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1 ull-length JCPyV genomes in urine and plasma samples from 1 patient with JCPyVAN and 20 stable renal
2 comparing matched pre- and post-chemotherapy samples from 10 cases, the mutational signatures, copy n
3  110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expan
4  between 2005 and 2014 (contrast group) with samples from 10 gadolinium-naive patients who had underg
5  we analyzed HIV populations in longitudinal samples from 10 HIV-1-infected children who initiated AR
6                               We studied 780 samples from 10 regional populations of Kazakhs, Uzbeks,
7 Test precision analyses were performed using samples from 10 subjects.
8 s, 1716 genes were sequenced in 113 FL tumor samples from 105 primarily treatment-naive individuals.
9 ed 66 malignant and 134 non-malignant tissue samples from 107 patients, who underwent ultrasound-guid
10 d preparations from serially collected fecal samples from 11 children (cases) who developed serum aut
11                          Testing 1556 faecal samples from 11 field sites, we identify high prevalence
12                                   In matched samples from 11 high-grade serous ovarian cancer patient
13 abolomic profiling was carried out on plasma samples from 117 adults with 21-hydroxylase deficiency r
14                            We obtained liver samples from 12 patients with ALD and cirrhosis and 9 he
15                                        Blood samples from 125 healthy Kenyan children were analysed b
16                              Screening blood samples from 14 patients tested D816V-negative.
17 uses, and validated these findings in plasma samples from 1421 participants of the MDCS (Malmo Diet a
18  global RNA expression levels in whole blood samples from 150 participants, representing patients in
19   Microarray analysis was performed on blood samples from 150 subjects, of whom 30 were uninfected co
20                 Studying 213 archival biopsy samples from 17 patients, we used somatic variants in hy
21 whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metas
22                              A subset of 212 samples (from 172 patients) was also cultured by using a
23  basis of ssNMR data from 37 cortical tissue samples from 18 individuals, we find that a single Abeta
24                                              Samples from 18 PNPO deficient patients (1 day-25 years)
25 -1 (HHpgV-1), was also detected by NGMS in 4 samples from 2 persons in the clinical trial.
26 dation by collecting fingerprick whole blood samples from 20 participants to assess iron status using
27 d to investigate reactivity to antivenoms in samples from 20 patients with specific IgE antibodies to
28                            Nasal lavage (NL) samples from 20 subjects who were exposed to HMW (n = 10
29 t and Utilization Project National Inpatient Sample from 2000 to 2012.
30                                        Wheat samples from 2013 and 2014 harvests were sourced from UK
31 it, CD154+TcM were measured in cryopreserved samples from 214 children younger than 21 years (Nationa
32 f mean telomere lengths, consisting of 1,808 samples from 22 cohorts born between 1993 and 2014.
33      We address this issue by genotyping 511 samples from 23 populations of Sicily, Southern Italy, G
34 des (including metabolites) related to 24743 samples from 2301 sampling sites.
35 anthropometric traits in up to 191,161 adult samples from 26 cohorts.
36 Cell-free DNA (cfDNA) was isolated from 6 AH samples from 3 children with Rb, including 2 after prima
37                              We studied sera samples from 3 groups of subjects aged >/=65 years (n =
38                           We collected blood samples from 3 relatives with CRC in Spain (65, 62, and
39 riod, serum and/or cerebrospinal fluid (CSF) samples from 3,969 patients were tested with the CrAg LF
40 Between Jan 15 and Dec 18, 2012, we obtained samples from 302 Ugandan volunteers and 302 UK individua
41                                With one-time sampling from 32 sites in rivers of the plateau, we foun
42 was 88% (71%-100%; 7113 questionnaires/blood samples from 3320 PWID).
43 Meth update, we have increased the number of samples from 3610 to 32 701, the number of diseases from
44                We use airborne data of plume samples from 37 unique flares in the Bakken region of No
45                                         Soil samples from 38 homes were analyzed to determine whether
46                           We collected blood samples from 42 patients with chronic HCV infection who
47 y an adverse change in panel score in paired samples from 43 incident patients with pulmonary arteria
48 erformed metabolic profiling on brain tissue samples from 43 individuals ranging in age from 57 to 95
49                              Screening blood samples from 44 of 58 patients tested D816V-positive.
50 evaluated against the combined LYT EIA using samples from 471 well-characterized Lyme patients and co
51  type 17 lymphocytes were measured in sputum samples from 48 participants with asthma.
