ライフサイエンスコーパス: retinal

1 Optic nerve and retinal abnormalities were the most frequent findings.

2 ction, pigment regeneration with this locked retinal analogue requires delineation also in cone cells

3 Models of retinal and choroidal angiogenesis, including oxygen-ind

4 these results suggest that VEGF protects the retinal and glomerular microvasculature, not only throug

5 ollow-up of many ocular diseases, especially retinal and neuro-ophthalmologic pathologic conditions.

6 Outer retinal and renal glomerular functions rely on specializ

7 cles were "gulped" in conjunctival, corneal, retinal, and scleral cells, similar to the behavior obse

8 ng and endothelial cell proliferation during retinal angiogenesis.

9 ger choroidal neovascularization (CNV) area, retinal angiomatous proliferation (RAP) lesion, GA in th

10 o contribute significantly to enhancement of retinal antioxidant defense system and preservation of h

11 SA severity is independently associated with retinal arteriolar narrowing and attenuated vascular pul

12 To study the incidence and risk factors for retinal artery occlusion (RAO) in cardiac surgery.

13 Retinal artery occlusion was identified by International

14 Vertebrate rhodopsin (Rh) contains 11-cis-retinal as a chromophore to convert light energy into vi

15 covalently tethered inverse agonist (11-cis-retinal) as the native ligand.

16 s, including visual pigment regeneration and retinal attachment to the RPE.

17 athway play a key role in spontaneous lizard retinal axon regeneration in the presence of Nogo-A.

18 he spatiotemporal dynamics of RNA and LPS in retinal axons during arborization in vivo.

19 y proposes a new interpretation of the outer retinal bands that leads to a more accurate interpretati

20 Here, by studying functional blood-retinal barrier (BRB) formation in mice, we found that i

21 ally contribute to the inner vs. outer blood-retinal barrier function.

22 relatively impermeable blood-brain and inner retinal barriers) that regulates tissue-fluid homeostasi

23 esults confirm that quantum coherence of the retinal-based protein system, even in a living neuron, c

24 t ablates inner retinal neurons, regenerated retinal bipolar neurons (BPs), although reduced in numbe

25 Pathological proliferation of retinal blood vessels commonly causes vision impairment

26 n vivo, GSK101 increased the permeability of retinal blood vessels in wild type but not in TRPV4 knoc

27 Retinal break associated with induction of posterior vit

28 ction with further possible formation of the retinal breaks.

29 +) homeostasis and barrier function in human retinal capillaries and suggest that TRPV4 may different

30 groups: mean (SD) vessel density of the deep retinal capillary plexus was 54.4% (4.7%) in the amblyop

31 e retina, and which conjointly identify this retinal cell population in its entirety when using antib

32 Retinal thickness was measured, retinal cell types were labeled by immunohistochemistry

33 differentiation and maintenance of specific retinal cell types.

34 (RGB) cones in the retina, but not in other retinal cell types.

35 ination and early differentiation of various retinal cell types.

36 w that vasopressin is also expressed in many retinal cells that project to the SCN.

37 ages of different ocular lineages, including retinal cells, lens cells, and ocular-surface ectoderm.

38 S1, regulates ERK signaling and apoptosis in retinal cells.

39 safety, but exploratory data including BCVA, retinal center point thickness, and the number of ranibi

40 Peripheral retinal changes are more prevalent in eyes with AMD than

41 c mouse models with deficient or spontaneous retinal/choroidal neovascularization, as well as models

42 , regenerated instead with a six-carbon-ring retinal chromophore featuring a C(11)=C(12) double bond

43 cal properties of light interacting with the retinal chromophore has remained largely unexplored.

44 hromophore exchange rate of the bound 11-cis-retinal chromophore with free 9-cis-retinal from Rho in

45 a C13=C14, C15=N double-isomerization of the retinal chromophore, whereas the intracircular photoconv

46 uncontrolled, dose-escalation study at 5 US retinal clinics between November 2012 and March 2015 (Re

47 lopathy can develop neovascular membranes as retinal complications of pigment epithelial detachments.

