ライフサイエンスコーパス: retinotectal

1 dance or synaptogenesis, particularly in the retinotectal and motor systems.

2 undamental differences in the development of retinotectal and retinocollicular maps.

3 Avian retinotectal and rodent retinocollicular systems are gen

4 the expression of ephrin-As on axons of the retinotectal and vomeronasal projections suggests that t

5 Here we imaged retinotectal axon arbor location and structural plastici

6 ion also increased the growth of presynaptic retinotectal axon arbors.

7 Accurate retinotectal axon pathfinding depends upon the correct e

8 l(ty54)) mutant was identified by defects in retinotectal axon projections.

9 ic HS sequences are essential for regulating retinotectal axon targeting and suggest that regionalise

10 an increase in the synaptic excitability of retinotectal axon terminals.

11 tectal neurons can modify the development of retinotectal axons in Xenopus.

12 tinotectal axons was investigated by imaging retinotectal axons labeled with the fluorescent indicato

13 As growing retinotectal axons navigate from the eye to the tectum,

14 n 5-HT it induces, on the terminal arbors of retinotectal axons rather than on their parent cells.

15 of melatonin on calcium dynamics in Xenopus retinotectal axons was investigated by imaging retinotec

16 since depolarization-evoked calcium rises in retinotectal axons were inhibited by GABA(C) receptor bl

17 ta therefore support the hypothesis that, in retinotectal axons, melatonin reduces cAMP levels, there

18 ls, GABA(C) receptors mediate inhibition, in retinotectal axons, the opposite appears to occur since

19 involvement in the unilateral containment of retinotectal axons.

20 ury to optic tectal neurons without damaging retinotectal axons.

21 dynamics of presynaptic sites within labeled retinotectal axons.

22 uRs) counteracted the effect of melatonin on retinotectal axons.

23 We find that in the Xenopus retinotectal circuit, during a period in development whe

24 or permissive for shaping development of the retinotectal circuit.

25 excitation and inhibition in the developing retinotectal circuit.

26 induce persistent modification of developing retinotectal circuits via spike timing-dependent plastic

27 development of the temporonasal axis of the retinotectal/collicular map, but the role of these molec

28 We show that the laminar specificity of retinotectal connections does not depend on self-sorting

29 nor OMR were found to be dependent on intact retinotectal connections.

30 ation was examined in the developing Xenopus retinotectal connections.

31 which is required for Eph receptor-dependent retinotectal development in chick and for development of

32 te missorted axons in the optic tract during retinotectal development in zebrafish.

33 e test the role of axon-axon interactions in retinotectal development, by devising a technique to sel

34 increased SC concentrations of 5-HT altered retinotectal development.

35 t a novel role for netrin in later phases of retinotectal development.

36 cing intracellular calcium concentrations in retinotectal fibers in the frog optic tectum in vitro.

37 ectum, using confocal imaging of DiI-labeled retinotectal fibers in whole-mount tecta of embryos pret

38 This result provides evidence that the retinotectal fibers serving the pupil light reflex are l

39 inase II (CaMKII) promotes the maturation of retinotectal glutamatergic synapses in Xenopus.

40 Despite several studies, knowledge of the retinotectal guidance molecules is far from being comple

41 iling and identified several novel candidate retinotectal guidance molecules.

42 al layers, as demonstrated by destruction of retinotectal input by intraocular application of the dru

43 Glutamatergic retinotectal inputs mediated principally by NMDA recepto

44 from a selective elimination of feedforward retinotectal inputs.

45 euromodulator that binds to receptors in the retinotectal laminae of the amphibian optic tectum.

46 ularia), species capable of regenerating the retinotectal map as adults.

47 Although retinotectal map formation is a prominent manifestation

48 for their function as putative regulators of retinotectal map formation.

49 The retinotectal map is the best characterized model system

50 me period when significant refinement of the retinotectal map occurs.

51 uit, during a period in development when the retinotectal map undergoes activity-dependent refinement

52 priate to contribute to the formation of the retinotectal map, and we suggest that these methods be u

53 e influence the fine-scale topography of the retinotectal map, indicating that lineage relationships

54 nt sets of guidance cues to give rise to the retinotectal map.

55 of the tectum, where they form a compressed retinotectal map.

56 the retina and controls the formation of the retinotectal map.

57 is is important for establishing the correct retinotectal map.

58 both before and after the development of the retinotectal map.

59 ion of molecules that are needed to form the retinotectal map.

