ライフサイエンスコーパス: sarcoplasmic reticulum

1 tracellular fluxes in both the cytoplasm and sarcoplasmic reticulum.

2 iculum Ca2+ ATPase (SERCA2a), located in the sarcoplasmic reticulum.

3 ith type 1 ryanodine receptors (RyR1) in the sarcoplasmic reticulum.

4 rticularly spontaneous Ca2+ release from the sarcoplasmic reticulum.

5 alignment with the terminal cisternae of the sarcoplasmic reticulum.

6 r Thr-17 relieves this inhibition in cardiac sarcoplasmic reticulum.

7 mall space between sarcolemma and junctional sarcoplasmic reticulum.

8 ious rates in the release of Ca(2+) from the sarcoplasmic reticulum.

9 es detachment of transverse tubules from the sarcoplasmic reticulum.

10 ing calcium ions from the cytoplasm into the sarcoplasmic reticulum.

11 mainly dependent on [Ca2+]i release from the sarcoplasmic reticulum.

12 ific inhibition of IRE-1 signaling at the ER/sarcoplasmic reticulum.

13 res such as the endoplasmic reticulum or the sarcoplasmic reticulum.

14 lease probably due to Ca(2+) overload in the sarcoplasmic reticulum.

15 sensitive release channels on the peripheral sarcoplasmic reticulum.

16 erize structural changes in mitochondria and sarcoplasmic reticulum.

17 current mediated by Ca(2+) released from the sarcoplasmic reticulum.

18 are caused by cyclic Ca(2+) release from the sarcoplasmic reticulum, although Ca(2+) influx via plasm

19 tors of the release of calcium ions from the sarcoplasmic reticulum, an essential step in muscle exci

20 er beating rate, disorganised sarcomeres and sarcoplasmic reticulum and a blunted response to isopren

21 se in the amount of Ca(2+) stored within the sarcoplasmic reticulum and activated Ca(2+)/calmodulin-d

22 ebral arterial smooth muscle which comprised sarcoplasmic reticulum and caveolae.

23 uscles of SHR showed reduced activity of the sarcoplasmic reticulum and decreased sarcolemmal calcium

24 tudies uncovered progressive dilation of the sarcoplasmic reticulum and ectopic and misaligned transv

25 the dyad, linking the transverse tubule and sarcoplasmic reticulum and ensuring close proximity of C

26 the Ca needed for contraction comes from the sarcoplasmic reticulum and is released by the process of

27 hat can prolong the AP duration and load the sarcoplasmic reticulum and likely contributes to the alt

28 e underwent extensive remodeling of both the sarcoplasmic reticulum and mitochondria, including alter

29 ults in the rapid release of Ca(2+) from the sarcoplasmic reticulum and muscle contraction.

30 or, and protein phosphatase 2A (PP2A) to the sarcoplasmic reticulum and perinuclear space.

31 contact, of the junctions between junctional sarcoplasmic reticulum and T tubules (couplons), and of

32 ultrastructural abnormalities of junctional sarcoplasmic reticulum and transverse tubules, and (4) a

33 bules), the intracellular calcium store (the sarcoplasmic reticulum), and the co-localisation of thes

34 r in the regulation of calcium uptake in the sarcoplasmic reticulum, and by probing its dynamical act

35 channels (ryanodine receptors, RyR2) in the sarcoplasmic reticulum, and the frequency of Ca(2+) spar

36 consisting of ryanodine receptors (RyRs) at sarcoplasmic reticulum apposing CaV1.2 channels at t-tub

37 he nominally cytoplasmic CA isoform CAII and sarcoplasmic reticulum-associated CAXIV.

38 similar to those present in the lumen of the sarcoplasmic reticulum at rest, whereas Ca(2+) concentra

39 cell shortening, Ca transient amplitude and sarcoplasmic reticulum Ca content compared with sham car

40 cell shortening, Ca transient amplitude, and sarcoplasmic reticulum Ca content in colon ascendens ste

41 ak from the sarcoplasmic reticulum, reducing sarcoplasmic reticulum Ca content, Ca transient amplitud

42 t the T tubules and regulates arrhythmogenic sarcoplasmic reticulum Ca leak.

