ライフサイエンスコーパス: salmonellae

1 lence by manipulating the mouse host and the salmonellae.

2 xpression of a variety of unrelated genes in salmonellae.

3 ted in equivalent virulence of Spv+ and Spv- salmonellae.

4 uired very recently, after speciation of the salmonellae.

5 y slightly attenuated relative to InvA+ Spv- salmonellae.

6 eased in vivo replication rate for wild-type salmonellae.

7 ancestor of all the contemporary lineages of salmonellae.

8 caused by groups A, B, C, and D nontyphoidal salmonellae.

9 e important for gastrointestinal survival of salmonellae.

10 reagents suitable for serotyping strains of salmonellae.

11 tions elicited by typhoidal and nontyphoidal salmonellae.

12 morphine pellet followed by inoculation with salmonellae.

13 ctions mediated by enteric pathogens such as salmonellae.

14 to kill the vast majority of nontransformed salmonellae.

15 Of the serotyped salmonellae, 14% (21/152) were Salmonella enterica serov

16 difications reduce TLR4-signaling as part of Salmonellae adaptation to host environments.

17 n increased splenic infection with wild-type salmonellae after oral inoculation; however, Spv- salmon

18 aneously in wild-type and MsbB- strain 14028 salmonellae and accounts for about one-third of all of t

19 emonstrate specific binding affinity between salmonellae and cholesterol.

20 synthetic pathway is shared by virtually all salmonellae and must be maintained by selection, yet no

21 ease caused by the intramacrophage pathogens salmonellae and mycobacteria.

22 alters how macrophages recognize or process salmonellae and prevents the rapid onset of proinflammat

23 Intracellular pathogenic organisms such as salmonellae and shigellae are able to evade the effects

24 ncreased early (0 to 4 h) blood clearance of salmonellae and significantly decreased numbers of bacte

25 g challenge with the intracellular pathogens salmonellae and Staphylococcus aureus.

26 The long-standing association between Salmonellae and their animal hosts has resulted in the a

27 s complex in overall structure than those of salmonellae and Vibrio cholerae.

28 The salmonellae are a diverse group of bacteria within the f

29 Nontyphoidal Salmonellae are a major cause of life-threatening bacter

30 Upon interaction with epithelial cells salmonellae are able to elicit transepithelial signallin

31 Nontyphoidal salmonellae are among the leading causes of food-borne d

32 Salmonellae are associated with a wide spectrum of invas

33 Non-subspecies I salmonellae are commensals of cold-blooded vertebrates a

34 Nontyphoidal salmonellae are enteric pathogens that cause acute gastr

35 Salmonellae are enterobacteria that have the unique abil

36 Salmonellae are gastrointestinal pathogens of man and an

37 Salmonellae are gram-negative bacteria that cause gastro

38 Nontyphoidal Salmonellae are highly prevalent food-borne pathogens.

39 Salmonellae are pathogenic bacteria that cause significa

40 ractory to boosting with orally administered salmonellae at 7 weeks.

41 Mice infected with salmonellae become hypersusceptible to endotoxin.

42 ex, subspecies I, to which 99% of pathogenic salmonellae belong.

43 lt suggested an existing interaction between salmonellae, bile, and eukaryotic cell invasion.

44 during biofilm development, specifically how salmonellae bind to cholesterol, and suggest a target fo

45 We have previously demonstrated that salmonellae, but not Escherichia coli or Yersinia entero

46 Salmonellae can exist in an asymptomatic carrier state i

47 These data suggest that salmonellae can sense and respond to bile to increase re

48 Salmonellae can use ethanolamine (EA) as a sole source o

49 o involve fewer virulence genes than that of Salmonellae, complex virulence-regulatory networks have

50 teric bacterial pathogens, including group B salmonellae, conjugates composed of the detoxified LPS o

51 Salmonellae coordinate SPI-1 expression with anatomical

52 The reasons why non-subspecies I salmonellae do not circulate in populations of warm-bloo

53 portant role in vivo in host defense against salmonellae during the early stages of infection.

54 Genome comparisons of the closely related salmonellae emphasize the insights that can be gleaned f

55 Salmonellae encode two virulence-associated TTSS.

56 Salmonellae encode two virulence-associated type III sec

57 During infection of their hosts, salmonellae enter intestinal epithelial cells.

58 Salmonellae establish infection and avoid clearance by t

59 We have shown that salmonellae form bile-mediated biofilms on human gallsto

60 We have previously demonstrated that salmonellae form biofilms on human gallstones and choles

61 ge, and we have previously demonstrated that salmonellae form biofilms on human gallstones in vitro.

62 In our assays, salmonellae formed full biofilms on the surfaces of gall

63 tion into susceptible BALB/c mice, wild-type salmonellae grew at the expected rate of approximately 1

64 Salmonellae have been shown to be competent for conjugat

65 As enteric pathogens, the salmonellae have developed systems by which they can sen

66 Previous studies on the O-Ag capsule of salmonellae have focused primarily on its role in bacter

67 l drive a revolution in the understanding of Salmonellae in many different niches that are critical f

68 ce, epidemiology, and genetic relatedness of salmonellae in nondomestic birds.

69 mine if the spv genes affected the growth of salmonellae in nonphagocytic cells, an invA::aphT mutati

70 var Typhi (S. Typhi) differs from most other salmonellae in that it causes a life-threatening systemi

71 hesis for the creation of lactose-fermenting salmonellae in the environment is presented.