60 s an axon guidance molecule, plays a role in retinotectal mapping along the medial-lateral axis, coun

61 ephrin-B cytoplasmic domain is critical for retinotectal mapping in this axis.

62 requirement for endogenous EphA receptors in retinotectal mapping, show that the receptor intracellul

63 ation along RGC axons are critical events in retinotectal mapping.

64 ong the D-V axis of the retina and influence retinotectal mapping.

65 onal EphAs and has a key role in controlling retinotectal mapping.

66 ss-of-function analysis of EphA receptors in retinotectal mapping.

67 f their expression gradients with developing retinotectal maps and gradients of cellular development

68 The zebrafish retinotectal mutants represent a new resource for the st

69 Lesions of the retinotectal neuropil primarily abolished orienting move

70 est that nucleus isthmi input can facilitate retinotectal neurotransmission, and the mechanism could

71 To address how the highly stereotyped retinotectal pathway develops in zebrafish, we used fixe

72 ssed distractors and implicate a role of the retinotectal pathway in many blindsight phenomena.

73 These fibers may represent either a novel retinotectal pathway or collateral branches from centrif

74 e that NO has some signaling function in the retinotectal pathway, but this function is not critical

75 P, to determine its capacity to activate the retinotectal pathway.

76 At later stages, the retinotectal projection also degenerates in ako mutants.

77 -thymidine neuronography, we have mapped the retinotectal projection and the spatiotemporal progressi

78 olved in refinement of the topography of the retinotectal projection as well as in other aspects of r

79 visual system, topographic refinement of the retinotectal projection depends on electrical activity.

80 The retinotectal projection has long been studied experiment

81 The retinotectal projection has served as an important model

82 resent a detailed phenotypic analysis of the retinotectal projection in nev and show that dorsonasal

83 glion cell axons of the developing and adult retinotectal projection in vivo.

84 The retinotectal projection is a premier model system for th

85 ptor-mediated elimination of the ipsilateral retinotectal projection is completely mediated via nitri

86 A transient ipsilateral retinotectal projection is normally eliminated during em

87 ing of retinal axons after the time that the retinotectal projection is normally topographically orga

88 The retinotectal projection is the predominant model for stu

89 have been implicated in the formation of the retinotectal projection map.

90 conclusion that the effect of 5,7-DHT on the retinotectal projection may primarily be a function of t

91 dertaken to determine whether changes in the retinotectal projection of 5,7-DHT-treated animals were

92 r introduction of radiolabeled NT-3 into the retinotectal projection of chick embryos.

93 We used the retinotectal projection of goldfish to test this idea in

94 Here, we show that in the developing retinotectal projection of young Xenopus tadpoles, visua

95 , resulted in abnormalities in the uncrossed retinotectal projection similar to those observed in the

96 o the embryonic chick eye in vivo caused the retinotectal projection to develop without normal topogr

97 st that Tctp supports the development of the retinotectal projection via its regulation of pro-surviv

98 The degree of rescue of the ipsilateral retinotectal projection was compared in embryos treated

99 Thus, the paradigmatic chick retinotectal projection, due to its neighborhood preserv

100 In the visual retinotectal projection, ELF-1, a ligand in the tectum,

101 d in oligodendrocytes along the regenerating retinotectal projection, mirroring up-regulation of endo

102 ions during the formation of the topographic retinotectal projection, we coexpressed cytosolic fluore

103 of neuronal processes in the Xenopus tadpole retinotectal projection.

104 tectum influences topographic mapping of the retinotectal projection.

105 lso prevented elimination of the ipsilateral retinotectal projection.

106 axons and in retaining the laterality of the retinotectal projection.

107 ormal terminal distribution of the uncrossed retinotectal projection.

108 N-cadherin in the development of the Xenopus retinotectal projection.

109 ific abnormalities in the development of the retinotectal projection.

110 ng CNS development, including patterning the retinotectal projection.

111 f proximal branches during refinement of the retinotectal projection.

112 necessary for the normal development of the retinotectal projection.

113 inal innervation in spinal motoaxons and the retinotectal projection.

114 f optic axons, or during regeneration of the retinotectal projection.

115 inal OFF pathway controls turn movements via retinotectal projections and establishes correct orienta

116 Developing chick retinotectal projections extend rostrally in the superfi

117 elimination of topographically inappropriate retinotectal projections in a dose-dependent manner.

118 they have different roles in the guidance of retinotectal projections in vivo.

