ライフサイエンスコーパス: secretory granule

1 unusually rich in endolysosomal organelles (secretory granules).

2 let amyloid polypeptide, all proteins of the secretory granule.

3 enzymatic processing events in the immature secretory granule.

4 e and functionality of a medically important secretory granule.

5 uced secretion of MUC5AC from the post-Golgi secretory granules.

6 related with the V1-V0 association status in secretory granules.

7 ic compartment after permeabilization of the secretory granules.

8 ely, and located in the cytoplasm outside of secretory granules.

9 e probe (D1-SG) to measure calcium and pH in secretory granules.

10 ss activates at pH~5.5 within the dense core secretory granules.

11 utive pathway along with their entrapment in secretory granules.

12 sion of Muc6 and Tff2 and reduced numbers of secretory granules.

13 ling of the readily releasable pool (RRP) of secretory granules.

14 ocessed to CpepGFP that is co-stored in beta-secretory granules.

15 ase in the number of membrane-docked insulin secretory granules.

16 insulin and the presence of mature endocrine secretory granules.

17 tether formation between isolated eosinophil secretory granules.

18 13-2 priming requirement for a population of secretory granules.

19 adation was properly processed and sorted to secretory granules.

20 nzyme, and the return of internalized PAM to secretory granules.

21 M though the endocytic pathway and back into secretory granules.

22 function in the lumen of peptide-containing secretory granules.

23 ial/lysosome trafficking, and generate large secretory granules.

24 sors, accumulating product peptide in mature secretory granules.

25 upports the glucose-dependent recruitment of secretory granules.

26 s to segregate from each other into distinct secretory granules.

27 more likely to distribute homogeneously into secretory granules.

28 lpha is present on a subpopulation of mature secretory granules.

29 xit the Golgi and are packaged into immature secretory granules.

30 netics of loss of proteinaceous content from secretory granules.

31 torage of pro-TRH-derived peptides in mature secretory granules.

32 ditionally been viewed strictly as regulated secretory granules.

33 n aggregation in the trans-Golgi network and secretory granules.

34 tides to other peptides present in beta cell secretory granules.

35 , and responsible for zinc accumulation into secretory granules.

36 GFP localized to the trans-Golgi network and secretory granules.

37 nce of microvillus inclusions, and subapical secretory granules.

38 Ctr2 on the storage of proteoglycans in the secretory granules.

39 ed to be stored as amyloids within endocrine secretory granules.

40 the proteins and peptides of the beta cells' secretory granules.

41 sized and endocytosed membrane proteins into secretory granules.

42 elease, or (d) control the pH inside insulin secretory granules.

43 o detectable return of the mutant protein to secretory granules.

44 not affect receptor localization to insulin secretory granules.

45 ompartments, including synaptic vesicles and secretory granules.

46 R distention (ER-crowding) and deficiency of secretory granules.

47 Under conditions mimicking the immature secretory granule (37 degrees C, pH 6), amylin forms amy

48 ofile of platelet dense-body granules, these secretory granules act according to general biochemical/

49 It is proposed that the maturing secretory granules act as a distribution center for secr

50 Syt isoforms are usually sorted to separate secretory granules and are differentially activated by d

51 n showed that CRF-BP was localized mainly in secretory granules and CRF2alphaR in the endoplasmic ret

52 ted with a significant decrease in number of secretory granules and features of crinophagy.

53 the isoforms of Rab3, is present on insulin secretory granules and has been implicated in regulation

54 B (CGB), a calcium binding protein found in secretory granules and in the lumen of the endoplasmic r

55 This serine protease is abundant in the secretory granules and is exocytosed upon bacterial chal

56 to label and then monitor synaptic vesicles, secretory granules and other endocytic structures in a v

57 MSC-derived JG-like cells contained renin in secretory granules and released active renin in response

58 mbrane, where it accumulated specifically at secretory granules and rendered them more prone to under

59 ic pigs showed a marked reduction of insulin secretory granules and severe dilation of the endoplasmi

60 cells do indeed possess distinct subsets of secretory granules and that these subsets use different

61 und that myosin 1b controls the formation of secretory granules and the associated regulated secretio

62 actomyosin complex promote the biogenesis of secretory granules and thereby regulate hormone sorting

63 oduced by endoproteolytic cleavage of PAM in secretory granules and transit of membrane PAM though th

64 s detector will aid future studies of single secretory granules and vesicles and their insoluble matr

65 necessary features for biological studies of secretory granules and vesicles, which store transmitter

66 network (TGN) (with spillover into immature secretory granules) and endosomes.

