ライフサイエンスコーパス: secretome

1 s significantly altered the quality of their secretome.

2 through its diverse metabolite and adipokine secretome.

3 tein in mammals, is actively degraded by the secretome.

4 spectrometry of heart extracts and a fungal secretome.

5 ure from the Mycobacterium marinum bacterial secretome.

6 predominant difference in the pks2(-) mutant secretome.

7 processing of these proteins in the biofilm secretome.

8 ied 11 enriched in the mesenchymal stem cell secretome.

9 ates angiogenic components of the tumor cell secretome.

10 characterization of the B. pseudomallei T2SS secretome.

11 characterized by proteomics analysis of the secretome.

12 -directed EMT activation and Sec23a-mediated secretome.

13 hanisms, including a potent immunomodulatory secretome.

14 port the effect of InhA1 on the B. anthracis secretome.

15 zone and activated to release arrhythmogenic secretome.

16 he inhA1 secretome than in the parent strain secretome.

17 labeling of the C. thermocellum cellulosomal secretome.

18 hemical biology tools for characterizing the secretome.

19 helial traits and Sec23a-mediated tumor cell secretome.

20 changes compared with the normal fibroblast secretome.

21 e media in the presence of the entire Jurkat secretome.

22 hemical biology tools for characterizing the secretome.

23 gulation and the regulation of the mammalian secretome.

24 hologous proteins belong to the core Frankia secretome.

25 racellular matrix components to modulate the secretome.

26 d among the strains, termed the core Frankia secretome.

27 uced growth factors and cytokines in the CMV secretome.

28 ication technology, to comprise the root cap secretome.

29 a key signature in cataloguing the parasite secretome.

30 (CLIC3) is an abundant component of the CAF secretome.

31 h soluble and exosomal fractions of the hMSC secretome.

32 cardial recovery via the components of their secretome.

33 c alterations that include a proinflammatory secretome.

34 categorize the A. fumigatus putative in vivo secretome.

35 g the expression of a complex pro-metastatic secretome.

36 the role of VEGF in modifying the angiogenic secretome.

37 unstressed cells, particularly targeting the secretome.

38 ng several predicted members of the parasite secretome.

39 cells also predicts their cell-type-specific secretome.

40 lineages, despite their diverse genomes and secretomes.

41 cted to specific organs, specific stages, or secretomes.

42 d by the greatest extent in both NSF and SSc secretomes.

43 the relationship between the TIF and plasma secretomes.

44 To better define the L. pneumophila type II secretome, a 2D electrophoresis proteomic approach was u

45 ntify 58 new native substrates in fibroblast secretomes after incubation with MT6-MMP.

46 Secretome alone did, however, evoke VF in 2 sham coronar

47 terized, including platelet releasates (the 'secretome'), alpha and dense granules, membrane and cyto

48 ells and/or inhibiting their proinflammatory secretome also improves cardiovascular function, enhance

49 The core secretome also includes extracellular solute-binding pro

50 ights into the global beta-cell sheddome and secretome, an important prerequisite to uncover novel me

51 ranscription-PCR (RT-PCR), Western blot, and secretome analyses established that S. Paratyphi A expre

52 Protein microarray secretome analyses revealed angiogenin as the most robus

53 The secretome analysis identified 1694 spots per sample, amo

54 We recently performed a bioinformatic secretome analysis in bone marrow cells from patients wi

55 We performed secretome analysis of the conditioned medium from tumor-

56 Global gene expression and secretome analysis reveals that TGFss superfamily member

57 Secretome analysis suggested R. solani employs largely d

58 Our D-SCM secretome analysis yielded 144 secreted factor candidate

59 pillary networks in ECs stimulated with HCMV secretome and activated effector caspases.