48 Retinal cone density, estimated RGC density, and cone-to

49 P90 to facilitate the stable assembly of the retinal cyclic GMP (cGMP) phosphodiesterase (PDE6) holoe

50 ll-deficient mice developed profound RPE and retinal damage at doses that caused minimal effects in w

51 retina which may contribute to ameliorating retinal damage induced by HFD.

52 tion as assessed using motor performance and retinal degeneration assays respectively.

53 lar cause of autosomal recessive early onset retinal degeneration in a consanguineous pedigree.

54 Although PR1 slows the progression of retinal degeneration in models of RP in vitro, in vivo a

55 cause rhodopsin mislocalisation and eventual retinal degeneration in XLRP.Mutations in the Retinitis

56 al and morphological features of MNU-induced retinal degeneration using scotopic electroretinography

57 The central retinal degeneration was similar to that of cblC deficie

58 es FTLD-related behavioral abnormalities and retinal degeneration without improving lipofuscin, C1q,

59 Stargardt disease is a juvenile onset retinal degeneration, associated with elevated levels of

60 anifestations, including reduced vision with retinal degeneration, the underlying mechanism of which

61 reby restoring vision in patients blinded by retinal degeneration.

62 r genetic findings in nonsyndromic inherited retinal degenerations associated with CLN3 mutations.

63 therapy shows promise for treating inherited retinal degenerations; however, relevant animal models a

64 tages of RP is very similar to that of other retinal degenerative diseases such as age-related macula

65 to understanding the cause of rhegmatogenous retinal detachment and vitreoretinal interface disorders

66 Retinal detachment associated with basketball-related in

67 on over the first month following iatrogenic retinal detachment for the delivery of adeno-associated

68 erior uveitis associated with macular serous retinal detachment related to anti-PD-1 treatment, and t

69 ing vitrectomy surgery with silicone oil for retinal detachment with established PVR (Grade C) were r

70 the first occurrence of vitreous hemorrhage, retinal detachment, anterior segment neovascularization,

71 plications including vitreous hemorrhage and retinal detachment.

72 e evaluated for basketball-related traumatic retinal detachment.

73 etastatic cancer, who had evidence of serous retinal detachments confirmed by optical coherence tomog

74 es active at a restricted time window during retinal development.

75 zon in improving accuracy and reliability of retinal diagnosis for research and clinical practice in

76 partial APC/C inactivation severely inhibits retinal differentiation independently of cell-cycle defe

77 cizumab use increased each year for diabetic retinal disease (2.4 injections/1000 patients with diabe

78 ing in a pediatric population with inherited retinal disease (IRD).

79 Of the 31 patients with ERM seen in retinal disease clinics, 16 were women and 15 were men;

80 could help to form a better understanding of retinal disease diagnosis and prognosis.

81 (2.4 injections/1000 patients with diabetic retinal disease in 2009 to 13.6 per 1000 in 2015) while

82 nes related to phagocytosis, metabolism, and retinal disease in humans.

83 Inherited retinal disease is a common cause of visual impairment a

84 al and genetic heterogeneity associated with retinal diseases makes stem-cell-based therapies an attr

85 tions have the potential to address blinding retinal diseases that affect hundreds of millions worldw

86 ese clinical efforts for several significant retinal diseases, describe the challenges involved and d

87 ent a novel class of potential therapies for retinal diseases, such as age-related macular degenerati

88 l be safe and effective for individuals with retinal diseases.

89 lied to any of the existing mouse models for retinal disorders and may be valuable for documenting im

90 in a number of degenerative and inflammatory retinal disorders such as age-related macular degenerati

91 r transfer across the BRB (K1, k2) and total retinal distribution volume VTDuring ABCB1 inhibition, r

92 may be one of the main reasons for a general retinal dysfunction.

93 e-related macular degeneration and inherited retinal dystrophies, aoong others.

94 nd genotype of patients with CRB1-associated retinal dystrophies.

95 ons in the SRD5A3 gene may cause early-onset retinal dystrophy, a previously underdescribed feature o

96 isolated neurological involvement to JS with retinal dystrophy, additional brain abnormalities (e.g.,

97 tis Pigmentosa GTPase Regulator (RPGR) cause retinal dystrophy, but how this arises at a molecular le

98 Our study describes a retinal dystrophy-related phenotype spectrum as well as

99 sa (RP) is the most common form of inherited retinal dystrophy.

