ライフサイエンスコーパス: protective role

1 lack of MDRO acquisition, consistent with a protective role.

2 nduced PD-like phenotypes and plays a neural protective role.

3 that the granuloma can also serve a bacteria-protective role.

4 of the oil, whereas vitamin E content had a protective role.

5 Hyd groups were able to partially mimic this protective role.

6 ther hemerythrin (HerB; Cj1224) also plays a protective role.

7 ychloroquine and low-dose aspirin may have a protective role.

8 s, suggesting that this modification plays a protective role.

9 f the diet, such as vitamin K1, could play a protective role.

10 eperfusion damage where CB2 receptors play a protective role.

11 ing Th1 cells, and regulatory T cells play a protective role.

12 ude of ADCC in HIV infection, abrogating its protective role.

13 g results, demonstrating both pathogenic and protective roles.

14 hich functions were required for its various protective roles.

15 of RhoA stimulation, and this pathway has a protective role against cell death.

16 The spleen plays an integral protective role against encapsulated bacterial infection

17 viscoelasticity of ocular tissues may have a protective role against glaucoma.

18 ressive nephron loss or whether APA exerts a protective role against glomerular damage and during Ang

19 17) is an inflammatory cytokine that plays a protective role against intracellular parasites.

20 ulus fibrosus cells, however, demonstrated a protective role against key inflammatory (IL-1beta and T

21 gest that epithelial mTORC1 activity plays a protective role against lung injury, and its inhibition

22 i-PhtD but not anti-PcpA antibodies showed a protective role against mouse NP colonization.

23 e adiponectin-T-cadherin association plays a protective role against neointimal and atherosclerotic p

24 to the mechanisms involved and the potential protective role against osteoporosis.

25 phic lateral sclerosis, respectively, play a protective role against oxidative stress.

26 by ROS production and that autophagy plays a protective role against PA-induced podocyte apoptosis.

27 cids are of particular interest due to their protective role against several human diseases.

28 polymerase eta (Pol eta) plays an essential protective role against skin cancer caused by cyclobutan

29 3 ubiquitin-protein ligase 1 (HACE1) plays a protective role against stress-induced tumorigenesis in

30 f the adult human brain, where it may have a protective role against tau pathology.

31 Resveratrol may play a protective role against the frailty syndrome (FS) becaus

32 icipate in hemozoin formation, may suggest a protective role against the heme released from unprocess

33 Green space and vegetation may play a protective role against urban violence.

34 (TEC) expression of this protein may have a protective role and attenuate overt allograft rejection.

35 . aureus infection, IL-10 plays an important protective role and is required to prevent bacterial dis

36 results suggest that YAP activation exerts a protective role and represents a pharmacological target

37 Consistent with a redox-protective role, approximately half of the dioxygen-usin

38 c fluorimetry was used for examining the HMP protective role at the LA binding site.

39 s and antibodies have a variety of potential protective roles at each stage of Mtb infection and post

40 ardioprotection, which suggested a potential protective role beyond the cardiomyocyte.

41 e RV144 vaccine, suggesting that they play a protective role, but a mechanism providing such protecti

42 uroblastoma cells, and that CRLF1 serves its protective role by a cell autonomous mechanism that is i

43 n, Langerhans cells of genital mucosa play a protective role by internalizing virions in Birbeck Gran

44 e receptors in aged B-MSCs compromises their protective role by perturbing the potential of B-MSCs to

45 kade or antiangiogenic therapy, uncovering a protective role by stroma in this cancer.

46 Host defense peptides play an important host-protective role by their microcidal action, immunomodula

47 tively, these results demonstrate SP-D plays protective roles by inhibiting apoptosis and modulating

48 ly, our results demonstrate Cl-amidine plays protective roles by significantly decreasing BM and thym

49 eases, but there are examples where it has a protective role; deciphering the mechanisms underlying t

50 tion by a negative feedback loop and plays a protective role during atherosclerosis-associated foam c

51 indicate that endothelial EPAS1 has a global protective role during glomerular hypertensive injuries

52 e previous studies showed that IL-17 plays a protective role during infection with mucosal pathogens,

53 iduals to inflammatory disorders have a host-protective role during infection with Mycobacterium tube