52                  We collected bile and blood samples from 50 patients undergoing therapeutic endoscop
53 nd superoxide dismutase 3 in ascending aorta samples from 50 tricuspid and 70 patients with BAV under
54              We apply ichorCNA to 1439 blood samples from 520 patients with metastatic prostate or br
55 sma samples, 204 urine samples and 46 saliva samples from 55 male college athletes ages 18-25 years.
56                   In a screen of nephrectomy samples from 56 patients with RCC, we found that MARCKS
57                             We collected HCC samples from 59 patients who underwent surgical resectio
58  level of FFAs and level of MIR122 in plasma samples from 6 healthy individuals, collected before and
59 ected water, hand rinse, food, soil, and fly samples from 608 households.
60  prospectively collected serial weekly stool samples from 66 patients who underwent HCT, starting pre
61                In this study, we analyzed 82 samples from 67 families with IRD.
62                                              Samples from 68 individuals (58 PDAC patients, 10 health
63                     Testing was performed on samples from 683 subjects (306 males and 377 females); 1
64 rmed microRNA (miRNA) profiling in 318 serum samples from 69 liver transplant recipients enrolled in
65                     We obtained liver biopsy samples from 69 patients with chronic HCV infection and
66                            Pretransplant DNA samples from 696 CBUs with malignant diseases were genot
67               We obtained fixed liver biopsy samples from 71 consecutive patients diagnosed with seve
68                              We tested blood samples from 755 HIV-uninfected adults with presumptive
69    We performed discovery analyses on plasma samples from 759 participants of the Framingham Heart St
70 ediments through integration of data (33,198 samples) from 777 grab surveys.
71 ned and tested serum, whole blood, and urine samples from 8 patients among the 18 who were transporte
72       Viral genome was detected in 21 (2.3%) samples from 9 herds (2%), while virus was successfully
73 ed among longitudinal, intraindividual blood samples from 9 of 15 patients and in most of the patient
74                        In an analysis of HCC samples from 956 patients, we found almost 25% to expres
75 n and doped with arsine and a propylene real sample from a cracker plant were analyzed using both ext
76  the anticoagulant used but was reduced in a sample from a patient with dyslipidaemia.
77 state, and structure of selenium in biofilms sampled from a contaminated aquifer near Rifle, CO.
78 (114/110)Cd) of archived fertilizer and soil samples from a 66 year-long agricultural field trial in
79 , river/sea-spiked environmental samples and samples from a bioreactor for sulfate reduction to sulfi
80 olite screening of cerebrospinal fluid (CSF) samples from a canine model of MPS I revealed a marked e
81                                  Conversely, samples from a clinical trial with the mTORC1 inhibitor
82 ealistic complex networks emerge as discrete samples from a continuous hyperbolic geometry enclosed i
83 icas (AF, 12.2 [95% CI, 8.9-15.6]), based on samples from a country with universal rotavirus vaccinat
84 crepancy analysis using results for retested samples from a second NAAT (Xpert C. difficile/Epi test;
85                              The NS platform samples from a select subpopulation of cells within a la
86 miRNAs that are consistently detected in all samples from a single biofluid, and profiles of miRNA ar
87                         In lesional PRP skin samples from a single patient, upregulated expression le
88                            We analyzed serum samples from a subset of 47 children who had received a
89 drial gene, and analyzed representative BMSB samples from across its current global range using an Ap
90               We collected fecal and mucosal samples from adult patients who met the Rome III criteri
91 n this study, we analyzed longitudinal blood samples from advanced stage non-small cell lung cancer (
92                                              Samples from age-matched non-neuropathic individuals wer
93 ux from the SJB using continuous atmospheric sampling from aircraft collected during the TOPDOWN2015
94  Illumina GenoChip Array, also including new samples from Albanian- and Greek-speaking ethno-linguist
95 CR were applied to nasopharyngeal swab (NPS) samples from all acutely HBoV1-infected children and fro
96                       We also obtained blood samples from anonymised waste material of age-and-sex-ma
97 a-derived N was relatively more important in samples from Antarctic continental shelf waters, though
98 examined alterations in glycolysis in sputum samples from asthmatic patients and primary human nasal
99 , S, P, Cu, Fe, Mn and Zn in 72 guarana seed samples from Bahia state.
