ライフサイエンスコーパス: saccharide

1 g no functional group with which to bind the saccharide.

2 he lipid may not be covalently linked to the saccharide.

3 which contained Vsa protein, lipid, DNA, and saccharide.

4 shows that Trp49 does not contact the bound saccharide.

5 ril interactions from the perspective of the saccharide.

6 form, and in complex with a tetra- or hepta-saccharide.

7 ows high selectivity for glucose, over other saccharides.

8 es, which could be inhibited by N-acetylated saccharides.

9 produce near-quantitative levels of soluble saccharides.

10 ancer cells manifested by truncated O-linked saccharides.

11 quence of variable recognition of peripheral saccharides.

12 be due to the molecular architectures of the saccharides.

13 removal of side-chain Kdo from the LPS core saccharides.

14 hat contain purified, or partially purified, saccharides.

15 red to have progressively truncated LPS core saccharides.

16 n shown to be effective for the synthesis of saccharides.

17 nd cAMP was triggered by the introduction of saccharides.

18 detection of characteristic oxonium ions of saccharides.

19 rin since they shared the same compositional saccharides.

20 determined to be fructose > glucose > other saccharides.

21 stress, with carbon accumulating as complex saccharides.

22 a nontypical binding preference with sample saccharides.

23 t eliminated the mitogenic activity of these saccharides.

24 tions of J(CH) and J(CC) values in ionizable saccharides.

25 y and a different acetylation pattern of the saccharides.

26 ain enhanced selectivity for ribose and rare saccharides.

27 hing, which is diminished in the presence of saccharides.

28 importance of the multivalent binding to PG saccharides.

29 eUmChlE was also active towards feruloylated saccharides.

30 p, deprotection affords water-soluble 2-thio saccharides.

31 ed MOS indicated minimal amounts of branched saccharides.

32 ers to conjugates bearing a larger number of saccharides.

33 nation complexes, peptides, nucleobases, and saccharides.

34 f alpha-FucN3 linkages relevant to bacterial saccharides.

35 enzyme, the glycan chains consist of 8 or 4 saccharides.

36 d to be glycosylated with a similar terminal saccharide, 4-(3-hydroxybutanamido)-4,6-dideoxy-2-O-meth

37 lectronegative substituent effect on 3JCC in saccharides, a structural factor undocumented previously

38 minimal functional units and that additional saccharides adjacent to these units can alter binding ou

39 physiologically important substances such as saccharides, alpha-hydroxycarboxylates, and catecholamin

40 LMW) organic compounds, including alkaloids, saccharides, amino acids, nucleosides, nucleic bases, an

41 ns in cellular components (lipids, proteins, saccharides, amino acids...) and cellular functions (cel

42 purine moiety as well as the polyoxygenated saccharide and a labile glycosidic bond in the nucleosid

43 with respect to the relative orientation of saccharide and peptide moieties.

44 ing has been invoked recently in crystalline saccharide and protein systems.

45 BaF3/FGFR2b cells, heparin with at least 10 saccharides and 6-O-, 2-O-, and N-sulfates were required

46 sidues at the reducing ends of the S. sonnei saccharides and aminooxy linkers bound to BSA or a recom

47 tegral membrane protein EIIC that transports saccharides and assists in their phosphorylation.

48 mall intestine accumulate mannose-containing saccharides and glycogen particles in their apical cytop

49 ropolymerized 3-aminophenylboronic acid with saccharides and hydroxy acids also confirm that the obse

50 nsidering sensors for polyols, particularly, saccharides and hydroxy acids.

51 rmed to determine the relative enrichment of saccharides and inorganic ions in nascent fine (PM2.5) a

52 Maximal enrichments of saccharides and ions coincided with the second of two ph

53 329S, was found to bind the tetra- and hepta-saccharides and may represent a higher-affinity site emp

54 sity B-coefficients of transfer (DeltatB) of saccharides and other parameters such as isobaric expans

55 n regarding the hydration characteristics of saccharides and play a pivotal role in the study of tast

56 or reduce fermentable oligo-, di-, and mono-saccharides and polyols.