54 s, the microbiota plays a critical and often protective role during infections, both by modulating im

55 animals, we determined that microglia play a protective role during lesioning, whereby neuronal loss

56 Platelets play a protective role during pneumococcal pneumonia independen

57 hat the TWEAK/Fn14 signaling complex plays a protective role during the acute stage of intestinal inf

58 erall, these findings show that Fn14 plays a protective role during the acute stages of intestinal in

59 enetically attenuated rodent parasite play a protective role during the preerythrocytic stages of mal

60 nscription factors IRF-3 and IRF-7, have key protective roles during OROV infection.

61 that alveolar macrophages may play a limited protective role early after exposure to aerosolized ANDV

62 = .028), whereas a strong independent renal-protective role emerged for ascorbic acid (0.27; .12-.57

63 ce similar to wild-type mice in support of a protective role for A2A signaling.

64 Collectively, these data demonstrate a novel protective role for ApoA-I in colitis and CAC and unrave

65 model of genital infection, we demonstrate a protective role for both Chlamydia-specific immunoglobul

66 dentify a rich source of Bregs and suggest a protective role for CB-derived Bregs against cGVHD devel

67 ted an human lymphocyte antigen (HLA)-linked protective role for CD8(+) T cells.

68 cells to heat induced apoptosis indicating a protective role for CDK5 in inhibiting heat-induced apop

69 0.54 (95% CI, 0.31-0.96)], consistent with a protective role for CXCL5 in coronary atherosclerosis.

70 blocking the CA-CypA interaction suggests a protective role for CypA against high concentrations of

71 vides evidence for a previously unrecognized protective role for EGF in AD and a new role for EGF in

72 genetically or pharmacologically confirms a protective role for EGFR signaling in AD.

73 This study establishes a new protective role for endogenous cardiac myocyte P2X4R in

74 mune setting relative to naive, as well as a protective role for epitope-specific CD8(+) T cells agai

75 and population-based studies has supported a protective role for flavonoids in relation to risk of ce

76 reduced BTL and thus demonstrating a crucial protective role for FXR in the gut-liver axis.

77 Our data do not support a graft-protective role for HLA-G after LTX, but show that end-s

78 culosis (Mtb) infection, a discriminatory or protective role for humoral immunity remains unclear.

79 These results indicate a protective role for IFN-beta in neuronal homeostasis and

80 Taken together the data suggest a protective role for IFN-gamma in EAE by regulating the r

81 Thus, our study supports a protective role for IFN-gamma in the demyelination of br

82 7A monoclonal antibody, suggesting a disease-protective role for IL-17A in the cecum.

83 s study describes a previously unappreciated protective role for IL-17RA signaling in regulation of t

84 Animal models of infection have identified a protective role for interleukin-18 (IL-18).

85 Together, our results reveal a protective role for IRF5 in lupus-associated atheroscler

86 milarly treated wild-type mice, suggesting a protective role for mast cells in exposure to nominal en

87 mentary animal studies implicating a pivotal protective role for maternal Tregs are summarized.

88 ectively, these results establish a dominant protective role for MAVS, IRF-3 and IRF-7, and IFNAR in

89 xperimental and epidemiologic data support a protective role for melatonin in breast cancer etiology,

90 These results indicate a protective role for miR-124 through the inhibition of SM

91 These results suggest a protective role for mucosal HIV-1 envelope-specific IgA

92 While a protective role for neutralizing antibody responses is w

93 fibrosis after muscle overload, indicating a protective role for normal stem cell activity in reducin

94 These data provide the first evidence of a protective role for opioids during infection and suggest

95 nd carcinogenesis, and they identify a novel protective role for p21 against the generation of DNA da

96 our knowledge, this is the first report of a protective role for PAT in skin carcinogenesis.