67 transporter, which transports zinc into the secretory granule, and type II diabetes.

68 ease in the readily releasable pool (RRP) of secretory granules, and decreased stimulus-evoked Ca(2+)

69 unofluorescence shows PtdIns(3,4)P(2) at the secretory granules, and fluorescent PtdIns(3,4)P(2) can

70 in response to glucose, package insulin into secretory granules, and secrete quantities of insulin co

71 rgeting and retention of soluble proteins in secretory granules are incompletely understood.

72 steps are often observed and suggesting that secretory granules are preferentially released by compou

73 retory proteins that are not stored in large secretory granules are secreted by either the minor regu

74 Thus, these secretory granules are tethered to their target plasma m

75 eptides stored in large dense core vesicles (secretory granules) are released through calcium-regulat

76 is likely to permit protein "packing" in the secretory granule at approximately 50% higher density th

77 he behavior of individual insulin-containing secretory granules at the plasma membrane of living cell

78 lts indicate that the ATPase activity of the secretory granule Atp8a1 is activated by phospholipids b

79 s document a process whereby the contents of secretory granules become available to the immune system

80 wed insights into the behavior of individual secretory granules before and during exocytosis.

81 Insulin is also stored within the secretory granules before secretion, and has been shown

82 We show that F-actin is also involved in secretory granule biogenesis and that myosin 1b cooperat

83 etogranin III (SgIII) protein is involved in secretory granule biogenesis in mast cells.

84 Chromogranin A (CgA) may be critical for secretory granule biogenesis in sympathoadrenal cells.

85 Chromogranin A (CHGA) triggers catecholamine secretory granule biogenesis, and its catestatin fragmen

86 , a CgA-SgIII complex may play a key role in secretory granule biogenesis.

87 to recruit F-actin to the Golgi region where secretory granules bud.

88 o-localized with insulin in Min6B1 beta-cell secretory granules but did not undergo plasma membrane t

89 essential for the recruitment of NMII to the secretory granules but plays a key role in the assembly

90 e signal peptide), were normally targeted to secretory granules, but nonetheless caused substantial E

91 propose that CgA promotes the biogenesis of secretory granules by a mechanism involving a granulogen

92 eptide, and proinsulin together with insulin secretory granules by electron microscopy.

93 ZCs, suggesting that MIST1 establishes large secretory granules by inducing RAB transcription.

94 go on the basis of their readily discernible secretory granules by routine histology, these cells are

95 Willebrand factor, which is stored in unique secretory granules called Weibel-Palade bodies (WPBs).

96 We propose that, in contrast to other secretory granules, cargo aggregation alone is not suffi

97 Secretory granules carrying fluorescent cargo proteins a

98 BH) within the lumen of the Golgi network or secretory granules, catalyzing the conversion of dopamin

99 e plane parallel to the plasma membrane that secretory granules change position within several hundre

100 Confocal imaging of GFP-tagged secretory granules combined with the use of impermeant e

101 Both CTSL and CTSB colocalize to the secretory granule compartment of skin mast cells.

102 e development and a deficiency in a specific secretory granule component.

103 ionic proteoglycans, these data suggest that secretory granule composition in mast cells is dependent

104 hat cell death was accompanied by leakage of secretory granule compounds into the cytosol and that th

105 cells, the polypeptides stored in dense core secretory granules condense as ordered arrays.

