ライフサイエンスコーパス: secretion system

1 s components of the virulence-critical ESX-1 secretion system.

2 d into the host cell by the Dot/Icm type IVb secretion system.

3 onella pathogenicity island 2 (SPI-2) type 3 secretion system.

4 host cell by the pathogen's Dot/Icm type IV secretion system.

5 nd the TssF and TssG proteins of the type VI secretion system.

6 e invaded host cell by the bacterial type IV secretion system.

7 related to the loss of the RD1-encoded ESX-1 secretion system.

8 ane as unfolded amyloid precursors through a secretion system.

9 or proteins into host cells using a Type III secretion system.

10 ation, nutrient acquisition, and the type IV secretion system.

11 ector of the Pseudomonas aeruginosa type III secretion system.

12 ransport apparatus categorized as a type III secretion system.

13 blished components of the flagellar type III secretion system.

14 nd assembly/function of the Dot/Icm Type IVb secretion system.

15 pilus systems as well as the related Type II secretion system.

16 virulence due to hyperactivity of the type 3 secretion system.

17 syringe-like organelle known as the type III secretion system.

18 o other membrane proteins to form the type 1 secretion system.

19 nto competing bacterial cells by the type VI secretion system.

20 , and lapE operons, encoding a LapA-specific secretion system.

21 d into the host cell via the Dot/Icm type IV secretion system.

22 ivered into plant cells through the type III secretion system.

23 it suggested a defect in the ESX-1 type VII secretion system.

24 and G35/A36 during export through the type I secretion system.

25 ified the mRNA for the regulator of type III secretion system.

26 ore than 300 effector proteins by a type IVb secretion system.

27 its vacuolar membrane via the SPI-2 type III secretion system.

28 e presence of functional Salmonella type III secretion systems.

29 mbrane space, as has been found for type III secretion systems.

30 ucts into the host cytosol using specialized secretion systems.

31 major subunit of the flagellum, by bacterial secretion systems.

32 affect bacterial virulence, including toxin secretion systems.

33 karyotic microvesicles and bacterial surface secretion systems.

34 e contact-dependent lysis of other bacterial secretion systems.

35 ria exchange polymorphic toxins using type V secretion systems.

36 These processes depend on type 6 secretion system 1 (T6SS-1), which is required for virul

37 rsecretion of SPI-1 effectors via type three secretion system 1.

38 Da early secretory antigenic target (ESAT-6) secretion system 1] is required for both virulence and h

39 is encoded in the cryptic E. coli type three secretion system 2 (ETT2) locus and herein renamed EtrB,

40 quired for activating the virulence type III secretion system 2 in response to bile salts.

41 because T6SS-1 and some effectors of type 3 secretion system 3 (T3SS-3), which is also required for

42 ia an unknown mechanism by bacterial type VI secretion system 5 (T6SS-5), which is an essential virul

43 ive T6SS but also the Gram-positive type VII secretion system, a pathway recently implicated in inter

44 V tag, which can pass through the type three secretion system, allowed visualization and quantificati

45 An efficient secretion system and chaperone network ensures that the

46 the phoP gene that interferes with the ESX-1 secretion system and inhibits secretion of ESAT-6.

47 tein that is secreted by the Dot/Icm type IV secretion system and interferes with the caspase-11-indu

48 The Cdz system uses a type I secretion system and is unrelated to previously describe

49 m and is actively suppressed by the type III secretion system and its effector proteins.

50 potential of the S. maltophilia Xps type II secretion system and its StmPr1 and StmPr2 substrates.

51 ophilia strain K279a encodes the Xps type II secretion system and that Xps promotes rounding, actin r

52 pe ATPases associated with bacterial type II secretion system and type IV pilus formation were shown

53 ion Substance, PrgC) and the Prg/Pcf type IV secretion system and, in turn, conjugatively transfer th

54 tins are major components of type II and III secretion systems and are linked to extrusion of type IV

55 dle and rod proteins from bacterial type III secretion systems and flagellin, respectively.

56 revealed the roles of modified ion channels, secretion systems and unique machinery for surface movem

57 e conserved conjugation machinery (a type IV secretion system), and the potential to transfer DNA to

58 type III secretion system, the Yts2 type II secretion system, and the Tad pilus.

