ライフサイエンスコーパス: serine

1 rocytes enhanced production and release of d-serine.

2 ric disease through abnormal production of D-serine.

3 so far, been mainly limited to cysteine and serine.

4 ding induced by the replacement of H375 by a serine.

5 n two CRF01_AE Envs (CM244 and 92TH023) by a serine.

6 which was rescued by adding extracellular D-serine.

7 that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2alpha a

8 ylation of histone H4 antagonizes histone H4 serine 1 phosphorylation (H4S1ph), and that downregulati

9 )-catalyzed phosphorylation of histone H3 at serine 10 or 28 and expression of immediate-early (IE) g

10 lcNAcylated by O-GlcNAc transferase (OGT) at serine 109.

11 included previously described sites such as serine 116 and newly found sites such as serine 2652 thr

12 d that forms a boronic ester reversibly with serine 117.

13 KII-mediated phosphorylation level of GluN2B serine 1303 (S1303) in the PVN, but not in the hippocamp

14 Phosphorylation of TRPC6 at serine 14 enhances channel conductance by boosting membr

15 The phosphorylation site at serine 14 of TRPC6 is embedded in a basophilic kinase mo

16 imerization of TRPC6 are not altered, making serine 14 phosphorylation a potential drug target to int

17 peroxide showed increased activity of p53 at Serine 15.

18 pendent kinases (CDKs) phosphorylate PAH1 at serine 162, which reduces both its activity and membrane

19 The phosphorylation of Amot at Serine 176 shifts localization of this complex to the pl

20 ently, additional phosphorylation of ZBP1 at serine 181 (Ser181) was described in non-neuronal cells.

21 Here, we show that serine 193 (S193) is phosphorylated in Atoh1's bHLH doma

22 n-regulated TMPRSS2 (transmembrane protease, serine 2) gene to the open reading frame of ERG, encodin

23 ce of fusions of the transmembrane protease, serine 2, gene (TMPRSS2) with the erythroblast transform

24 Mechanistically, chromatin occupancy of serine 2-unphosphorylated RNA polymerase II is increased

25 d method identified the aged soman adduct on serine 203 in peptide FGESAGAAS.

26 as serine 116 and newly found sites such as serine 2652 throughout the protein.

27 s spectrometry identified phosphorylation on Serine 269 in Su(H), potentially serving as a point of c

28 that, after AKT-mediated phosphorylation at serine 319, FOXO1 binds to IQGAP1, a hub for activation

29 Functionally, serine 34/35 phosphorylation enhances autophagosome recr

30 DNA replication, but specifically blocks the serine 345 phosphorylation of the DNA damage checkpoint

31 of p66Shc facilitates its phosphorylation on serine 36 and translocation to the mitochondria, where i

32 that Aurora A directly phosphorylates YY1 at serine 365 in the DNA-binding domain.

33 residues such as histidine or tryptophan for serine 375 (S375H/W) in the gp120 Phe 43 cavity, where P

34 Serine 384 (S384) is the critical cyclin E phosphorylati

35 phagy is inhibited, p53 is phosphorylated at serine-392 by PINK1, a kinase associated with mitophagy,

36 ro Specifically, Neto2 was phosphorylated at serine 409 (Ser-409) by Ca(2+)/calmodulin-dependent prot

37 und CK1 catalyzed TDP-43 phosphorylations at serines 409/410, which were diminished or absent in GADD

38 Phosphorylation of NBS1 serine 432 by CDK2 in S/G2 dissociates NBS1 from TRF2, p

39 The serine 482 variant of the human PGC1A protein had a shor

40 like autophagy activating kinase 1 (Ulk1) at serine 555.

41 ences within the MRE11 C terminus containing serines 558/561 and 688/689.

42 nt of the Mre11/Rad50/Nbs1 (MRN) complex, at serine 649 (S649) during DDR.

43 PINK1 phosphorylation of serine 65 in parkin's UBL and serine 65 of ubiquitin ful

44 phorylation of serine 65 in parkin's UBL and serine 65 of ubiquitin fully activate ubiquitin ligase a

45 Additionally, mutations of serines 688/689, which abolish PIH1D1 binding, also resu

46 lation of the AMPA GluA1 receptor subunit at serine 831 (S831), a CaMKII site, along with an increase

47 roliferator-activated receptor gamma through serine 84 phosphorylation and promoting activator protei

48 K1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction a

49 ically, NEM increased the phosphorylation of serine 940 (Ser-940), whereas it decreased phosphorylati

50 d-Serine, a coagonist of the NMDAR, plays a significant ro

51 and hundreds of other targets indicates that serine ADPr is a widespread modification.