106 Their secretory granules contain four cytotoxic proteins, incl

107 cathepsin D, whereas regulated exocytosis of secretory granules containing histamine and TNF-alpha wa

108 as limited to the subpopulation of mast cell secretory granules containing serotonin and cathepsin D,

109 Dense-core secretory granule (DCG) biogenesis is a prerequisite ste

110 prohormones widely distributed in dense-core secretory granules (DCGs) of endocrine, neuroendocrine,

111 esses underlying the formation of dense core secretory granules (DCGs) of neuroendocrine cells are po

112 The biogenesis of dense-core secretory granules (DCGs), organelles responsible for th

113 t cells are characterized by an abundance of secretory granules densely packed with inflammatory medi

114 ings implicate histone proteolysis through a secretory granule-derived serglycin-tryptase axis as a n

115 Consequently, secretory granules did not mature.

116 transition, DeltaPsi and ROS increased, and secretory granules disappeared.

117 techolamine release from cells as individual secretory granules discharge their contents during the p

118 the processes of movement and exocytosis of secretory granules do not significantly contribute to AT

119 -cell secretory machinery and contributes to secretory granule docking, most likely through interacti

120 eracts with membrane-bound components of the secretory granule-docking machinery and with the granule

121 telets based on several types of cytoplasmic secretory granules, each sequestering distinct chemical

122 of membrane-enclosed compartments, including secretory granules, endosomes, and lysosomes.

123 ssion and effector-cell responses, including secretory granule exocytosis and cytokine production.

124 Our findings imply that secretory granule exocytosis pathways in other cell type

125 r accumulated in the trans-Golgi network and secretory granule exocytosis was more responsive to secr

126 t cells is their high content of cytoplasmic secretory granules filled with various preformed compoun

127 MCs co-opt their secretory granules for antigen processing and presentati

128 esent CMV antigen to TH1 cells, co-opting MC secretory granules for antigen processing and presentati

129 otein family proposed to function in priming secretory granules for exocytosis.

130 e native disulfide bonds, and is exported to secretory granules for processing and secretion.

131 ecular events leading to hormone sorting and secretory granule formation at the level of the TGN are

132 e only known role of clathrin in dense-cored secretory granules formation is to remove missorted prot

133 The secretory granule-forming activity of a series of human

134 philic granules and plasma-membrane-enriched/secretory-granule fraction.

135 m defective formation and secretion of large secretory granules from Paneth and goblet cells.

136 During this process, secretory granules fuse with the plasma membrane and del

137 utant GCK proteins with a sensor for insulin secretory granule fusion also revealed that blockade of

138 jor Ca(2+) sensor for exocytosis, triggering secretory granule fusion and insulin secretion.

139 translocation occurs at the vicinity of the secretory granule fusion sites.

140 ing expression of beta-cell genes regulating secretory granule fusion.

141 ions of both proteins cluster at sites where secretory granules have docked.

142 sistent with this, they lacked the prominent secretory granules identified by histochemistry and immu

143 The state of secretory granules immediately before fusion with the pl

144 their release of cognate neuropeptides from secretory granules in axon terminals.

145 es was an important step in the evolution of secretory granules in ciliates.

146 alyses confirmed that WFS1 also localizes to secretory granules in human neuroblastoma cells.

147 or the first time that DENV localizes within secretory granules in infected skin mast cells.

148 unoprecipitate and colocalize on a subset of secretory granules in INS-1 cells.

149 fluorophore) within the lumen of individual secretory granules in living chromaffin cells, and relat

150 zes formation and cargo storage of regulated secretory granules in neuroendocrine cells, contributes

151 ne substitution and colocalizes with BDNF in secretory granules in neurons.

152 the expression of CgA reduced the number of secretory granules in normal sympathoadrenal cells (PC12

153 Zymogen secretory granules in pancreatic acinar cells express tw

154 transmembrane protein that also localizes to secretory granules in pancreatic beta cells.

155 fferent secretory pathways from the maturing secretory granules in parotid acinar cells.

156 This was associated with the loss of secretory granules in PC, suggesting an increase in degr

157 te and release the contents of intracellular secretory granules in response to the cross-linking of F

158 destly enlarged acinar cells and accumulated secretory granules in salivary glands of Atg5(f/f);Aqp5-

159 sites of expression within A. caninum L3 to secretory granules in the glandular esophagus and the ch

160 produced as a component of Paneth cell (PC) secretory granules in the small intestine.