59 athogens that express flagellin and type III secretion systems, and activating mutations in NLRC4 cau

60 hat function in cell wall synthesis, diverse secretion systems, and antibiotic efflux pumps.

61 the assembly of the sorting platform in both secretion systems, and elucidate the structural basis fo

62 h is then secreted from the cell by a type 1 secretion system apparatus encoded by lktB and lktD.

63 isome (iT3SS) and flagellar (fT3SS) type III secretion systems are 2 virulence factors associated wit

64 Type III secretion systems are complex nanomachines used for inje

65 Type III secretion systems are found in many Gram-negative bacter

66 Specialized secretion systems are infamous for their contribution to

67 and Xanthomonas campestris, use the type III secretion system as a molecular syringe to inject type I

68 BPs detect the presence of bacterial protein secretion systems as "patterns of pathogenesis" associat

69 y to ring-forming proteins found in type III secretion systems, assembles into an oligomeric ring in

70 outer membrane protein 85)/TpsB (two-partner secretion system B) family of bacterial, plastid and mit

71 omplex, IcmSW, for translocation through the secretion system, but its role in pathogenicity has rema

72 troduction of a functional Shigella type III secretion system, but none of its effectors, into a labo

73 e protease htrA, and components of a type VI secretion system, but the genome does not harbor genes f

74 lori (Hp) strains that carry the cag type IV secretion system (cag-T4SS) to inject the cytotoxin-asso

75 One cancer-linked locus is the cag type 4 secretion system (cagT4SS), which translocates an oncopr

76 A bacterial type IVB secretion system called Dot/Icm is essential for intrace

77 response, Y. enterocolitica uses a type III secretion system consisting of an injectisome and effect

78 re, we report self-regulated, self-reporting secretion systems consisting of liquid-storage compartme

79 plants are more susceptible to the type III secretion system-deficient bacterial strain Pseudomonas

80 The Pseudomonas aeruginosa type III secretion system delivers effector proteins directly int

81 Our discovery that the type VI secretion system delivers toxins between bacterial cells

82 aein vitro model system for study of type IV secretion system-dependent (T4SS) pathogenesis in the Br

83 destruction by restricting fusion of type IV secretion system-dependent Brucella-containing vacuoles

84 sxH, which is secreted by the Esx-3 type VII secretion system, directly inhibits the endosomal sortin

85 We show that the presence of bacterial secretion systems directs cytosolic carbohydrate-binding

86 vered into host cells by the Dot/Icm type IV secretion system during infection.

87 of two homologous Shigella flexneri type III secretion system effector E3 ligases IpaH1.4 and IpaH2.5

88 Exoenzyme Y (ExoY) is a type III secretion system effector found in 90% of the Pseudomona

89 ins bearing deletions in individual type III secretion system effector genes to determine whether thi

90 icans were identified, including the type VI secretion system effector Hcp1, suggesting that protein

91 The type III secretion system effector protein NleE from enteropathog

92 h induces ER stress by injecting the type IV secretion system effector protein VceC into host cells,

93 inhibits TRIF signaling through the type III secretion system effector YopJ.

94 Y. pestis type III secretion system effectors YopJ and YopM can interfere w

95 erm given to E. coli that possess a type III secretion system encoded in the locus of enterocyte effa

96 irulence process carried out by the type III secretion system encoded within Salmonella pathogenicity

97 A multicomponent secretion system ensures the safe transport of the aggre

98 lence of the more recently discovered ESAT-6 secretion system (ESS) has remained particularly scarce.

99 The type VII secretion system ESX-1 [6-kDa early secretory antigenic

100 e mechanisms, including the type VII protein secretion system ESX-1, biosynthesis of polyketide lipid

101 Here we show that the ESX secretion-system family member ESX-4 is essential for co

102 n effector proteins secreted by its type III secretion system for the pathogenesis of plants.

103 el apparatus, a widespread exopolysaccharide secretion system found in environmental and pathogenic b

104 mology to components of type II, III, and IV secretion systems found in Gram-negative bacteria.

