ライフサイエンスコーパス: sarcoplasmic

1 B6a localized to myonuclei while DNAJB6b was sarcoplasmic.

2 Similarly, hnRNPA1 and hnRNPA2/B1 formed sarcoplasmic aggregates in patients with LGMD1D.

3 ase channels located in the membranes of the sarcoplasmic and endoplasmic reticulum.

4 t was shown that radicals were formed in the sarcoplasmic and myofibrillar fractions as well as in th

5 myosin, arginine kinase, myosin light chain, sarcoplasmic calcium-binding protein, and hemocyanin are

6 oxide synthase 2-positive muscle fibers with sarcoplasmic colocalization of markers of regeneration a

7 to sarcomere mutation-positive HCM, whereas sarcoplasmic endoplasmic reticular calcium ATPase 2 abun

8 educed in HCM regardless of genotype, as was sarcoplasmic endoplasmic reticular calcium ATPase 2/phos

9 (45)Ca sarcoplasmic endoplasmic reticular calcium ATPaseuptake

10 S100A1, sarcoplasmic endoplasmic reticulum Ca(2+)ATPase and phos

11 r assist device-supported hearts, S100A1 and sarcoplasmic endoplasmic reticulum Ca(2+)ATPase showed n

12 S100A1 and sarcoplasmic endoplasmic reticulum Ca(2+)ATPase, both ke

13 We measured S100A1, the sarcoplasmic endoplasmic reticulum Ca(2+)ATPase, phospho

14 This compound is a potent inhibitor of the sarcoplasmic-endoplasmic reticulum Ca(2+)-ATPase calcium

15 channels that are known to be present in the sarcoplasmic/endoplasmic reticulum (ER/SR) membranes.

16 channels that are known to be present in the sarcoplasmic/endoplasmic reticulum (ER/SR) membranes.

17 Sarcoplasmic/endoplasmic reticulum Ca(2+) adenosine trip

18 (RyR1), dihydropyridine receptor (DHPR), and sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase (SERCA)

19 ticulum Ca(2+) content via rescue of control sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase levels

20 y that resemble PII-type ATPases such as the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase (SERCA)

21 Sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase (SERCA2

22 concentration regulatory proteins, that is, sarcoplasmic/endoplasmic reticulum calcium ATPase 2 and

23 argets the ryanodine receptor present in the sarcoplasmic/endoplasmic reticulum to promote Ca(2+) rel

24 ticulum (EnR) homeostasis through preserving sarcoplasmic/EnR calcium ATPase 2b (SERCA2b) function in

25 that LGMD1D mutations in DNAJB6 disrupt its sarcoplasmic function suggesting a role for DNAJB6b in Z

26 n staining with unique amorphous nuclear and sarcoplasmic inclusions.

27 tural abnormalities including ringed fibres, sarcoplasmic masses or Z-band disorganization, which are

28 P, this processing modified the 1-D SDS-PAGE sarcoplasmic patterns in a direct-dependent manner and e

29 ical role in vertebrates, and as the primary sarcoplasmic pigment in meat, influences quality percept

30 ns, namely mince (M), washed mince (WM), and sarcoplasmic protein (SP), were investigated.

31 veral peptides derived from myofibrillar and sarcoplasmic proteins are sufficiently resistant to proc

32 od for evaluating proteolytic degradation of sarcoplasmic proteins during the processing of dry-cured

33 al sodium dodecyl sulphate (SDS)-soluble and sarcoplasmic proteins in frozen (-10 degrees C for 3 mon

34 inhibitor from common carp (Cyprinus carpio) sarcoplasmic proteins resulted in 2.8% yield with purifi

35 rolox/g), whereas the ex vivo hydrolysate of sarcoplasmic proteins showed the highest DPPH scavenging

36 dentification and relative quantification of sarcoplasmic proteins through individual quantification

37 antify changes in the abundance of the major sarcoplasmic proteins throughout the ham dry-curing proc

38 For this purpose, extraction of sarcoplasmic proteins was followed by trypsin digestion

39 ivo hydrolysate, whereas the peptide PW from sarcoplasmic proteins was identified only in the in vitr

40 The sarcoplasmic proteins were hydrolyzed faster than the my

41 differences in abundance of myofibrillar and sarcoplasmic proteins were observed between samples and

42 total of five non-redundant myofibrillar and sarcoplasmic proteins.