57 This study aimed to assess the contents of saccharides and potential fructooligosaccharides (FOS) o

58 J-couplings within the N-acetyl fragment of saccharides and related structures to be used for more c

59 A chemosensor array for saccharides and saccharide derivatives, fully operationa

60 emand for chemosensors which target multiple saccharides and saccharide derivatives, in aqueous media

61 affected significantly the contents of these saccharides and sFOS.

62 ctures and physicochemical properties of the saccharides and their degradation species correlate well

63 information available in the NMR spectra of saccharides and to advance our understanding of the corr

64 apid and sensitive analysis of underivatized saccharides and was used for determination of sugars in

65 kDa), heparin-derived oligosaccharides (4-22 saccharides), and chemically modified heparins (2-O-, 6-

66 stances (EPS), and lipids using the protein, saccharide, and lipid signatures, respectively, together

67 drolyze lignocellulosic biomass into soluble saccharides, and the bacterium Escherichia coli, which m

68 cation and order of activation for potential saccharide antigens used in conjugate vaccine developmen

69 Saccharides are complex, subtly variable, and camouflage

70 Three of four saccharides are conserved in all serotypes.

71 All saccharides are intimately bound through hydrogen bond,

72 manipulations at the C1 anomeric position of saccharides are one of the central goals of preparative

73 is labeling pattern is expected for 4-carbon saccharides arising from the pentose phosphate pathway.

74 or use in other real-world samples involving saccharides as well as for sensing other desired analyte

75 rnover linked to the stepwise elimination of saccharides attached to the termini of N-glycans.

76 chromatography and identified as HA-[32P]UDP saccharides based on their degradation by snake venom ph

77 Saccharide-based systems with inherent pH- and temperatu

78 couplings matched the experimental values in saccharides bearing an ionizable substituent.

79 edictions match the experimental findings in saccharides bearing ionizable functionality.

80 particularly useful for the sequencing of HS saccharides, because the lack of contaminating isomeric

81 Two of them bind to the saccharide binding site of the RBP and are able to fully

82 he near-infrared fluorescence in response to saccharide binding.

83 pothesized that one or more of the secondary saccharide-binding sites harboring the aromatic residues

84 that the aromatic residues at the secondary saccharide-binding sites in HSAmy play a critical role i

85 Since HSAmy possesses several secondary saccharide-binding sites in which aromatic residues are

86 that a conjugate of nucleobase, peptide, and saccharide binds to peptides from molecular nanofibrils

87 This barrier is assembled from saccharide building blocks not found in mammals, includi

88 s on the concentration of negatively charged saccharides but is independent of oligosaccharide length

89 tocks that harbor easy-to-access fermentable saccharides by incorporating self-destructing lignin; an

90 ates that present patches of electropositive saccharide C-H bonds engage more often in CH-pi interact

91 Uncoupled saccharide can be recovered in its original form.

92 nstrate how these nanomolecules grafted with saccharides can exhibit dramatically improved binding af

93 use of phenylboronic acid as a receptor for saccharide capture onto the substrate and the ability of

94 Contacts between aromatic surfaces and saccharide CH groups are common motifs in natural carboh

95 at binding of two FGF1 molecules to the same saccharide chain is a prerequisite for subsequent FGFR2c

96 antibody levels were a function of both the saccharide chain length and their loading on the protein

97 doglycan (PG), a complex polymer composed of saccharide chains cross-linked by short peptides, is a c

98 pecies were covalently attached to polyamino-saccharide chains of chitosan (CHIT) and allowed to inte

99 The conjugates contained an average of 19 saccharide chains per BSA.

100 Here, we show that the saccharide component of LOS/LPS have direct, high-affini

101 of three allosteric ligands: muramic acid (a saccharide component of the peptidoglycan), the cell wal

102 ) but instead 4-linked glucose as their main saccharide component, with low levels of glucosamine and

103 Abundant saccharide components in milk, such as lactose and lacto

104 nd/or nitrogen sources could alter monomeric saccharide composition and concentrations of the free EP

105 omeric oligosaccharides, which have the same saccharide composition but different types of sequences,

106 mass spectrometry due to their complexity in saccharide composition, polydispersity, and sequence het

107 he most complex natural matrices in terms of saccharides composition, this innovative approach can be

108 ach molecule were a good reflection of their saccharide compositions.