43 waves is a highly nonlinear function of the sarcoplasmic reticulum Ca load.

44 mined the subcellular mechanisms involved in sarcoplasmic reticulum Ca loss that mediate altered Ca h

45 sim) in adult cardiac myocytes during cyclic sarcoplasmic reticulum Ca release, by simultaneous live

46 mic reticular calcium ATPase 2 abundance and sarcoplasmic reticulum Ca uptake are depressed in both s

47 Stimulation of sarcoplasmic reticulum Ca(2)(+) ATPase with forskolin or

48 Our results demonstrate that despite severe sarcoplasmic reticulum Ca(2)(+) leak, PLN-KO suppresses

49 uppressed the triggered activities evoked by sarcoplasmic reticulum Ca(2)(+) overload.

50 n RyR2-R4496C+/- ventricular myocytes during sarcoplasmic reticulum Ca(2)(+) overload.

51 hate receptors (IP3 R) and upon depletion of sarcoplasmic reticulum Ca(2+) .

52 Sarcolipin (SLN) is a novel regulator of sarcoplasmic reticulum Ca(2+) ATPase (SERCA) in muscle.

53 fects and that murine PDE3A1 associates with sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2), phospho

54 e-type versus Fork-type; P<0.01), because of sarcoplasmic reticulum Ca(2+) ATPase pump potentiation c

55 o changes in expression of phospholamban and sarcoplasmic reticulum Ca(2+) ATPase, increased levels o

56 Calsequestrin1 (CSQ1), a sarcoplasmic reticulum Ca(2+) buffering protein, inhibit

57 dling proteins, intracellular [Ca(2+)]i, and sarcoplasmic reticulum Ca(2+) content and increases in p

58 crease in amplitude of Ca(2+) transients and sarcoplasmic reticulum Ca(2+) content in LQT2 myocytes.

59 n of transient outward potassium current and sarcoplasmic reticulum Ca(2+) content via rescue of cont

60 , reduced Ca(2+) spark dimensions, increased sarcoplasmic reticulum Ca(2+) content, and augmented the

61 arcoplasmic reticulum Ca(2+) leak, augmented sarcoplasmic reticulum Ca(2+) content, increased the mag

62 are associated with reductions (2.9-fold) in sarcoplasmic reticulum Ca(2+) content.

63 , sarcoplasmic reticulum Ca(2+) release, and sarcoplasmic reticulum Ca(2+) handling proteins in post-

64 vation of neuronal nitric oxide synthase and sarcoplasmic reticulum Ca(2+) handling proteins, and ide

65 osphorylated neuronal nitric oxide synthase, sarcoplasmic reticulum Ca(2+) handling proteins, intrace

66 iculum Ca(2+) release, and the expression of sarcoplasmic reticulum Ca(2+) handling proteins.

67 d enhanced ryanodine receptor (RyR)-mediated sarcoplasmic reticulum Ca(2+) leak in LQT2 cells.

68 Diastolic sarcoplasmic reticulum Ca(2+) leak or sarcolemmal Ca(2+)

69 )]Bulk=100 nmol/L) is dictated mainly by the sarcoplasmic reticulum Ca(2+) leak rather than sarcolemm

70 SN also reduced sarcoplasmic reticulum Ca(2+) leak, augmented sarcoplasm

71 also increased ryanodine receptor activity (sarcoplasmic reticulum Ca(2+) leak/load relationship) an

72 loss without marked changes in cytosolic and sarcoplasmic reticulum Ca(2+) levels, likely owing to al

73 Ca(2+)-dependent mechanism without altering sarcoplasmic reticulum Ca(2+) load and by increasing uns

74 Ca(2+) concentration transients and a lesser sarcoplasmic reticulum Ca(2+) load due to a down-regulat

75 Sarcoplasmic reticulum Ca(2+) load was not changed with

76 lasmic reticulum which, in turn, changes the sarcoplasmic reticulum Ca(2+) load, diastolic Ca(2+) rel