161 nduction of cytotoxic effector molecules and secretory granules, in situ motility, or ability to form

162 a plethora of bioactive compounds from their secretory granules, including mast cell-restricted prote

163 ecretion at millimolar concentrations within secretory granules inside the beta-cells.

164 The results show that secretory granules interact stochastically with a target

165 cterial cell surface antigens by discharging secretory granules into the lumen of small intestinal cr

166 lg1 in controlling the formation of specific secretory granules involved in VWF exocytosis in endothe

167 oreover that 7B2-dependent routing of PC2 to secretory granules is cell line-specific.

168 ntrast, formation of much larger dense-cored secretory granules is driven by selective aggregation of

169 The lipid composition of insulin secretory granules (ISG) has never previously been thoro

170 Our recent study of insulin secretory granules (ISG) suggested that phosphatidylseri

171 In neuroendocrine PC12 cells, immature secretory granules (ISGs) mature through homotypic fusio

172 asurements of serotonin released from intact secretory granules isolated from mast cells, after remov

173 y Protein (PSP) is bound to the membranes of secretory granules isolated from rat parotids.

174 l-Palade bodies within endothelial cells are secretory granules known to release von Willebrand Facto

175 chinery for sorting proteins into mucocysts, secretory granule-like vesicles in the ciliate Tetrahyme

176 ecovered in subcellular fractions containing secretory granule-localized proteases.

177 coinciding with that of a mast cell-specific secretory granule marker, mouse mast cell protease 6.

178 Myo5c puncta colocalize with secretory granule markers such as chromogranin A and Rab

179 de that Syt IV is an essential component for secretory granule maturation.

180 to involve their selective retention during secretory granule maturation.

181 hat other factors, such as the low pH of the secretory granule, may also play a role.

182 ammatory mediators in Paneth cell dense core secretory granules mediate tumor necrosis factor-alpha-i

183 regulates the rapid exocytosis of preformed secretory granule mediators.

184 ors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker fo

185 e to secretion, the sudden appearance of the secretory granule membrane in the plasma membrane.

186 Our analysis identifies the pancreatic secretory granule membrane major glycoprotein 2 (GP2) as

187 lpha-amidating monooxygenase (PAM), a type I secretory granule membrane protein, as a gamma-secretase

188 ssential for neuropeptide biosynthesis, is a secretory granule membrane protein.

189 hereas transmitter release was not affected, secretory granule membrane recapture after exocytosis wa

190 It is often assumed that upon fusion of the secretory granule membrane with the plasma membrane, lum

191 ssed by measuring dopamine-beta-hydroxylase (secretory granule membrane) internalization is severely

192 ysis of purified whole secretory granules or secretory granule membranes uncovered their association

193 anule phenotypes) based on lysozyme-positive secretory granule morphology.

194 esicles was unchanged by TCF7L2 suppression, secretory granule movement increased and capacitance cha

195 binds specifically to ISGs and not to mature secretory granules (MSGs), and Syt IV binds to syntaxin

196 ra cell ultrastructure (except for increased secretory granule numbers) were all normal.

197 romogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic n

198 me peptides derived from proteins present in secretory granules of endocrine cells, and a number were

199 dly aggregates and forms fibrils, yet within secretory granules of healthy individuals, IAPP does not

200 Human beta-tryptase is stored in secretory granules of human mast cells as a heparin-stab

201 ode tetramer-forming tryptases stored in the secretory granules of mast cells (MCs) ionically bound t

202 zed with tryptases in the heparin-containing secretory granules of mast cells.

203 Although most commonly associated with secretory granules of neuroendocrine cells, chromogranin

204 hich are stored and released from dense-core secretory granules of neuroendocrine cells, have been im

205 critical element for insulin storage in the secretory granules of pancreatic beta cells.

206 Insulin is stored within the secretory granules of pancreatic beta-cells, and impairm

207 testinal symptoms and seroreactivity against secretory granules of Paneth cells.