109 ce their contents of monosaccharides and non-saccharide compounds.

110 Saccharides comprise a significant fraction of organic m

111 firmed the bonding of the anomeric region of saccharide configuration of lactulose with WPH.

112 These synthetic saccharide conjugates elicited significantly higher leve

113 Stability of di- and tri-saccharide conjugates of anthocyanidins slightly, but si

114 of synthetic antifouling polymer composed of saccharide containing N-substituted polypeptide (glycope

115 pharmaceuticals, common monosaccharides, and saccharides containing free hydroxyl groups.

116 Saccharide-containing monomers exhibited unique behavior

117 acid on the terminal galactose of a neutral saccharide core (binding order GT1b = GD1a >> GM3; no bi

118 determined and discussed in terms of solute (saccharide)-cosolute (sodium gluconate) interactions.

119 DeltaH degrees (), and DeltaS degrees () for saccharide CTI.

120 ereas the stabilizing effect per mole of all saccharides decreased.

121 e used a set of mutants that have successive saccharide deletions from the nLc4 alpha chain to charac

122 A chemosensor array for saccharides and saccharide derivatives, fully operational in aqueous med

123 ensors which target multiple saccharides and saccharide derivatives, in aqueous media at physiologica

124 ducing three membrane protein complexes from saccharide detergents and show how reducing their overal

125 However, many of the saccharide detergents widely employed in structural biol

126 nknown phase II metabolites, conjugates with saccharides, disaccharides, malonic acid, and sulfate, w

127 ed with the capability of adapting the inter-saccharide distances and orientations in the presence of

128 sition, without regard to the arrangement of saccharide domains typically found in vertebrate HS.

129 diverse organisms utilizes the in vivo oligo saccharide donor in preference to certain larger and/or

130 her a sugar nucleotide donor or lipid-linked saccharide donor.

131 as focused on reactions of nucleophiles with saccharide donors equipped with a leaving group.

132 ng drug molecules, amino acids and peptides, saccharides, dyes, hydrocarbons, perfluorinated hydrocar

133 (iii) The saccharide effect depends on the global regulatory prote

134 (ii) The saccharide effect results in increased levels of TcuB ac

135 stereoselective synthesis of beta-(1-->2)-C-saccharides employing 3-deoxy- and 3-C-branched glycals

136 elective fucose cleavage from the H2-antigen saccharide enables efficient removal of H2 antigen from

137 chain conformation in biologically important saccharides, especially those where this structural elem

138 gh this was improved through the addition of saccharide excipients without detriment to the biologica

139 ferent from that of phages binding cell wall saccharides, for which structural information is availab

140 These saccharides formed 1:1:1 complexes with FGF1 and FGFR2c,

141 In comparison to saccharide-free peptoids, the interfacial saccharide res

142 rides, the structural diversity displayed in saccharides from tissue or cell sources cannot be readil

143 of multiple concentrations of each of seven saccharides (glucose, galactose, fructose, sucrose, treh

144 ing this method, bioactive molecules such as saccharides, glycoalkaloids, flavonoids, organic acids,

145 on of a group of small molecules, called non-saccharide glycosaminoglycan mimetics (NSGMs), as direct

146 well as discriminating compounds within each saccharide group.

147 Saccharides have a central role in the nutrition of all

148 ion behaviour and the basic taste quality of saccharides have been studied from measured apparent mol

149 en unmet as existing molecular receptors for saccharides have generally not shown sufficient degrees

150 re of lignin coexisting with poly- and oligo-saccharides, have very low but variable oxygen permeabil

151 and chain length of heparin, since long (>22 saccharides) heparin chains with sulfation on the 6-O an

152 On the other hand, an approximately 70-saccharide, high-affinity heparin-catalyzed AT inhibitio

153 as a training set for identifying a specific saccharide in a real-world beverage sample.

