ライフサイエンスコーパス: saddle

1 nvolves the active site and, indirectly, the saddle.

2 orphyrin conformations: planar, ruffled, and saddled.

3 , the porphyrin core is found to be severely saddled.

4 Near a saddle a system moves slowly and the state may be percei

5 rt toward the deepest potential wells in the saddle and 5.5-kilometer crater regions.

6 The estimated numerical contribution of saddled and ruffled components is 0.68:0.32, respectivel

7 an otherwise normal pattern of dorsal orange saddles and lateral blotches, our results indicate that

8 s ligands with DFT retain the characteristic saddling and ruffling only if the protein matrix is take

9 constant Gaussian curvature (spherical caps, saddles, and cones) or zero mean curvature (Enneper's su

10 hese orthonormal deformations, which include saddling (B2u), ruffling (B1u), doming (A2u), waving (Eg

11 The melting then rapidly accelerates as the saddle between the two domes gets lower, producing nine

12 For both modelled pulses, the saddle between the two ice domes becomes subject to surf

13 d catheter connected to a laser-lithographed saddle coil at the distal tip.

14 ocatheter prototype with lithographed double-saddle coils at the distal tip was deflected with real-t

15 This mechanism of an ice 'saddle collapse' probably explains MWP-1A and the 8,200-

16 grees ), illustrating the flexibility of the saddle conformation and its dependence on the packing.

17 also shows the macrocycle to be in a mainly saddled conformation, but with a significant ruffled com

18 ImH) complex shows the macrocycle to be in a saddled conformation, with the ligands in perpendicular

19 nalized derivatives in crown-crown and crown-saddle conformations, as well as in complexes with water

20 rown conformer of TTPC was observed, a crown-saddle conformer of TAAC was also assigned in aqueous so

21 ed to produce less than 30% of the wild-type saddling deformation.

22 tions and experiments, we study how the bulk saddle deformations of each hole interact to create defe

23 region known to be sensitive to ruffling and saddling deformations, as well as increased vibrational

24 etween the N-terminal domain and DNA for the saddle diminishes the DNA binding affinity of the full-l

25 (96 cm(-1)) that can be correlated with the saddling distortion observed in the X-ray structure.

26 ctra of porphyrin-protein complexes reveal a saddling distortion of the porphyrin.

27 ppears, probably indicating a decreased heme saddling distortion.

28 also applies to low-dimensional systems with saddle-dynamics.

29 dle; these are located in regions with local saddle geometry to minimize the nematic distortions and

30 the porphyrin core adopts relatively purely saddled geometry.

31 vature-positive for spheres and negative for saddles-has proven a versatile tool to guide the self-as

32 As saddle height increased, peak stresses decreased.

33 Edge weights endcode the corresponding saddle heights and thus measure the difficulties of thes

34 While PPM-saddle horn distance increased in both groups (1.5+/-1.3

35 espectively; P<0.05 versus preischemia), APM-saddle horn distance increased in Control (1.0+/-1.2 mm;

36 ng; P.001), only slightly decreased the PPM-"saddle horn" distance (0.3+/-0.3 mm reduction; P.03), an

37 smaller versus pre-cinching; P.001), and PM-"saddle horn" distances (0.9+/-0.7 and 1.0+/-0.8 mm reduc

38 apillary muscle from the midseptal annulus ("saddle horn") was greater in CIMR(+) animals: 6.5+/-3.2

39 r (PPM) PM tips and the mid-septal annulus ("saddle horn") were calculated from 3-D marker coordinate

40 d posterior PM tips and mid-septal annulus ("saddle horn") were calculated from the 3-dimensional (3D

41 llary muscle tip distances to midseptal MA ("saddle horn"), and distance of each leaflet marker to th

42 ositioned both PM tips closer to the annular saddle horn.

43 A saddle in megathrust slip separates the northwestern edg

44 It partially shields the DNA binding saddle in octameric TBP, shifting upon dissociation to m

45 the first aspect of the classical "inverted saddle" interstitial direct current waveform of SD.

46 data suggest that the predominant process is saddle inversion accompanied by simultaneous rotation of

47 Saddle inversion becomes slow on the 2D NMR time scale a

48 consistent with the expected J-coupling and saddle inversion dynamics, respectively.

49 A saddle is predicted in the folding progress surface (pro

50 The position of the saddle is sensitive to the intrinsic delta C degrees of

51 individual hemes and show that ruffling, not saddling, is the dominant factor influencing the frequen

52 ts were within 95-98% of human estimates; at Saddle Island, the model estimated 894 seals compared to

53 TBP does not bind DNA using its TATA-binding saddle, it does photocross-link to a 22-bp sequence that

54 ition the ring clearly resembles that of the saddle (K form) of N(4)P(4)Cl(8).