43 We propose that VCP sustains sarcoplasmic proteostasis, in part, by controlling the i

44 iprotein complexes at discrete plasmalemmal, sarcoplasmic reticular and myofilament sites, reveals di

45 omal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum (ER/SR) Ca(2+) sensor, is unclear

46 lcium (Ca(2+) ) release channels on the endo/sarcoplasmic reticulum (ER/SR).

47 se of their associations with the junctional sarcoplasmic reticulum (jSR).

48 e include the Ca(2+) release channels of the sarcoplasmic reticulum (ryanodine receptors or RyR2s) an

49 that lysosomes form close contacts with the sarcoplasmic reticulum (separation approximately 25 nm).

50 arcolemma triggering Ca(2+) release from the sarcoplasmic reticulum (SR) - a process termed Ca(2+) -i

51 d Ca(2+) release from central non-junctional sarcoplasmic reticulum (SR) and centripetal propagation

52 action depends on release of Ca(2+) from the sarcoplasmic reticulum (SR) and reuptake by the Ca(2+)ad

53 ]i , in particular the relative roles of the sarcoplasmic reticulum (SR) and surface membrane, are un

54 Calcium cycling between the sarcoplasmic reticulum (SR) and the cytosol via the sarc

55 reviously unidentified junctions between the sarcoplasmic reticulum (SR) and transverse-tubules (TTs)

56 d spontaneous Ca(2+) release events from the sarcoplasmic reticulum (SR) as a potential cause of proa

57 unction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine recept

58 f systolic Ca(2+) decrease with age, whereas sarcoplasmic reticulum (SR) Ca content increases.

59 We find that when CRU firings are sparse and sarcoplasmic reticulum (SR) Ca load is high, increasing

60 f Ca wave initiation sites), cellular scale (sarcoplasmic reticulum (SR) Ca load), and tissue scale (

61 Calcium (Ca) sparks are the fundamental sarcoplasmic reticulum (SR) Ca release events in cardiac

62 y of beta-adrenergic stimulation to regulate sarcoplasmic reticulum (SR) Ca(2+) -release.

63 Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to nor

64 nts started to appear, eventually leading to sarcoplasmic reticulum (SR) Ca(2+) depletion.

65 isoproterenol were associated with increased sarcoplasmic reticulum (SR) Ca(2+) leak and frequent dia

66 it a higher open probability of RyR2, higher sarcoplasmic reticulum (SR) Ca(2+) leak in diastole and

67 Abnormal sarcoplasmic reticulum (SR) Ca(2+) leak via the ryanodin

68 nodine receptor 2 (RyR2) phosphorylation and sarcoplasmic reticulum (SR) Ca(2+) leak.

69 ased intracellular Ca(2+) leak and increased sarcoplasmic reticulum (SR) Ca(2+) load compared with ag

70 ise showed an extensive fragmentation of the sarcoplasmic reticulum (SR) Ca(2+) release channel, the

71 V is associated with rapid remodeling of the sarcoplasmic reticulum (SR) Ca(2+) release channel/ryano

72 myocytes ensures synchronized activation of sarcoplasmic reticulum (SR) Ca(2+) release during systol

73 KEY POINTS: Spontaneous sarcoplasmic reticulum (SR) Ca(2+) release events increa

74 o explore whether subclinical alterations of sarcoplasmic reticulum (SR) Ca(2+) release through cardi

75 ransverse (t) tubule depolarization triggers sarcoplasmic reticulum (SR) Ca(2+) release through ryano

76 ack a transverse tubule system, dividing the sarcoplasmic reticulum (SR) Ca(2+) store into the periph

77 e by Ca(2+) -induced Ca(2+) release from the sarcoplasmic reticulum (SR) Ca(2+) store.

