxanthin produc

247 central adiposity, rather than reflecting a protective physiologic effect of higher body-fat content

248 Bacteria have the natural ability to install protective postsynthetic modifications onto its bacteria

249 , such as anti-oxidant, antiviral, and liver-protective properties.

250 uce adipose tissue (fat) to produce the vaso-protective protein adiponectin.

251 We show that the redox-protective protein thioredoxin-1 (TRX1) increases with p

252 ants and compare the prevalence of 3 malaria-protective red blood cell polymorphisms in BWF cases vs

253 r human cell models, TRAP1 overexpression is protective, rescuing HTRA2 and PINK1-associated mitochon

254 of both F and G proteins of AMPV-C induces a protective response against the AMPV-C disease.

255 hagocytic activity and representative of the protective response against type III GBS polysaccharide.

256 of gene expression to nevertheless initiate protective responses remains unclear.

257 s to the immune system to block or misdirect protective responses.

258 indicate that endothelial EPAS1 has a global protective role during glomerular hypertensive injuries

259 model of genital infection, we demonstrate a protective role for both Chlamydia-specific immunoglobul

260 nducible NO synthase, suggesting a potential protective role for these IFN-gamma-producing cells.

261 ed acute GVHD, consistent with an additional protective role for this cytokine independent of effects

262 sion, our data indicate that IL-22BP plays a protective role in acute liver damage, via controlling I

263 Recent data also suggest a protective role in colitis.

264 t time that RAGE inhibition has an essential protective role in COPD.

265 logical evidence that Vitamin D might play a protective role in HL.

266 Thus, CD14 plays a protective role in IBD development by enhancing intestin

267 st that epithelial expression of NUPR1 has a protective role in response to injury after renal transp

268 changes in the gut microbiota that played a protective role in the development of cardiovascular dis

269 The potential protective role of B cells in controlling cCMV-related d

270 se progression and provides insight into the protective role of C1q in early atherosclerosis.

271 Our findings highlight the protective role of CH25H during ZIKV infection and the p

272 miR-218-5p mimic or inhibitor demonstrated a protective role of miR-218-5p in cigarette smoke-induced

273 thus elucidates a pathogenic, as opposed to protective, role for IL-17A during Gram-positive bacteri

274 In contrast, both pathogenic and protective roles have been associated with T cell-depend

275 ds and proteins, which may in turn alter the protective skin barrier function.

276 d CPT reactivity significantly and increased protective specific antibodies.

277 somal dynamics, promotes normal induction of protective stress genes, and rescues stress sensitivity

278 The protective T allele at rs7178051 was also associated wit

279 or shielding during puncture events through protective tissue.

280 the unique characteristics of the skin as a protective tissue.

281 Additionally, protective TLR ligands induce sustained augmentation of

282 ith sensitization to food fails to stimulate protective tolerogenic pathways, leading to the developm

283 s, but the formation mechanism of their wear protective tribofilms is not yet well understood.

284 ction against the vaccine-specific and cross-protective types in unvaccinated individuals born in 199

285 dies and protective efficacy using a broadly protective vaccine candidate.

286 le for vaccine-induced CD4(+) cells in cross-protective vaccine efficacy.

287 The protective vaccine elicited unconventional CD8 T cell re

288 nt combination contributes to a more broadly protective vaccine while demonstrating an attractive saf

289 e responses, vDeltaK1L vaccination induced a protective VACV-specific CD8(+) T cell response and prot

290 and recapitulated the mechanism of the CARD9 protective variant using small molecules.

291 tial neuromuscular blockade facilitates lung-protective ventilation during partial ventilatory suppor

292 l on clinical outcomes and adherence to lung-protective ventilation in patients with acute respirator

293 Lung-protective ventilation is used to prevent further lung i

294 iologists physical status 3, despite current protective ventilation practices.

295 by extending the therapeutic effects of lung protective ventilation.

296 f Science, Bardina et al. (2017) explore the protective versus pathogenic roles of DENV-immune antibo

297 laining why DLK inhibition is only partially protective, we identify leucine zipper kinase (LZK) as c

298 gh often ineffective in neonates they can be protective when adequately stimulated.

299 PIV5-RSV F was equally protective when administered intranasally or subcutaneou

300 ed that melanocortin obesity syndrome may be protective with respect to obesity-associated cardiovasc