ライフサイエンスコーパス: retinoblastoma tumor suppressor

1 ellular senescence through activation of the retinoblastoma tumor suppressor.

2 e regulator, was initially identified as the retinoblastoma tumor suppressor.

3 pocket family of proteins that includes the retinoblastoma tumor suppressor.

4 53 tumor suppressor, and the function of the retinoblastoma tumor suppressor.

5 (CDK2) and concomitant dephosphorylation of retinoblastoma tumor suppressor.

6 s deficient in MIF have significantly higher retinoblastoma tumor suppressor and lower E2F transcript

7 -phase entry through the inactivation of the retinoblastoma tumor suppressor and related pocket prote

8 e patterns--loss of H3K4 methylation--to the retinoblastoma tumor suppressor and the H3K4 demethylase

9 The product of the retinoblastoma tumor suppressor gene (Rb) can control ce

10 The retinoblastoma tumor suppressor gene (Rb) has many funct

11 The loss of the retinoblastoma tumor suppressor gene (RB) is common in m

12 ctivity of a crucial E2F target in vivo, the retinoblastoma tumor suppressor gene (Rb).

13 The retinoblastoma tumor suppressor gene (RB-1) is a key reg

14 The retinoblastoma tumor suppressor gene (RB1) and its relat

15 radiation (IR) and germline mutations in the retinoblastoma tumor suppressor gene (RB1) are the stron

16 The Retinoblastoma tumor suppressor gene (RB1) plays a role

17 The retinoblastoma tumor suppressor gene (RB1; encoding RB)

18 The retinoblastoma tumor suppressor gene plays important rol

19 The retinoblastoma tumor suppressor gene product (pRb) is in

20 The retinoblastoma tumor suppressor gene product (Rb) binds

21 Functional inactivation of the retinoblastoma tumor suppressor gene product (RB) is a c

22 ed from normal mice or mice deficient in the retinoblastoma tumor suppressor gene product do not disp

23 dependent kinase activity phosphorylates Rb (retinoblastoma tumor suppressor gene product) family pro

24 lation of p27(kip1), hyperphosphorylation of retinoblastoma tumor suppressor gene product, and cellul

25 ro kinase assay using recombinant, truncated retinoblastoma tumor suppressor gene protein (Rb protein

26 Mutations of the retinoblastoma tumor suppressor gene RB are frequently o

27 Mutations in the retinoblastoma tumor suppressor gene Rb are involved in

28 The retinoblastoma tumor suppressor gene Rb is essential for

29 tremely sensitive to loss of function of the retinoblastoma tumor suppressor gene RB.

30 tic DNA templates and a PCR product from the retinoblastoma tumor suppressor gene.

31 DNA templates and on a PCR product from the retinoblastoma tumor suppressor gene.

32 d the inactivation of Rb, the product of the retinoblastoma tumor suppressor gene.

33 d in part by pRB, the protein product of the retinoblastoma tumor suppressor gene.

34 The product of the retinoblastoma tumor-suppressor gene (pRB), a nuclear ph

35 wnregulate the levels of hyperphosphorylated retinoblastoma tumor-suppressor gene (Rb) and cyclin D1,

36 The retinoblastoma tumor-suppressor gene (Rb1) is centrally

37 Although the retinoblastoma tumor-suppressor gene (RB1) is frequently

38 Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components

39 he function of short RNAs synergize with the retinoblastoma tumor suppressor homolog lin-35 in negati

40 The retinoblastoma tumor suppressor homolog MAT3 is a Volvox

41 16(INK4A) expression is not a consequence of retinoblastoma tumor suppressor inactivation but is trig

42 The retinoblastoma tumor suppressor is frequently inactivate

43 ggesting that in cervical cancer cells where retinoblastoma tumor suppressor is inactivated, CDK4/CDK

44 eins, which is essential for blockade of the retinoblastoma tumor suppressor, is also important for a

45 cyclin E promoter was repressed by wild-type Retinoblastoma tumor suppressor p105 protein (pRB) and b

46 action of E2F transcription factors and the retinoblastoma tumor suppressor/p107/p130 family of pock