208 APC present exogenous peptides derived from secretory granules of the beta-cell, giving rise to uniq

209 ZnT8 mediates zinc enrichment in the insulin secretory granules of the pancreatic beta cell.

210 polypeptide (proIAPP), and processed in the secretory granules of the pancreatic beta-cells.

211 Efficient sorting and packaging into the secretory granules of the regulated secretory pathway in

212 It is stored in secretory granules of vascular endothelial cells, the We

213 Our proteomic analysis of purified whole secretory granules or secretory granule membranes uncove

214 n directing endocytosed membrane PAM back to secretory granules or to a degradative pathway.

215 examerization, steps in formation of nascent secretory granules, or other unknown molecular events.

216 ibute to sorting during the formation of the secretory granules, or sorting by retention during matur

217 lar mechanisms involved in the maturation of secretory granules, organelles that store hormones and n

218 yntaxins, and VAMPs) are known regulators of secretory granule/plasma membrane fusion events.

219 ropic hormone, growth hormone) into separate secretory granule pools.

220 or whether there is heterogeneity within the secretory granule population in mast cells.

221 ease revealed that subapical accumulation of secretory granules precedes occurrence of microvillus in

222 ons might account for the disorganization of secretory granules previously reported in Paneth cells f

223 atively low pH environment in the pancreatic secretory granules prior to its release to the extracell

224 mouse, we recently identified the beta cell secretory granule protein, chromogranin A (ChgA), as a n

225 AL1 in INS-1 cells reduces the expression of secretory granule proteins prochromogranin A and proICA5

226 Here we show that serglycin, a secretory granule proteoglycan of hematopoietic cells, c

227 Serglycin (SG), the hematopoietic cell secretory granule proteoglycan, is crucial for storage o

228 oupled to compensatory endocytosis, allowing secretory granule recycling.

229 We conclude that Epac2A controls secretory granule release by binding to the exocytosis m

230 change factors (GEFs), which interact with a secretory granule resident protein, modulate cargo secre

231 ense-body granules are one prominent type of secretory granule responsible for storing small molecule

232 Copper loading decreases cleavage of PAM in secretory granules, secretion of soluble enzyme, and the

233 mice to examine the role of Syn-2 in insulin secretory granule (SG) exocytosis.

234 Secretory granule (SG) maturation has been proposed to i

235 Munc18-2 in mast cells inhibits cytoplasmic secretory granule (SG) release but not CCL2 chemokine se

236 role of MyRIP in myosin Va (MyoVa)-dependent secretory granule (SG) transport and secretion in pancre

237 n receptor) complexes that mediate fusion of secretory granule (SG) with plasma membrane (PM).

238 ated PE-induced juxtanuclear accumulation of secretory granules (SG) containing ANP propeptides (pro-

239 s from these mice had a severe deficiency of secretory granules (SGs) and insulin.

240 tors (FcepsilonRI) triggers degranulation of secretory granules (SGs) and the release of many allergi

241 Before undergoing neuroexocytosis, secretory granules (SGs) are mobilized and tethered to t

242 ells had a severe reduction in the number of secretory granules (SGs) docked onto the plasma membrane

243 flammatory mediators prestored in mast cells secretory granules (SGs) enhances immune responses such

244 Insulin secretory granules (SGs) exist in different functional p

245 binding protein that localizes to and primes secretory granules (SGs) for Ca(2+)-evoked secretion in

246 of exocytosis, during which the membranes of secretory granules (SGs) fuse with each other to form a

247 Exocytosis of secretory granules (SGs) requires their delivery to the

248 Secretory granules (SGs) sequester significant calcium.

249 cretory cells relies on the timely fusion of secretory granules (SGs) with the plasma membrane.

250 release inflammatory mediators, contained in secretory granules (SGs), which play important roles in

251 exocytosis of predocked and newcomer insulin secretory granules (SGs).

252 is found at millimolar concentrations in the secretory granule, significantly inhibits hIAPP amyloid

253 degraded via direct fusion with lysosomes, a secretory granule-specific autophagic process known as c

254 in the intestinal mucosa that do not contain secretory granules, such as brush or caveolated cells.