55 Several mutations in the saddle led to a surprising increase in transcription, th

56 ine-rich domain of BCMA and BAFF-R both have saddle-like architectures, which sit on the horseback-li

57 (GPRG(POG)(7)C-carbamidomethyl)(3), mapped a saddle-like binding cleft on CBD.

58 lar) anchoring conditions to induce complex, saddle-like deformations.

59 lometers across, but there is a 10-kilometer saddle-like depression with attributes of a large degrad

60 counterparts, algal blades, have a typical, saddle-like midsurface and rippled edges.

61 omplexity of the lipid bilayer, organized on saddle-like minimal surfaces.

62 R out-of-plane vibrational mode gamma(15), a saddling-like mode that is strong in the wild-type enzym

63 thalpy of unfolding approaches zero near the saddle making the unfolding largely invisible to DSC und

64 Dimeric molecule 20 contains two saddle moieties with very similar conformations, theta =

65 point and the checkpoint is represented by a saddle node loop bifurcation.

66 rges are well-defined mathematical events: a saddle-node and homoclinic bifurcation, respectively.

67 ition from subthreshold activity to spiking, saddle-node and Hopf bifurcation.

68 it occurs through a type of bifurcation - a saddle-node bifurcation - that possesses an intrinsic ir

69 ether occur when the system passes through a saddle-node bifurcation as the probe position is varied.

70 slowing down, 2) the scaling laws suggest a saddle-node bifurcation governing slowing down, and 3) t

71 e is a dynamical threshold, resulting from a saddle-node bifurcation mainly determined by IK1 and INC

72 Because of the saddle-node bifurcation, the system can automatically de

73 etween these regimes occurs as a result of a saddle-node bifurcation.

74 can be understood in terms of an underlying saddle-node bifurcation.

75 furcation, and the competition model has two saddle-node bifurcations (in which case the system exhib

76 Two saddle-node bifurcations occur for increasing N (mono --

77 nfiguration changes due to the occurrence of saddle-node bifurcations.

78 t disorders at the time of enrollment (e.g., saddle-nose deformity).

79 odes involve the same region of the arms and saddle of HU.

80 The structure shows the prototypical beta-saddle of LAGLIDADG homing endonucleases that is contrib

81 These data suggest that the DNA-binding saddle of monomeric unliganded yeast TBP is only partial

82 cated on the top surface and the DNA-binding saddle of the C-terminal domain differs between TBP and

83 ecially Trp256) are directly involved in the saddling of the porphyrin substrate.

84 is, on the surface opposite the DNA-facing "saddle" of TBP) and onto the side of the first TBP repea

85 Some residues within the DNA-binding "saddle" of the C-terminal domain are protected upon form

86 e four residues surrounding the "DNA binding saddle" of the C-terminal domain.

87 ifest as plaquelike, polypoid, semiannular ("saddle") or annular lesions.

88 Amplicon sequencing of several independent saddle pattern mutants from different genetic background

89 regions of two Clark isolines having similar saddle phenotypes mediated by CHS siRNAs but different g

90 coordinate and the average structure of the saddle point along that coordinate.

91 of the potential energy surface, namely the saddle point and the conical intersection.

92 The saddle point connecting these isomers lies 0.6 kcal/mol

93 The saddle point corresponds to a crossing of two interactin

94 onding with the second H atom, bypassing the saddle point entirely.

95 The recognition that the saddle point governing the HAT mechanism is on the shoul

96 of activation from the initial state to the saddle point in PEL and the following step of relaxation

97 r, it has become increasingly clear that the saddle point of the free-energy surface in most reaction

98 However, the C(s) symmetric second-order saddle point on the B3LYP energy surface is only 0.3 kca

99 tio calculations identified a 'roaming-type' saddle point on the ground state.

100 transition state is a surface, not a single saddle point on the potential energy surface.

101 different branch of the seam separated by a saddle point on the seam.

102 Here we show how the saddle point region that connects the two minima is enco

103 amics and the conventional analysis based on saddle point structure.

104 conical intersection structures and relevant saddle point structures are presented for the reactions

105 We found no first-order saddle point structures for "center-to-center" proton tr

106 on average to transverse the region near the saddle point where bonding changes occur.

107 ) structure is a local maximum (second-order saddle point).

108 screte eigenstates (e.g. Dyson's disordered, saddle point, and metabolically active toy cell states).

109 ransition-state region, rather than a single saddle point, contributes to reaction kinetics.

110 th the smallest spacing are localized at the saddle point.

111 illation frequency decreasing to zero at the saddle point.

112 o equilibrium C2h configurations via the D2h saddle point.

113 in a problem statement similar to that of a saddle-point problem.

114 plane N-inversion correspond to second-order saddle points (SOSP) on the potential energy surface.