100 nd a single deposition and looks at the cell samples from below.
101                           BD2-depleted urine samples from bladder infected mice supported increased U
102                                              Samples from Bos taurus, Ovis aries, Sus scrofa domestic
103 nmental sources, including solid and aqueous samples from both natural and waste sources.
104 ssion was transiently reduced in whole blood samples from both omalizumab- and placebo-treated subjec
105 tested poultry, wild bird, and environmental samples from case patient households and surrounding are
106 esis were significantly enriched in baseline samples from CD patients achieving remission.
107 nature of the volatile fraction of black tea samples from Ceylon by applying the principles of sensom
108 uginosa We were able to detect PQS in sputum samples from CF patients infected with P. aeruginosa but
109 rom the first and third trimesters and urine samples from children at age 3 or 4 years.
110 er than oxidation rates of urea-derived N in samples from coastal Georgia, USA (means +/- SEM: 382 +/
111 edictability and the density with which they sampled from communities of images.
112                      Thirty two and 28 urine samples from confirmed and seronegative healthy human su
113                           Finger-prick blood samples from consenting individuals of all ages provided
114 e developed clinical T1D) were compared with samples from controls.
115 ng candidates in exosomes, plasma and tissue samples from CRC patients and healthy controls.
116       In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV
117 strategy was developed to discriminate among samples from different altitudes and latitudes.
118  systematic comparison was obtained by using samples from different environmental sources, including
119                                   Grape seed samples from different localities of Mendoza province (A
120 The experimental work involved a set of five samples from different locations, processed in triplicat
121                                              Samples from different origins were analysed by UV-vis a
122                                              Samples from different plant species and tissues (i.e.,
123 ent analysis showed a clear separation among samples from different weeks and revealed the main compo
124 omes were identified in leaf-pocket-enriched samples from ditch grown A. filiculoides.
125 DNA was found in 75% of genitourinary tissue samples from donors (18 of 24) with high JCV antibody le
126                         We collected 95 dust samples from dormitory common areas and student rooms on
127 in-line to optimize recovery, and the eluted samples from each cartridge were analyzed separately to
128                                       Tissue samples from eight different organs and from blood were
129 tion on global gene expression in myocardial samples from end-stage CCC patients, compared to control
130 luding the only Late Pleistocene Homotherium sample from Eurasia [4].
131           Here we report sequencing of 5,205 samples from families with ASD, accompanied by clinical
132                                              Samples from farmworker households had higher indoor air
133 e allograft samples showing acute rejection, samples from FCRx recipients did not show upregulation o
134 nd antioxidant activity of thirty nine honey samples from Finland, Sweden, Norway and Denmark.
135     Nineteen hot pepper (Capsicum annuum L.) samples from five countries and twenty samples from Roma
136 validated by using matching serum and plasma samples from five IBD patients.
137 ncentrations of 65 flame retardants in water samples from five Lake Michigan tributaries.
138  authors compared postmortem neuronal tissue samples from five patients who had undergone four to 18
139 We performed array tomography on human brain samples from five patients with dementia with Lewy bodie
140 ta set of 143 mammoth mitochondrial genomes, sampled from fossils recovered from across their Holarct
141 h presence with coronary heart disease using samples from four case-control studies that together enr
142 the microbial community in mangrove sediment samples from four different locations within a vast mang
143                                              Samples from four distant basins in Chile were genotyped
144 g CARD-SGS to blood mononuclear cells in six samples from four HIV-infected donors (one with viremia
145                We deep-sequence longitudinal samples from four immunocompromised patients with long-t
146  both in mice deficient in PGRN and in human samples from FTLD patients due to GRN mutations.
147 ipants were selected using stratified random sampling from general surgery residency programs across
148 ch datasets correspond to natural duplicates sampled from genes with high expression and identified o
149                           Trichodesmium spp. sampled from geographically isolated ocean provinces (th
150 ss-defect filtering to four PAH-contaminated samples from geographically distant sites and detected 2
151 nucleotides capable of distinguishing plasma samples from HBOC patients as BRCA1-mutated and BRCA1 no
152 s representing two conditions, e.g. multiple samples from healthy and diseased subjects.