97 seemingly contradictory studies indicating a protective role for platelets in malaria infection by di

98 tion during female oogenesis, highlighting a protective role for Polo kinase and the pericentriolar m

99 These findings suggest a protective role for SP-A in limiting MMF-stimulated muci

100 njointly, these findings indicate a critical protective role for the amphibian type I IFN response du

101 We demonstrate a protective role for the endocytic protein p18 in endothe

102 Consistent with a protective role for the microbiome, treatment of pDC-dep

103 idence has suggested both a pathogenic and a protective role for the proinflammatory cytokine IFN-gam

104 aken together, our findings indicate a novel protective role for the TL1A/DR3 axis in the regulation

105 nducible NO synthase, suggesting a potential protective role for these IFN-gamma-producing cells.

106 ed acute GVHD, consistent with an additional protective role for this cytokine independent of effects

107 virus attachment to host cells and support a protective role for transmembrane mucins under physiolog

108 tissue-resident MZ and RP macrophages and a protective role for two distinct splenic neutrophil popu

109 f EGF on keratinocytes may contribute to the protective roles for EGFR in AD pathogenesis.

110 thus elucidates a pathogenic, as opposed to protective, role for IL-17A during Gram-positive bacteri

111 ndings demonstrate a pathogenic, rather than protective, role for MAIT cells during infection.

112 f atopy remains unclear, although a possible protective role has been hypothesized.

113 In contrast, both pathogenic and protective roles have been associated with T cell-depend

114 sion, our data indicate that IL-22BP plays a protective role in acute liver damage, via controlling I

115 IgG4 plays a protective role in allergy by acting as a blocking antib

116 pDCs may play a protective role in asthma and are key players in the inn

117 OGG1 plays a protective role in atherogenesis by preventing excessive

118 rotein E (apoE) secretion plays an important protective role in atherosclerosis.

119 Our study demonstrates that NLRP12 has a protective role in bone via suppression of alternative N

120 New work suggests that fucose can have a protective role in both gut-centered and systemic infect

121 t required for axon degeneration and serve a protective role in C. elegans axons.

122 AS-1, the TIR/BB loop mimetic, plays a protective role in cardiac ischemia/reperfusion (I/R) bu

123 e effects of DPP4 inhibition seem to exert a protective role in cardiovascular disease at least in pr

124 irrhosis (n = 216), suggesting it may have a protective role in cirrhosis progression.These findings

125 We found that AHR plays a protective role in colitis-associated colorectal tumorig

126 Recent data also suggest a protective role in colitis.

127 We hypothesized that IL-6 plays a protective role in conditions of heat stroke.

128 t time that RAGE inhibition has an essential protective role in COPD.

129 T cells have a pivotal protective role in defense against infection and cancer

130 CES2 plays a protective role in development of NAFLD.

131 produced in response to injury and serves a protective role in early stages of injury and is detrime

132 r NLRs that activate immunity, NLRX1 plays a protective role in experimental autoimmune encephalomyel

133 n genders, we proposed that estrogens play a protective role in females and showed that these hormone

134 Wellbeing might also have a protective role in health maintenance.

135 CR5 endocytosis, suggesting that they play a protective role in HIV infection.

136 logical evidence that Vitamin D might play a protective role in HL.

137 we demonstrated that IFN-lambda exhibited a protective role in hMPV infection in vitro and in an exp

138 II interferons (IFN-lambdas) play a critical protective role in hMPV infection.

139 show that PBA has a previously undiscovered protective role in host mucosal defense during infection

140 Thus, CD14 plays a protective role in IBD development by enhancing intestin

141 Lcn2 exerts mostly a protective role in infectious and inflammatory bowel dis

142 pyrin domain containing 12 (NLRP12) plays a protective role in intestinal inflammation and carcinoge

143 ivity in the coronary circulation, and has a protective role in ischemia reperfusion.

144 Furthermore, in contrast to its protective role in limiting CNS autoimmunity and prevent

145 sults suggest that gammadelta T cells play a protective role in limiting the CHIKV-induced inflammato

146 These results indicate that SOCS3 has a protective role in LPS-induced ALI by suppressing C/EBPd

147 ependent proteasome pathways, and this had a protective role in LPS-induced septic shock.

