ライフサイエンスコーパス: secretagogue

1 lates fat deposition and is a potent insulin secretagogue.

2 activity of osteocalcin, which is an insulin secretagogue.

3 g cells of secretory cargo in the absence of secretagogue.

4 omosyn similar to that of application of the secretagogue.

5 eins were stored and released in response to secretagogue.

6 ide that acts as a glucose-dependent insulin secretagogue.

7 of the cells with ATP, an established mucin secretagogue.

8 d in the cells after the addition of a mucin secretagogue.

9 We find that 23G3 is a potent secretagogue.

10 monooxygenase release is more responsive to secretagogue.

11 f T2DM demonstrate that P5 is a weak insulin secretagogue.

12 ry granule exocytosis was more responsive to secretagogue.

13 ng urinary oxalate excretion, via an unknown secretagogue.

14 and specific for muscarinic receptor, as the secretagogue.

15 the entire length of tropomyosin, were weak secretagogues.

16 s very poorly responsive to Ca(2+)-elevating secretagogues.

17 sponse to glucose (15 mm) and other nutrient secretagogues.

18 retion stimulated by noncarbohydrate insulin secretagogues.

19 onfirmed that they were increased by insulin secretagogues.

20 glucose, KCl, and a combination of multiple secretagogues.

21 ch was not possible from studying individual secretagogues.

22 ynthesis, resulting in a reduced response to secretagogues.

23 l insulin responses to glucose and beta-cell secretagogues.

24 with physiological or supramaximal doses of secretagogues.

25 e a step toward developing therapeutic GLP-1 secretagogues.

26 the cells and later released in response to secretagogues.

27 hibited surfactant secretion, independent of secretagogues.

28 ges in AMPK activity in the actions of other secretagogues.

29 phorylation was not observed with other fuel secretagogues.

30 rtant differences from conventional chloride secretagogues.

31 ct mitochondrial metabolism as novel insulin secretagogues.

32 decrease in the level of HMG-CoA produced by secretagogues.

33 n in islet cells was not affected by insulin secretagogues.

34 inar cells stimulated with calcium-releasing secretagogues.

35 ere hyper-responsive to in vivo injection of secretagogues.

36 th compounds were similar for several common secretagogues.

37 refore secrete less chloride when exposed to secretagogues.

38 not corticosterone, in response to different secretagogues.

39 esters, and analogs of cAMP, all key insulin secretagogues.

40 d secretion during stimulation with nutrient secretagogues.

41 n secretion in response to glucose and other secretagogues.

42 parable to that from beta-cells treated with secretagogues.

43 not abrogated by inhibiting degranulation to secretagogues.

44 ecretion of gut peptide by other gut peptide secretagogues.

45 glucagon secretion even after treatment with secretagogues.

46 The ghrelin receptor growth hormone secretagogue 1 receptor (GHSR) is present in hypothalami

47 Some growth hormone secretagogues act as agonists at the ghrelin receptor an

48 We show that these PRL secretagogues act on primary pituitary cells and thus ar

49 de-binding proteins that mediate the insulin secretagogue action of cAMP, the possible contributions

50 l homeobox 1 gene expression and the insulin secretagogue action of pancreatic beta-cells.

51 ivation of the CaSR on neuronal and hormonal secretagogue actions.

52 Here we report that basic secretagogues activate mouse mast cells in vitro and in

53 mosyn-syntaxin 1A interaction in response to secretagogue activation is an important mechanism allowi

54 Insulin secretagogues acutely stimulated 1.5-5-fold increases in

55 for dual oral agent therapy with an insulin secretagogue and sensitizer.

56 de generated by adipsin, as a potent insulin secretagogue and show that the C3a receptor is required

57 role of irisin as a new pancreatic beta-cell secretagogue and survival factor and its potential role

58 be induced by physiologic concentrations of secretagogues and by in vivo stimulation of the pancreas

59 of human islet cells was affected by insulin secretagogues and explore the role of cadherins in the s

60 model to study mast cell activation by basic secretagogues and identify MRGPRX2 as a potential therap

61 New secretagogues and mechanisms continue to be identified a

62 Islets showed good physiologic responses to secretagogues and restored normoglycemia in streptozotoc

63 beta-cells, release C-peptide in response to secretagogues and survive in vivo following transplantat

64 o E- and N-cadherins is regulated by insulin secretagogues and that E- and N-cadherin engagement prom

65 secretion occurred in response to different secretagogues and was mediated by alterations in KATP ch

66 nts include sulfonylureas, which are insulin secretagogues, and thiazolidinediones, which are insulin

67 (-/-) mice demonstrate increased severity of secretagogue- and diet-induced pancreatitis in compariso

68 imental models of rodent acute pancreatitis, secretagogue- and duct injection-induced pancreatitis.