78 Depletion of sarcoplasmic reticulum (SR) Ca(2+) stores activates stor

79 on of STIM1 in mice resulted in depletion of sarcoplasmic reticulum (SR) Ca(2+) stores of SANCs and l

80 ation in RyR1 decreases the amplitude of the sarcoplasmic reticulum (SR) Ca(2+) transient, resting cy

81 Ang II-stimulated Nox2 activity increased sarcoplasmic reticulum (SR) Ca(2+) uptake in transgenic

82 Ca2+ sparks, arrhythmogenic Ca2+ waves, sarcoplasmic reticulum (SR) Ca2+ leak, and SR Ca2+ conte

83 alaemia, increased Ca2+ transient amplitude, sarcoplasmic reticulum (SR) Ca2+ load, SR Ca2+ leak and

84 tion which led to increased steepness of the sarcoplasmic reticulum (SR) Ca2+ release slope.

85 ctivity was not altered, implicating altered sarcoplasmic reticulum (SR) calcium leak in the activati

86 To address this question, sarcoplasmic reticulum (SR) calcium release in a mouse s

87 pin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of anim

88 Although abnormal Ca(2+) release from the sarcoplasmic reticulum (SR) has been linked to arrhythmo

89 tion is triggered by Ca(2+) release from the sarcoplasmic reticulum (SR) in response to plasma membra

90 nhancement of Ca(2+) uptake and release from sarcoplasmic reticulum (SR) in sinoatrial nodal cells (S

91 X-1 (HS-associated protein X-1) localizes to sarcoplasmic reticulum (SR) in the heart and interacts w

92 9) may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and sk

93 lysosomes are intimately associated with the sarcoplasmic reticulum (SR) in ventricular myocytes; a m

94 Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation-co

95 and type 1 ryanodine receptor (RyR1) in the sarcoplasmic reticulum (SR) is thought to underlie both

96 contribute to heart failure by rendering the sarcoplasmic reticulum (SR) leaky for Ca(2+).

97 eceptor Ca(2+) release channel (RyR2) in the sarcoplasmic reticulum (SR) membrane and the SR Ca(2+) b

98 C-A) is a major component of the nuclear and sarcoplasmic reticulum (SR) membranes of cardiac and ske

99 Does this rule apply inside the sarcoplasmic reticulum (SR) of a working cell?

100 ry of spark amplitude is controlled by local sarcoplasmic reticulum (SR) refilling whereas refractori

101 ry of spark amplitude is controlled by local sarcoplasmic reticulum (SR) refilling whereas refractori

102 Intracellular Local Ca releases (LCRs) from sarcoplasmic reticulum (SR) regulate cardiac pacemaker c

103 l matrix includes local Ca(2+) delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) t

104 ubules (ATs) with extensive junctions to the sarcoplasmic reticulum (SR) that include ryanodine recep

105 s mediated by increased Ca(2+) leak from the sarcoplasmic reticulum (SR) through the RyR1.

106 Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is

107 R2), a Ca(2+) release channel located in the sarcoplasmic reticulum (SR), or calsequestrin 2 (CASQ2),

108 coupling of the contractile apparatus to the sarcoplasmic reticulum (SR), which serves as the reservo

109 in muscle and alters the composition of the sarcoplasmic reticulum (SR).

110 KAP18 in a multiprotein signalosome in human sarcoplasmic reticulum (SR).

111 -mediated calcium (Ca(2+) ) release from the sarcoplasmic reticulum (SR).

112 axation by regulating Ca(2+) uptake into the sarcoplasmic reticulum (SR).

113 ibrillar space (MS) and a calcium store, the sarcoplasmic reticulum (SR).

114 o induce Ca(2+) release from striated muscle sarcoplasmic reticulum (SR).