115 -from the ground state, through intermediate saddle points and finally to the configurations of separ

116 y surface (such as multiple minima, valleys, saddle points and ridges) that correspond to characteris

117 tive energetic accessibility of the reaction saddle points and the D0/D1 conical intersection seams.

118 c alveolar flow--characterized by stagnation saddle points associated with alveolar vortices--governs

119 ectronic dispersion whose miniband edges and saddle points can be reached by electrostatic gating.

120 frequencies corresponding to the first-order saddle points corresponding to endo-TS1 and exo-TS1 allo

121 These structures, formally saddle points for concerted displacements on the potenti

122 First-order saddle points for the proton transfer from H3S+ to both

123 n seam of the two lowest states and reaction saddle points located on the shoulders of this seam.

124 in the atomic displacements and stresses at saddle points of the potential energy landscape, we show

125 All sandwich dimers (4a-e) are found to be saddle points on the potential energy surfaces.

126 are predicted to be second- or higher-order saddle points that lie more than 40 kcal/mol higher than

127 s into two degenerate I = 1 Dirac cones, and saddle points with a linear Dirac spectrum emerge.

128 unction has multiple intermediate states and saddle points, and is hence a "rough" free energy landsc

129 the structural resemblances of both types of saddle points, significant differences are found in term

130 tric and energetic proximity to the reaction saddle points.

131 surface is a complex terrain of valleys and saddle points.

132 mediate states correspond to local minima or saddle points.

133 appears to reflect a dual origin: a strongly saddled porphyrin skeleton, which alleviates electrostat

134 Two radiologists selected those with saddle pulmonary embolism and evaluated the clot burden

135 gh ominous in appearance, most patients with saddle pulmonary embolism are hemodynamically stable and

136 Most patients with saddle pulmonary embolism found on computed tomography a

137 Two of 37 saddle pulmonary embolism patients (5.4%) died in the ho

138 Saddle pulmonary embolism represents a large clot and a

139 Saddle pulmonary embolism was found in 37 of 680 patient

140 For patients with saddle pulmonary embolism, the median age was 60 yrs and

141 ocus, which restrict pigment to the hilum or saddle region of the seed coat, respectively.

142 tion, increased height (P<0.001), and deeper saddle shape (ratio of height to intercommissural diamet

143 s increased, a long flat lamina deforms to a saddle shape and/or develops undulations that may lead t

144 Late-systolic MVD annular saddle shape deepened but annular area excessively enlar

145 Flattening of the annular saddle shape is associated with progressive leaflet bill

146 The fact that the saddle shape is conserved across mammalian species provi

147 The saddle shape of the mitral annulus confers a mechanical

148 The saddle shape of the mitral annulus imparts a more subtle

149 l significant nonplanar distortions (i.e., a saddle shape) and remarkably large Stokes-shifted emissi

150 (P<0.0001) indicating flattening of annular saddle shape, redundant leaflet surfaces (P<0.0001), gre

151 The p180C adopts an elongated asymmetric saddle shape, with a three-helix bundle in the middle an

152 D, but height was similar resulting in lower saddle shape.

153 he annulus remained dynamic without systolic saddle-shape accentuation (P=0.30).

154 MD versus FED display poorer contraction and saddle-shape accentuation in early systole and abnormal

155 MVD annulus remains dynamic without systolic saddle-shape accentuation.

156 ction (P=0.99), height increase (P=0.11), or saddle-shape deepening (P=0.35).

157 ion with early-systolic area contraction and saddle-shape deepening contributing to mitral competency

158 loss of early-systolic area contraction and saddle-shape deepening despite similar magnitude of vent

159 ural diameter ratio, which appraises annular saddle-shape depth) were measured throughout the cardiac

160 P, ZnTTFP, and CuTTFP revealed that a severe saddle-shape distortion was observed with the dithiole r

161 ions the CLEC-2N structure face down in the "saddle"-shaped binding site which lies between the aggre

162 n=12), rigid, complete St Jude Medical rigid saddle-shaped (n=12), Carpentier-Edwards Physio (n=12),

163 ramework structure consists of unprecedented saddle-shaped [Be(12)(OH)(12)](12+) rings connected thro

164 nular phantoms encompassing flat to markedly saddle-shaped annular heights.

165 ble band (COS; n=12), St Jude complete rigid saddle-shaped annuloplasty ring (RSA; n=10), Carpentier-

166 , strains increased significantly with rigid saddle-shaped annuloplasty ring, Carpentier-Edwards Phys

167 ncremental unwinding of an initially twisted saddle-shaped apoA-I double belt structure.

168 s to account for cell division planes in the saddle-shaped boundary region.

169 double belt structures with the same general saddle-shaped conformation of both our previous molecula

170 ne)-9, 10-dihydroanthracene moieties adopt a saddle-shaped conformation.

171 duced in the luminal domain which binds to a saddle-shaped crevice on a distal tip of BoNT/B.