69 cell depends on anaplerosis in which insulin secretagogues are metabolized by mitochondria into molec

70 ated islets in response to glucose and other secretagogues are not well understood.

71 These secretagogues are released from the intestinal epithelia

72 nknown protein kinase in response to various secretagogues as well as reductions in [Cl]i and cell vo

73 f suggests a dual role for metabolic insulin secretagogues, as an initial sharp increase in insulin s

74 increased adrenocorticotropic hormone (ACTH) secretagogue biosynthesis in the paraventricular nucleus

75 The recognition that gastrin is not only a secretagogue but also a trophic hormone has led to new r

76 , neither MMS nor KIC (10 mm) was an insulin secretagogue, but when added together KIC (2 mm) and MMS

77 odel of pancreatitis induced by supramaximal secretagogue (caerulein) stimulation.

78 Other secretagogues can increase production of succinyl-CoA se

79 Nutrient secretagogues can increase the production of succinyl-Co

80 Although secretagogues can increase the production of succinyl-Co

81 The amino acid leucine is a potent secretagogue, capable of inducing insulin secretion.

82 secretory responses to the calcium-dependent secretagogue carbachol or cAMP analog 8-bromo-cAMP, indi

83 r cell preparations were challenged with the secretagogue carbamylcholine, a subpopulation of zymogen

84 ther citrate, for the synthesis SC-CoAs from secretagogue carbon in mitochondria and the transfer of

85 Secretagogues (cerulein, carbachol, and bombesin) can in

86 Interestingly, a single secretagogue challenge failed to consistently elicit an

87 ement of antioxidants in response to a mixed secretagogue challenge is an early correlate of future b

88 irs the rapid replenishment of SGs following secretagogue challenge.

89 Stimulation of cells for 5 min with the secretagogue cholecystokinin enhanced the colocalization

90 d upon stimulation with the nutrient insulin secretagogue combination of leucine plus glutamine, indi

91 d are activated by anaphylatoxin C5a and the secretagogue compound 48/80.

92 e ion flux in rabbit ileum after exposure to secretagogues correlates inversely and highly significan

93 lls that receive input from two hypothalamic secretagogues, corticotrophin-releasing hormone (CRH) an

94 lls that receive input from two hypothalamic secretagogues, corticotrophin-releasing hormone (CRH) an

95 Upon application of common insulin secretagogues, current spikes resulting from detection o

96 The insulin secretagogue D-glucose also stimulates beta-cell p38 MAP

97 his is consistent with the fact that insulin secretagogues decrease the level of the mevalonate precu

98 Release of dopamine was evoked by chemical secretagogues delivered from micropipets that were calib

99 cay slope; all of these characteristics were secretagogue dependent.

100 cad/Fc and E-cad/Fc acquired, in a time- and secretagogue-dependent manner, a spreading form that was

101 henylated bovine serum albumin (DNP-BSA) and secretagogues (e.g., poly-L-lysine) was investigated by

102 ry process, because addition of an exogenous secretagogue elicited peroxidase secretion from 18-week-

103 In the secretagogue-elicited model, the DT-induced decrease in

104 These studies showed that pyruvate, a non-secretagogue, enters beta-cells and causes a transient r

105 r containing Zinquin, application of insulin secretagogues evoked an increase in fluorescence around

106 siologic techniques were used to measure the secretagogue-evoked increase in [Ca2+]i and consequent a

107 cs and responded to Weibel-Palade body (WPB) secretagogues except desmopressin.

108 liferation and all caseins were potent GLP-1 secretagogues (except kappa casein).