100 juvenile retinoschisis (XLRS), a hereditary retinal dystrophy.

101 gene replacement in RPE65-mediated inherited retinal dystrophy.

102 e than 250 genes are implicated in inherited retinal dystrophy; the encoded proteins are involved in

103 Retinal efflux rate constant k2 was significantly decrea

104 ganglion cells, quantitatively altering the retinal EFNAs gradient, disrupts cortico-collicular map

105 Interventions or Retinal emboli were ascertained from retinal photographs

106 cipants of 3 major Asian ethnic populations, retinal emboli were most commonly seen in Indian persons

107 ng in reduced migration and proliferation of retinal endothelial cells stimulated with VEGF.

108 reatment reduces ER-mitochondrial contact in retinal endothelial cells.

109 EGFR2, a major regulator of angiogenesis, in retinal endothelium and abrogate angiogenesis in the mou

110 odulate Wnt/Norrin signaling activity in the retinal endothelium and coordinate the timing of both va

111 pheres in vitreous on dilated biomicroscopic retinal examination.

112 erential effects on the growth of axons from retinal explants derived from different quadrants of the

113 A 30 degrees retinal field centered at the fovea was investigated usi

114 Retinal fluorescein angiography and optical coherence to

115 disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and ne

116 The evolution of the retinal fovea, trichromatic vision and orbital convergen

117 d 11-cis-retinal chromophore with free 9-cis-retinal from Rho in an in vitro phospholipid/detergent b

118 Inheritance pattern and causative mutation; retinal function as assessed by VA, visual fields, and e

119 n in 17 of 19 subjects and normal full-field retinal function in all subjects.

120 To compare retinal function via full-field electroretinographic (ff

121 Retinal function was used as a direct marker of brain ne

122 er regeneration, consistent with recovery of retinal function.

123 mproving our understanding of how they shape retinal function.

124 tood, the mechanisms promoting the growth of retinal ganglion cell (RGC) axons toward visual targets

125 rldwide, and is characterized by progressive retinal ganglion cell (RGC) death.

126 Regulated retinal ganglion cell (RGC) differentiation and axonal g

127 ecies, we found a temporal area with maximum retinal ganglion cell density ( approximately 5,000-7,00

128 Retinal ganglion cell density was estimated at the same

129 attenuated visual dysfunction, and prevented retinal ganglion cell loss in experimental optic neuriti

130 ification and the anatomical location of the retinal ganglion cell soma.

131 eath signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons.

132 ABSTRACT: How retinal ganglion cells (RGCs) process and integrate syna

133 e (within 8 degrees of the central field) to retinal ganglion cells and associated central visual fie

134 Melanopsin-expressing retinal ganglion cells are intrinsically photosensitive

135 use of cannabis could alter the function of retinal ganglion cells in humans.

136 We studied the morphology and diversity of retinal ganglion cells in Steller's sculpin Myoxocephalu

137 Here, we identified calretinin positive retinal ganglion cells in the common marmoset Callithrix

138 We recorded from OFF delta retinal ganglion cells in the guinea pig retina and moni

139 pression of ephrin-A3 (Efna3) in a subset of retinal ganglion cells, quantitatively altering the reti

140 immediately after axonal injury in purified retinal ganglion cells.

141 he topographic organization and magnitude of retinal ganglion density reflect the specific ecological

142 sis, outer nuclear layer (ONL) thinning, and retinal gliosis.

143 ure to assess independently the longevity of retinal GT.

144 chamber and vitreous inflammation, sectoral retinal hemorrhages in areas of ischemia, and predilecti

145 ut the mechanisms driving the development of retinal high-acuity areas (HAAs).

146 a specialists, image reading center experts, retinal histologists, and optics engineers.

147 T2D induced progressive changes in retinal histology.

148 Muller glia play diverse, critical roles in retinal homeostasis, which are presumably enabled by the

149 nsistent with lateral inhibition mediated by retinal horizontal cells that receive nonselective input

150 through space produces one global pattern of retinal image motion (optic flow), rotation another.

151 tion, which are inherently confounded in the retinal image.