154 s are commonly used as molecular sensors for saccharides in aqueous media.

155 the differential solubility of its component saccharides in aqueous-ethanol solutions.

156 d optimized to afford both anomers of common saccharides in high anomeric selectivities.

157 ETD effectively dissociates GAGs up to eight saccharides in length, but the low resolution of the ion

158 otal role in the study of taste behaviour of saccharides in mixed aqueous solutions.

159 ng showed the presence of mannose-containing saccharides in the epithelium of proximal kidney tubules

160 c owing to the frequent occurrence of acidic saccharides in the glycan, rendering traditional proteom

161 binders (proteins, lipids, nucleic acids and saccharides) in the matrix.

162 etching vibration were determined in various saccharides including FOS (1-kestose, nystose and kestop

163 ereas the stabilizing effect per mole of all saccharides increased, and that the absolute stability o

164 Saccharide-induced regulons were predicted through the c

165 creen-printed electrode through boronic acid-saccharide interactions, with the boronic acid units spe

166 Escherichia coli, which metabolizes soluble saccharides into desired products.

167 ted by ultrafiltration and freeze-dried with saccharides (inulin and sucrose).

168 A minimum length of at least 12-14 saccharides is required for inhibition, after which inhi

169 In addition, a number of these saccharides (L-arabitol, D-fructose, sucrose, D-glucose,

170 ural and semi-synthetic heparan sulfate (HS) saccharide libraries are a valuable resource for investi

171 In contrast, saccharide libraries can be generated by partial digesti

172 r generation of structurally diverse natural saccharide libraries from HS variants that is fast (appr

173 The di or tri-saccharide ligands in MBPs are accommodated in long rela

174 The galectin family of lectins recognizes saccharide ligands on a variety of microbial pathogens,

175 aose, cross-ring cleavage, which can provide saccharide linkage information, is the dominant fragment

176 he complexity of heparin and heparan sulfate saccharides makes their purification, including many iso

177 harides by using chromatographic methods and saccharide mapping.

178 e three-dimensional conformation of terminal saccharides may partly explain reduced enzymatic activit

179 erial surface, CA forms a loosely associated saccharide mesh that coats the bacteria, often within bi

180 ies involved in osmotic stress tolerance and saccharide metabolism that support phenomic studies.

181 romatographic fractionation of the resulting saccharide mixtures.

182 the distinct stimuli-sensitive properties of saccharide-modified polymers to mediate drug release und

183 ps to allow selective attachment of specific saccharide moieties by chemical glycosylation.

184 t heparin fragments containing two- or eight-saccharide monomers protect against amylin cytotoxicity

185 supramolecular entities displaying different saccharide motifs in a controlled manner is of critical

186 mutual influence of varying densities of the saccharide motifs in the binding properties toward diffe

187 ugar, strongly suggesting that "mismatching" saccharide motifs may modulate carbohydrate-lectin speci

188 ermined for use in conformational studies of saccharide N-acetyl side-chains in solution by NMR spect

189 aterials according to their proteinaceous or saccharide nature.

190 lysis of vinyl ether groups from unsaturated saccharides occurs independently of the alpha or beta co

191 HIL on APC to a heparin/heparan sulfate-like saccharide of syndecan-4 on activated T cells, we posite

192 agarose gels loaded with various non-gelling saccharides of increasing molecular weights.

193 Both CeOB1 and CeOB2 contain OB (oligo-saccharide/oligo-nucleotide binding) folds, which exhibi

194 The design and synthesis of amide-linked saccharide oligomers and polymers, which are predisposed

195 no acids of viral glycoproteins and sulfated saccharides on the GAG chain.

196 Poly-amido-saccharides (PAS) are carbohydrate-based, enantiopure sy

197 Enantiopure poly-amido-saccharides (PASs) with a defined molecular weight and n

198 Herein, right-handed helical poly amido-saccharides (PASs) with beta-N-(1-->2)-d-amide linkages

199 amide linkage to give enantiopure poly-amido-saccharides (PASs).