77 f mutant ryanodine receptor type 2 channels, sarcoplasmic reticulum Ca(2+) load, measured by caffeine

78 There are reduced Ca(2+) transient and sarcoplasmic reticulum Ca(2+) load, together with decrea

79 infrequently occurring Ca(2+) sparks, larger sarcoplasmic reticulum Ca(2+) loads, and spontaneous Ca(

80 eceptor agonists by preventing cytosolic and sarcoplasmic reticulum Ca(2+) overload and calcium/calmo

81 otoxin (but not ranolazine), suggesting that sarcoplasmic reticulum Ca(2+) release and Na(+) current

82 Simulations suggest that potentiated sarcoplasmic reticulum Ca(2+) release and Na(+)/Ca(2+) e

83 L-type Ca(2+) current (ICaL) reactivation or sarcoplasmic reticulum Ca(2+) release and Na(+)/Ca(2+) e

84 In the heart, sarcoplasmic reticulum Ca(2+) release and signaling are

85 hese models: one relies mainly on fractional sarcoplasmic reticulum Ca(2+) release and uptake, and th

86 Furthermore, ryanodine receptor 1 (the sarcoplasmic reticulum Ca(2+) release channel required f

87 s CaMKII-dependent activation of spontaneous sarcoplasmic reticulum Ca(2+) release events that can co

88 ure for synchronization and stabilization of sarcoplasmic reticulum Ca(2+) release in healthy cardiom

89 enge slowed late repolarization, potentiated sarcoplasmic reticulum Ca(2+) release, and initiated EAD

90 orylation of neuronal nitric oxide synthase, sarcoplasmic reticulum Ca(2+) release, and sarcoplasmic

91 pterin, the dimers of nitric oxide synthase, sarcoplasmic reticulum Ca(2+) release, and the expressio

92 l, flecainide did not inhibit RyR2-dependent sarcoplasmic reticulum Ca(2+) release.

93 omal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca(2+) sensor.

94 (fl/fl) mice post HF revealed both increased sarcoplasmic reticulum Ca(2+) spark frequency and disrup

95 crease Ca(2+) influx to enhance refilling of sarcoplasmic reticulum Ca(2+) stores, slow muscle fatigu

96 Ca(2+) load due to a down-regulation of the sarcoplasmic reticulum Ca(2+)-adenosine triphosphatase p

97 h there is some evidence that suppression of sarcoplasmic reticulum Ca(2+)-ATP-ase (SERCA2) contribut

98 The membrane protein complex between the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) and phospho

99 The calcium pump sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) counter-tra

100 namics (MD) simulations of the calcium pump (sarcoplasmic reticulum Ca(2+)-ATPase (SERCA)) in complex

101 injury is associated with downregulation of sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) and al

102 Down-regulation of sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) in the

103 merization of phospholamban, which activates sarcoplasmic reticulum Ca(2+)-ATPase and increases cytos

104 ed myocardial oxidative stress and decreased sarcoplasmic reticulum Ca(2+)-ATPase protein expression

105 The sarcoplasmic reticulum Ca(2+)-ATPase SERCA promotes musc

106 ATP has dual roles in the reaction cycle of sarcoplasmic reticulum Ca(2+)-ATPase.

107 Enhanced sarcoplasmic reticulum Ca(2+)-leak via ryanodine recepto

108 Ca(2+)-spark frequency and total sarcoplasmic reticulum Ca(2+)-leak were increased in atr

109 uster promotes AF via enhanced RyR2-mediated sarcoplasmic reticulum Ca(2+)-leak.

110 Increased sarcoplasmic reticulum Ca(2+)-release and AF susceptibil

111 embrane proteins, such as bacteriorhodopsin, sarcoplasmic reticulum Ca(2+)ATPase (SERCA1a), and its a

112 hosphorylation states on the activity of the sarcoplasmic reticulum Ca-ATPase (SERCA).