47 The p16(INK4a)-cyclin D-retinoblastoma tumor suppressor pathway is disrupted in

48 whose inactivation suppresses defects in the retinoblastoma tumor suppressor pathway, and we successf

49 part independent of the inactivation of the retinoblastoma tumor suppressor pRb and is dependent on

50 Inactivation of the retinoblastoma tumor suppressor (pRB) alters the express

51 Inactivation of the retinoblastoma tumor suppressor (pRb) is a common oncoge

52 The retinoblastoma tumor suppressor (pRb) protein associates

53 cogenic activities is destabilization of the retinoblastoma tumor suppressor (pRB) through a ubiquiti

54 heterodimers from repression mediated by the retinoblastoma tumor suppressor (pRB) triggers cell cycl

55 E7 is its binding to and inactivation of the retinoblastoma tumor suppressor (pRb), but at least 18 o

56 to bind to and induce the degradation of the retinoblastoma tumor suppressor, pRb, and related "pocke

57 The retinoblastoma tumor suppressor, pRB, plays a central ro

58 ion with p53, and partially resistant to the retinoblastoma tumor suppressor, pRB.

59 Mutations in the gene encoding the retinoblastoma tumor suppressor predispose humans and mi

60 transcription factor E2F is a target of the retinoblastoma tumor suppressor protein (pRB) and may me

61 domain, which is required for binding of the retinoblastoma tumor suppressor protein (pRb) and pRb-li

62 of proliferation and differentiation by the retinoblastoma tumor suppressor protein (pRB) and relate

63 cells, CAK interacts with and phosphorylates retinoblastoma tumor suppressor protein (pRb) and retino

64 A oncoprotein can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the tr

65 ibits cell proliferation, interacts with the retinoblastoma tumor suppressor protein (pRb) and the tr

66 rgo G1 arrest because of inactivation of the retinoblastoma tumor suppressor protein (pRb) by the pap

67 suppressor protein or by inactivation of the retinoblastoma tumor suppressor protein (pRb) by transdu

68 The retinoblastoma tumor suppressor protein (pRb) can associ

69 studies have shown that inactivation of the retinoblastoma tumor suppressor protein (pRb) can cause

70 The retinoblastoma tumor suppressor protein (pRB) can inhibi

71 Inactivation of the retinoblastoma tumor suppressor protein (pRB) contribute

72 The retinoblastoma tumor suppressor protein (pRb) controls c

73 Viral oncoproteins that inactivate the retinoblastoma tumor suppressor protein (pRb) family bot

74 The E7 protein of HPV-16 binds all retinoblastoma tumor suppressor protein (pRB) family mem

75 Inactivation of the retinoblastoma tumor suppressor protein (pRb) has been i

76 Retinoblastoma tumor suppressor protein (pRB) inhibition

77 The retinoblastoma tumor suppressor protein (pRB) is a trans

78 The retinoblastoma tumor suppressor protein (pRB) is a trans

79 cells, p53, p21, Bax, and hypophosphorylated retinoblastoma tumor suppressor protein (pRb) levels inc

80 The retinoblastoma tumor suppressor protein (pRB) negatively

81 During infection, UL97 phosphorylates the retinoblastoma tumor suppressor protein (pRb) on sites o

82 Downregulation of Cdc25A led to reduction in retinoblastoma tumor suppressor protein (pRb) phosphoryl

83 The mammalian retinoblastoma tumor suppressor protein (pRb) regulates

84 cooperate with removal of the E2F inhibitor retinoblastoma tumor suppressor protein (pRB) to drive c

85 Only the under-phosphorylated form of the retinoblastoma tumor suppressor protein (pRB) was detect

86 le arrest depends on an interaction with the retinoblastoma tumor suppressor protein (pRb), but diffe

87 factors is the key downstream target of the retinoblastoma tumor suppressor protein (pRB), which is

88 encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which nor

89 nuclear p21, and hypophosphorylation of the retinoblastoma tumor suppressor protein (pRb), with no e

90 The targets of E1A protein include the retinoblastoma tumor suppressor protein (pRb).

91 regulated most closely by phosphorylation of retinoblastoma tumor suppressor protein (pRb).