200 ns to evaluate the effects of peptide versus saccharide pathway structure on coupling magnitude.

201 A new class of functional saccharide-peptide copolymer-based hydrogels was synthes

202 These data suggest our saccharide-peptide hydrogels as promising synthetic extr

203 annan trisaccharide [beta-(Man)(3)] by novel saccharide-peptide linker chemistry to create glycopepti

204 Heparin-like saccharides play an essential role in binding to both fi

205 n isolated from cloudwaters, to biotransform saccharides present in the atmosphere was evaluated usin

206 acrocycle and especially the topology of the saccharide presentation in space influence the biologica

207 is Communication we describe a two-component saccharide probe with logic capability.

208 Analysis of the generated saccharide products revealed a novel HS design, involvin

209 The neutral saccharide profile of the wheat bran was dominated by ar

210 Nevertheless, these saccharides promoted FGF2-mediated cell growth.

211 e from a commercial precursor using a single saccharide protecting group.

212 o-derivatized carbohydrates affords covalent saccharide-protein constructs.

213 lead to antibody responses to the inner core saccharides provides an impetus to further explore this

214 This method allows saccharide quantitation in multivalent pneumococcal vacc

215 ccessible pocket of the putative dimolybdate-saccharide reactive complex during epimerization.

216 es that do not process 6''-carboxyl-modified saccharides, recent structural studies reveal that this

217 Saccharide recognition using the nIR photoluminescence o

218 binding ligands to pendant diols useful for saccharide recognition.

219 tent regardless of the peptide length or the saccharide removed.

220 pecific sulfatases selective for the type of saccharide residue and the attachment position of the su

221 mdiolates of structure R 2NN(O)NO-R' (R' = a saccharide residue) are potential prodrugs of the nitric

222 namics revealed a tight complex in which all saccharide residues are restrained without undergoing su

223 barrier' effect associated with the hydrated saccharide residues as well as steric hindrance from the

224 eak noncovalent interactions influence which saccharide residues bind to proteins, and how they are p

225 Semipurified heparin oligomers with 12 saccharide residues identified the fully sulfated specie

226 for HS20 binding were between six and eight saccharide residues in length.

227 ealed that an oligosaccharide longer than 19 saccharide residues is necessary to display anti-IIa act

228 to saccharide-free peptoids, the interfacial saccharide residues of glycopeptoids formed a higher num

229 Heparin oligomers with chain lengths of 10 saccharide residues or higher provide strong inhibition

230 queous interface enriched in highly hydrated saccharide residues.

231 ied N-sulfo-oligosaccharides having up to 21 saccharide residues.

232 n of IdoA and sulphations in the surrounding saccharide residues.

233 estigated why low levels of glucose or other saccharides restored growth of an apbC strain on Tcb.

234 e enabled exact mass measurements of heparin saccharides roughly up to degree-of-polymerization 20, l

235 insertion contributes to the differences in saccharide selectivity and host defense function and com

236 Using a well-known boronic acid-based saccharide sensor (3), this work reveals a new mechanism

237 fficult challenge of heparin/heparan sulfate saccharide separation and will enhance structure-activit

238 and other alcohol) groups characteristic of saccharides, similar to biogenic carbohydrates found in

239 and analysis of heterogeneous mixtures of HS saccharide species.

240 We propose that, depending on saccharide structure, there are different architectures

241 relations between JCC magnitude and sign and saccharide structure.

242 arensis requires a detailed knowledge of the saccharide structures that can be recognized by protecti

243 sible catalytic mode strictly depends on the saccharide substrate structures.

244 Our data demonstrate that the saccharide substrates display distinct conformations whe

245 ST for distinguishing the fine structures of saccharide substrates.

246 ronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mamm

247 Our work shows that saccharides systematically decrease the agarose gel thin

248 h distributions were obtained from the (poly)saccharide taylorgrams, including non-UV absorbing polym

249 HS is composed of sulfated saccharides that are biosynthesized through a complex pa

250 egulated by the sulphation pattern of nearby saccharides that is genetically controlled by the hepara

251 n (GAG) family are highly polyanionic linear saccharides that play important roles in a variety of ph

252 immune system, metabolic pathways involving saccharides that provide cells with energy, and energy a

253 ype capsules differed in the identity of one saccharide, the pendant phosphopolyalcohol, and the O-ac

254 (NAG) and N-acetylmuramic disaccharide (NAM) saccharides, the latter of which has a peptide stem.