115 cal, regenerative release of Ca(2+) from the sarcoplasmic reticulum (SR).

116 mporal dynamics of Ca(2+) in the cytosol and sarcoplasmic reticulum (SR).

117 e channel ryanodine receptor 1 (RyR1) in the sarcoplasmic reticulum (SR).

118 ally, EHD3-deficient myocytes show increased sarcoplasmic reticulum [Ca], increased spark frequency,

119 er beating rate, disorganised sarcomeres and sarcoplasmic reticulum and a blunted response to isopren

120 se in the amount of Ca(2+) stored within the sarcoplasmic reticulum and activated Ca(2+)/calmodulin-d

121 ebral arterial smooth muscle which comprised sarcoplasmic reticulum and caveolae.

122 uscles of SHR showed reduced activity of the sarcoplasmic reticulum and decreased sarcolemmal calcium

123 tudies uncovered progressive dilation of the sarcoplasmic reticulum and ectopic and misaligned transv

124 the dyad, linking the transverse tubule and sarcoplasmic reticulum and ensuring close proximity of C

125 the Ca needed for contraction comes from the sarcoplasmic reticulum and is released by the process of

126 hat can prolong the AP duration and load the sarcoplasmic reticulum and likely contributes to the alt

127 e underwent extensive remodeling of both the sarcoplasmic reticulum and mitochondria, including alter

128 ults in the rapid release of Ca(2+) from the sarcoplasmic reticulum and muscle contraction.

129 ultrastructural abnormalities of junctional sarcoplasmic reticulum and transverse tubules, and (4) a

130 consisting of ryanodine receptors (RyRs) at sarcoplasmic reticulum apposing CaV1.2 channels at t-tub

131 similar to those present in the lumen of the sarcoplasmic reticulum at rest, whereas Ca(2+) concentra

132 cell shortening, Ca transient amplitude and sarcoplasmic reticulum Ca content compared with sham car

133 cell shortening, Ca transient amplitude, and sarcoplasmic reticulum Ca content in colon ascendens ste

134 ak from the sarcoplasmic reticulum, reducing sarcoplasmic reticulum Ca content, Ca transient amplitud

135 t the T tubules and regulates arrhythmogenic sarcoplasmic reticulum Ca leak.

136 waves is a highly nonlinear function of the sarcoplasmic reticulum Ca load.

137 mined the subcellular mechanisms involved in sarcoplasmic reticulum Ca loss that mediate altered Ca h

138 sim) in adult cardiac myocytes during cyclic sarcoplasmic reticulum Ca release, by simultaneous live

139 mic reticular calcium ATPase 2 abundance and sarcoplasmic reticulum Ca uptake are depressed in both s

140 hate receptors (IP3 R) and upon depletion of sarcoplasmic reticulum Ca(2+) .

141 Sarcolipin (SLN) is a novel regulator of sarcoplasmic reticulum Ca(2+) ATPase (SERCA) in muscle.

142 fects and that murine PDE3A1 associates with sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2), phospho

143 e-type versus Fork-type; P<0.01), because of sarcoplasmic reticulum Ca(2+) ATPase pump potentiation c

144 o changes in expression of phospholamban and sarcoplasmic reticulum Ca(2+) ATPase, increased levels o

145 Calsequestrin1 (CSQ1), a sarcoplasmic reticulum Ca(2+) buffering protein, inhibit

146 dling proteins, intracellular [Ca(2+)]i, and sarcoplasmic reticulum Ca(2+) content and increases in p

147 crease in amplitude of Ca(2+) transients and sarcoplasmic reticulum Ca(2+) content in LQT2 myocytes.

148 n of transient outward potassium current and sarcoplasmic reticulum Ca(2+) content via rescue of cont

149 , reduced Ca(2+) spark dimensions, increased sarcoplasmic reticulum Ca(2+) content, and augmented the

150 arcoplasmic reticulum Ca(2+) leak, augmented sarcoplasmic reticulum Ca(2+) content, increased the mag

151 are associated with reductions (2.9-fold) in sarcoplasmic reticulum Ca(2+) content.