109 behavioral stressor implicate enhanced ACTH secretagogue expression in the increased HPA response to

110 Glucose is the main physiological secretagogue for insulin secretion by pancreatic beta-ce

111 Kisspeptins are potent secretagogues for GnRH, and the Kiss1 gene is a target f

112 etagogue, or histamine, a Weibel-Palade body secretagogue from MCs, potentiated DVT in wild-type mice

113 lycemia occurred in mice deficient in the GH secretagogue ghrelin as a result of knockout of the gene

114 The recently discovered growth hormone secretagogue, ghrelin, is a potent agonist at the human

115 an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising resu

116 y active agonist of the human growth hormone secretagogue (GHS) receptor.

117 pression of ghrelin mRNAs and growth hormone secretagogue (GHS) receptors could be detected in human

118 etermined the effects of an orally active GH secretagogue (GHS) treatment that causes a release of en

119 ntly a nonpeptidyl small m.w. compound, a GH secretagogue (GHS), was found to induce the production o

120 80) was discovered as a human growth hormone secretagogue (GHS).

121 in novel chemical entities as growth hormone secretagogues (GHSs), a small database of peptides and n

122 by approximately one-half in response to the secretagogues glucose, glutamine plus leucine, or pyruva

123 In addition to being an insulin secretagogue, glucose regulates proliferation and surviv

124 Distinct from its role as an intestinal secretagogue, guanylin may also have a role in intestina

125 ic patients who had taken insulin or insulin secretagogues had a significantly higher risk of pancrea

126 Its potency as an insulin secretagogue has led to pharmaceutical interest in devel

127 Among them, compound 24 is a potent GLP-1 secretagogue, has low effect on gallbladder volume, and

128 Secretagogues have also been shown to enhance the transl

129 apy and the administration of growth hormone secretagogues, have been encouraging.

130 The WPB secretagogue histamine evoked exocytosis of these fluore

131 However, the secretagogue hyperstimulation model of pancreatitis is t

132 napproved drug, including the growth hormone secretagogue ibutamoren, the peroxisome proliferator-act

133 Activation of trypsinogen by secretagogues in acinar cells was prevented by pharmacol

134 in the GLP-1 secretory response to different secretagogues in murine GLUTag L cells, as well as in th

135 Isolated acini were stimulated by various secretagogues in the presence or absence of cell-permean

136 ranted to determine the potential role of GH secretagogues in the treatment of CHF.

137 t not that of insulin, is activated by these secretagogues in vivo.

138 imately 40% reduction in response to insulin secretagogues in vivo.

139 retion (IS) in response to glucose and other secretagogues including nonfuel stimuli.

140 cretory actions of cAMP- and cGMP-generating secretagogues, including cholera toxin and heat stable E

141 tionic substances, collectively called basic secretagogues, including inflammatory peptides and drugs

142 Stimulation of these cells with a range of secretagogues, including K(+), BaCl(2), and forskolin, d

143 nase complex and would, in part, account for secretagogues increasing the islet level of succinyl-CoA

144 bition of endogenous GEF1 activity decreases secretagogue-independent release of hormone precursors,

145 in the KO beta-cells in response to the same secretagogues, indicating reduced insulin secretion.

146 In the present study we measured secretagogue-induced acid secretion from wild-type and D

147 Secretagogue-induced acid secretion in wild-type mouse g

148 ved in Kcnn4(-/-) mice results from enhanced secretagogue-induced ACTH output from anterior pituitary

149 esult consistent with findings demonstrating secretagogue-induced activation of RhoA.

150 d potassium (BK) channels in spontaneous and secretagogue-induced activity.

151 e-activated (BK) channels in spontaneous and secretagogue-induced activity.

152 uorescent 70 kDa dextran to demonstrate that secretagogue-induced bulk endocytosis also occurs in bov

153 in depletion causes a near-complete block in secretagogue-induced exocytosis.

154 Secretagogue-induced histamine release, inflammation and

155 However, in isolated islets, secretagogue-induced insulin release (by glucose, GLP-1,

156 nhibitor exhibited reduced sulfonylurea- and secretagogue-induced insulin secretion.

157 The secretagogue-induced interaction was strongly reduced by

158 experimental models of acute pancreatitis (a secretagogue-induced model and a model elicited by retro

159 type and Tpl2(-/-) mice subjected to either secretagogue-induced or bile salt-induced pancreatitis.