52 Further identification of serine ADPr on HMG proteins and hundreds of other target

53 h 8/4 or 9/3 structures efficiently inserted serine, alanine and cysteine in response to stop and sen

54 In contrast, miropin uniquely blocked many serine and cysteine endopeptidases of disparate architec

55 unctional groups, such as the side chains of serine and cysteine, using electrophilic probes.

56 Restriction of dietary serine and glycine can reduce tumour growth in xenograft

57 ed survival following dietary restriction of serine and glycine in these models was further improved

58 nd their phages employ the 8/4 structure for serine and histidine tRNAs, while minor cysteine and sel

59 be particularly relevant in the PFC, where D-serine and its converting enzyme are highly expressed.

60 hingolipid biosynthesis: the condensation of serine and palmitoyl-CoA.

61 found that Alr2 could interconvert l- and d-serine and that Alr2 bound to l- and d-serine with appro

62 nserved canonical extensin repeat, Ser-Hyp4, serine and the consecutive C4-hydroxyprolines (Hyps) are

63 we report the mass spectrometry analysis of serine and threonine pyrophosphorylation, a protein modi

64 numerous nuclear and cytoplasmic proteins on serine and threonine.

65 e measurement of NMDAR function in glycine/D-serine and/or glutamate sensitive modes.

66 oting ER retention, while mutation of target serines and drug inhibition of GSK-3 activity coordinate

67 two amino acids engendered by dehydration of serines and threonines, respectively.

68 Finally, we demonstrate that l- and d-serine are also co-germinants for C. difficile spores.

69 mary uptake pathways, glucose, glutamine and serine, are each characterized by three features: (1) me

70 Here we report that serine-arginine protein kinase 2 (SRPK2) phosphorylates

71 SR (serine-arginine)-rich proteins influence multiple steps

72 sible for shuttling specific cargoes such as serine/arginine-rich splicing factors from the cytoplasm

73 The versatile functions of SR (serine/arginine-rich) proteins in pre-mRNA splicing and

74 minants and reveal that Alr2 can accommodate serine as a substrate.

75 nal inputs and reveal a potential role for d-serine as an endogenous modulator of circuit refinement.

76 olecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (SdrD), which serve ke

77 gn and characterization of expanded-spectrum serine beta-lactamase inhibitors that potently inhibit c

78 c acid and avibactam are clinically deployed serine beta-lactamase inhibitors, important as a defence

79 ycolysis, the pentose phosphate pathway, and serine biosynthesis seems to be spatially regulated by t

80 onist, D-serine, which is synthesized from L-serine by the neuronal enzyme serine racemase (SR).

81 ns and differs from PRDM9a by an arginine-to-serine change (R764S) in ZF9 and by replacement of ZF11

82 ly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), whic

83 Phosphorylation of a highly conserved serine cluster in the intracellular domain of E-Cadherin

84 ry mutations targeting this highly conserved serine cluster.

85 In this research, one specific serine codon of the 1Ax1 gene corresponding to the extra

86 r that has properties that set it apart from serine complexes of different sizes or from complexes co

87 the four major protease mechanistic classes-serine, cysteine, aspartyl, and metallo-proteases-and de

88 This last step diverges from what occurs in serine-dependent MCP hydrolases.

89 of HDAC1 and identify calcineurin-dependent serine dephosphorylation as the signal modulating the ne

90 Hence, D-serine dietary supplementation was initiated.

91 munication improvements after 17 months of D-serine dietary supplementation.

92 ine synthesis, many others rely on exogenous serine for optimal growth.

93 arbouring a substitution of leucine 150 to a serine fully rescued pmr1 Mn-sensitivity at all concentr

94 Under nonpathological conditions, d-serine functions as a neurotransmitter and coagonist for

95 rform significant amount of respiration, use serine-glycine cycle and produce ethanol in mitochondria

96 served that reversion of amino acid 375 to a serine (H375S) resulted in a loss of functionality of bo

97 Receptor co-agonists, glycine and D-serine, have intriguingly emerged as potential regulator

98 vity-dependent proximity ligation (ADPL), to serine hydrolase and cysteine protease enzymes enables q

99 ion as a directed fragment library targeting serine hydrolases and related enzymes.

100 Serine hydrolases are susceptible to potent reversible i

101 alkynylated probe identified Pks13 and Ag85 serine hydrolases as major targets.