152 , sarcoplasmic reticulum Ca(2+) release, and sarcoplasmic reticulum Ca(2+) handling proteins in post-

153 vation of neuronal nitric oxide synthase and sarcoplasmic reticulum Ca(2+) handling proteins, and ide

154 osphorylated neuronal nitric oxide synthase, sarcoplasmic reticulum Ca(2+) handling proteins, intrace

155 iculum Ca(2+) release, and the expression of sarcoplasmic reticulum Ca(2+) handling proteins.

156 d enhanced ryanodine receptor (RyR)-mediated sarcoplasmic reticulum Ca(2+) leak in LQT2 cells.

157 Diastolic sarcoplasmic reticulum Ca(2+) leak or sarcolemmal Ca(2+)

158 )]Bulk=100 nmol/L) is dictated mainly by the sarcoplasmic reticulum Ca(2+) leak rather than sarcolemm

159 SN also reduced sarcoplasmic reticulum Ca(2+) leak, augmented sarcoplasm

160 loss without marked changes in cytosolic and sarcoplasmic reticulum Ca(2+) levels, likely owing to al

161 Ca(2+)-dependent mechanism without altering sarcoplasmic reticulum Ca(2+) load and by increasing uns

162 Ca(2+) concentration transients and a lesser sarcoplasmic reticulum Ca(2+) load due to a down-regulat

163 Sarcoplasmic reticulum Ca(2+) load was not changed with

164 f mutant ryanodine receptor type 2 channels, sarcoplasmic reticulum Ca(2+) load, measured by caffeine

165 There are reduced Ca(2+) transient and sarcoplasmic reticulum Ca(2+) load, together with decrea

166 otoxin (but not ranolazine), suggesting that sarcoplasmic reticulum Ca(2+) release and Na(+) current

167 Simulations suggest that potentiated sarcoplasmic reticulum Ca(2+) release and Na(+)/Ca(2+) e

168 L-type Ca(2+) current (ICaL) reactivation or sarcoplasmic reticulum Ca(2+) release and Na(+)/Ca(2+) e

169 In the heart, sarcoplasmic reticulum Ca(2+) release and signaling are

170 hese models: one relies mainly on fractional sarcoplasmic reticulum Ca(2+) release and uptake, and th

171 Furthermore, ryanodine receptor 1 (the sarcoplasmic reticulum Ca(2+) release channel required f

172 ure for synchronization and stabilization of sarcoplasmic reticulum Ca(2+) release in healthy cardiom

173 enge slowed late repolarization, potentiated sarcoplasmic reticulum Ca(2+) release, and initiated EAD

174 orylation of neuronal nitric oxide synthase, sarcoplasmic reticulum Ca(2+) release, and sarcoplasmic

175 pterin, the dimers of nitric oxide synthase, sarcoplasmic reticulum Ca(2+) release, and the expressio

176 l, flecainide did not inhibit RyR2-dependent sarcoplasmic reticulum Ca(2+) release.

177 omal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca(2+) sensor.

178 (fl/fl) mice post HF revealed both increased sarcoplasmic reticulum Ca(2+) spark frequency and disrup

179 crease Ca(2+) influx to enhance refilling of sarcoplasmic reticulum Ca(2+) stores, slow muscle fatigu

180 Ca(2+) load due to a down-regulation of the sarcoplasmic reticulum Ca(2+)-adenosine triphosphatase p

181 h there is some evidence that suppression of sarcoplasmic reticulum Ca(2+)-ATP-ase (SERCA2) contribut

182 The calcium pump sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) counter-tra

183 namics (MD) simulations of the calcium pump (sarcoplasmic reticulum Ca(2+)-ATPase (SERCA)) in complex

184 Down-regulation of sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) in the

185 merization of phospholamban, which activates sarcoplasmic reticulum Ca(2+)-ATPase and increases cytos