92 e of underphosphorylated, growth-suppressive retinoblastoma tumor suppressor protein (pRb).

93 of growth-regulatory proteins, including the retinoblastoma tumor suppressor protein (pRb).

94 These include the retinoblastoma tumor suppressor protein (Rb) and histone

95 at least 3 h prior to phosphorylation of the retinoblastoma tumor suppressor protein (Rb) and the res

96 tumor-derived virus mutations do not affect retinoblastoma tumor suppressor protein (Rb) binding by

97 ment of E2F1 and concomitant dissociation of retinoblastoma tumor suppressor protein (Rb) from surviv

98 Disruption of murine retinoblastoma tumor suppressor protein (Rb) in mature p

99 The retinoblastoma tumor suppressor protein (RB) is a negati

100 The retinoblastoma tumor suppressor protein (RB) is a potent

101 Expression of the retinoblastoma tumor suppressor protein (Rb) is required

102 The retinoblastoma tumor suppressor protein (RB) is targeted

103 xhibit overexpression of hyperphosphorylated retinoblastoma tumor suppressor protein (Rb) or a marked

104 The retinoblastoma tumor suppressor protein (Rb) pathway is

105 ibition of cyclin D3 and Cdk4 expression and retinoblastoma tumor suppressor protein (Rb) phosphoryla

106 The retinoblastoma tumor suppressor protein (RB) plays a cri

107 The retinoblastoma tumor suppressor protein (Rb) plays a vit

108 The retinoblastoma tumor suppressor protein (RB) plays impor

109 fferentiation and hypophosphorylation of the retinoblastoma tumor suppressor protein (RB) typically a

110 Hepatitis C virus (HCV) downregulates the retinoblastoma tumor suppressor protein (Rb), a central

111 The retinoblastoma tumor suppressor protein (RB), a critical

112 he pathway that controls the activity of the retinoblastoma tumor suppressor protein (Rb), which in t

113 ent kinase activity, and underphosphorylated retinoblastoma tumor suppressor protein (RB).

114 h encodes proteins capable of binding to the retinoblastoma tumor suppressor protein (Rb).

115 ells, a key regulator of this process is the retinoblastoma tumor suppressor protein (RB).

116 the hypophosphorylated (active) form of the retinoblastoma tumor suppressor protein (Rb).

117 7 is associated with its ability to bind the retinoblastoma tumor suppressor protein (Rb).

118 e to bind to and inhibit the function of the retinoblastoma tumor suppressor protein (RB).

119 on-gamma, in solid tumor cells, requires the retinoblastoma tumor suppressor protein (Rb).

120 t inducible in tumor cells defective for the retinoblastoma tumor suppressor protein (Rb).

121 Interestingly, cells lacking the retinoblastoma tumor suppressor protein also display arr

122 e genes encoding TS and RR was enriched with retinoblastoma tumor suppressor protein and histone H3 t

123 The retinoblastoma tumor suppressor protein and its family m

124 cell cycle regulatory proteins including the retinoblastoma tumor suppressor protein and the coactiva

125 that was associated with phosphorylation of retinoblastoma tumor suppressor protein and the up-regul

126 Western blot analysis of the retinoblastoma tumor suppressor protein antigen from ker

127 of HPV-16 E7 involved in degradation of the retinoblastoma tumor suppressor protein as well as regio

128 phorylated growth inhibitory 105 kDa form of retinoblastoma tumor suppressor protein coimmunoprecipit

129 rmally RA-induced hypophosphorylation of the retinoblastoma tumor suppressor protein consistent with

130 not only by E2Fs but also by members of the retinoblastoma tumor suppressor protein family and by RN

131 Mutations which impaired binding of the retinoblastoma tumor suppressor protein family members p

132 The retinoblastoma tumor suppressor protein has been shown t

133 The retinoblastoma tumor suppressor protein has been shown t

134 Both protein kinase C and the retinoblastoma tumor suppressor protein have been linked

135 n which we expressed a fragment of the human retinoblastoma tumor suppressor protein in fission yeast