152 ch eye independently for ROP features in a 5 retinal-image set from each session.

153 the brain extracts depth from two different retinal images represents a tractable challenge in senso

154 ven a training set of proximal stimuli (e.g. retinal images), a response noise model, and a cost func

155 Structural retinal imaging biomarkers are important for early recog

156 Infants underwent serial digital retinal imaging in both eyes starting at 32 weeks' postm

157 ding full ophthalmic examination, multimodal retinal imaging, perimetry, and electrophysiology.

158 and OCTA are gaining popularity in pediatric retinal imaging.

159 e examined the efficacy of dark exposure and retinal inactivation with tetrodotoxin to promote anatom

160 tion is based on integration of the relevant retinal information over space.

161 biochemical, and immunological components of retinal injury after alkali burn and explored a novel ne

162 adult mice to generate neurons from MG after retinal injury.

163 The direction-selective retinal input is linearly amplified by intracollicular c

164 trast, the midbrain, which receives parallel retinal input, encodes orientation poorly, if at all.

165 n in the mind's eye after termination of its retinal input.

166 ntly stronger for LGN neurons than for their retinal inputs, indicating a role for extraretinal mecha

167 rP(Sc) combined with inflammation results in retinal iron-dyshomeostasis, a potentially toxic host re

168 Inflammation-mediated leukostasis, retinal ischemia, and neovascularization and their contr

169 Each retinal layer thickness was calculated for 9 ETDRS secto

170 To evaluate the segmentation of retinal layers among 3 OCT angiography instruments in th

171 We assessed thickness of the retinal layers and we rated individual layer segmentatio

172 ervised automated segmentation of individual retinal layers is possible.

173 changes in choroidal thickness (CT) and all retinal layers of diabetic patients without diabetic ret

174 ion leads to a clear separation of the outer retinal layers.

175 , creating an apical and basal separation of retinal layers.

176 severity of the various ischemic fundus and retinal lesions and of the optic disc during the acute p

177 We revealed that the central retinal lesions either do not impair motion detection or

178 s to thousands of RGCs simultaneously at pan-retinal level, including dorsal and ventral locations.

179 When the corresponding retinal locations in the two eyes are presented with inc

180 beta-cleavage of PrP(C) is observed in mouse retinal lysates.

181 ransient hyperglycemia during pregnancy, and retinal microvascular changes in pregnant women at 26-28

182 In vitro studies using human retinal microvascular endothelial cells (HRMECs) showed

183 Our findings showed that abnormal retinal microvascular morphology was evident in pediatri

184 9% to 4.0%, P = .33) and similar evidence of retinal misregistration (100% vs 73%; P = .09) by any te

185 ive error (monocular diplopia), 2 (8%) mixed retinal misregistration (central-peripheral rivalry-type

186 Aniseikonia and retinal misregistration are similar between patients wit

187 Eleven of 25 diplopic patients (44%) had retinal misregistration as the sole cause (central-perip

188 ditional deletion of Dicer1 (Dicer-CKOMG) in retinal Muller glia (MG).

189 ed to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell comple

190 To quantify retinal nerve fiber layer (RNFL) changes in patients wit

191 hout VF defects were compared with regard to retinal nerve fiber layer (RNFL) thickness, drusen morph

192 uroretinal parameters, minimum rim width and retinal nerve fiber layer thickness, in addition to peri

193 indings including severity of IOP elevation, retinal nerve fiber layer thinning, or electrodiagnostic

194 w individual cells collaborate to form a pan-retinal network.

195 ) channels play important roles in mammalian retinal neurons, including photoreceptors, bipolar cells

196 , after a chemical lesion that ablates inner retinal neurons, regenerated retinal bipolar neurons (BP

197 croglia/macrophages associate with apoptotic retinal neurons.

198 s assessed the effects of these compounds on retinal neurovascular injury induced by hyperglycemia.

199 Fully automated analysis of retinal OCT images from clinical routine provides a prom

200 me was the association between peripapillary retinal OCT parameters and directly measured elevated in

201 stitute the main target of stabilizing extra-retinal oculomotor influences.

202 lining order, were nystagmus associated with retinal/optic nerve disease in 23 (32.4%), idiopathic or

203 cent reporters in complex human iPSC-derived retinal organoids.