186 ed myocardial oxidative stress and decreased sarcoplasmic reticulum Ca(2+)-ATPase protein expression

187 The sarcoplasmic reticulum Ca(2+)-ATPase SERCA promotes musc

188 ATP has dual roles in the reaction cycle of sarcoplasmic reticulum Ca(2+)-ATPase.

189 Enhanced sarcoplasmic reticulum Ca(2+)-leak via ryanodine recepto

190 Ca(2+)-spark frequency and total sarcoplasmic reticulum Ca(2+)-leak were increased in atr

191 uster promotes AF via enhanced RyR2-mediated sarcoplasmic reticulum Ca(2+)-leak.

192 Increased sarcoplasmic reticulum Ca(2+)-release and AF susceptibil

193 embrane proteins, such as bacteriorhodopsin, sarcoplasmic reticulum Ca(2+)ATPase (SERCA1a), and its a

194 hosphorylation states on the activity of the sarcoplasmic reticulum Ca-ATPase (SERCA).

195 Patients with mutations in RyR2 or in the sarcoplasmic reticulum Ca-binding protein calsequestrin

196 sine formation in lymphocytes as an index of sarcoplasmic reticulum Ca-release-induced adenosine 5'-t

197 vidence has suggested a role for spontaneous sarcoplasmic reticulum Ca2+ -release events in long-stan

198 ent AF, but the occurrence and mechanisms of sarcoplasmic reticulum Ca2+ -release events in paroxysma

199 creased sarcoplasmic reticulum Ca2+ leak and sarcoplasmic reticulum Ca2+ -release events, causing del

200 However, mRNA and protein levels of the sarcoplasmic reticulum Ca2+ ATPase (SERCA) regulatory pr

201 een linked to Ca2+ cycling proteins, such as sarcoplasmic reticulum Ca2+ ATPase (SERCA2a), located in

202 D amplitude and timing include cytosolic and sarcoplasmic reticulum Ca2+ concentrations, inwardly rec

203 sed, activation of X-ROS signaling increases sarcoplasmic reticulum Ca2+ leak and contributes to glob

204 Increased diastolic sarcoplasmic reticulum Ca2+ leak and related delayed aft

205 enhanced SERCA2a activity promote increased sarcoplasmic reticulum Ca2+ leak and sarcoplasmic reticu

206 ady-state pacing, likely because of enhanced sarcoplasmic reticulum Ca2+ leak.

207 d stretching does not significantly increase sarcoplasmic reticulum Ca2+ leak; and 4) when the chemic

208 Ca2+ -transient amplitude and sarcoplasmic reticulum Ca2+ load (caffeine-induced Ca2+

209 studies point to a combination of increased sarcoplasmic reticulum Ca2+ load related to phospholamba

210 role in the normal sympathetic regulation of sarcoplasmic reticulum Ca2+ release or cardiac contracti

211 bound to >70% of RyR2 monomers and inhibits sarcoplasmic reticulum Ca2+ release.

212 state contractions and increased spontaneous sarcoplasmic reticulum Ca2+ sparks mediated by enhanced

213 In adult skeletal muscle, depletion of sarcoplasmic reticulum calcium activates STIM1/Orai1-dep

214 eased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a criti

215 virus serotype 1 (AAV1) vector carrying the sarcoplasmic reticulum calcium ATPase gene (AAV1/SERCA2a

216 eticulum stress, as well as an activation of sarcoplasmic reticulum calcium ATPase isoform 2 and citr

217 e activity in Runx1-deficient mice increased sarcoplasmic reticulum calcium content and sarcoplasmic

218 forms raise the interesting possibility that sarcoplasmic reticulum calcium handling and cardiac cont

219 onged calcium-transient duration and reduced sarcoplasmic reticulum calcium loading and release, cons

220 The sarcoplasmic reticulum calcium pump (SERCA) is regulated

221 o-cell differences through intracellular and sarcoplasmic reticulum calcium regulation.