105 , genetic analysis indicated that the type I secretion system gene, lipD, is required for SlpB secret

106 nd that gene PA2374, proximal to the type VI secretion system H3 (H3-T6SS), functions synergistically

107 The ATPases of ESX secretion systems have a unique domain architecture amon

108 Type III protein secretion systems have specifically evolved to deliver b

109 In M. tuberculosis, these secretion systems have taken on roles in virulence, and

110 y binding was also observed for the type III secretion system homolog HrcN and the type VI ATPase Clp

111 ases to be the substrates of the Xps type II secretion system in S. maltophilia strain K279a.

112 eview, we summarize the current knowledge of secretion systems in Acinetobacter species, and highligh

113 d homologs of this toxin are associated with secretion systems in many Gram-negative and Gram-positiv

114 port systems, and observe cross-talk between secretion systems in the pathobiology of medically relev

115 e production and upregulation of the type VI secretion system; in turn, it repressed the type III sec

116 Helicobacter pylori type IV secretion system injects the oncoprotein CagA into epith

117 Among these are type VI secretion systems, insecticidal protein complexes, and b

118 sults illustrate that insertion of bacterial secretion systems into PV membranes stimulates Galectin-

119 Type III secretion system is a key bacterial symbiosis and pathog

120 This secretion system is commonly found in commensal and path

121 We determined that the Llo Dot/Icm secretion system is critical for virulence.

122 The type III secretion system is employed by many pathogens, includin

123 The Dot/Icm-type IVB secretion system is essential for the biogenesis of the

124 We found that the bacterial SPI-2 type III secretion system is required for ROS evasion strategies

125 A type 3 secretion system is used by many bacterial pathogens to

126 Although FapF represents a unique type of secretion system, it shares mechanistic features with a

127 but posited to be driven by a polysaccharide secretion system known as the junctional pore complex (J

128 Through a type VII secretion system, M. tuberculosis releases a heterodimer

129 retion (T4S) systems are versatile bacterial secretion systems mediating transport of protein and/or

130 In this model, the protein secretion system of insulin-producing pancreatic beta ce

131 es to access comprehensive information about secretion systems of B. mallei and B. pseudomallei.

132 to the architecture of various dual membrane secretion systems of distinct function.

133 ormation for orthologous proteins related to secretion systems of the two pathogens.

134 ations that influence sensitivity to Type VI secretion system peptidoglycan endopeptidases and recogn

135 ce, proteolysis, quorum sensing, Type III/IV secretion systems, phages and toxins in the disease-asso

136 rived bacterial apparatuses, such as type VI secretion systems, Photorhabdus virulence cassettes, and

137 apparatus in Brucella belongs to the type IV secretion systems present in many pathogenic bacteria an

138 The type III secretion system protein EspD is a critical factor requi

139 nce attenuation experiments for 52 B. mallei secretion system proteins and 98 virulence attenuation e

140 Despite recent progress, the secretion system proteins for B. mallei and B. pseudomal

141 lly curated database, DBSecSys, of bacterial secretion system proteins for B. mallei.

142 of action for B. mallei and B. pseudomallei secretion system proteins inferred from the available li

143 tenuation experiments for 61 B. pseudomallei secretion system proteins.

144 possess sequence similarities with bacterial secretion system proteins.

145 the Liberibacter virulence traits, including secretion systems, putative effectors, and lipopolysacch

146 tory antigen target 6 kDa secretion) protein secretion systems require FtsK/SpoIIIE family ATPases bu

147 ression of FPI genes, which encode a Type VI secretion system required for intramacrophage growth.

148 erons, LEE1 to LEE5, which encode a type III secretion system, several effectors, chaperones, and reg

149 part on its pathogenicity island 2 type III secretion system (SPI-2 T3SS), which is required to tran

150 Salmonella switches from assembling type III secretion system structural components to secreting effe

151 cular biofilms were enriched with pathogenic secretion systems suggesting a highly competitive microb

152 with human disease and none encoded a type 3 secretion system synonymous with typical enterohaemorrha

153 ter species produce both a functional type I secretion system (T1SS) and a contact-dependent inhibiti

154 saccharide and the pullulanase (PulA) type 2 secretion system (T2SS) are required for full effectiven

155 socomialis M2 possesses a functional type II secretion system (T2SS) that is required for full virule

156 pecies of Acinetobacter, including a type II secretion system (T2SS), a type VI secretion system (T6S

157 Bacterial type 2 secretion systems (T2SS), type 4 pili, and archaeal flag

158 Many Gram-negative bacteria use type 2 secretion systems (T2SSs) to secrete proteins involved i

159 asion of S. Paratyphi A occurs in a type III secretion system (T3SS) 1-independent manner and results

160 AE lesion formation, including a type three secretion system (T3SS) and effectors, are carried withi

161 some upon sensing components of the type III secretion system (T3SS) and flagellar apparatus.