60 co pattern searches to define a pneumococcal secretome and analyzed the transcriptome of the clinical

61 ing components of the differentiating stroma secretome and designed a potential therapeutic strategy

62 mor interstitial fluid (TIF) encompasses the secretome and holds the key to several of the phenotypic

63 a-derived MCSF induces changes in microglial secretome and identified insulin-like growth factor-bind

64 ysin as a major determinant of the S. aureus secretome and identified the phenol-soluble modulins as

65 tant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (

66 of the most abundant proteins of the CyHV-3 secretome and is structurally very similar to carp Il10

67 entification of 609 N-glycopeptides from the secretome and lysates of Huh7 cells.

68 racterization of the platelet transcriptome, secretome and proteome also suggest that additional func

69 Analysis of the secretome and receptome of the alveolar niche reveals fu

70 atherosclerotic-MSCs underlies their altered secretome and reduced immunopotency.

71 e increased ER-Golgi trafficking, an altered secretome and sensitivity to the retrograde transport in

72 rgoing glutathionylation and apply it to the secretome and the proteome of human monocytic cells.

73 termine interactions between the immune cell secretome and the TRACER-identified active transcription

74 d plasma protein profiles with ex vivo islet secretome and transcriptome analyses.

75 Analyses of the melanoma secretome and validation in clinical specimens showed th

76 -infected human small airway epithelial cell secretome and was differentially expressed in smaller ai

77 this study, we have examined the M. marinum secretomes and identified four proteins specific to ESX-

78 as well as for expression of the senescence secretome, and (iv) p35 is up-regulated in senescing cel

79 ted with the initial growth medium, isolated secretome, and living bacteria, and characterized for th

80 cellular proteins were identified in the RPE secretome, and only 8 were found to be selectively cleav

81 ructure, was observed in the presence of the secretome, and the rate limiting step of the reaction wa

82 sis, but the components of the niche and its secretome are only partially understood.

83 located on the outer membrane and within the secretome are responsible for Mn(II) oxidation.

84 proteins processed by the secretory pathway (secretome) are critical players in the development of mu

85 strate the feasibility of harnessing the MSC secretome as a defined, noncellular strategy to improve

86 nderstanding of the properties of the cancer secretome, as its clinical evaluation may change the the

87 which exocytic vesicles harboring a venomous secretome assembled a sophisticated predatory structure

88 Both components of the gastric gland secretome associate non-covalently and show increased ex

89 As a complement to expression data, the secretome associated with N. crassa growth on Miscanthus

90 found in individual datasets) and Fugu (14%) secretomes based on analysis of their nearly complete pr

91 parasite Plasmodium falciparum constitute a "secretome" carrying a host-targeting (HT) signal, which

92 greatly aid the annotation of the parasite "secretome" catalog of proteins that are targeted to the

93 inhibition of oncogenic drivers induces vast secretome changes in drug-sensitive cancer cells, parado

94 The functional effect of the LVCP secretome changes throughout the lifespan, with activate

95 SCs v/s DMSCs (DPSC, SCAP & DFSC) along-with secretome characterization.

96 ing capability, one with a transcriptome and secretome closer to normal fibroblasts (CAF-N) and the o

97 of this tRNA specifically drive synthesis of secretome components, resulting in a type II collagen-ri

98 atory properties are highly variable and the secretome composition following infusion is uncertain.

99 otic mesenchymal stromal cells or with their secretome (conditioned medium) in a transwell system.

100 Labile secretome constituents appear to be responsible.

101 ry and immunoassays, and found that the HCMV secretome contains over 1,000 cellular proteins, many of

102 transiently controlled antiinflammatory MSC secretome could be achieved at target sites of inflammat

103 tify novel effector proteins, we coupled our secretome data with a machine learning algorithm (SIEVE,

104 in patients with ileal CD, because the PBMC secretomes derived from patients with CD were unable to

105 In senescent cells, p95HER2 elicits a secretome enriched in proteases, cytokines, and growth f

106 argeting senescent cells or modulating their secretome for anti-aging therapy may have negative conse

107 supernatants from HCMV-infected cells (HCMV secretomes) for growth factors, by mass spectrometry and

108 Secretomes from 95% of Serratia marcescens, 71% of Pseud

109 Bacterial cells and secretomes from a subset of tested species of bacteria i

110 Virus-free supernatant (secretome) from HCMV-infected ECs induces AG.

111 compared the expression of secreted factors (secretome) from MDA-PCa-118b and MDA-PCa-133 by cytokine

112 ontrol of secreted factors, and we show that secretome genes are preferentially controlled by synergi

113 reted, the characterization of the bacterial secretome has remained challenging.