160 f decreasing extracellular pH (pHe) in early secretagogue-induced pancreatitis (zymogen activation an

161 ation that occurs during the early stages of secretagogue-induced pancreatitis is not altered by admi

162 These data demonstrate that the severity of secretagogue-induced pancreatitis is significantly ameli

163 Secretagogue-induced pancreatitis was achieved by 12 hou

164 In secretagogue-induced pancreatitis, large amounts of tryp

165 acid load might sensitize the acinar cell to secretagogue-induced pancreatitis.

166 essential early event in the pathogenesis of secretagogue-induced pancreatitis.

167 n inhibitor-I (PSTI-I) in mice could prevent secretagogue-induced pancreatitis.

168 nge sensitizes the pancreatic acinar cell to secretagogue-induced zymogen activation and injury and m

169 acini, lowering pHe from 7.6 to 6.8 enhanced secretagogue-induced zymogen activation and injury, but

170 c beta cells are believed to convert insulin secretagogues into products that are translocated to the

171 mon to glucose, amino acid, and organic acid secretagogues, involving flux through the pyruvate/isoci

172 ked by a maximal concentration of the strong secretagogue ionomycin (1 microM), for which there was a

173 c beta-cells in response to glucose or other secretagogues is tightly coupled to membrane potential.

174 on, although its function regarding specific secretagogues is unclear.

175 Secretion induced by basic secretagogues (KCl and Arg) was not affected by these dr

176 ment, and under chronic challenge by insulin secretagogues, loss of Sorcs1 leads to diabetes.

177 n contrast with the ability of IL-3 to alter secretagogue-mediated cytosolic calcium responses follow

178 The frequencies of use of insulin, insulin secretagogues, metformin, and other antidiabetic medicat

179 in the regulation of pancreatic secretion by secretagogues, modulatory proteins and neural pathways a

180 aimed to assess whether glutamine, a potent secretagogue of GLP-1 in vivo, increases GLP-1 release,

181 eased responsiveness to kisspeptin, the main secretagogue of GnRH.

182 RF1 is not a typical sensitizer, mimetic, or secretagogue of insulin.

183 esponse to KCl and norepinephrine, a natural secretagogue of TRH.

184 ssels with calcium ionophore A23187, a known secretagogue of Weibel-Palade bodies, induced immediate

185 released upon stimulation with histamine, a secretagogue of Weibel-Palade bodies, slowed down leukoc

186 Stimulation of endothelium with histamine, a secretagogue of WPBs, or injection of serotonin normaliz

187 ent, and by measuring the effects of insulin secretagogues on cPLA(2) distribution, on changes in [Ca

188 (2)beta in beta-cells incubated with insulin secretagogues or thapsigargin, that this requires prior

189 imulation either by mastoparan, a wasp venom secretagogue, or by the physiological mechanism of antig

190 Topical application of compound 48/80, an MC secretagogue, or histamine, a Weibel-Palade body secreta

191 in response to P2Y2 receptor agonists and to secretagogues, phorbol 12-myristate 13-acetate (PMA) and

192 be differentially regulated by hypothalamic secretagogues provides a mechanism for differential cont

193 be differentially regulated by hypothalamic secretagogues provides a mechanism for differential cont

194 on-signaling ghrelin receptor growth hormone secretagogue R1b (GHS-R1b) has been suggested to simply

195 tive, and orally bioavailable growth hormone secretagogue receptor (GHS-R) antagonists are reported.

196 vailable tetralin carboxamide growth hormone secretagogue receptor (GHS-R) antagonists were discovere

197 on, ghrelin and its receptor (growth hormone secretagogue receptor (GHS-R)) are widely expressed in a

198 t is mediated by its receptor Growth Hormone Secretagogue Receptor (GHS-R), but the physiologically r

199 f the peptide's receptor, the growth hormone secretagogue receptor (GHS-R), in the caudal brainstem.

200 bed endogenous ligand for the growth hormone secretagogue receptor (GHS-R), is produced by stomach ce

201 an endogeneous ligand for the growth hormone secretagogue receptor (GHS-R).

202 s an endogenous ligand of the growth hormone secretagogue receptor (GHS-R).

203 genous ligand for the type 1a growth hormone secretagogue receptor (GHS-R1a) and the only currently k

204 The growth hormone secretagogue receptor (GHSR) (ghrelin receptor) plays an

205 Growth hormone secretagogue receptor (GHSR) 1a is the only molecularly

206 eased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased

207 Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pa

208 at Ghrl and ghrelin receptor (growth hormone secretagogue receptor (GHSR)) are expressed in thymic st

209 action with its receptor, the growth hormone secretagogue receptor (GHSR).