113 Patients with mutations in RyR2 or in the sarcoplasmic reticulum Ca-binding protein calsequestrin

114 sine formation in lymphocytes as an index of sarcoplasmic reticulum Ca-release-induced adenosine 5'-t

115 ally, EHD3-deficient myocytes show increased sarcoplasmic reticulum [Ca], increased spark frequency,

116 vidence has suggested a role for spontaneous sarcoplasmic reticulum Ca2+ -release events in long-stan

117 ent AF, but the occurrence and mechanisms of sarcoplasmic reticulum Ca2+ -release events in paroxysma

118 creased sarcoplasmic reticulum Ca2+ leak and sarcoplasmic reticulum Ca2+ -release events, causing del

119 However, mRNA and protein levels of the sarcoplasmic reticulum Ca2+ ATPase (SERCA) regulatory pr

120 een linked to Ca2+ cycling proteins, such as sarcoplasmic reticulum Ca2+ ATPase (SERCA2a), located in

121 D amplitude and timing include cytosolic and sarcoplasmic reticulum Ca2+ concentrations, inwardly rec

122 sed, activation of X-ROS signaling increases sarcoplasmic reticulum Ca2+ leak and contributes to glob

123 Increased diastolic sarcoplasmic reticulum Ca2+ leak and related delayed aft

124 enhanced SERCA2a activity promote increased sarcoplasmic reticulum Ca2+ leak and sarcoplasmic reticu

125 ady-state pacing, likely because of enhanced sarcoplasmic reticulum Ca2+ leak.

126 d stretching does not significantly increase sarcoplasmic reticulum Ca2+ leak; and 4) when the chemic

127 Ca2+ -transient amplitude and sarcoplasmic reticulum Ca2+ load (caffeine-induced Ca2+

128 studies point to a combination of increased sarcoplasmic reticulum Ca2+ load related to phospholamba

129 role in the normal sympathetic regulation of sarcoplasmic reticulum Ca2+ release or cardiac contracti

130 bound to >70% of RyR2 monomers and inhibits sarcoplasmic reticulum Ca2+ release.

131 state contractions and increased spontaneous sarcoplasmic reticulum Ca2+ sparks mediated by enhanced

132 In adult skeletal muscle, depletion of sarcoplasmic reticulum calcium activates STIM1/Orai1-dep

133 eased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a criti

134 virus serotype 1 (AAV1) vector carrying the sarcoplasmic reticulum calcium ATPase gene (AAV1/SERCA2a

135 eticulum stress, as well as an activation of sarcoplasmic reticulum calcium ATPase isoform 2 and citr

136 raction of interstitial fibrosis, normalized sarcoplasmic reticulum calcium ATPase-2a activity and ex

137 ss volume fraction of interstitial fibrosis, sarcoplasmic reticulum calcium ATPase-2a activity, expre

138 e activity in Runx1-deficient mice increased sarcoplasmic reticulum calcium content and sarcoplasmic

139 forms raise the interesting possibility that sarcoplasmic reticulum calcium handling and cardiac cont

140 onged calcium-transient duration and reduced sarcoplasmic reticulum calcium loading and release, cons

141 The sarcoplasmic reticulum calcium pump (SERCA) is regulated

142 o-cell differences through intracellular and sarcoplasmic reticulum calcium regulation.

143 Calcium transient amplitude and fractional sarcoplasmic reticulum calcium release were larger and a

144 Flecainide acetate directly suppresses sarcoplasmic reticulum calcium release-the cellular mech

145 interacting with messenger RNA encoding the sarcoplasmic reticulum calcium uptake pump SERCA2a (also

146 are strongly correlated with fluctuations in sarcoplasmic reticulum calcium, because of strong releas

147 as associated with altered protein levels of sarcoplasmic reticulum calcium-regulatory proteins parti

148 effect on the mechanisms responsible for the sarcoplasmic reticulum charge-compensating counter curre

149 We found that CFTR localizes to the sarcoplasmic reticulum compartment of airway smooth musc

150 ases that are present despite a reduction of sarcoplasmic reticulum content.