172 the individual lipid leaflets have the same saddle-shaped curvature as the hypothetical stalk-interm

173 of FliN from Thermotoga maritima revealed a saddle-shaped dimer formed mainly from beta strands.

174 bridization change in the former case versus saddle-shaped distortion originating from conflicting in

175 tween the domains and are perpendicular to a saddle-shaped DNA binding surface, formed by two four-st

176 nation of open structures and doubly curved, saddle-shaped edges.

177 and release, which we explain in terms of a saddle-shaped exoskeletal spring mechanism.

178 " of some amphibians and amniotes, lacking a saddle-shaped flare on one wall of the ampulla.

179 ), it has been proposed that D-shaped versus saddle-shaped mitral annulus (MA) segmentation is more b

180 1 and 7 carbons of a fifth PDI to produce a saddle-shaped molecule (PDI(5)).

181 Functionalized derivatives of the saddle-shaped molecule tetrabenzo[8]circulene were succe

182 eling analysis which (1) identified a common saddle-shaped nucleophilic region on the surfaces of bot

183 Conversion from a discoidal to a saddle-shaped particle involves loss of helicity and for

184 helicity provide additional support for the saddle-shaped particle model.

185 down and equilibration further supports the saddle-shaped particle model.

186 hthacene has also been determined; this is a saddle-shaped polycyclic aromatic hydrocarbon.

187 Minor-groove recognition by the saddle-shaped protein induces the same conformational ch

188 siological three-dimensional shapes, but not saddle-shaped rigid rings or flexible bands, increase AM

189 Relaxation back into saddle-shaped structures after cool down and equilibrati

190 Saddle-shaped structures are present in each protein tha

191 Their dimeric, saddle-shaped structures support the proposal that 14-3-

192 two active centers that bind pterins, and a saddle-shaped surface that resembles nucleic acid bindin

193 lication and fusion events have produced the saddle-shaped TBP molecule, with its two direct-repeat s

194 l dimerization domain of SIP sits across the saddle-shaped upper surface of Siah1, with two extended

195 nt stimulation, we discovered characteristic saddle-shaped VF* maps that were in excellent agreement

196 A "saddle-shaped" mitral annulus with an optimal ratio betw

197 TA, which appeared to be different from the "saddle-shaped" mitral annulus, suggesting an annuloplast

198 lipid bilayers is sensitive to kappa(m), the saddle splay (Gaussian curvature) elastic modulus of the

199 edge, this is the first determination of the saddle splay (Gaussian) modulus in a lipid system consis

200 o only marginally stable against spontaneous saddle splay deformation, which is incompatible with lon

201 eory is extended to account for nonvanishing saddle splay modulus within lipid monolayers and perturb

202 e explain after considering the influence of saddle splay on the elastic free energy.

203 for measuring M, the ratio of the Gaussian (saddle splay) elastic modulus to the bending elastic mod

204 ic membranes: defensins selectively generate saddle-splay ("negative Gaussian") membrane curvature in

205 membranes by generating topologically active saddle-splay ("negative Gaussian") membrane curvature th

206 ase higher than that of the L(d) phase and a saddle-splay (Gauss) modulus difference with the Gauss m

207 tor deformations, can be rationalized by the saddle-splay contribution to the free energy.

208 The enhancement of saddle-splay curvature generation and relaxation of lipi

209 we show that the requirement for generating saddle-splay curvature implies that a decrease in argini

210 adened the range of lipid compositions where saddle-splay curvature was induced.

211 s of the spontaneous twist, we determine the saddle-splay elastic constant for chromonic liquid cryst

212 For toroidal droplets, we find that the saddle-splay energy screens the twisting energy, resulti

213 ene polymers increased the amount of induced saddle-splay membrane curvature and broadened the range

214 A mechanism of action based on saddle-splay membrane curvature generation is broadly en

215 Importantly, saddle-splay membrane curvature generation places constr

216 f the system, in the vicinity of an unstable saddle steady state that separates the basins of attract

217 bution of a ruffled component in the overall saddled structure compared to all other complexes in thi

218 ationary points-successive minima, joined by saddles-that rise monotonically in energy from basin bot

219 upon dissociation to monomers to expose the saddle to DNA.

220 ometries of the porphyrin cores (from purely saddled to saddled with 30% ruffling).

221 mplex models and big data we anticipate that saddle-transitions will be encountered frequently in the

222 mandibular, full-thickness, alveolar ridge, saddle-type defects following surgical implantation of r

223 In fact, the saddle-type mechanism also applies to low-dimensional sy

224 ntly encounter an additional non-bifurcative saddle-type mechanism leading to critical transitions.

225 We develop an early warning sign for the saddle-type transition.

226 the porphyrin cores (from purely saddled to saddled with 30% ruffling).

227 Young faculty members in surgery are saddled with many clinical time constraints that often a