102 class of irreversible inhibitors that target serine hydrolases in both cells and animal models.

103 nes as putative mycolic acid mimics to block serine hydrolases involved in their biosynthesis.

104 s applied to pooled plasma samples to enrich serine hydrolases using a fluorophosphonate (FP2) activi

105 ntial of targeting mycomembrane biosynthesis serine hydrolases.

106 etrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-met

107 opyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to impr

108 sults reveal a pivotal modulatory role for d-serine in neurodevelopment.

109 n of NMDA EPSCs was rescued by addition of D-serine in the extracellular medium.

110 find that HAstV-2 capsid spike containing a serine in this loop is immunogenic and elicits antibodie

111 rylatable slr1-6SA-GFP protein, in which six serines in SR/RS clusters are substituted with alanines,

112 Bacteriophage serine integrases are extensively used in biotechnology

113 We show here that serine integrases can be fused to their cognate RDFs to

114 HIV-1 particles and suggest that channeling serine into lipid biosynthesis may not be a cardinal cel

115 The amino acid serine is known to form a very stable octamer that has p

116 gulating seven of those polar metabolites (L-serine, L-leucine, glucose, fructose, myo-inositol, citr

117 diffusible molecules, specifically acyl homo serine lactones, such as N-(3-oxo-dodecanoyl)-l-homoseri

118 n their premature responding and glycine and serine levels in vmPFC during the performance of the sta

119 injury, hippocampal neurons downregulated d-serine levels, while astrocytes enhanced production and

120 tudied at constant growth rate using carbon (serine)-limited continuous chemostat cultures.

121 erent amounts, but only the (R)-isoform of l-serine-Lipid 654.

122 Two PSMA-I&T-derived inhibitors with all-L-serine- (MAS3) and all-D-serine- (mas3) chelating moieti

123 hibitors with all-L-serine- (MAS3) and all-D-serine- (mas3) chelating moieties were evaluated in para

124 e important implications for understanding D-serine-mediated N-methyl-D-aspartate receptor plasticity

125 p12 loci have been implicated in the glycine/serine metabolic pathway.

126 or of l-serine over the normally preferred l-serine-O-sulfate ( approximately 1200-fold change in kca

127 For example, both singly protonated serine octamers and anionic octamers complexed with two

128 Here, we investigate anionic serine octamers coordinated with two chloride ions using

129 consistent with the facilitatory effect of D-serine on fear extinction.

130 The ameliorative effects of D-serine on mutant DISC1-associated behaviors and abnormal

131 cus, resulting in a phenylalanine instead of serine on position 223.

132 it composition after activation by glycine/D-serine or glutamate and hence presents the first plate-b

133 ate can be influenced by the introduction of serine or threonine at sequence position 69 (Eos notatio

134 t of sugar moieties to the hydroxyl group of serine or threonine on proteins/peptides.

135 on (L-glycero-L-manno) and is beta-linked to serine or threonine residues.

136 mination substrate specificity in favor of l-serine over the normally preferred l-serine-O-sulfate (

137 In all eukaryotes analyzed to date, serine palmitoyltransferase is a highly conserved hetero

138 n orthologue to be a functional, homodimeric serine palmitoyltransferase localized to the endoplasmic

139 n, isolation, and analyses of the Toxoplasma serine palmitoyltransferase, an enzyme catalyzing the fi

140 as evolutionarily related to the prokaryotic serine palmitoyltransferase, identified in the Sphingomo

141 However, it remains unknown whether d-serine participates in the establishment of precise neur

142 umour cells reduces flow through the PPP and serine pathways, thereby depleting the antioxidants NADP

143 ediates into the pentose phosphate (PPP) and serine pathways.

144 nts 912 References 912 Subtilases (SBTs) are serine peptidases that are found in all three domains of

145 We show that mutation to serine permits loop flexibility and recovers MAb PL-2 bi

146 Activity of TFEB is inhibited upon its serine phosphorylation by mTOR The overall mechanisms by

147 analysis, Ser-164 was identified as a major serine phosphorylation site in SIRT1 in obese, but not l

148 cent subunits and regulating factors such as serine phosphorylation.

149 enhanced STAT1-mediated gene expression via serine phosphorylation.