151 -signaling nanodomains between lysosomes and sarcoplasmic reticulum dependent on NAADP and TPC2 compr

152 he necessity to restore Ca(2+) levels in the sarcoplasmic reticulum during prolonged exercise.

153 liable activation of Ca(2+) release from the sarcoplasmic reticulum during the plateau of the ventric

154 Experiments using sarcoplasmic reticulum-entrapped Ca(2+) indicator demons

155 omal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum (ER/SR) Ca(2+) sensor, is unclear

156 lcium (Ca(2+) ) release channels on the endo/sarcoplasmic reticulum (ER/SR).

157 VT VMs and PCs than respective controls, and sarcoplasmic reticulum fractional release was greater in

158 ]i is increased by manoeuvres that decrease sarcoplasmic reticulum function.

159 ut negligible inotropic response, suggesting sarcoplasmic reticulum immaturity.

160 lex, which modulates Ca(2+) release from the sarcoplasmic reticulum in cardiomyocytes.

161 rastructural alterations of mitochondria and sarcoplasmic reticulum in muscle and abnormal collagen f

162 l role of abnormal calcium releases from the sarcoplasmic reticulum in producing repetitive electrica

163 rotein, obscurin, and stabilizes the network sarcoplasmic reticulum in skeletal muscle.

164 in sAnk1.5 regulates the organization of the sarcoplasmic reticulum in striated muscles.

165 Orai1 channels in complex with STIM1 in the sarcoplasmic reticulum is one such potential disease mec

166 tructural bridge between the plasmalemma and sarcoplasmic reticulum, is essential for precise Ca(2+)-

167 se of their associations with the junctional sarcoplasmic reticulum (jSR).

168 efine a role for NAADP and TPC2 at lysosomal/sarcoplasmic reticulum junctions as unexpected but major

169 Importantly, a mismatch between sarcoplasmic reticulum load and L-type Ca(2+) trigger ca

170 nm) pore connects the transport sites to the sarcoplasmic reticulum lumen through a chain of water mo

171 and modulate sequestration of Ca(2+) in the sarcoplasmic reticulum lumen.

172 nd nearly fully opened at 2 mum cytosolic or sarcoplasmic reticulum luminal Ca(2+), and Ca(2+)- and v

173 d sarcoplasmic reticulum calcium content and sarcoplasmic reticulum-mediated calcium release, preserv

174 ated that sAnk1 and SLN can associate in the sarcoplasmic reticulum membrane and after exogenous expr

175 g sites (ECC couplons) comprising plasma and sarcoplasmic reticulum membrane calcium channels are imp

176 Rescue of mutated SERCA1 to sarcoplasmic reticulum membrane can re-establish resting

177 a lattice to form clusters in the junctional sarcoplasmic reticulum membrane.

178 he intracellular calcium gradient across the sarcoplasmic reticulum membrane.

179 erized by a selective reduction of SERCA1 in sarcoplasmic reticulum membranes.

180 under conditions that mimic environments in sarcoplasmic reticulum membranes.

181 spryn and RyR2 co-localise at the junctional sarcoplasmic reticulum of isolated cardiomyocytes.

182 dantrolene inhibits Ca(2+) release from the sarcoplasmic reticulum of skeletal and cardiac muscle pr

183 the principal Ca(2+) storage protein of the sarcoplasmic reticulum of skeletal muscle.

184 A2a, the protein that pumps calcium into the sarcoplasmic reticulum of the cardiomyocyte, seems promi

185 ediated release of Ca(2+) (J(leak)) from the sarcoplasmic reticulum of ventricular myocytes occurs in

186 increased distance between mitochondria and sarcoplasmic reticulum on electron microscopy, and 3) ni

187 Ca(2+) influx or release from mitochondria, sarcoplasmic reticulum, or acidic stores.

188 g Ca(2+) sparks in mice with knockout of the sarcoplasmic reticulum protein triadin.