153 ific (98.5%) when compared against those for samples from healthy control individuals.
154 e reductions between prospectively collected samples from healthy controls (2.66 units/mg protein) an
155 ctivation and signaling assays of 30 primary samples from hematopoietic stem cell transplantation pat
156                           Treatment of blood samples from hemorrhagic fever virus (HFV)-infected pati
157 healthy controls (2.66 units/mg protein) and samples from heterozygote female carriers (1.91 units/mg
158 uantification of HIV-1 Gag p24 production in samples from HIV-infected individuals.
159    Pet allergen thresholds that discriminate samples from homes with cats or dogs from those without
160  with expected IFX concentrations in diluted samples from IBD patients.
161 ue from PrEP Participant A despite extensive sampling from ileum, rectum, lymph nodes, bone marrow, C
162             A pilot study was conducted with samples from immigrants to the United States that were s
163                                       Saliva samples from individuals with CP (n = 75), AgP (n = 20),
164 es of fibroblast lines and post-mortem brain samples from individuals with either adult-onset or juve
165 ssion profiling of 4,383 lncRNAs in 82 liver samples from individuals with NASH (n = 48), simple stea
166           We also obtained intestinal tissue samples from infants (2 and 7 months old) undergoing sur
167  immunostaining were applied to liver tissue samples from infants with BA.
168 t treatment did not inactivate EBOV in blood samples from infected NHPs.
169 aterally projecting neurons suggests a broad sampling from inputs on the ipsilateral side.
170 date genes were measured in peripheral blood sampled from ischemic stroke patients at emergency depar
171  collected in 2015, and in one of 108 (0.9%) samples from January to May and 159 of 442 (36.0%) sampl
172 s from January to May and 159 of 442 (36.0%) samples from July to October 2016.
173 odes for the carbapenemase OXA-48, in lysate samples from Klebsiella pneumoniae.
174 , cultured murine primary RPE cells, and RPE samples from live mice.
175           A monitoring study with strawberry samples from local markets was carried out by immunoassa
176      We evaluated our results on human serum samples from lymphoma patients and healthy control subje
177 med a whole-transcriptomic analysis of blood samples from Malian children with cerebral or uncomplica
178 esponse using small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomize
179                                        Fecal samples from mice with maternal separation and from Sox9
180     We were unable to detect EBV-2 in T-cell samples from mothers but could detect EBV-2 in samples o
181 A gene sequencing in prediagnostic mouthwash samples from n = 81/160 EAC and n = 25/50 ESCC cases/mat
182                    miRNA profiling in plasma samples from neonatal PA patients and age-matched contro
183                                   Cord blood samples from neonates born to mothers supplemented with
184       Among the 111 patients enrolled, stool samples from nine were TC positive and four were EIA pos
185 r concentrations of both pesticides than did samples from non-farmworker households.
186 ute to the current number of sequenced exRNA samples from normal healthy individuals.
187 d that the association in MHC is stronger in samples from North America than those from Europe.
188  proposed method to measure 124 human plasma samples from orchard workers and cotton farmers with lon
189  end-stage CCC patients, compared to control samples from organ donors.
190 yzed also by Western blot in ascending aorta samples from other 10 tricuspid aortic valve, 10 BAVnon-
191         Matched urine and finger-prick blood samples from participants >/=2 years of age with fever (
192                                 Twenty serum samples from patients after AHSCT without cGVHD were use
193                              We analyzed HCC samples from patients to determine if these inhibitory p
194 as also increased in left ventricular tissue samples from patients with acute MI.
195                                       Plasma samples from patients with AD (n = 179) were analysed fo
196     Levels of MIR122 were decreased in liver samples from patients with ALD and mice on the Lieber-De
197                             Peripheral blood samples from patients with ALF had a higher proportion o
198  same approach with 25 additional diagnostic samples from patients with BCR-ABL1-positive BCP-ALL, we
199                                  We analysed samples from patients with childhood medulloblastoma who
200        In analyses of paired blood and liver samples from patients with chronic HCV infection before,
201 of these modulators has been tested in human samples from patients with congenital myotonic dystrophy
202                           We obtained plasma samples from patients with DLB (n=37), AD (n=20), MCI wi
203              The authors obtained myocardial samples from patients with end-stage heart failure at ti
204                            We analyzed blood samples from patients with HCV-CV before and after DAA t
205 ons derived from human HD iPSCs and in brain samples from patients with HD.