210 y known ghrelin receptor, the growth hormone secretagogue receptor (GHSR).

211 Endogenous ghrelin receptors [growth hormone secretagogue receptor (GHSR)] are also present in extrah

212 the endogenous ligand for the growth hormone secretagogue receptor (GHSR; ghrelin receptor).

213 elin are mediated through the growth hormone secretagogue receptor 1a (ghrelin receptor), a peptidic

214 xhibits dual affinity for the growth hormone secretagogue receptor 1a (GHS-R1a) and the cluster of di

215 n receptor, also known as the growth hormone secretagogue receptor 1a (GHS-R1a), is a G-protein-coupl

216 and acts at its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), in the hypothalamus t

217 Ghrelin is an endogenous ligand for the GH secretagogue receptor 1a (GHSR1a, ie, ghrelin receptor).

218 a potent agonist at the human growth hormone secretagogue receptor 1a (hGHSR1a).

219 elin acts as a ligand for the growth hormone secretagogue receptor and can stimulate the release of g

220 A novel neuronal growth hormone secretagogue receptor circuit involving urocortin 1 neur

221 ogical states and because the growth hormone secretagogue receptor has been identified in blood vesse

222 is the natural ligand for the growth hormone secretagogue receptor in the pituitary gland, thus fulfi

223 ting KATP conductance via the growth hormone secretagogue receptor subtype 1a-Galphai -PI3K-Erk1/2-KA

224 s natural ligand for the growth hormone (GH) secretagogue receptor that has recently been isolated fr

225 ynaptic ghrelin receptor, the growth hormone secretagogue receptor type 1a (GHS-R1a), in VP neurons c

226 ch binds to and activates the growth hormone secretagogue receptor type 1a (GHS-R1a), is considered t

227 in, the natural ligand of the growth hormone secretagogue receptor type 1a (GHS-R1a), is mainly secre

228 The growth hormone secretagogue receptor, GHSR1a, mediates the biological a

229 the endogenous ligand for the growth hormone secretagogue receptor, has been implicated not only in t

230 ural endogenous ligand of the growth hormone secretagogue receptor, it potently stimulates growth hor

231 ive blood-brain transport and growth hormone secretagogue receptor-1 agonist activity.

232 (+) cells, while ghrelin- and growth hormone secretagogue receptor-deficient (GHS-R-deficient) mice d

233 ary cells express significant growth hormone secretagogue receptor.

234 ncrease feeding by binding at growth hormone secretagogue receptors (GHS-R), the only sites of action

235 duced in the stomach, acts on growth hormone secretagogue receptors (GHSRs) in hypothalamic neurons t

236 Growth hormone secretagogue receptors (GHSRs) in the central nervous sy

237 Much information is available on how secretagogue receptors acutely couple through heterotrim

238 Secretagogue receptors and their intracellular signaling

239 The major secretagogue receptors on acinar cells include those bin

240 The secretagogue receptors present on acinar cells, especial

241 interaction with endothelial growth hormone secretagogue receptors.

242 s structurally related to the growth hormone secretagogue receptors.

243 sms by which cholecystokinin (CCK) and other secretagogues regulate pancreatic acinar function are mo

244 secretion by the parietal cell involves the secretagogue-regulated re-cycling of the H+-K+-ATPase at

245 y of these pseudogranules, which we show are secretagogue responsive, to recruit membrane proteins.

246 n of immature content proteins and producing secretagogue-responsive mature granules.

247 The use of glucagon secretagogues reveals a positive correlation between alp

248 Different secretagogues selectively release vesicles from the RRP

249 Our secretagogue-siRNA conjugate prevented cytokine-induced

250 l line was used to test the efficacy of this secretagogue-siRNA conjugate.

251 The purpose of this study was to create a secretagogue-small interfering RNA (siRNA) conjugate to

252 The absence of AC6 reduced cAMP-dependent secretagogue-stimulated amylase secretion, and abolished

253 es approximately 180-220 nm in diameter, and secretagogue-stimulated exocytosis of CgA from A35C cell

254 sually distinguished two sequential steps of secretagogue-stimulated exocytosis: fusion of individual

255 eta catalytic activity and that BEL inhibits secretagogue-stimulated insulin secretion from these cel

256 entration, distribution, and modification in secretagogue-stimulated rat pancreatic acinar cells.