119 es between the organization of the uncrossed retinotectal projections of 5-HT-treated animals vs. eit

120 tp deficiency results in stunted and splayed retinotectal projections that fail to innervate the opti

121 placed over the SC on either P-1 or P-3, and retinotectal projections were assessed via anterograde t

122 ormalities in both the crossed and uncrossed retinotectal projections when these animals reach adulth

123 tain the refined topographic organization of retinotectal projections.

124 roposed role in specification of topographic retinotectal projections.

125 f cytoarchitecture as well as the pattern of retinotectal projections.

126 The role of GABA(C) receptors in retinotectal responses was also evaluated.

127 to be anteroposterior mapping labels for the retinotectal/retinocollicular projection.

128 d occur with S-cone stimuli invisible to the retinotectal route.

129 ELF-1 could determine nasal versus temporal retinotectal specificity, and providing a direct demonst

130 rons indicate that CPG15 expression promotes retinotectal synapse maturation by recruiting functional

131 f ephrin-B signaling increased the number of retinotectal synapses and stabilized the axon arbors of

132 These fine structural changes at retinotectal synapses are consistent with the role that

133 elatively immature synaptic circuit in which retinotectal synapses are formed on developing filopodia

134 Retinotectal synapses comprise the majority of synapses

135 LTP of retinotectal synapses in developing Xenopus was also rev

136 ely occluded long-term potentiation (LTP) of retinotectal synapses induced by direct electrical stimu

137 in the number of docked synaptic vesicles at retinotectal synapses made by RGC axons expressing GFP-T

138 e report that LTP and LTD induced in vivo at retinotectal synapses of Xenopus tadpoles undergo rapid

139 Mutant retinotectal synapses release less glutamate, per vesicl

140 Xenopus tectal neurons shows that convergent retinotectal synapses undergo activity-dependent coopera

141 um, which induced persistent potentiation of retinotectal synapses, led to a rapid modification of sy

142 short period after the initial formation of retinotectal synapses, spike visual RFs of tectal neuron

143 ncement can be attributed to potentiation of retinotectal synapses.

144 vity-induced long-term potentiation (LTP) of retinotectal synapses.

145 s morphological and functional maturation of retinotectal synapses.

146 ownstream of NMDA receptor activation during retinotectal synaptic competition because NMDA receptor

147 It is possible, however, that BDNF modulates retinotectal synaptic connectivity by differentially inf

148 As tectal cell dendrites elaborate, retinotectal synaptic responses acquire an AMPA receptor

149 ing the formation of topographic maps in the retinotectal system have long been debated.

150 ects of sensory stimuli in refinement of the retinotectal system in Xenopus.

151 of the optic nerve in the developing Xenopus retinotectal system induces long-term potentiation (LTP)

152 lead on several parameters of the developing retinotectal system of frog tadpoles was tested.

153 recise axon pathfinding and targeting in the retinotectal system of the zebrafish (Danio rerio).

154 xpression of Homer in the developing Xenopus retinotectal system results in axonal pathfinding errors

155 ultrastructural organization of the Xenopus retinotectal system to understand better the maturation

156 , ligands for EphB2, in the developing chick retinotectal system using riboprobes, immunocytochemistr

157 alization of guidance cues in the developing retinotectal system, a three-compartment chamber was cre

158 However, in the developing Xenopus retinotectal system, activity-induced synaptic modificat

159 In the developing retinotectal system, APP, contactin 4 and NgCAM are expr

160 In the zebrafish retinotectal system, retinal ganglion cells (RGCs) proje

161 In addition, as has been demonstrated in the retinotectal system, some of these genes are likely to c

162 report here that, in the developing Xenopus retinotectal system, the receptive field of tectal neuro

163 and physiological development of the Xenopus retinotectal system.

164 R2Ct) in optic tectal neurons of the Xenopus retinotectal system.

165 fication also exists in an intact developing retinotectal system.

166 f optimal shape, as might be relevant in the retinotectal system.Two distinct spatial limits on guida

167 5 protein is exported along RGC axons to the retinotectal terminals and may act as a neurotrophin car

168 sential for vertebrate eye morphogenesis and retinotectal topographic mapping.

169 ial interactions suggest that development of retinotectal topography critically depends on cell-speci

170 eviously proposed role in the development of retinotectal topography.

171 re did not interfere with the development of retinotectal topography.

172 lopmental increase in AMPA receptor-mediated retinotectal transmission and increased GABAergic synapt

173 epolarizing Cl- conductances that facilitate retinotectal transmission by NMDA receptors.

174 etinorecipient layers of the frog tectum, on retinotectal transmission.

175 aling within these structures or anterograde retinotectal trophic support.