206 s, and examined expression using lung tissue samples from patients with IPF and controls.
207 l mouse model of pulmonary fibrosis and lung samples from patients with IPF were used to examine the
208                                Compared with samples from patients with lupus nephritis or healthy bl
209 tion of EVs was significantly higher in bile samples from patients with malignant CBD stenoses than c
210 s From January 2010 to December 2013, 42,145 samples from patients with newly diagnosed or suspected
211 on bead arrays were applied to analyze serum samples from patients with OA (n = 273), control subject
212 nia) braziliensis, and L (V) guyanensis] and samples from patients with other infectious diseases.
213 low nuclear CASZ1 staining is found in tumor samples from patients with poor prognosis.
214   We now use this model, in conjunction with samples from patients with premalignant lesions, to defi
215 ersion mutations were only detected in tumor samples from patients with recurrent disease (five of 16
216 detected in renal biopsy specimens and urine samples from patients with renal TILs correlated with re
217                                              Samples from patients with Still's disease and bacterial
218                       Using dried blood spot samples from patients with suspected malaria at 37 healt
219 Abeta40 fibril structure is most abundant in samples from patients with t-AD and PCA-AD, whereas Abet
220  immune response (IL17A and IL23) in mucosal samples from patients with UC compared with patients wit
221 ly measure specific antibody levels in serum samples from patients with varied infectious or autoimmu
222 ined skin biopsies and contemporaneous blood samples from patients within 24 hours of onset of dengue
223                                       In PTC samples from patients, upregulation of TGF-beta, p27, p6
224 rmination of type 1 and type 2 EBV in saliva samples from people from a wide range of geographic and
225 ntibody responses, convalescence-phase serum samples from people previously exposed to primary DENV4
226  loci for CHDMs in more than 2,000 blood DNA samples from population controls between 20 and 69 years
227 uses from Vietnam were generated, comprising samples from poultry outbreaks and active market surveil
228 We found that rhPAPPA and PAPPA in the serum samples from pregnant women or conditioned medium of tro
229      We analyzed 128 suitable frontal cortex samples, from prion-affected patients (variant Creutzfel
230 and anaerobic culture in 97 sonication fluid samples from prosthetic joint and other orthopedic devic
231 y sections and by Western blotting in plasma samples from rats subjected to renal ischemia-reperfusio
232 ylogeny and virome profile analyses of fecal samples from recipients indicated longitudinal changes i
233                                        Fecal samples from REG3A-TG mice had lower levels of ROS than
234 m L.) samples from five countries and twenty samples from Romanian producers were analyzed.
235 (24.4 and 24.6% GLA of total fatty acids for samples from San Pietro Island and Sardinia Island, resp
236         The ZIKV-NS1 IgG cross-reactivity by samples from secondary DENV infection cases ranged from
237                                        Brain samples from selected pigs were also bioassayed in mice
238       This study characterized MPs in sludge samples from seven WWTPs in Ireland which use anaerobic
239 nvestigations were able to discriminate only samples from Sicily and Latium, respectively.
240                         Using protein counts sampled from single cell proteomics distributions to con
241        Using the damselfly Coenagrion puella sampled from six populations, we designed an outdoor lon
242 was performed on multiple culture time point samples from six monoclonal isolates, and single nucleot
243  frozen and 10 fresh CMV DNA-positive plasma samples from solid-organ transplant recipients (SOTRs) w
244 ost and its associated microbes and viruses) sampled from some of Earth's most remote and pristine co
245 3) the endosphere, rhizosphere and soil were sampled from soybeans under eCO2 and maize under eO3.
246                     DISMS2 performs well for samples from species with and without database annotatio
247 dance of [M + Na](+) adducts was observed in samples from spinal cord with demyelination, while the i
248                       Geographically diverse samples from strawberry exhibiting symptoms of Strawberr
249 40 dilution was determined for all available samples from study participants enrolled after the last
250 ucleotide sequencing data derived from blood samples from study patients.
