1 sIgA Abs also visibly reduced toxin binding to the lumin
2 sIgA binding and retro-translocation by M cells was char
3 Hcbetatre-Ad2F-immunized mice produced
a sIgA response equivalent to mice coimmunized with CT.
4 ds to both human secretory immunoglobulin
A (
sIgA) and complement factor H (FH).
5 In addition, secretory immunoglobulin
A (
sIgA) antibodies were detected in the saliva and mucosal
6 PspK bound human secretory immunoglobulin
A (
sIgA) but not the complement regulator factor H and did
7 e of whole human secretory immunoglobulin
A (
sIgA), M6 protein-specific sIgA, and M6 protein-specific
8 ial extracts were assayed for bound
amylase,
sIgA, lactoferrin, and lysozyme.
9 remes for unstimulated whole saliva
amylase,
sIgA, lactoferrin, and lysozyme in an initial screening
10 t component, containing amylase activity
and sIgA, bound to hydroxyapatite to promote adhesion of S.
11 for the first time that although both FH
and sIgA binding has been localized to the alpha-helical dom
12 Thus, we conclude that FH
and sIgA can bind concurrently to the alpha-helical region o
13 cally, preincubation of D39 with both FH
and sIgA led to a 21-fold increase in adherence.
14 In this study, we investigated FH-
and sIgA-mediated pneumococcal adherence to human cell lines
15 ble to induce the production of EHEC IgG
and sIgA in sera and feces.
16 ied whole sIgA, M protein-specific sIgA,
and sIgA preabsorbed with M protein were able to decrease si
17 These PspC variants bind FH yet fail to
bind sIgA.
18 Both sIgA and IgG antibodies compete for the attachment of so
19 he binding of FH to PspC is not inhibited
by sIgA.
20 At 100-fold molar excess
concentration,
sIgA (but not IgG) Abs inhibited ricin attachment to the
21 Women with cholera did not
develop sIgA anti-CtxB responses in serum.
22 d Th2 cytokines and production of fecal
EHEC sIgA, with pVAX-56.2 reducing EHEC cecum colonization.
23 Endogenous sIgA was found associated with the apical membrane of co
24 sIgA was bound at UC; strain differences
for sIgA were inconsistent across sites.
25 Furthermore,
sIgA had an additive effect on adherence to HUVEC; speci
26 a live HCMV vaccine, 8 had IgG to gB, 4
had sIgA, and 2 had mucosal IgA in samples collected 10-20 m
27 seropositive adults, 10 had IgG to gB, 5
had sIgA, and 0 had mucosal IgA.
28 ents of a gB vaccine, 8 had IgG to gB, 7
had sIgA, and 7 had mucosal IgA in samples collected just be
29 ntrast, nonspecific high rates of anti-
hsp60 sIgA antibodies suggest chronic or repeat stimulation fr
30 model system of intestinal epithelia,
human sIgA and IgG contribute to the uptake of V. cholerae by
31 Secretory
IgA (
sIgA) Abs are polymeric Igs comprised of two or more IgA
32 with Hcbetatre produced weak secretory
IgA (
sIgA) and plasma IgG Ab response.
33 secretions were analyzed for secretory
IgA (
sIgA) antibody against the B subunit of cholera toxin (C
34 its, bind and retro-transport secretory
IgA (
sIgA) from the tear film.
35 ht salivary antigen and (iii) secretory
IgA (
sIgA) light chain and alpha-amylase.
36 Secretory
IgA (
sIgA) plays a critical role in providing protection agai
37 t differences for tear IgA or secretory
IgA (
sIgA) reactivity to hsp60 or for tear sIgA and IgG react
38 immunization routes elicited secretory
IgA (
sIgA) responses at multiple mucosal sites.
39 n of FlaA-specific intestinal secretory
IgA (
sIgA) responses required immunization with higher doses
40 the immunoglobulins (Ig)G and secretory
IgA (
sIgA) that function together in host defense.
41 , including factor H (FH) and secretory
IgA (
sIgA) via the secretory component.
42 and zinc bound to human milk secretory
IgA (
sIgA) was investigated.
43 B) neutralize, levels of IgG, secretory
IgA (
sIgA), and mucosal IgA1 antibodies to HCMV were measured
44 the levels of SFB coated with secretory
IgA (
sIgA), which resulted from the significantly different l
45 The role of specific
IgA (
sIgA) in oral immunotherapy (OIT) and natural tolerance
46 ceptor for secretory immunoglobulin A (
IgA) (
sIgA) facing the lumen of the epithelial surfaces.