189 Immunostaining showed mislocalization of the sarcoplasmic reticulum proteins Serca1 and Ryr1 in a pat

190 nger function, reduction of Ca(2+) uptake to sarcoplasmic reticulum, reduced K(+) currents, and incre

191 dine receptor would lead to Ca leak from the sarcoplasmic reticulum, reducing sarcoplasmic reticulum

192 o RyR1 that triggers Ca(2+) release from the sarcoplasmic reticulum, retrograde signaling from RyR1 t

193 e include the Ca(2+) release channels of the sarcoplasmic reticulum (ryanodine receptors or RyR2s) an

194 type channel, in contrast to that of cardiac sarcoplasmic reticulum RyR.

195 that lysosomes form close contacts with the sarcoplasmic reticulum (separation approximately 25 nm).

196 arcolemma triggering Ca(2+) release from the sarcoplasmic reticulum (SR) - a process termed Ca(2+) -i

197 tromal-interacting molecule 1 (STIM1) in the sarcoplasmic reticulum (SR) and Ca(2)(+) selective Orai1

198 d Ca(2+) release from central non-junctional sarcoplasmic reticulum (SR) and centripetal propagation

199 action depends on release of Ca(2+) from the sarcoplasmic reticulum (SR) and reuptake by the Ca(2+)ad

200 ]i , in particular the relative roles of the sarcoplasmic reticulum (SR) and surface membrane, are un

201 Calcium cycling between the sarcoplasmic reticulum (SR) and the cytosol via the sarc

202 reviously unidentified junctions between the sarcoplasmic reticulum (SR) and transverse-tubules (TTs)

203 d spontaneous Ca(2+) release events from the sarcoplasmic reticulum (SR) as a potential cause of proa

204 unction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine recept

205 f systolic Ca(2+) decrease with age, whereas sarcoplasmic reticulum (SR) Ca content increases.

206 We find that when CRU firings are sparse and sarcoplasmic reticulum (SR) Ca load is high, increasing

207 f Ca wave initiation sites), cellular scale (sarcoplasmic reticulum (SR) Ca load), and tissue scale (

208 Calcium (Ca) sparks are the fundamental sarcoplasmic reticulum (SR) Ca release events in cardiac

209 y of beta-adrenergic stimulation to regulate sarcoplasmic reticulum (SR) Ca(2+) -release.

210 in Ca(2+) transient amplitudes and increased sarcoplasmic reticulum (SR) Ca(2+) content, without chan

211 Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to nor

212 nts started to appear, eventually leading to sarcoplasmic reticulum (SR) Ca(2+) depletion.

213 determined by measuring cytosolic and intra-sarcoplasmic reticulum (SR) Ca(2+) dynamics in intact an

214 The charge translocation associated with sarcoplasmic reticulum (SR) Ca(2+) efflux is compensated

215 PH2 is believed to have an important role in sarcoplasmic reticulum (SR) Ca(2+) handling and modulati

216 isoproterenol were associated with increased sarcoplasmic reticulum (SR) Ca(2+) leak and frequent dia

217 it a higher open probability of RyR2, higher sarcoplasmic reticulum (SR) Ca(2+) leak in diastole and

218 Sarcoplasmic reticulum (SR) Ca(2+) leak through ryanodin

219 Abnormal sarcoplasmic reticulum (SR) Ca(2+) leak via the ryanodin

220 nodine receptor 2 (RyR2) phosphorylation and sarcoplasmic reticulum (SR) Ca(2+) leak.