251 sensitively and specifically distinguish ASD samples from TD samples (AUC is 0.88).
252           Hence, the best practice is now to sample from the Boltzmann distribution, which generates
253  initial inoculum, a filtered clinical stool sample from the index gastroenteritis case cluster that
254 sis that retrieve the characteristics of the sample from the measurement of the profile of its refrac
255    In 22,627 audio samples of natural speech sampled from the daily interactions of 143 healthy adult
256 s with periodontitis, subgingival plaque was sampled from the deepest pocket of each quadrant by usin
257                            Among 93 positive samples from the 80 patients, 41 were positive on both g
258  high-precision (41)K/(39)K measurements for samples from the Bay of Islands ophiolite, and we docume
259 EBF1) was assessed in 559 pretreatment tumor samples from the California Childhood Leukemia Study.
260 ring somatic mutations in sequential patient samples from the clinical trial and correlated these wit
261  Deep sequencing was applied to blood plasma samples from the cohort to detect cases of superinfectio
262 alytical method was then applied to 291 food samples from the first French total diet study on infant
263      The method was then applied to 141 food samples from the first French total diet study on infant
264 c carbon (DOC) were fractionated in sediment samples from the four wetlands (ZR: Zhaoniu River; ZRCW:
265     The state of preservation of wood in two samples from the Hanson Logboat, currently on display in
266 cant association with depressive symptoms in samples from the independent population-based Rotterdam
267 and then validated the models using data and samples from the INTERMAP UK cohort (n=225) and a health
268 rrelations were found between serum and dust samples from the living rooms for BDE-47 (p < 0.035), BD
269 5' ends and expression profiles across 1,829 samples from the major human primary cell types and tiss
270                              The analysis of samples from the NW region of Spain showed that these su
271  distribution of the same element in subsoil samples from the same area, taking soil forming processe
272                      Longitudinal plasma SOD samples from the same patients (n = 4) showed decreased
273 sing bulk and single-cell data, we find that samples from the same tumor mass share genomic and expre
274 formation products (TPs) in archived topsoil samples from the Swiss Soil Monitoring Network (NABO) fr
275                                     Plankton samples from the tropical and subtropical Pacific, Atlan
276                         Using large, diverse samples from the United States, Canada, Denmark, and The
277 showed enzyme activity levels lower than all samples from these two other groups as well as seven adu
278       Stochastic stability is essential when sampling from these models, as done in computational neu
279                                      We used samples from three Nordic data sets (involving a total o
280 ed a targeted metabolomic analysis of plasma samples from TN HBOC patients taking into account their
281                        Among 259 photic-zone samples from transects and time-series, Ostreococcus max
282                                  Analysis of samples from transitional and persistent phases of infec
283 umor regression, including regression in PDX samples from triple-negative breast cancer.
284 sis showed a clear separation of goldenberry samples from two different farming systems.
285  A first study was conducted by analyzing 52 samples from two durum and common wheat varieties.
286                               Using clinical samples from two groups of patients, our study revealed
287 itative tau measurements in postmortem brain samples from two progressive supranuclear palsy (PSP) ca
288 verall, 452 formalin-fixed paraffin-embedded samples from two prospective, randomized DLBCL trials (R
289 subset of patients with rich pharmacokinetic samples from two selected disease-specific expansion coh
290 ples were collected for RNA-sequencing, with samples from uninfected C57BL/6 WT and C57BL/6 IL-17RA K
291 ients infected with P. aeruginosa but not in samples from uninfected patients.
292            We additionally dated animal bone samples from units G1 and G1-G3 These dates suggest a co
293 r, revealed clear separation of HTST-treated samples from untreated counterparts as observed from ana
294 ein expression did not differ between tumour samples from variant and wild-type carriers.
295  in vitiligo cell line PIG3V and skin biopsy samples from vitiligo patients, whereas its predicted ta
296 ng symbiont communities from amphibian hosts sampled from wetlands of California, USA, we quantified
297     M. tuberculosis was identified in all 39 samples from which DNA was successfully extracted.
298 at should be used to describe the biological samples from which the sequencing data are derived.
299 h amplicon deep-sequencing placental malaria samples from women in Malawi and Benin, we assessed sequ
300 onent at the highest titer was found only in samples from women with TFI, but there was also an exces

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