255 emical or in vitro enzymatic synthesis of HS saccharides, the structural diversity displayed in sacch

256 are critical for the development of related saccharide therapeutics, and the data here establish tha

257 The stereoselective synthesis of saccharide thioglycosides containing 1,2-cis-2-amino gly

258 hesis of highly yielding and alpha-selective saccharide thioglycosides containing 1,2-cis-2-amino gly

259 -cis-2-amino glycosidic linkages because the saccharide thioglycosides obtained can serve as donors f

260 hanged the inhibitory potencies of competing saccharides to more closely resemble those of CL-43.

261 ld protocol is presented for the coupling of saccharides to proteins.

262 The binding of saccharides to these receptors was assessed colorimetric

263 visualization of glycoconjugates in alkynyl-saccharide-treated cells at extremely low concentration

264 se, etc.), the recognition of other types of saccharide under natural (aqueous) conditions is less we

265 The N-glycan's first saccharide unit accounts for the entire acceleration of

266 al and biological properties imparted by the saccharide units and are unique from synthetic polymers.

267 ed to achieve stepwise removal of individual saccharide units from the nonreducing termini of the mul

268 Norovirus interactions with other saccharide units of the HBGAs were variable and involved

269 The approach added saccharide units to insulin to create insulin analogs wi

270 ong the ganglioside retention, the number of saccharide units, and their sequence.

271 ngths in these HS block co-polymers were ~40 saccharide units.

272 s FGF1 binds with a minimal footprint of 4.2 saccharide units.

273 to 3000 daltons, corresponding from 5 to 10 saccharide units.

274 the stabilization is derived from the next 2 saccharide units.

275 thermic, and the binding site spans about 12 saccharide units.

276 Whereas several saccharide uptake systems are shared between the differe

277 for their bioorthogonal ligation to a model saccharide using a Huisgen alkyne-azide cycloaddition, t

278 A new route to the anthrose saccharide was developed from D-galactose.

279 n-specific immunogold label showed that this saccharide was distributed evenly over the fiber surface

280 ric interactions even when a large excess of saccharide was present.

281 The chromatographic separation of all saccharides was performed on a BEH amide column using an

282 ar interactions between the antibody and the saccharide, we determined the X-ray crystal structure of

283 Oxidized saccharides were analyzed by monosaccharide composition

284 lcohols, polyols, ethyl esters, mono- and di-saccharides were associated with the classification of s

285 Relative to sodium, individual saccharides were enriched 14-1314-fold in fine SSA, 3-13

286 rates of these receptors in the presence of saccharides were exploited in order to identify patterns

287 Saccharides were monitored for activation by sodium peri

288 The saccharides were then arrayed covalently on glass slides

289 Nonsulfated or nonpolymeric saccharides were without effect.

290 ses, containing mainly hemicellulose-derived saccharides, were refined by physicochemical methods to

291 in recognizing the terminal HBGA fucose, the saccharide which forms the primary conserved interaction

292 d derivative binds even at neutral pH to the saccharides which could expand the application towards b

293 Other saccharides, which are found to crystallize in more open

294 sensor arrays for rapid screening of target saccharides will be available.

295 s are observed for oxides in the presence of saccharides with closely related compositions and struct

296 ith mono- and oligosaccharides, deoxysugars, saccharides with free hydroxyl groups, pyranose, and fur

297 SAX provides an orthogonal method to isolate saccharides with higher purity.

298 structures, progressively exposing different saccharides with increased protein age.

299 consist of tetra-, penta-, hexa-, and hepta-saccharides with molecular weights of 689, 851, 1013 and

300 ymerization efficiency of the alpha(2 --> 8) saccharides; with the treatment all oligomers produced a