114 Secretome HT signals, including those of major virulence

115 In this study, we characterized the secretome (i.e., the global pattern of secreted proteins

116 Global quantitative analysis of the hypoxic secretome identified lysyl oxidase (LOX) as significantl

117 CSp-EMVs alter fibroblast phenotype and secretome in a salutary positive-feedback loop.

118 2 gene products from the wildtype M. marinum secretome in a single CZE-tandem mass spectrometry (MS/M

119 vivo and observed significant changes to the secretome in response to let-7 therapy.

120 rcted heart by flow cytometry and macrophage secretome in vitro.

121 served between the TIF and plasma angiogenic secretomes in triple negative MDA-MB-231 breast cancer x

122 The Bacillus anthracis secretome includes protective antigen, lethal factor, an

123 kines were significantly induced in the HCMV secretomes including interleukin-6 (IL-6), granulocyte m

124 s have been developed to characterize these 'secretomes', including the yeast secretion trap (YST) sc

125 tumor microenvironment alter the tumor cell secretome, including those proteins required for tumor g

126 roblasts was also inhibited by S. marcescens secretomes indicating that the effect is not cornea spec

127 Atrial myocardium secretome induces the adipogenic differentiation of adul

128 issue explants, we could show that the total secretome inhibited preadipocyte differentiation.

129 herapeutic cells for TBI, and lncRNAs in the secretome is an important mechanism of cell therapy.

130 However, how the secretome is regulated remains incompletely understood.

131 t of proteins encoded by the genome, and the secretome is the part of it secreted from the cell.

132 ates but also by modulating the B. anthracis secretome itself.

133 at the genome, transcriptome, proteome, and secretome levels.

134 By screening a secretome library, we found that the human immunorecepto

135 present preliminary evidence that the liver secretome may be directly suppressed by PPARalpha, but i

136 gest that celecoxib-driven alteration of the secretome may be involved in some of its clinical side e

137 Proteins in the core secretome may be involved in the actinorhizal symbiosis.

138 upregulated MAPK signaling in the pancreatic secretome may reflect the pathophysiological development

139 Whether cells and secretomes mediating MF represent therapeutic targets in

140 an et al. propose that ribosomes translating secretome messenger RNAs (mRNAs) traffic from the cytoso

141 ses, and proteases found in the core Frankia secretome might facilitate hyphal penetration through th

142 trated that CMV but not herpes simplex virus secretomes not only induce AG/WH but also promote neoves

143 xpression of secreted cellular proteins (the secretome) occur that have profound effects on host-cell

144 Bioinformatics predicted a secretome of >320 proteins and conservation of the signa

145 This signal predicts a secretome of 300-400 effectors for the human malaria par

146 ur analysis revealed an unexpectedly complex secretome of 410 proteins with venomous and lytic but al

147 Here we define the complete secretome of A. nosocomialis strain M2 in minimal medium

148 rometry was used to identify proteins in the secretome of aCPCs and nCPCs, and the literature-based n

149 ST266, the biological secretome of Amnion-derived Multipotent Progenitor cells

150 ete protein spots was altered in the biofilm secretome of an mep72 mutant, including type III secreti

151 Finally, evaluation of the secretome of astrocytes grown in monolayer identified a

152 related pathways were overrepresented in the secretome of ATP-stimulated cells.

153 Finally, the secretome of B. subtilis might be used for the green syn

154 The secretome of cancer and stromal cells generates a microe

155 The secretome of CD158d-stimulated senescent NK cells promot

156 We have analyzed the secretome of cells carrying latent HCMV and have identif

157 identified specific pathways affected by the secretome of CPCs in the setting of myocardial infarctio

158 A proteomic analysis of the secretome of cultured dermal fibroblasts from patients w

159 CXCR2-activating chemokines were part of the secretome of cultured primary benign intestinal adenomas

160 The potential secretome of each Frankia strain comprised 4-5% of the t

161 on of self-assembled peptides to deliver the secretome of embryonic stem cells (ESCs).