221 ased intracellular Ca(2+) leak and increased sarcoplasmic reticulum (SR) Ca(2+) load compared with ag

222 ise showed an extensive fragmentation of the sarcoplasmic reticulum (SR) Ca(2+) release channel, the

223 V is associated with rapid remodeling of the sarcoplasmic reticulum (SR) Ca(2+) release channel/ryano

224 myocytes ensures synchronized activation of sarcoplasmic reticulum (SR) Ca(2+) release during systol

225 KEY POINTS: Spontaneous sarcoplasmic reticulum (SR) Ca(2+) release events increa

226 vation can induce potentially arrhythmogenic sarcoplasmic reticulum (SR) Ca(2+) release that involves

227 o explore whether subclinical alterations of sarcoplasmic reticulum (SR) Ca(2+) release through cardi

228 ransverse (t) tubule depolarization triggers sarcoplasmic reticulum (SR) Ca(2+) release through ryano

229 ack a transverse tubule system, dividing the sarcoplasmic reticulum (SR) Ca(2+) store into the periph

230 e by Ca(2+) -induced Ca(2+) release from the sarcoplasmic reticulum (SR) Ca(2+) store.

231 Depletion of sarcoplasmic reticulum (SR) Ca(2+) stores activates stor

232 on of STIM1 in mice resulted in depletion of sarcoplasmic reticulum (SR) Ca(2+) stores of SANCs and l

233 ation in RyR1 decreases the amplitude of the sarcoplasmic reticulum (SR) Ca(2+) transient, resting cy

234 Ang II-stimulated Nox2 activity increased sarcoplasmic reticulum (SR) Ca(2+) uptake in transgenic

235 Ca2+ sparks, arrhythmogenic Ca2+ waves, sarcoplasmic reticulum (SR) Ca2+ leak, and SR Ca2+ conte

236 alaemia, increased Ca2+ transient amplitude, sarcoplasmic reticulum (SR) Ca2+ load, SR Ca2+ leak and

237 tion which led to increased steepness of the sarcoplasmic reticulum (SR) Ca2+ release slope.

238 ctivity was not altered, implicating altered sarcoplasmic reticulum (SR) calcium leak in the activati

239 To address this question, sarcoplasmic reticulum (SR) calcium release in a mouse s

240 usceptibility has been attributed to a leaky sarcoplasmic reticulum (SR) caused by missense mutations

241 pin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of anim

242 Sarcoplasmic reticulum (SR) function was blocked, and ce

243 Although abnormal Ca(2+) release from the sarcoplasmic reticulum (SR) has been linked to arrhythmo

244 Mitochondria are near the sarcoplasmic reticulum (SR) in cardiac myocytes, and evi

245 tion is triggered by Ca(2+) release from the sarcoplasmic reticulum (SR) in response to plasma membra

246 nhancement of Ca(2+) uptake and release from sarcoplasmic reticulum (SR) in sinoatrial nodal cells (S

247 X-1 (HS-associated protein X-1) localizes to sarcoplasmic reticulum (SR) in the heart and interacts w

248 9) may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and sk

249 lysosomes are intimately associated with the sarcoplasmic reticulum (SR) in ventricular myocytes; a m

250 Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation-co

251 and type 1 ryanodine receptor (RyR1) in the sarcoplasmic reticulum (SR) is thought to underlie both

252 HYD alone or in combination with NTG reduced sarcoplasmic reticulum (SR) leak, improved SR Ca(2+) reu

253 contribute to heart failure by rendering the sarcoplasmic reticulum (SR) leaky for Ca(2+).

254 ndence of RyR closed time, with the measured sarcoplasmic reticulum (SR) lumen Ca(2+) dependence of R

255 uestrin (CASQ) is the major component of the sarcoplasmic reticulum (SR) lumen in skeletal and cardia

256 eceptor Ca(2+) release channel (RyR2) in the sarcoplasmic reticulum (SR) membrane and the SR Ca(2+) b

257 C-A) is a major component of the nuclear and sarcoplasmic reticulum (SR) membranes of cardiac and ske

258 Does this rule apply inside the sarcoplasmic reticulum (SR) of a working cell?

259 dine receptor, RyR1, the Ca2+ channel of the sarcoplasmic reticulum (SR) of skeletal muscle.