148 x comprising the main source of ROS, plays a protective role in many ocular conditions by inhibiting

149 demonstrating that CHCHD10 normally exerts a protective role in mitochondrial and synaptic integrity

150 These findings suggest that CIB1 plays a protective role in MPTP/MPP(+)-induced neurotoxicity by

151 Based on our results, PDGF-BB may play a protective role in muscular dystrophies by enhancing mus

152 ich sensitize to death, E2F4 plays a crucial protective role in neuronal death evoked by DNA damage,

153 er, we propose a model by which E2F4 plays a protective role in neurons from ischemic insult by formi

154 steroid hormones are hypothesized to play a protective role in pancreatic cancer risk.

155 hypothesis that serum DBP or 25(OH)D plays a protective role in pancreatic cancer.

156 e a critical observation that H2S also has a protective role in paramyxovirus infection by modulating

157 at exclusive breastfeeding may have a stress-protective role in postpartum depression; however, less

158 We also demonstrate that CYGB has a protective role in proliferating keratinocytes grown und

159 channel has recently been proposed to play a protective role in prostate cancer by impairing cell mot

160 CR3 and its ligands are recognized to play a protective role in pulmonary fibrosis.

161 In conclusion, dectin-1 exerts an important protective role in pulmonary paracoccidioidomycosis by c

162 adenosine by nonhematopoietic cells plays a protective role in RA and suggests that strategies able

163 These results indicate that 20-HETE has a protective role in renal IR injury by maintaining medull

164 icate that lung macrophages serve a critical protective role in respiratory F. tularensis LVS infecti

165 st that epithelial expression of NUPR1 has a protective role in response to injury after renal transp

166 regulated in the depressed brain and plays a protective role in rodent models of affective disorders.

167 parents, particularly mothers, plays a small protective role in safer sex behavior among adolescents;

168 ar whether SUMOylation plays a pathogenic or protective role in SBMA.

169 ceptor BI (SR-BI or Scarb1) plays a critical protective role in sepsis.

170 ed with increased mRNA expression may play a protective role in the bone morphogenetic protein recept

171 -coding RNA that has been found to exhibit a protective role in the cellular models of Parkinson dise

172 he Sigma-1 receptor (S1R) is known to play a protective role in the central nervous system including

173 of Alzheimer's disease, and seems to play a protective role in the clinical progression of the disea

174 early-life exposure to H. pylori may play a protective role in the development of allergy.

175 dermal barrier function and have a potential protective role in the development of atopic dermatitis-

176 changes in the gut microbiota that played a protective role in the development of cardiovascular dis

177 secretory capacity that allowed it to play a protective role in the interstitial space.

178 protein chitinase 3-like-1 (CHI3L1) plays a protective role in the lung by ameliorating cell death a

179 roglial cells play a previously unrecognized protective role in the maintenance of BBB integrity foll

180 meostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart

181 HIFs play a protective role in the pathophysiology of myocardial isc

182 In conclusion, Gal-3 plays a protective role in the pathways that lead to the inflamm

183 pressing sites in AMI, and histamine plays a protective role in the process of AMI through inhibition

184 we demonstrate that the Ron receptor plays a protective role in the progression of diet-induced obesi

185 idence that the transporter also plays a key protective role in the regulation of cellular Cu via reg

186 lls (ILC2s) are a subset of ILCs that play a protective role in the response to helminth infection, b

187 fully support embryogenesis by maintaining a protective role in TNFalpha-induced apoptosis.

188 gh the NLRC4 inflammasome is known to have a protective role in tumorigenesis, there is an increased

189 Thus, androgens play a crucial protective role in type 2 airway inflammation by negativ

190 Shock Protein 70 (Hsp70) plays an important protective role in various neurodegenerative disorders o

191 Macrophages have protective roles in immunity to pathogens, tissue develo

192 ur study suggests that Malat1 plays critical protective roles in ischemic stroke.SIGNIFICANCE STATEME

193 Platelets may also have protective roles in killing microbes, such as bacteria.

194 Fatty acids play important functional and protective roles in living systems.

195 pid emulsifying protein linked to a range of protective roles in obesity, diabetes, and cardiovascula

196 e a novel mechanism by which n-3 PUFAs exert protective roles in reducing Abeta accumulation via medi

197 Whereas these cytokines have protective roles in response to mucosal damage or infect

198 Finally, SIRT1 plays protective roles in several neurodegenerative diseases i

199 terleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut mucosa is controversial and