136 iolet radiation-induced dephosphorylation of retinoblastoma tumor suppressor protein in human skin an

137 hosphorylation of this fragment of the human retinoblastoma tumor suppressor protein is dependent on

138 independent of its ability to inactivate the retinoblastoma tumor suppressor protein pRB and the rela

139 targets of the HPV-16 E7 oncoprotein are the retinoblastoma tumor suppressor protein pRB and the rela

140 teady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decrease

141 E2F and retinoblastoma tumor suppressor protein pRB are importan

142 The retinoblastoma tumor suppressor protein pRb is a key reg

143 The retinoblastoma tumor suppressor protein pRB is conventio

144 The retinoblastoma tumor suppressor protein pRb restricts ce

145 osphorylated, growth suppressive form of the retinoblastoma tumor suppressor protein pRB was detected

146 ated family member, is in a complex with the retinoblastoma tumor suppressor protein Rb and activates

147 ntral ATPase domain, a domain that binds the retinoblastoma tumor suppressor protein Rb, and a C-term

148 cells, presumably because of mutation at the retinoblastoma tumor suppressor protein that allows func

149 M okadaic acid, resulted in an inhibition of retinoblastoma tumor suppressor protein translocation to

150 ted and ultraviolet-irradiated keratinocytes retinoblastoma tumor suppressor protein was localized to

151 tein, and accumulation of hypophosphorylated retinoblastoma tumor suppressor protein(105) was inhibit

152 tion of growth inhibitory hypophosphorylated retinoblastoma tumor suppressor protein(105).

153 functional role for the cyclin D1/Cdk4/pRb (retinoblastoma tumor suppressor protein) pathway in dela

154 ts activation of p57Kip2 expression, and the retinoblastoma tumor suppressor protein, a known Id2 inh

155 pression of cyclin E, phosphorylation of the retinoblastoma tumor suppressor protein, and a doubling

156 ion-induced depletion in hyperphosphorylated retinoblastoma tumor suppressor protein, and accumulatio

157 in a rapid depletion in hyperphosphorylated retinoblastoma tumor suppressor protein, and the accumul

158 mmortalizing activity, LMP1 does not bind to retinoblastoma tumor suppressor protein, but instead blo

159 of transcription and differentiation by the retinoblastoma tumor suppressor protein, contains a JmjC

160 Interestingly, unlike retinoblastoma tumor suppressor protein, MDMX, and p14(A

161 es 103 to 107), necessary for binding to the retinoblastoma tumor suppressor protein, pRB, and the re

162 E2F1 that facilitates complex formation with retinoblastoma tumor suppressor protein, pRB, and we fou

163 In vitro phosphorylation of the retinoblastoma tumor suppressor protein, pRB, by cyclin

164 best known for its ability to inactivate the retinoblastoma tumor suppressor protein, pRb, many other

165 The retinoblastoma tumor suppressor protein, RB, contains at

166 at examining the precise function(s) of the retinoblastoma tumor suppressor protein, RB, have been h

167 1/cip1) and promote dephosphorylation of the retinoblastoma tumor suppressor protein, Rb, in MCF-7 br

168 The retinoblastoma tumor suppressor protein, Rb, interacts d

169 The retinoblastoma tumor suppressor protein, RB, is a negati

170 The antiproliferative action of the retinoblastoma tumor suppressor protein, RB, is disrupte

171 cogene that functions by inactivation of the retinoblastoma tumor suppressor protein, RB.

172 inetics, and relative phosphorylation of the retinoblastoma tumor suppressor protein, using primary t

173 d overriding the checkpoint functions of the retinoblastoma tumor suppressor protein.

174 and depletion of hyperphosphorylation of the retinoblastoma tumor suppressor protein.

175 sphorylated and hyperphosphorylated forms of retinoblastoma tumor suppressor protein.

176 accompanied by unchecked inactivation of the retinoblastoma tumor suppressor protein.

177 k4/6 activity and active, hypophosphorylated retinoblastoma tumor suppressor protein.

178 generation of a complex also containing the retinoblastoma tumor suppressor protein.