162 detected as novel candidate proteins in the secretome of HEK-293 cells.

163 ences the phenotypic characteristics and the secretome of human cardiac progenitor cells (CPCs), and

164 Here we compare the secretome of human mammary normal and cancer-associated

165 The secretome of hypoxic palmitate-treated macrophages promo

166 genicity partly through their effects on the secretome of LKR-13 cells.

167 The tumour-promoting secretome of melanoma cells treated with the kinase inhi

168 we demonstrate that PGC-1alpha modulates the secretome of mouse embryonic fibroblasts.

169 Proteomics analysis of the secretome of murine aortic smooth muscle cells, after mi

170 First, we demonstrated that the secretome of obese adipocytes decreased the expression o

171 eview classifies and catalogues the effector secretome of oomycetes.

172 Mass spectrometric analysis of the secretome of P. aeruginosa derived from an acute infecti

173 results provide molecular insights into the secretome of P. destructans, and identify serine endopep

174 The type III secretome of P. syringae is highly variable and dynamic,

175 ysis of many of the effectors comprising the secretome of P. syringae pv tomato DC3000 led to the ide

176 Already, it is evident that the effector secretome of pathogenic oomycetes is more complex than e

177 es of human ileal tissue, we showed that the secretome of peripheral blood mononuclear cells (PBMCs)

178 resented and positionally constrained in the secretome of Phytophthora relative to other eukaryotes.

179 ding enzymes, are integral components of the secretome of Pleurotus ostreatus, a white rot fungus.

180 antitative proteomic approach to analyze the secretome of primary neurons after acute BACE1 inhibitio

181 ibited the production of the proinflammatory secretome of senescent cells using a JAK inhibitor (JAKi

182 as inflammatory mediators that demarcate the secretome of senescent cells, also referred to as the se

183 We show that the secretome of senescent fibroblasts, which are selectivel

184 Furthermore, the secretome of the broad host range AG8 isolate may be sha

185 with genes encoding the surface proteome and secretome of the parasite.

186 vation was that GRP-78 was identified in the secretome of these cells and in the bone matrix, suggest

187 R constitute a major folding machine for the secretome of this organism.

188 uantitative mass spectrometry to compare the secretome of wild-type B. thailandensis to that of a mut

189 sed a proteomic approach to characterize the secretome of X. fastidiosa, both in vitro and in planta,

190 inhibitor I9 domain was more abundant in the secretomes of a wide range of necrotising fungi relative

191 these, Protein S (PROS1) was elevated in the secretomes of all of the androgen-independent prostate c

192 The secretomes of both SSc and NSF fibroblasts display a pat

193 Unlike the secretomes of cellulolytic fungi, which typically compri

194 gorithms were used to predict the individual secretomes of each strain, and the set of secreted prote

195 matography-mass spectrometry analysis of the secretomes of encapsulated organisms yielded detailed ge

196 The predicted secretomes of Frankia sp. are relatively small and inclu

197 eted by PEL cell lines after comparison with secretomes of human cell lines representative of diverse

198 secretion of cellular IL-10 and CCL8 in the secretomes of latently infected cells.

199 ld detect structural differences between the secretomes of pancreatic cancer and non-cancerous cells.