150 rowth in the presence of the chemoattractant serine, pointing to a physiological relevance of the obs

151 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) 3:1 mol/mole and at neutral pH, the peptid

152 Thymus-specific serine protease (TSSP) is expressed by thymic epithelial

153 S13 is a member of the type II transmembrane serine protease (TTSP) family.

154 The serine protease cathepsin G recapitulated the effects of

155 A canonical model entails a C1r2s2 with its serine protease domains tightly packed together in the c

156 Clip domain serine protease homologs (SPHs) are positive and negativ

157 The function of serine protease inhibitor 2A (Spi2A) was studied in mous

158 i2A) was studied in mouse TH2 cells, and the serine protease inhibitor B3 (SERPINB3) and SERPINB4 gen

159 at alpha-1 antitrypsin (AAT; Prolastin-C), a serine protease inhibitor used for the treatment of AAT

160 otease TMPRSS2, but Zhou et al. found that a serine protease inhibitor was more protective than a cat

161 ng pathway and alpha1-antitrypsin protein (a serine protease inhibitor) expression and downregulation

162 The variant is located in the gene encoding serine protease inhibitor, low levels of which are assoc

163 ioactive peptide from the alpha1-antitrypsin serine protease inhibitor.

164 pider Cupiennius salei The chymotrypsin-like serine protease is a 28-kDa heterodimer with optimum act

165 t addition of subtilisin (50 nm to 2 mum), a serine protease secreted by the non-pathogenic bacterium

166 ontrolling maturation of the subtilisin-like serine protease SUB1 in exoneme secretory vesicles.

167 than on the cell surface acid pH-independent serine protease TMPRSS2, but Zhou et al. found that a se

168 Activation Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in ac

169 Factor D is a trypsin-like serine protease with a narrow specificity for arginine i

170 king mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1) and MASP-3 contain zymogenic

171 ative C3 by mannan-binding lectin-associated serine protease-2 bound to LP-activation complexes captu

172 LP-specific mannan-binding lectin-associated serine protease-2.

173 ne defenders against infection, express four serine proteases (NSPs) that play roles in the control o

174 cies, antimicrobial peptides, and neutrophil serine proteases (NSPs).

175 substrate specificity of cysteine proteases, serine proteases and metalloproteinases.

176 Although serine proteases are found ubiquitously in both eukaryot

177 We conclude that serine proteases derived from commensal bacteria can dir

178 Cysteine and serine proteases function via protease-activated and mas

179 Although trypsin-like serine proteases have flexible surface-exposed loops and

180 mational flexibility of uPA and trypsin-like serine proteases in general.

181 selective towards thrombin than to the other serine proteases of the coagulation cascade.

182 We recently identified the StmPr1 and StmPr2 serine proteases to be the substrates of the Xps type II

183 ma kallikrein-kinin system (KKS) consists of serine proteases, prekallikrein (pKal) and factor XII (F

184 , which regulate the proteolytic activity of serine proteases.

185 n, a protease homologous to other allosteric serine proteases.

186 demonstrated that the type II transmembrane serine proteinase (TTSP) matriptase acts as a novel init

187 Each of the three serine proteinase activity-based probe-labelled enzymes

188 kinase-type plasminogen activator (uPA) is a serine proteinase that upon binding to the urokinase-typ

189 We have identified three different serine proteinases from the German cockroach that may, v

190 Transforming growth factor-beta (TGF-beta), serine proteinases such as trypsin, and proteinase-activ

191 rypsin-like elastases (CELAs) are pancreatic serine proteinases that digest dietary proteins.

192 is a G protein-coupled receptor activated by serine proteinases.

193 hesized from L-serine by the neuronal enzyme serine racemase (SR).

194 ession quantitative trait locus of the human serine racemase (SRR) gene, was associated with fear-rel

195 the astrocytic d-serine-synthesizing enzyme serine racemase after CCI injury improved synaptic plast

196 O-Lys(114) hydrogen-bonding network in human serine racemase lowers the pKa of the Ser(84)re-face bas

197 T-based FLIM approach, we demonstrate that D-serine rapidly induces a conformational change of the Gl

198 ask-related recruitment of vmPFC glycine and serine release, and the loss of an inverse relationship

199 43 hemichannel activity is associated with D-serine release.

200 f the MIA group from NosJ-MIA to a conserved serine residue (Ser102) on NosK.

201 sulin receptor substrate-1 phosphorylated at serine residue 312 in neurons and oligodendrocytes in th

202 ceptor substrate 1 (IRS-1) phosphorylated at serine residue 312 was more apparent in inclusion bearin

203 MST4 phosphorylates ATG4B at serine residue 383, which stimulates ATG4B activity and

204 sidue plays a role in activating an adjacent serine residue carrying out nucleophilic attack, opening

205 y ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allow

206 d ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signatur

207 osphorylation at an evolutionarily conserved serine residue near the carboxyl terminus (Ser-883 in Xe

208 A serine residue on the DIV S2 helix was found to be suffi

209 in activation, we demonstrated a key role of serine residue S1163 of the alphaE chain intracellular d

210 sphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress respo

211 sitides but undergoes phosphorylation on the serine residue within a CaMKII target motif.