204 ls re-aggregated within hours, forming tight retinal organoids.

205 with limited understanding of the resulting retinal pathologies.

206 ests altered function as the likely cause of retinal pathology.

207 how that retbindin ablation in mice causes a retinal phenotype characterized by time- and dose-depend

208 A more severe retinal phenotype was found in the Dlx1/Dlx2/Brn3b-null

209 ions or Retinal emboli were ascertained from retinal photographs obtained from both eyes of all parti

210 visually driven signals as they flow through retinal photoreceptor, bipolar, and ganglion cells.

211 While luminance adaptation can begin at the retinal photoreceptors, contrast adaptation has been sho

212 t animals indicate a contribution from inner retinal photoreceptors.

213 The images were graded by 2 retinal physicians and average measurements used.

214 research subject for developmental biology, retinal physiology, cell biology, and other investigatio

215 at the ARMS2/HTRA1 locus with subretinal/sub-retinal pigment epithelial (RPE) hemorrhage related to n

216 Fundus examination revealed midperipheral retinal pigment epithelial atrophy and intraretinal pigm

217 Human retinal pigment epithelial cells were treated with vario

218 To evaluate the features of acute retinal pigment epitheliitis (ARPE) at onset and in the

219 usen phenotypes, including the occurrence of retinal pigment epithelium (RPE) abnormalities, choroida

220 roduced by neighboring epithelial cells, the retinal pigment epithelium (RPE) and podocytes, respecti

221 d induced pluripotent stem cells to generate retinal pigment epithelium (RPE) from an individual suff

222 To report on the presence of retinal pigment epithelium (RPE) humps in high myopia, a

223 lipid profiles specifically localized to the retinal pigment epithelium (RPE) in Abca4 (-/-) Stargard

224 interface between the neural retina and the retinal pigment epithelium (RPE) is critical for several

225 s calculated from the SD-OCT and the area of retinal pigment epithelium (RPE) loss from the FAF.

226 ated kinase 1/2 (ERK1/2) is increased in the retinal pigment epithelium (RPE) of age-related macular

227 rmalities in regions with normally appearing retinal pigment epithelium (RPE) were the loss of the PO

228 lated macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell monolayer essen

229 h the coordinated terminal maturation of the retinal pigment epithelium (RPE), fenestrated choroid en

230 of TGF-beta signaling in the entire eye, the retinal pigment epithelium (RPE), or the vascular endoth

231 ciations of ocular and systemic factors with retinal pigment epithelium (RPE)-Bruch's membrane (BM) c

232 ls in a model of chronic degeneration of the retinal pigment epithelium (RPE).

233 Quantifying preserved retinal pigment epithelium and EZ areas on FAF and OCT i

234 tors then export the lactate as fuel for the retinal pigment epithelium and for neighboring Muller gl

235 Finally, in primary human fetal retinal pigment epithelium cells, ligand binding to TLR2

236 l mice had thickening of Bruchs membrane and retinal pigment epithelium dysfunction.

237 pment of ischemic infarction of the choroid, retinal pigment epithelium, outer part of the retina and

238 d modify proangiogenic signaling produced by retinal pigmented epithelial (RPE) cells under different

239 One of the major biological functions of the retinal pigmented epithelium (RPE) is the clearance of s

240 stheses based on tailored stimulation (e.g., retinal prostheses), and for closed-loop neural stimulat

241 ity provides a new logic for enhanced-acuity retinal prosthetics.

242 Retinal reattachment reached only with air endotamponade

243 ates the tractional component of non-RRD and retinal schisis assotiated with MGS.

244 dema was limited to approximately 5% between retinal screening examinations at 4 years among patients

245 total, 1787 patients with diabetes received retinal screening photographs with remote expert interpr

246 To evaluate telemedicine retinal screenings for patients with type 1 or 2 diabete

247 Retinal sensitivity was related to cognitive status (nor

248 exuses, as well as from the all-plexus inner retinal slab.

249 iginating either from moving objects or from retinal slip caused by self-motion.

250 ferent colors, we find that Muller glia tile retinal space with minimal overlap.