200 tudy, we used cytokine arrays to analyze the secretomes of poorly and highly metastatic colorectal ca

201 We compared the secretomes of the parent strain to those of strains miss

202 We compared the genome-based secretomes of three Frankia strains representing diverse

203 y a host-targeting (HT) signal present on a "secretome" of hundreds of parasite proteins engaged in r

204 Blood stage malaria parasites target a 'secretome' of hundreds of proteins including virulence d

205 fferences among the extracellular proteomes (secretomes) of three isogenic strains of B. anthracis th

206 As such, the nature of the microbial secretome often influences the function of a community (

207 s and regional differences in the epithelial secretome participating in RSV lower respiratory tract i

208 With the aid of secretome phage display, we identified a highly conserve

209 omics enabled the identification of a unique secretome pool from these lignocellulose-degrading commu

210 Trapping of platelet secretome prepared ex vivo, or platelet-sized fluorosphe

211 ation in resistin release and the neutrophil secretome profile were observed following exposure to di

212 granule marker, and by determination of the secretome profile, using mass spectrometry.

213 s in other fungal genomes and found that the secretome profiles cluster the tested basidiomycetes int

214 ce-associated secretory phenotype, and their secretome promotes vascular remodeling and angiogenesis.

215 veal unique, up-regulated, or down-regulated secretome proteins among the strains.

216 alysis revealed the interaction of DPSC/SCAP secretome proteins and these proteins were found to be a

217 Approximately one third of secretome proteins are exosomal; the remainder are from

218 By using a secretome proteomics approach, we identified insulin-lik

219 not exosome-depleted, fractions of the hMSC secretome recapitulated the effects observed with hMSC c

220 r morpholino-based screen for members of the secretome required for vascular development, we identifi

221 Analysis of the Xf secretome revealed a putative lipase/esterase (LesA) tha

222 LC-MS/MS analysis of stem cell secretome revealed the presence of different proteins re

223 f the P. placenta genome, transcriptome, and secretome revealed unique extracellular enzyme systems,

224 sing a proteomics approach with fractionated secretome samples, we were able to identify a spectrum o

225 The cancer-specific lung metastasis secretome signatures (LMSSs) displayed significant progn

226 This therapy-induced secretome stimulates the outgrowth, dissemination and me

227 Through the use of secretome studies, in vitro bacterial interaction assays

228 Eliminating exosomes from the cancer cell secretome, targeting Rab27a, abolished differentiation a

229 nd one-third were more abundant in the inhA1 secretome than in the parent strain secretome.

230 ntrast, little is known about changes in the secretome that accompany latent infection, yet this is l

231 dentify proteins from the cardiomyocyte (CM) secretome that are directly targeted by the muscle-speci

232 One component of the secretome that is gaining increasing attention is the ex

233 in mammary fibroblasts induces an oncogenic secretome that remodels the extracellular milieu acceler

234 ADD dependent and identify the TRAIL-induced secretome to drive monocyte polarization to myeloid-deri

235 eceptor on ECs abolished the ability of HCMV secretome to increase survivin expression and activated

236 Addition of the HCMV secretome to preformed vessels extended neovessel surviv

237 academic and commercial users at http://www.secretomes.umn.edu/AMOD/.

238 secretomes with polymyxin B agarose rendered secretomes unable to inhibit epithelial cell migration.

239 SK9-interacting proteins in the HepG2 cells' secretome using co-immunoprecipitation combined with mas

240 The platform enables control of cells' secretome, viability, proliferation and differentiation,

241 oad efficacy or host specificity, a combined secretome was constructed from a monocot specific isolat

242 The adipogenic property of the atrial secretome was enhanced in AF patients.

243 When this root cap secretome was proteolytically degraded during inoculatio

244 relevance of the p95HER2-induced senescence secretome, we show that p95HER2-induced senescent cells

245 The secretomes were analyzed using two complementary mass sp

246 nctional classification showed that PEL cell secretomes were enriched in proteins specifically involv

247 ts of glutathionylation, particularly in the secretome where the protein concentration is much lower,

248 The cancer secretome, which resembles the parent cell make-up, is c

249 nce of deleterious OIS- or TIS-related tumor secretomes, which can promote both drug resistance and t

250 dentified as up-regulated in the prfA(L140F) secretome, while the secretion of two proteins was found

251 Secretome-wide predictions and confocal microscopy revea

252 Here we review the Bordetella virulence secretome with an emphasis on factors that translocate i

253 LPS depletion of S. marcescens secretomes with polymyxin B agarose rendered secretomes