257 deconvolution and electron microscopy and by secretagogue-stimulated release assays.

258 TPase by bafilomycin A1 markedly reduced the secretagogue-stimulated release of CgA-EAP by perturbing

259 al deconvolution fluorescence microscopy and secretagogue-stimulated release studies demonstrate that

260 n microscopy, subcellular fractionation, and secretagogue-stimulated release, examining a series of f

261 bioactive peptides that feed back to inhibit secretagogue-stimulated release.

262 rescent protein localization in the basal or secretagogue-stimulated state.

263 dent beta-cells causes a rapid inhibition of secretagogue-stimulated subcellular Ca(2+) signaling and

264 KS) is a central regulatory molecule linking secretagogue stimulation at the cell surface to mucin gr

265 In PC-12 cells overexpressing tomosyn, secretagogue stimulation in the presence of lysophosphat

266 Secretagogue stimulation leads to an enlargement of the

267 et-induced insulin resistance, pharmacologic secretagogue stimulation of beta-cells with an incretin

268 in a Ca(2+)-sensitive manner in response to secretagogue stimulation of pancreatic beta-cells.

269 Downstream events involved in secretagogue stimulation of pancreatic secretion have be

270 We demonstrate that secretagogue stimulation results in the rapid translocat

271 olecystokinin for 40 min, demonstrating that secretagogue stimulation transiently alters the associat

272 d WPB exocytosis and is present on WPBs, and secretagogue stimulation triggers an increased recruitme

273 cholic acid-3-sulfate (TLCS) or supramaximal secretagogue stimulation with caerulein.

274 pancreatic acini appropriately responded to secretagogue stimulation with the secretion of digestive

275 ure can sensitize pancreatic acinar cells to secretagogue stimulation, resulting in dysregulation of

276 th the apical plasma membrane in response to secretagogue stimulation.

277 When succinate esters are the secretagogue, succinyl-CoA can be generated via the succ

278 This effect was not seen with secretagogues such as glucose that stimulate secretion v

279 inophils are activated by various classes of secretagogues, such as cytokines (e.g., IL-5), lipid med

280 a simple mathematical model of a hormone and secretagogue system with concentration dependent secreti

281 secretion, tomosyn-2, in response to insulin secretagogues targets it to degradation by the Hrd-1 E3-

282 teral region and blocks secretion induced by secretagogues that act via calcium.

283 Secretagogues that stimulate gastric acid secretion indu

284 ors blocked amylase secretion in response to secretagogues that use calcium as a second messenger (e.

285 Na-K-Cl cotransporter NKCC1 is activated by secretagogues through a phosphorylation-dependent mechan

286 Current therapeutic strategies for SS use secretagogues to induce secretion via muscarinic recepto

287 vascular or diffusion delivery of beta-cell secretagogues to islets, we showed that reduced insulin

288 The binding of secretagogues to parietal cells generates changes in sec

289 n one of the latter occasions, the beta-cell secretagogue tolbutamide was infused in a dose of 1.0 g/

290 -2-chloroethylamide effectively counteracted secretagogue-triggered excessive hMMC degranulation.

291 ssion of the ghrelin receptor growth hormone secretagogue type 1a (GHS-R1a) in the hypothalamus and p

292 monstrate that obestatin is a potent insulin secretagogue under hyperglycemic condition, and obestati

293 ed with reduced risk, and insulin or insulin secretagogue use was associated with increased risk of p

294 n secretion in response to arginine or other secretagogues was identical to that in cells from health

295 experiments in response to glucose and other secretagogues was similar in islets isolated from Pdx1(+

296 and because neutrophil elastase is a potent secretagogue, we examined the hypothesis that LTB(4) cau

297 By using these secretagogues, we developed a paradigm in which phorbol

298 Among various endogenous secretagogues, we found that PGE2 had the lowest EC50 va

299 ALA is a highly potent GLP-1 secretagogue which also increases the intracellular leve

300 a antagonist, namely, the role as an insulin secretagogue with potential value for diabetes treatment