200 ndin (PG) E2 is a bioactive lipid that plays protective roles in the lung, particularly during allerg

201 ntly recruited to the oral cavity, and their protective role is highlighted in cases where their numb

202 g evidence suggests that in addition to this protective role, Leishmania mitochondrial SOD may also i

203 We define such a protective role linked to DNA damage from oxidative stre

204 In this context, a protective role may be played by group III metabotropic

205 Experimental evidence supports a protective role of 25-hydroxyvitamin D [25(OH)D] in brea

206 in this study, the mechanism underlying the protective role of 6-MP in endothelial cell activation i

207 The protective role of a small tidal volume (VT) has been es

208 These data argue against a protective role of accumbal indirect pathway D2Rs in alc

209 The study objective was to investigate the protective role of activating transcription factor 4 (AT

210 A protective role of ApoE and ApoE-mimetic peptide (ApoE(1

211 the evidence for an important cardiovascular protective role of apolipoprotein C-III deficiency.

212 Together, this study demonstrates a protective role of Aptx in vivo and suggests that its lo

213 These findings unravel a novel protective role of ATGL against hepatic inflammation whi

214 The protective role of B cells and humoral immune responses

215 The potential protective role of B cells in controlling cCMV-related d

216 dicate that Cdk5 is required to maintain the protective role of basal autophagy in the initial respon

217 y we report that ibrutinib reverses the cyto-protective role of BMSC on FLT3-ITD AML survival.

218 The protective role of breast-feeding demonstrates the impor

219 There is conflicting evidence on the protective role of breastfeeding in relation to allergic

220 nts for memory CD8 T-cell activation and the protective role of bystander responses.

221 The study also reveals a unique protective role of c-Rel in autoimmune diabetes, which i

222 se progression and provides insight into the protective role of C1q in early atherosclerosis.

223 There was no evidence supporting a protective role of catechins in the development of HCC.

224 metabolism and inflammation, corroborating a protective role of CD40 on T cells in the metabolic synd

225 Consequently, the protective role of cell-mediated immunity in the control

226 Our findings highlight the protective role of CH25H during ZIKV infection and the p

227 Much experimental evidence supports a protective role of dietary polyphenols against chronic d

228 between inflammation and morphogenesis, the protective role of enterocyte sloughing in enteric ische

229 aken together, these findings demonstrated a protective role of FST in SiO2 NP-induced oxidative stre

230 These results underscore the protective role of FtH and reveal the critical role of p

231 Here, we investigated the protective role of FXR against kidney damage induced by

232 Together, the protective role of GAPDH in retinal neurovascular degene

233 ts into the immune mechanisms underlying the protective role of GBV-C in HIV-infected patients.

234 The protective role of hemeoxygenase-1 (HO-1) in various inf

235 wellbeing and survival is consistent with a protective role of high wellbeing, but alternative expla

236 These studies establish that the protective role of Hsp31 against cellular stress is achi

237 tivity of ATP synthase, which may render the protective role of IF1 in ischemic hearts.

238 However, the mechanisms underlying the protective role of IFN-gamma in EAE have not been fully

239 endent atheroprotection, thus highlighting a protective role of IL-10(+) regulatory B cells in this s

240 To elucidate the protective role of IL-1RA, this study aimed to identify

241 A possible protective role of increased D2R levels in the striatum

242 re was no evidence of any trend supporting a protective role of L-ascorbic acid.

243 e in the aralar hemizygous mice prevents the protective role of L-lactate on glutamate excitotoxiciy

244 e utilization by neurons, which prevents the protective role of lactate on excitotoxicity, but not gl

245 ective vaccines, we have previously reported protective role of live attenuated centrin gene-deleted

246 In this study, we investigated the protective role of MD-2s in LPS-induced acute lung injur

247 s provide unambiguous evidence for a general protective role of microglia in prion pathogenesis.