222 Calcium transient amplitude and fractional sarcoplasmic reticulum calcium release were larger and a

223 Flecainide acetate directly suppresses sarcoplasmic reticulum calcium release-the cellular mech

224 interacting with messenger RNA encoding the sarcoplasmic reticulum calcium uptake pump SERCA2a (also

225 are strongly correlated with fluctuations in sarcoplasmic reticulum calcium, because of strong releas

226 as associated with altered protein levels of sarcoplasmic reticulum calcium-regulatory proteins parti

227 effect on the mechanisms responsible for the sarcoplasmic reticulum charge-compensating counter curre

228 We found that CFTR localizes to the sarcoplasmic reticulum compartment of airway smooth musc

229 ases that are present despite a reduction of sarcoplasmic reticulum content.

230 -signaling nanodomains between lysosomes and sarcoplasmic reticulum dependent on NAADP and TPC2 compr

231 he necessity to restore Ca(2+) levels in the sarcoplasmic reticulum during prolonged exercise.

232 liable activation of Ca(2+) release from the sarcoplasmic reticulum during the plateau of the ventric

233 VT VMs and PCs than respective controls, and sarcoplasmic reticulum fractional release was greater in

234 ]i is increased by manoeuvres that decrease sarcoplasmic reticulum function.

235 ut negligible inotropic response, suggesting sarcoplasmic reticulum immaturity.

236 lex, which modulates Ca(2+) release from the sarcoplasmic reticulum in cardiomyocytes.

237 rastructural alterations of mitochondria and sarcoplasmic reticulum in muscle and abnormal collagen f

238 l role of abnormal calcium releases from the sarcoplasmic reticulum in producing repetitive electrica

239 rotein, obscurin, and stabilizes the network sarcoplasmic reticulum in skeletal muscle.

240 Orai1 channels in complex with STIM1 in the sarcoplasmic reticulum is one such potential disease mec

241 efine a role for NAADP and TPC2 at lysosomal/sarcoplasmic reticulum junctions as unexpected but major

242 Importantly, a mismatch between sarcoplasmic reticulum load and L-type Ca(2+) trigger ca

243 nm) pore connects the transport sites to the sarcoplasmic reticulum lumen through a chain of water mo

244 and modulate sequestration of Ca(2+) in the sarcoplasmic reticulum lumen.

245 nd nearly fully opened at 2 mum cytosolic or sarcoplasmic reticulum luminal Ca(2+), and Ca(2+)- and v

246 ated that sAnk1 and SLN can associate in the sarcoplasmic reticulum membrane and after exogenous expr

247 g sites (ECC couplons) comprising plasma and sarcoplasmic reticulum membrane calcium channels are imp

248 Rescue of mutated SERCA1 to sarcoplasmic reticulum membrane can re-establish resting

249 he intracellular calcium gradient across the sarcoplasmic reticulum membrane.

250 a lattice to form clusters in the junctional sarcoplasmic reticulum membrane.

251 erized by a selective reduction of SERCA1 in sarcoplasmic reticulum membranes.

252 under conditions that mimic environments in sarcoplasmic reticulum membranes.

253 spryn and RyR2 co-localise at the junctional sarcoplasmic reticulum of isolated cardiomyocytes.

254 dantrolene inhibits Ca(2+) release from the sarcoplasmic reticulum of skeletal and cardiac muscle pr

255 the principal Ca(2+) storage protein of the sarcoplasmic reticulum of skeletal muscle.

256 A2a, the protein that pumps calcium into the sarcoplasmic reticulum of the cardiomyocyte, seems promi

257 increased distance between mitochondria and sarcoplasmic reticulum on electron microscopy, and 3) ni

258 Immunostaining showed mislocalization of the sarcoplasmic reticulum proteins Serca1 and Ryr1 in a pat

259 type channel, in contrast to that of cardiac sarcoplasmic reticulum RyR.

260 ainide or riluzole) acting primarily through sarcoplasmic reticulum stabilization.