162 pression dose of the antiphagocytic type III secretion system (T3SS) and induces functions counteract

163 The type 3 secretion system (T3SS) and the bacterial flagellum are

164 ic Escherichia coli (EPEC) uses the type III secretion system (T3SS) effector EspL to degrade the RHI

165 d others have demonstrated that the type III secretion system (T3SS) effector protein ExoT plays a pi

166 rium pathogenicity island-1 (SPI-1) type III secretion system (T3SS) effectors and translocases to in

167 xic to host cells, depending on the type III secretion system (T3SS) effectors encoded.

168 The Type Three Secretion System (T3SS) is a well-studied and attractive

169 The type III secretion system (T3SS) is essential in the pathogenesis

170 P. aeruginosa expresses a type III secretion system (T3SS) needle complex that induces NLRC

171 The type III secretion system (T3SS) of E. tarda has been identified

172 The SPI-2 type III secretion system (T3SS) of intracellular Salmonella ente

173 rs sense host-cell targeting by the type III secretion system (T3SS) of pathogenic Yersinia.

174 most potent virulence factors is a type III secretion system (T3SS) that injects toxins directly int

175 enic Gram-negative bacteria use the type III secretion system (T3SS) to deliver effector proteins int

176 ogens infect eukaryotes and use the type III secretion system (T3SS) to deliver effector proteins int

177 Citrobacter rodentium uses a type III secretion system (T3SS) to induce colonic crypt hyperpla

178 thogens, Shigella rely on a complex type III secretion system (T3SS) to inject effector proteins into

179 Many bacteria use a type III secretion system (T3SS) to inject effector proteins into

180 animals and plants use a conserved type III secretion system (T3SS) to inject virulence effector pro

181 scherichia coli uses a syringe-like type III secretion system (T3SS) to inject virulence or "effector

182 This pathogen utilizes the type III secretion system (T3SS) to suppress host defense respons

183 EHEC employs a type III secretion system (T3SS) to translocate 50 effector prote

184 The Yersinia type III secretion system (T3SS) translocates Yop effector protei

185 embrane damage by components of the type III secretion system (T3SS) translocon.

186 essential part of the P. aeruginosa type III secretion system (T3SS), and its oligomeric nature allow

187 Virulence is mediated by a type three secretion system (T3SS), causing the hallmark attaching

188 atory components of the P. syringae type III secretion system (T3SS), essential for colonization of t

189 e bacteria secrete proteins using a type III secretion system (T3SS), which functions as a needle-lik

190 Here, we have developed a bacterial type III secretion system (T3SS)-based protein delivery tool and

191 erize a regulatory node involving a type III secretion system (T3SS)-exported protein, BtrA, and demo

192 ce strategy of A/E pathogens is the type III secretion system (T3SS)-mediated delivery of effector pr

193 d on the integrity of the S. flexneri type 3 secretion system (T3SS).

194 ctors into the cell cytoplasm via a type III secretion system (T3SS).

195 ginosa virulence determinant is the type III secretion system (T3SS); the production of T3SS cytotoxi

196 Type III Secretion Systems (T3SS) are complex bacterial structure

197 Flagellar type III secretion systems (T3SS) contain an essential cytoplasmi

198 All type III secretion systems (T3SS) harbor a member of the YscU/Flh

199 membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily rel

200 sm requires a horizontally acquired type III secretion system (T3SS2) to infect the small intestine,

201 Type III secretion systems (T3SSs) are complex nanomachines that

202 Type III secretion systems (T3SSs) are essential devices in the v

203 Type III Secretion Systems (T3SSs) are structurally conserved nan

204 am-negative bacterial pathogens use type III secretion systems (T3SSs) for virulence.