248 Our results demonstrate protective role of Mincle in host defense against K. pne

249 erapeutic role in vivo, we now demonstrate a protective role of miR-143 in experimental pulmonary hyp

250 miR-218-5p mimic or inhibitor demonstrated a protective role of miR-218-5p in cigarette smoke-induced

251 TLV-1 infection, we investigated a potential protective role of miR-28-3p against de novo HTLV-1 infe

252 Ova-allergen challenge further confirmed the protective role of MNs-CIT.

253 Overall, the protective role of MTs in neurodegenerative processes is

254 Collectively, these findings support a protective role of Nur77 in OVA-induced airway inflammat

255 Moreover, given the protective role of Nurr1, this study also investigated h

256 ssion of AD and summarize data regarding the protective role of O-GlcNAc in AD models.

257 n increased circulating IL-1Ra, suggesting a protective role of PDE4B inactivation in vivo.

258 Our findings suggest that the protective role of Perforin-2 against listeriosis is bas

259 e smoke-induced emphysema identified a novel protective role of pulmonary mTORC1 signaling.

260 we investigated the mechanism underlying the protective role of RdCVF in RP.

261 age than resident cells, consistent with the protective role of recruited macrophages.

262 Beyond LS, they also highlight a protective role of SHP2 global LS-mimicking modulation t

263 ional epistatic relationship to Parkin and a protective role of SLP-2 in neurons.

264 endothelial dysfunction, suggesting a local protective role of Sphk1 in the endothelium.

265 The findings provide novel evidence for a protective role of SSRIs on some deleterious reproductiv

266 Finally, we tested the protective role of SUMOylation-mediated autophagy by exp

267 nflammatory monocytes, thus highlighting the protective role of TgIST against IFN-gamma-mediated kill

268 This study demonstrates a protective role of the ISG Ifit2 in encephalitis induced

269 Here, we review the genome-protective role of the mitotic DNA damage response (DDR)

270 absorption across Caco-2 cells and (ii) the protective role of the oil bioaccessible fraction (BF) a

271 findings provide evidence for the potential protective role of the reactive immune system in colorec

272 ients and individuals, suggesting a possible protective role of this SNP against CVD.

273 se was dramatically reduced, underlining the protective role of this unique subpopulation of innate g

274 Here we have investigated the protective role of this variant and its interaction with

275 This protective role of tyrosines is likely an evolutionary a

276 Our findings lend support for a protective role of VAPB in neuromuscular health.

277 doptive cell-transfer strategy to define the protective role of Vgamma2Vdelta2 T cells in a primate t

278 However, the in vivo mechano-protective roles of caveolae have only begun to be explo

279 nisms in perturbed communities, however, the protective roles of commensals are largely under recogni

280 owever, the mechanisms underlying the tissue-protective roles of IL-33 or ILC2s at surfaces such as t

281 g that glucose hypometabolism may impair the protective roles of O-GlcNAc within neurons and enable n

282 The protective roles of specific ISGs against the mouse hepa

283 interest surrounding the potentially cancer-protective roles of vitamin D, additional studies in dif

284 antitumor brain microenvironment with a key protective role played by the neurotrophin brain-derived

285 Thus, reactive astrocytes play a protective role, preserving visual function.

286 tokine interleukin-22, which usually plays a protective role, promotes pathogen colonization by suppr

287 in graft-versus-host disease (GVHD), however protective roles remain unclear.

288 ly, two human isoenzymes that play a special protective role, safeguarding DNA from DNDGIC, display a

289 uring red blood cell stages, indicative of a protective role seen in other organisms.

290 ntifying scenarios where the UPR(mt) plays a protective role, such as during bacterial infection, hem

291 R-responsive proteins, highlighting critical protective roles that CRTC1 selectively plays against NA

292 These findings highlight physiological protective roles that MafB may play against atherosclero

293 on on the T(SCM) compartment, as well as any protective role these cells may have in disease progress

294 Whilst we did not examine any protective role to re-challenge, it illustrates the diff

295 nthocyanins and ellagitannins, which exert a protective role towards degenerative diseases.

296 atopoietic cells during acute injury and the protective role upon its modulation offers potential for

297 This protective role was observed in conventional and germ-fr

298 itively with insulin secretion, suggesting a protective role, whereas TMEM132C was upregulated in hyp

299 ically relevant fatty acid, which may have a protective role with respect to the generation of beta-s

300 In periodontitis, Tregs play a protective role, with their natural recruitment being re