47 nst albumin, amylase, carbonic anhydrase
II,
sIgA, IgG, IgM, lactoferrin, lysozyme, proline-rich prot
48 a significant correlation of vaccine-
induced sIgA titers in rectal secretions with delayed acquisitio
49 iated with microbial induction of
intestinal sIgA.
50 ble to produce and secrete covalently
joined sIgA.
51 Significantly
less sIgA was bound at UC; strain differences for sIgA were i
52 The presence of antibodies (
mainly sIgA) in the lumen of the small intestine led us to expl
53 RPs), statherins, and histatins but not
MG1,
sIgA, secretory component, or cystatins.
54 Normally,
sIgA is the product of two different cell types with hea
55 Significant levels
of sIgA against goat IgG were present in tears of pre-immun
56 d from the significantly different levels
of sIgA obtained from the mothers' milk during the suckling
57 -immunized mice showed a more rapid onset
of sIgA and plasma IgG Ab responses that were supported by
58 The presence
of sIgA enhanced adherence to SK-MES-1 6-fold and to pharyn
59 e to efficiently produce large quantities
of sIgA of defined specificity in mammalian cells.
60 pression could be reversed by stimulation
of sIgA+ B cells with fibroblasts expressing CD40L; such a
61 The increased susceptibility
of sIgA+ B cells, but not of sIgM+/sIgD+ B cells, to Ig cro
62 ti-IgA-dextran pretreatment had no effect
on sIgA+ B cell survival.
63 Ig receptor cross-linking renders
postswitch sIgA+ B cells unresponsive to subsequent stimulation via
64 e IgM+ (sIgM+/sIgD+) B cells and
postswitch (
sIgA+) B cells.
65 suckling period and, later, of self-
produced sIgA in the small intestine.
66 We demonstrate that
purified sIgA+ B cells pretreated with anti-IgA-dextran at low co
67 minant Ig type in gastrointestinal
sections,
sIgA Abs are centrally important in adaptive immunity to
68 Serum sIgA remained unchanged after OIT.
69 Serum sIgA to ovalbumin and ovomucoid were determined at inclu
70 No specific trend on
serum sIgA was observed in five PEA-EA who developed natural t
71 TEA and PEA had similar
serum sIgA.
72 We aimed to study
serum sIgA in induced and natural tolerance to egg.
73 Thus,
serum sIgA seems not to be associated with induced or natural
74 )), L-selectin(int/-), and sIgM(+),
sIgG(-),
sIgA(+/-) lymphocytes.
75 ected with V. cholerae developed
significant sIgA anti-CtxB responses in endocervical samples (P< or
76 immunoglobulin A (sIgA), M6 protein-
specific sIgA, and M6 protein-specific serum IgG in the inhibitio
77 Purified whole sIgA, M protein-
specific sIgA, and sIgA preabsorbed with M protein were able to d
78 y IgA (sIgA) reactivity to hsp60 or for
tear sIgA and IgG reactivity to MOMP.
79 A can act as an endogenous adjuvant and
that sIgA is important for the antigen-sampling function of M
80 We conclude
that sIgA Abs in mucosal secretions may serve as receptor ana
81 In this study, we demonstrate
that sIgA Abs may also function in innate defense against ric
82 Here, we demonstrate
that sIgA antibodies isolated from pooled healthy human colos
83 nisms of action and of additional roles
that sIgA and its components play in human milk.
84 ort previous findings of others showing
that sIgA can act as an endogenous adjuvant and that sIgA is
85 The sIgA components were first separated by two-dimensional
86 The sIgA made using this approach has great potential as an
87 The local origin of
the sIgA antibodies was further shown by measuring antibodie
88 e led us to explore the participation of
the sIgA receptor and antibodies in the interaction of Caco-
89 of the characteristics and properties of
the sIgA should elucidate the mechanism leading to this prot
90 eptor ganglioside GM(1) colocalizes with
the sIgA receptor in cells of the epithelial monolayer.
91 Conjunctival M cells bind and
translocate sIgA from the tear film.
92 Purified
whole sIgA, M protein-specific sIgA, and sIgA preabsorbed with
93 Consistent with our previous
work,
sIgA, pIgR, and IL-4 decreased with PN, whereas the addi