205 Type III secretion systems (T3SSs) inject bacterial effector prot

206 Type 3 secretion systems (T3SSs) of bacterial pathogens translo

207 Salmonella species utilize type III secretion systems (T3SSs) to translocate effectors into

208 od and needle proteins of bacterial type III secretion systems (T3SSs).

209 fector proteins into host cells via type III secretion systems (T3SSs).

210 netii replication requires a Dot/Icm type 4B secretion system (T4BSS) that delivers bacterial effecto

211 Legionella pneumophila uses a type IVB secretion system (T4BSS) to export a large number of pro

212 We also demonstrate that the Coxiella type 4 secretion system (T4SS) is critical for the formation of

213 also found that heat-killed NMII and type 4 secretion system (T4SS) mutant NMII were unable to induc

214 that are translocated by the Dot/Icm type IV secretion system (T4SS) of several Legionella pneumophil

215 athogenicity island, which encodes a type IV secretion system (T4SS) that injects the CagA oncoprotei

216 athogenicity island, which encodes a type IV secretion system (T4SS) that translocates a pro-inflamma

217 lular bacterial pathogens that use a type IV secretion system (T4SS) to escape host defenses and crea

218 rophages, C. burnetii uses a Dot/Icm type IV secretion system (T4SS) to generate a phagolysosome-like

219 ve host cells by employing a Dot/Icm type IV secretion system (T4SS) to translocate effector proteins

220 . pneumophila depends on its Dot/Icm type IV secretion system (T4SS), which delivers more than 300 ef

221 he extracellular environment using a type IV secretion system (T4SS).

222 the elaboration of the H. pylori cag type IV secretion system (T4SS).

223 s cag pathogenicity island (cag PAI) type IV secretion system (T4SS).

224 Type IV secretion systems (T4SSs) are large multisubunit translo

225 Gram-negative bacteria use type IV secretion systems (T4SSs) for a variety of macromolecula

226 bacterium to another, is mediated by type IV secretion systems (T4SSs).

227 The type VI secretion system (T6SS) encoded by the Francisella patho

228 The type VI secretion system (T6SS) is a bacterial nanomachine used

229 The type VI secretion system (T6SS) is a contact-dependent bacterial

230 The bacterial type 6 secretion system (T6SS) is a dynamic apparatus that tran

231 The type VI secretion system (T6SS) is a lethal weapon used by many

232 Type VI secretion system (T6SS) is a macromolecular machine used

233 The type VI secretion system (T6SS) is a supra-molecular bacterial c

234 The Type VI secretion system (T6SS) is a versatile weapon deployed b

235 The type VI secretion system (T6SS) is a weapon of bacterial warfare

236 The type 6 secretion system (T6SS) is used by many Gram-negative ba

237 The bacterial type VI secretion system (T6SS) mediates antagonistic cell-cell

238 killing adjacent competitors via the Type VI secretion system (T6SS) precipitates phase separation vi

239 contraction of a long sheath of the type VI secretion system (T6SS) to deliver effectors into a targ

240 Bacteria use the type VI secretion system (T6SS) to kill neighboring cells.

241 B. cenocepacia employs a type VI secretion system (T6SS) to survive in macrophages by dis

242 terbacterial antagonism, such as the type VI secretion system (T6SS), a multiprotein needle-like appa

243 A. baumannii encodes a type VI secretion system (T6SS), an antibacterial apparatus of G

244 genetic architectures (GA1-3) of the type VI secretion system (T6SS), an effector delivery pathway th

245 a type II secretion system (T2SS), a type VI secretion system (T6SS), autotransporter, and outer memb

246 ous forms of attacks mediated by the type VI secretion system (T6SS), P1vir phage, and polymyxin B.

247 contains a CRISPR-Cas element and a type VI secretion system (T6SS).

248 tivation of a Pseudomonas aeruginosa type VI secretion system (T6SS).