255 Secretory granules, such as neuronal dense core vesicles

256 oA activity polarizes around JFC1-containing secretory granules, suggesting that it may control direc

257 Knockdown of Kv2.1 expression reduces secretory granule targeting to the plasma membrane.

258 l-Palade bodies (WPBs), endothelial-specific secretory granules that are central to primary hemostasi

259 in Weibel-Palade bodies (WPBs), cigar-shaped secretory granules that are generated in a wide range of

260 ore an array of proinflammatory mediators in secretory granules that are rapidly released upon activa

261 ic protein-protein interaction on individual secretory granules that is linked to a specific granule

262 tory proteins are stored in large dense-core secretory granules that undergo stimulated secretion in

263 M3B) is a novel cytokine, present in insulin secretory granules, that induces apoptosis of alpha and

264 Sperm contain a large dense-core secretory granule (the acrosome) whose contents are secr

265 a2+ stores in the endoplasmic reticulum, the secretory granules, the lysosomes, and the endosomes all

266 amounts of mMCP-6.heparin complexes in their secretory granules, the passive cutaneous anaphylaxis re

267 etrieval of the compound membrane of several secretory granules through a single membrane fission eve

268 elaying information about secretion from the secretory granule to the nucleus.

269 naling molecule that relays information from secretory granules to both cytosol and nucleus.

270 eviously unreported mechanism for delivering secretory granules to the immunological synapse, with gr

271 actin bundled by annexin A2 connected docked secretory granules to the plasma membrane and contribute

272 uiring the continued mobilization of insulin secretory granules to the plasma membrane.

273 ll on P-selectin after its mobilization from secretory granules to the surfaces of platelets and endo

274 ef(-/-) colon, including genes implicated in secretory granule traffic and functions.

275 otein known to be involved in melanosome and secretory granule trafficking to the plasma membrane in

276 f Myo5c and indicate that Myo5c functions in secretory granule trafficking.

277 ts direct observation of insulin packaged in secretory granules, trafficking of these granules to the

278 organelle, not the plasma membrane, and that secretory granules use a JFC1- and GMIP-dependent molecu

279 Multiple Rabs are associated with secretory granules/vesicles, but how these GTPases are c

280 -stimulated exocytosis: fusion of individual secretory granules (Weibel-Palade bodies [WPBs]) and sub

281 iability, reactive oxygen species (ROS), and secretory granules were assessed with parameter-indicati

282 apical vesicles that normally support mature secretory granules were dispersed.

283 PC secretory granules were released, and Crp-3/-5 mRNA expr

284 he high concentrations that are found in the secretory granule where it is stored.

285 f the normal component of pre-docked insulin secretory granules, whereas cells with elevated levels o

286 expression of RAB26 and RAB3D to form large secretory granules, whereas control, non-MIST1-expressin

287 Hormone secretion relies on secretory granules which store hormones in endocrine cel

288 driving the remodeling of membranes of large secretory granules, which are integrated into the plasma

289 rgic stimulation elicits exocytosis of large secretory granules, which gradually collapse with the ap

290 To study this mechanism, we used eosinophil secretory granules, which undergo stimulated homotypic f

291 peripheral tissues wherein the appearance of secretory granules with a particular protease phenotype

292 les (GUVs) and smaller liposomes or purified secretory granules with high temporal and spatial resolu

293 and Vamp7 are all required for the fusion of secretory granules with lysosomes.

294 ikely formed by cumulative fusion of several secretory granules with the cell membrane.

295 ropeptides, through the fusion of dense core secretory granules with the cell surface.

296 n to this system which relies on loading the secretory granules with the false transmitter dopamine,

297 es the translocation, docking, and fusion of secretory granules with the plasma membrane.

298 ased secretion of a product stored in mature secretory granules, with no effect on basal secretion; a

299 e of Trpm5 and that does not contain typical secretory granules yet expresses endogenous opioids (bet

300 ymorphisms in the SLC30A8 gene, encoding the secretory granule Zn(2)(+) transporter ZnT8, are associa