179 ed because its gene products can bind to the retinoblastoma tumor suppressor protein.

180 ependent of the ability of E7 to inhibit the retinoblastoma tumor suppressor protein.

181 lix-loop-helix transcription factors and the retinoblastoma tumor suppressor protein.

182 ays and inhibition of phosphorylation of the retinoblastoma tumor suppressor protein.

183 nd maturation by TGFbeta is dependent on the retinoblastoma tumor suppressor protein/E2 promoter bind

184 The retinoblastoma tumor-suppressor protein (pRb) is a criti

185 The retinoblastoma tumor-suppressor protein (pRb) is known t

186 The retinoblastoma tumor-suppressor protein (RB) is an impor

187 The retinoblastoma tumor-suppressor protein (Rb) plays a cri

188 The retinoblastoma tumor-suppressor protein, pRb, is a membe

189 receptor that is negatively regulated by the retinoblastoma tumor-suppressor protein.

190 F-1/DP1 transcription factor complex and the retinoblastoma tumor-suppressor protein.

191 The retinoblastoma tumor suppressor RB and its related prote

192 The retinoblastoma tumor suppressor RB controls the prolifer

193 In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivat

194 The retinoblastoma tumor suppressor RB is the downstream med

195 The retinoblastoma tumor suppressor RB is well known for its

196 In this regard, we have found that both the retinoblastoma tumor suppressor (Rb) and a novel nuclear

197 The retinoblastoma tumor suppressor (RB) and mismatch repair

198 gh some E2F functions are independent of the Retinoblastoma tumor suppressor (Rb) and related family

199 E-cadherin and the retinoblastoma tumor suppressor (Rb) are traditionally a

200 The retinoblastoma tumor suppressor (Rb) controls the prolif

201 y methylation were correlated with increased Retinoblastoma tumor suppressor (RB) expression, suggest

202 with earlier work, HPV16 E7 can bind to the retinoblastoma tumor suppressor (RB) family member p130

203 The retinoblastoma tumor suppressor (RB) is a central cell c

204 The retinoblastoma tumor suppressor (RB) is crucial for the

205 The retinoblastoma tumor suppressor (RB) is functionally ina

206 The retinoblastoma tumor suppressor (RB) is functionally ina

207 The retinoblastoma tumor suppressor (RB) is functionally ina

208 that only combined deletion of p27(Kip1) and retinoblastoma tumor suppressor (Rb) is sufficient to re

209 The integrity of the retinoblastoma tumor suppressor (RB) pathway is critical

210 ) type 16 E7 oncoprotein must inactivate the retinoblastoma tumor suppressor (Rb) pathway to bypass G

211 The role of the retinoblastoma tumor suppressor (RB) pathway, which is l

212 we demonstrate that Plk1 is a target of the retinoblastoma tumor suppressor (RB) pathway.

213 n is common in DCIS, as is disruption of the retinoblastoma tumor suppressor (RB) pathway.

214 oncogenic pathway and/or inactivation of the retinoblastoma tumor suppressor (RB) pathway.

215 The retinoblastoma tumor suppressor (RB) plays an important

216 The retinoblastoma tumor suppressor (RB) protein is function

217 Retinoblastoma tumor suppressor (Rb) protein stimulates

218 and has been implicated in the action of the retinoblastoma tumor suppressor (RB).

219 eminin is regulated transcriptionally by the retinoblastoma tumor suppressor (RB)/E2F pathway.

220 The retinoblastoma tumor suppressor, RB, assembles multiprot

221 The retinoblastoma tumor suppressor, RB, is a key regulator

222 The retinoblastoma tumor suppressor, RB, is a negative regul

223 The retinoblastoma tumor suppressor, RB, is thought to inhib

224 1 is required for the destabilization of the retinoblastoma tumor suppressor RB1 in HPV16 E7-expressi

225 the cell cycle defects caused by loss of the retinoblastoma tumor suppressor-related protein encoded

226 UL97 phosphorylated and inactivated the retinoblastoma tumor suppressor, stimulated cell cycle p

227 and cyclin A-dependent phosphorylation of a retinoblastoma tumor suppressor substrate.