260 ry of spark amplitude is controlled by local sarcoplasmic reticulum (SR) refilling whereas refractori

261 ry of spark amplitude is controlled by local sarcoplasmic reticulum (SR) refilling whereas refractori

262 Intracellular Local Ca releases (LCRs) from sarcoplasmic reticulum (SR) regulate cardiac pacemaker c

263 l matrix includes local Ca(2+) delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) t

264 ubules (ATs) with extensive junctions to the sarcoplasmic reticulum (SR) that include ryanodine recep

265 ian skeletal muscle, Ca(2+) release from the sarcoplasmic reticulum (SR) through the ryanodine recept

266 s mediated by increased Ca(2+) leak from the sarcoplasmic reticulum (SR) through the RyR1.

267 Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is

268 ts in Ca2+ cycling occur at the level of the sarcoplasmic reticulum (SR), a Ca2+ storage organelle in

269 R2), a Ca(2+) release channel located in the sarcoplasmic reticulum (SR), or calsequestrin 2 (CASQ2),

270 The buffering power, B, of the sarcoplasmic reticulum (SR), ratio of the changes in tot

271 coupling of the contractile apparatus to the sarcoplasmic reticulum (SR), which serves as the reservo

272 in muscle and alters the composition of the sarcoplasmic reticulum (SR).

273 KAP18 in a multiprotein signalosome in human sarcoplasmic reticulum (SR).

274 -mediated calcium (Ca(2+) ) release from the sarcoplasmic reticulum (SR).

275 axation by regulating Ca(2+) uptake into the sarcoplasmic reticulum (SR).

276 ibrillar space (MS) and a calcium store, the sarcoplasmic reticulum (SR).

277 o induce Ca(2+) release from striated muscle sarcoplasmic reticulum (SR).

278 cal, regenerative release of Ca(2+) from the sarcoplasmic reticulum (SR).

279 mporal dynamics of Ca(2+) in the cytosol and sarcoplasmic reticulum (SR).

280 ne depolarization to Ca(2+) release from the sarcoplasmic reticulum (SR).

281 e channel ryanodine receptor 1 (RyR1) in the sarcoplasmic reticulum (SR).

282 Depletion of the intracellular Ca store (sarcoplasmic reticulum, SR) may play an important role,

283 ainide or riluzole) acting primarily through sarcoplasmic reticulum stabilization.

284 An approach was developed to model the sarcoplasmic reticulum structure at the whole-cell scale

285 urce of reactive oxygen species (ROS) in the sarcoplasmic reticulum that may reduce SERCA2a function.

286 le are essential for Ca(2+) release from the sarcoplasmic reticulum that mediates excitation-contract

287 of the calcium release channel (RyR1) in the sarcoplasmic reticulum that supplies the calcium signal

288 Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (R

289 ne receptors (RyR1s) release Ca(2+) from the sarcoplasmic reticulum to initiate skeletal muscle contr

290 ptor (RyR1) mediates Ca(2+) release from the sarcoplasmic reticulum to initiate skeletal muscle contr

291 Ca(2+) uptake into sarcoplasmic reticulum vesicles by SERCA2A was inhibited

292 on RyR1 channel activity after incorporating sarcoplasmic reticulum vesicles into lipid bilayers.

293 sAnk1 interacts specifically with SERCA1 in sarcoplasmic reticulum vesicles isolated from rabbit ske

294 on the cytoplasmic domain of RyR in isolated sarcoplasmic reticulum vesicles.

295 ceptor activation, Ca(2+) mobilized from the sarcoplasmic reticulum via IP3Rs contributes to the decr

296 and T tubules (couplons), and of junctional sarcoplasmic reticulum volume; (4) have a propensity to

297 The Ca(2+) pool in the sarcoplasmic reticulum was increased, the activity of ca

298 KCNQ1 mainly resides in the jSR (junctional sarcoplasmic reticulum), whereas KCNE1 resides on the ce

299 changes in Ca(2+) available for pumping into sarcoplasmic reticulum which, in turn, changes the sarco

300 se during systole, gradually overloading the sarcoplasmic reticulum with Ca(2+).