ライフサイエンスコーパス: sarcolipin

1 hat the effect of sAnk1 is less than that of sarcolipin.

2 rt by generating a mouse model deficient for sarcolipin.

3 homology in its TM amino acid sequence with sarcolipin, a small protein inhibitor of the sarco(endo)

4 In its monomeric form, we found that sarcolipin adopts a helical conformation, with a compute

5 proteins of the calcium ATPase SERCA, namely sarcolipin and phospholamban, in explicit lipid bilayers

6 placing the SERCA inhibitors, phospholamban, sarcolipin, and myoregulin.

7 se to isoproterenol stimulation, implicating sarcolipin as a mediator of beta-adrenergic responses in

8 CA within the first transport cycle, whereas sarcolipin did not.

9 The absence of sarcolipin does not modify the expression level of other

10 These changes, along with increased sarcolipin expression, provide evidence for the recruitm

11 uorescence analysis confirmed the absence of sarcolipin in normal left ventricles and its marked upre

12 tably by phospholamban in cardiac muscle and sarcolipin in skeletal muscle.

13 vestigated the physiological significance of sarcolipin in the heart by generating a mouse model defi

14 ssociated with beta-adrenergic signaling and sarcolipin in the left ventricles of patients with isola

15 Our study documented that sarcolipin is a key regulator of SERCA2a in atria.

16 Sarcolipin is a novel regulator of cardiac sarcoplasmic

17 late Na(+) ,K(+) -ATPase, and phospholamban, sarcolipin, myoregulin and DWORF, which regulate the sar

18 The sarcolipin-null mice do not show any developmental abnor

19 Furthermore, atria from sarcolipin-null mice showed a blunted response to isopro

20 e evaluated the effects of phospholamban and sarcolipin on calcium translocation and ATP hydrolysis b

21 tylleucine and the integral membrane protein sarcolipin oriented in lipid bicelles.

22 However, how phospholamban and sarcolipin regulate SERCA is not fully understood.

23 An important finding is that ablation of sarcolipin resulted in an increase in atrial Ca2+ transi

24 ies revealed that, in the atria, ablation of sarcolipin resulted in an increase in the affinity of th

25 This suggests that, like sarcolipin, sAnk1 interacts with SERCA1 at least in part

26 e have detected directly the interactions of sarcolipin (SLN) and the sarcoplasmic reticulum Ca-ATPas

27 Phospholamban (PLN) and sarcolipin (SLN) are two single-pass membrane proteins t

28 vity is modulated by phospholamban (PLB) and sarcolipin (SLN) in cardiac and skeletal muscle.

29 The role of sarcolipin (SLN) in cardiac physiology was critically ev

30 Sarcolipin (SLN) is a 31 amino acid integral membrane pr

31 Sarcolipin (SLN) is a novel regulator of sarcoplasmic re

32 Sarcolipin (SLN) is a regulatory peptide present in sarc

33 Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmi

34 Sarcolipin (SLN) is an integral membrane protein that is

35 ic reticulum Ca(2+)-ATPase (SERCA)-inhibitor sarcolipin (SLN) is up-regulated >70-fold in nebulin kno

36 Sarcolipin (SLN), a 31 amino acid integral membrane prot

37 Here we show that sarcolipin (Sln), a newly identified regulator of the sa

38 We recently showed that sarcolipin (SLN), an uncoupler of the sarco(endo)plasmic

39 spholamban (PLB), an affinity modulator, and sarcolipin (SLN), an uncoupler.

40 ic genes [natriuretic peptide type A (Nppa), sarcolipin (Sln), and myosin light polypeptide 4 (Myl4)]

41 onal similarity with phospholamban (PLN) and sarcolipin (SLN), which inhibit SERCA, the membrane pump

42 in 1 (UCP1)-based) and skeletal muscle (i.e. sarcolipin (SLN)-based) thermogenesis processes play imp

43 al membrane proteins phospholamban (PLN) and sarcolipin (SLN).

44 al membrane proteins phospholamban (PLN) and sarcolipin (SLN).

45 mbrane domain in a manner similar to that of sarcolipin (SLN).

46 the unrestrained simulations, the resulting sarcolipin structures are in agreement with distances an

47 osomes containing SERCA and phospholamban or sarcolipin were adsorbed to a solid-supported membrane a

48 culum Ca2+ ATPase (SERCA) regulatory protein sarcolipin, which is predominantly expressed in normal a

49 onment of a small membrane-embedded protein, sarcolipin, which regulates the sarcoplasmic reticulum C