251 Using new methods for precisely controlling retinal stimulation, here we show that covert attention

252 fields, and electroretinography results; and retinal structural changes observed on clinical fundusco

253 effect of loss of P2X7 receptor function on retinal structure and function during aging.

254 To study changes in both retinal structure and function during the first month fo

255 Here, the recovery of retinal structure and function over the first month foll

256 treated Rho(P23H) mice with PR3 and assessed retinal structure and function.

257 ned the rescue of rod function and preserved retinal structure in the dog model.

258 ased in the laminin gamma3-null (Lamc3(-/-)) retinal superficial vascular plexus and consequently the

259 days-period following diagnosis of the first retinal tear.

260 Retinal tears complicating the course of a posterior vit

261 The mean number of retinal tears per eye was 1.36 +/- 0.5 (range = 1-2); bi

262 ye was 1.36 +/- 0.5 (range = 1-2); bilateral retinal tears were noted in 18.2% of eyes; 86.4% were my

263 ved primary care at the clinics and obtained retinal telescreening to determine the presence and seve

264 A significant decrease of retinal thickness and glial reactivity was observed with

265 documented with a mean reduction of central retinal thickness by 139.7 mum at 24 months (244.9 +/- 4

266 Retinal thickness measurements correlated with vascular

267 Retinal thickness was measured, retinal cell types were

268 -white spots, hyperfluorescence, and reduced retinal thickness were found using electroretinography (

269 mes included visual acuity, central subfield retinal thickness, and number of anti-VEGF injections.

270 VA; scar; geographic atrophy; retinal thickness, fluid; and number of anti-VEGF inject

271 mOPL, mONL, PR, and RPE parameters and total retinal thicknesses between groups for the different are

272 induce migration of fluid into the adjacent retinal tissue.

273 Our results show that the retinal transcriptome at advanced stages of RP is very s

274 With this goal, we analyzed the retinal transcriptome of two non-allelic forms of RP in

275 ceptor cell line, 661W, derived from a mouse retinal tumor that expresses several markers of cone pho

276 relationship between both static and dynamic retinal vascular caliber and the severity of obstructive

277 ocus is known to associate with variation in retinal vascular diameter, and the 2q34 and 1p12 loci ha

278 In 2 young children with retinal vascular disease, the MIOCTA images showed more

279 n the operating room for young children with retinal vascular disease.

280 Retinal vascular diseases are among the leading causes o

281 not cause BRB disintegration, it sensitizes retinal vascular endothelial cells (ECs) to VEGF-A, lead

282 pectrum of perivenular ischemia in eyes with retinal vascular obstruction (typically central or hemic

283 has emerged as a significant contributor to retinal-vascular diseases in the previous 2 decades.

284 that caffeine did not interfere with normal retinal vascularization development but selectively prot

285 ant and extended follow-up is needed because retinal vascularization is usually incomplete.

286 may allow noninvasive detailed evaluation of retinal vasculature during surgical procedures and in pa

287 The retinal vasculature is easily imaged, and may be a surro

288 ting promise as a technique to visualize the retinal vasculature with lower risk and cost than fluore

289 acterized by the abnormal development of the retinal vasculature.

290 face OCTA images of the superficial and deep retinal vasculatures using vessel-based and FAZ-based me

291 include vitreous haze (523 of 1153 [45.4%]), retinal vasculitis (374 of 874 [42.8%]), and choroidal i

292 We report a case of hemorrhagic occlusive retinal vasculitis (HORV) after prophylactic intracamera

293 rs affecting the visual outcome in eyes with retinal vasculitis and the rate of neovascularization re

294 Macular retinal VD, ganglion cell complex (GCC) thickness, and v

295 bstruction (typically central or hemicentral retinal vein obstruction) using en face optical coherenc

296 ent due to macular edema secondary to branch retinal vein occlusion (BRVO).

297 decreased visual acuity (VA) associated with retinal vein occlusion (RVO).

298 ough selective pericyte loss in stable adult retinal vessels surprisingly does not cause BRB disinteg

299 stribution volume VTDuring ABCB1 inhibition, retinal VT and influx rate constant K1 were significantl

300 the detection of MR overall, and 65%/94% for retinal whitening, 62%/100% for vessel discoloration, an