72 To gain further insight into salmonellae in these hosts, 22 Salmonella isolates from

73 ing infection of the gastrointestinal tract, salmonellae induce cytokine production and inflammatory

74 addition of 5'-methylthioadenosine increased Salmonellae-induced cell death.

75 ride, are important for host defense against Salmonellae infection.

76 Salmonellae initiate disease through the invasion of hos

77 d enzyme methods can cluster closely related salmonellae into epidemiologically relevant hierarchies.

78 fied ST313 lineage of invasive non-typhoidal Salmonellae (iNTS).

79 esistance to antimicrobial agents within the salmonellae is a worldwide problem that has been associa

80 inal study of antimicrobial resistance among salmonellae isolated from swine, we studied 484 Salmonel

81 or pathogenicity of several bacteria and for Salmonellae lacking components of AcrAB-TolC, expression

82 In the case of salmonellae, many virulence factors are regulated via Ph

83 Specific factors unique to nontyphoidal salmonellae may also be important for stimulation of the

84 e a unique niche in which lactose-fermenting salmonellae may arise.

85 Upon infection with salmonellae, mucosal expression of CCL2 is rapidly up-re

86 MsbB- salmonellae mutate extragenically to EGTA-tolerant deriv

87 ears, Streptococcus pneumoniae, nontyphoidal salmonellae (NTS), and Hib were the most frequently isol

88 ens of community-acquired BSI are nontyphoid salmonellae (NTS), Streptococcus pneumoniae, Escherichia

89 For Salmonellae, one such regulatory system is PhoP-PhoQ, wh

90 yphimurium or its flagella, but not by other salmonellae or S. typhimurium mutants unable to synthesi

91 We isolated nontyphoidal salmonellae organisms from blood (n = 35), bone marrow (

92 Nontyphoidal salmonellae, particularly Salmonella enterica serovar Ty

93 The Salmonellae PhoP-PhoQ virulence regulators induce resist

94 The Salmonellae PhoQ sensor kinase senses the mammalian phag

95 In a previous study, we reported that salmonellae possess the ability to stimulate tumor necro

96 Escherichia coli or Yersinia enterocolitica, salmonellae rapidly induce TNF-alpha expression in these

97 Attenuated salmonellae represent attractive candidates for the deli

98 ted that CCL2(-/-) macrophages infected with salmonellae resulted in dysregulated cytokine production

99 ococcus pneumoniae (eight) and non-typhoidal salmonellae (seven).

100 Invasion-defective salmonellae still exhibited the Spv phenotype.

101 In contrast, other pathogenic salmonellae, such as S. enterica serovars Typhimurium an

102 There is evidence of multidrug resistance in salmonellae that warrants vigilant monitoring and survei

103 ridization analysis revealed that, among the salmonellae, the fim gene cluster is present in all isol

104 Unlike other Salmonellae, the intracellular bacterial human pathogen

105 ribution of SPI-3 sequences varies among the salmonellae: the right end of the island, which harbors

106 al epithelial cells and are thought to allow salmonellae to enter and cross the intestinal epithelium

107 eature of salmonella pathogenesis and allows salmonellae to enter intestinal epithelial cells.

108 lial cell (IEC) lines, the capacity of these salmonellae to invade IECs, and the ability of the bacte

109 ich hilA and invasion genes are required for salmonellae to overcome a host clearance response elicit

110 , it was unclear which signals are sensed by salmonellae to promote PhoQ-mediated virulence.

111 viruses, but Campylobacter and nontyphoidal Salmonellae together account for about one fourth of cas

112 After ingestion, salmonellae traverse the upper digestive tract and initi

113 eudomonas aeruginosa, Klebsiella pneumoniae, Salmonellae typhi, Candida albicans, Rhizopus stolonifer

114 Previous studies have shown that attenuated salmonellae utilized as vaccine vectors engender strong

115 promoter exhibited negligible impairment of Salmonellae virulence.

116 ealed that the TNFalpha-inducing activity of salmonellae was associated with flagellin, a major compo

117 rface fibre produced by Escherichia coli and salmonellae, was proposed on the basis of genetic eviden

118 nellae after oral inoculation; however, Spv- salmonellae were defective at increasing splenic infecti

119 Furthermore, MMG-grown salmonellae were more resistant to acid stress and macro

120 InvA- Spv+ salmonellae were not significantly affected for splenic

121 ed with the wild-type strain, and InvA- Spv- salmonellae were only slightly attenuated relative to In

122 of T cells and B cells on the Spv phenotype, salmonellae were orally inoculated into nude and SCID BA

123 Overall, 70% (142/203) of the salmonellae were pansusceptible.

124 Salmonellae were recovered from nasal lymphoid tissues,

125 The results show that >200-fold more salmonellae were recovered in livers of the latter group

126 In the latter (heavily infected), salmonellae were seen within mononuclear cells, indicati

127 Furthermore, in contrast to most Salmonellae, which can infect a broad range of hosts, S.

128 However, salmonellae, which have a core that is chemically dissim

129 Unlike infections with most other Salmonellae, which result in self-limiting gastroenterit

130 rom challenge with a lethal dose of virulent salmonellae, with a dramatic reduction in bacterial numb

131 ions is known to directly kill intracellular salmonellae within macrophages.

132 nd possibly by inhibiting the replication of salmonellae within other macrophages.