261 An approach was developed to model the sarcoplasmic reticulum structure at the whole-cell scale

262 urce of reactive oxygen species (ROS) in the sarcoplasmic reticulum that may reduce SERCA2a function.

263 le are essential for Ca(2+) release from the sarcoplasmic reticulum that mediates excitation-contract

264 of the calcium release channel (RyR1) in the sarcoplasmic reticulum that supplies the calcium signal

265 Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (R

266 ne receptors (RyR1s) release Ca(2+) from the sarcoplasmic reticulum to initiate skeletal muscle contr

267 ptor (RyR1) mediates Ca(2+) release from the sarcoplasmic reticulum to initiate skeletal muscle contr

268 Ca(2+) uptake into sarcoplasmic reticulum vesicles by SERCA2A was inhibited

269 on RyR1 channel activity after incorporating sarcoplasmic reticulum vesicles into lipid bilayers.

270 sAnk1 interacts specifically with SERCA1 in sarcoplasmic reticulum vesicles isolated from rabbit ske

271 on the cytoplasmic domain of RyR in isolated sarcoplasmic reticulum vesicles.

272 The Ca(2+) pool in the sarcoplasmic reticulum was increased, the activity of ca

273 se during systole, gradually overloading the sarcoplasmic reticulum with Ca(2+).

274 bules), the intracellular calcium store (the sarcoplasmic reticulum), and the co-localisation of thes

275 KCNQ1 mainly resides in the jSR (junctional sarcoplasmic reticulum), whereas KCNE1 resides on the ce

276 are caused by cyclic Ca(2+) release from the sarcoplasmic reticulum, although Ca(2+) influx via plasm

277 r in the regulation of calcium uptake in the sarcoplasmic reticulum, and by probing its dynamical act

278 channels (ryanodine receptors, RyR2) in the sarcoplasmic reticulum, and the frequency of Ca(2+) spar

279 tructural bridge between the plasmalemma and sarcoplasmic reticulum, is essential for precise Ca(2+)-

280 Ca(2+) influx or release from mitochondria, sarcoplasmic reticulum, or acidic stores.

281 nger function, reduction of Ca(2+) uptake to sarcoplasmic reticulum, reduced K(+) currents, and incre

282 dine receptor would lead to Ca leak from the sarcoplasmic reticulum, reducing sarcoplasmic reticulum

283 o RyR1 that triggers Ca(2+) release from the sarcoplasmic reticulum, retrograde signaling from RyR1 t

284 Experiments using sarcoplasmic reticulum-entrapped Ca(2+) indicator demons

285 d sarcoplasmic reticulum calcium content and sarcoplasmic reticulum-mediated calcium release, preserv

286 tracellular fluxes in both the cytoplasm and sarcoplasmic reticulum.

287 current mediated by Ca(2+) released from the sarcoplasmic reticulum.

288 iculum Ca2+ ATPase (SERCA2a), located in the sarcoplasmic reticulum.

289 ith type 1 ryanodine receptors (RyR1) in the sarcoplasmic reticulum.

290 rticularly spontaneous Ca2+ release from the sarcoplasmic reticulum.

291 alignment with the terminal cisternae of the sarcoplasmic reticulum.

292 r Thr-17 relieves this inhibition in cardiac sarcoplasmic reticulum.

293 mall space between sarcolemma and junctional sarcoplasmic reticulum.

294 ious rates in the release of Ca(2+) from the sarcoplasmic reticulum.

295 ing calcium ions from the cytoplasm into the sarcoplasmic reticulum.

296 es detachment of transverse tubules from the sarcoplasmic reticulum.

297 lease probably due to Ca(2+) overload in the sarcoplasmic reticulum.

298 sensitive release channels on the peripheral sarcoplasmic reticulum.

299 erize structural changes in mitochondria and sarcoplasmic reticulum.

300 accumulated and co-localized with DNAJB6 at sarcoplasmic stress granules suggesting that these prote