249 Type VI secretion systems (T6SS) enable bacteria to engage neigh

250 tition systems have been described: type six secretion systems (T6SS); contact dependent inhibition (

251 Type VI secretion systems (T6SSs) are multiprotein complexes bes

252 Type VI secretion systems (T6SSs) are newly identified contracti

253 The type VII secretion system (T7SS) of Staphylococcus aureus is a mu

254 The type VII protein secretion system (T7SS) plays a critical role in the vir

255 Type VII secretion systems (T7SS) are used by both environmental

256 Type VII secretion systems (T7SSs), originally described in mycob

257 It employs a newly described type-IX secretion system (T9SS) for secretion of virulence facto

258 In the recently characterized Type IX Secretion System (T9SS), the conserved C-terminal domain

259 -terminal domain (CTD) that uses the type IX secretion system (T9SS), which is limited to this organi

260 ds on a secretory apparatus known as type IX secretion system (T9SS).

261 The TC is the only site within these secretion systems targeted by disease-protecting antibod

262 ion/defect in organelle trafficking) type IV secretion system targets the bacterial-derived MavN (mor

263 EE) genomic island, which encodes a type III secretion system that is essential to virulence.

264 D and IpaD of Gram-negative bacterial type-3 secretion systems that breach immune barriers and delive

265 llular virulence, including the Ysa type III secretion system, the Yts2 type II secretion system, and

266 1 B. pseudomallei proteins associated with 5 secretion systems, their 1,633 human- and murine-interac

267 Among protein secretion systems, there are specialized ATPases that se

268 n effector of the virulence-associated ESX-1 secretion system, though this induction was RegX3 indepe

269 regation substance) and PrgC - and a type IV secretion system through which the plasmid is delivered

270 egative bacterial pathogens, uses a type III secretion system to deliver multiple proteins, referred

271 t for replication and uses a Dot/Icm type IV secretion system to generate the large PV.

272 cluding SifA, through a specialized type III secretion system to hijack the host endosomal system and

273 yringae secretes effectors from its type III secretion system to infect plants.

274 It deploys a type III secretion system to inject effector proteins into host e

275 e a syringe-like apparatus called a type III secretion system to inject virulence factors into host c

276 into host cells via a prototypical type III secretion system to promote pathogenesis.

277 Legionella pneumophila, rely on the type IV secretion system to translocate a repertoire of effector

278 icates within macrophages by using a type IV secretion system to translocate bacterial effectors into

279 t of Legionnaire's disease, uses its type IV secretion system to translocate over 300 effector protei

280 thogenic Yersinia species utilize a type III secretion system to translocate Yop effectors into infec

281 uire intercellular communication mediated by secretion systems to coordinate appropriate molecular re

282 erial pathogens utilize virulence-associated secretion systems to inject, or translocate, effector pr

283 Bacteria utilise specialised protein secretion systems to interact with host organisms, compe

284 ttaching and effacing pathogens use type III secretion systems to introduce effectors targeting key s

285 uolar pathogens can use virulence-associated secretion systems to manipulate and acquire host iron.

286 bacterium tuberculosis uses the Type VII ESX secretion systems to transport proteins across its compl

287 In many Gram-negative bacteria, the type III secretion system transports effector proteins into host

288 The type III secretion system (TTSS) is a major virulence determinant

289 ulence in the absence of large, multiprotein secretion systems (Types I, II, III, IV, and VI), which

290 n and Orth describe one such tool-the Type 6 Secretion Systems used by bacteria to deliver a variety

291 he bacterium Brucella abortus uses a type IV secretion system (VirB T4SS) to generate a replication-p

292 ribed findings were dependent on the type IV secretion system (VirB) and the secreted BPE005 protein,

293 sed during infection and the type III and VI secretion systems were highly expressed in vivo.

294 luding membrane transport from which type VI secretion systems were in particular upregulated.

295 rotein, and vasK, a component of the type VI secretion system, were also found to exhibit some attenu

296 cuoles is dependent on the bacterial Dot/Icm secretion system, whereas the delivery of GBP2 to Yersin

297 SPI-2 encodes a type III secretion system, which functions as a nanomachine to in

298 n system; in turn, it repressed the type III secretion system, which is a hallmark of chronic infecti

299 han 6,000 amino acids secreted by the type I secretion system, which may be involved in attachment to

300 tiple virulence factors, including bacterial secretion systems, which represent key components of bac