212 that allows ERK phosphorylation at a second serine residue, Ser-96.

213 s partially rescued by removing the adjacent serine residue.

214 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via an ADP-ribosylated ubi

215 ificantly enhanced by phosphorylation of key serine residues in the IRF6 C-terminus.

216 fy HDAC1 and the phosphorylation of specific serine residues in the molecule as potential targets for

217 s studies have shown that phosphorylation of serine residues on synaptic proteins is a major regulato

218 cultured cells, phosphorylation of specific serine residues within the cluster is also required for

219 function of each of these two phosphorylated serine residues.

220 steine can be deselenized into an alanine or serine, resulting in nonselenoproteins.

221 ation; each contains a transmembrane domain, serine rich region and a conserved cytoplasmic domain.

222 , Leu847, and Gly848-located in the cysteine-serine-rich domain (CSRD).

223 Hyperphosphorylation of a serine-rich motif immediately after the PH domain decrea

224 tants by mutating known conserved regulatory serine (S) residues 255, 279/282, 365, 368, and 373 loca

225 Substitution of a conserved serine (S270A) interferes with SCF(Slmb) binding and sta

226 naling cascade leading to phosphorylation of serine S845 on GluA1 AMPA receptors and their traffickin

227 GLY, alanine (ALA), and serine (SER) all resulted in remarkable suppression of C

228 ect on hD4R levels is noted when cytoplasmic serine (Ser) and threonine (Thr) residues are mutated.

229 -2 reactions is necessary and sufficient for serine-specific ADPr of histones and PARP-1 itself.

230 eration in exon 3, which causes a leucine to serine substitution at codon 102 (Human Genome Variation

231 F-1 also mediates increased flux through the serine synthesis pathway and mitochondrial one-carbon (f

232 Inactivation of D-serine synthesis within the astroglial network resulted

233 While some cancer cells upregulate de novo serine synthesis, many others rely on exogenous serine f

234 yte-specific elimination of the astrocytic d-serine-synthesizing enzyme serine racemase after CCI inj

235 conditioning and extinction engages the SR/D-serine system in the brain.

236 The polo family serine threonine kinase Plk4 has been proposed as a ther

237 lar kinases that phosphorylate extracellular serine, threonine, and tyrosine residues of numerous pro

238 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in all fou

239 n of each individual complex, stabilizes the serine-threonine protein kinase PINK1 on the mitochondri

240 n using a few representative cancer-relevant serine/threonine and tyrosine kinases and their interpla

241 gene transcription are profoundly shaped by serine/threonine and tyrosine signaling kinases and comp

242 recruitment of ataxia-telangiectasia mutated serine/threonine kinase (ATM) to the damaged site, where

243 ate-activated protein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as

244 The tumor suppressor serine/threonine kinase 11 (LKB1/STK11) is one of the mo

245 vitro and in vivo by microtubule-associated serine/threonine kinase 3 (MAST3 kinase), an enzyme of p

246 We identified GCK-1, a conserved serine/threonine kinase [8], as a putative novel anillin

247 Here we examined the role of the serine/threonine kinase Akt in the generation of protect

248 expression of general control nonrepressed 2 serine/threonine kinase and increased expression of mamm

249 Expression of general control nonrepressed 2 serine/threonine kinase and mammalian target of rapamyci

250 RATIONALE: LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regu

251 tral element within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in develop

252 CD transactivation of microtubule associated serine/threonine kinase family member 4 (MAST4).

253 The serine/threonine kinase IL-1R-associated kinase (IRAK)4

254 Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wi

255 LKB1 is a multi-functional serine/threonine kinase that associates with actin at th

256 acting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in development an

257 protein of the MTOR complex 1 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncog

258 teracting protein kinase (HIPK) 2, a nuclear serine/threonine kinase, activates CREB through Ser271 p

259 We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3

260 is also a target of casein kinase 2 (CK2), a serine/threonine kinase, in proliferating myoblasts.

261 Protein kinase C (PKC) theta, a serine/threonine kinase, is involved in TH2 cell activat

262 extracellular penicillin-binding-protein and serine/threonine kinase-associated (PASTA) domains which

263 of bacterial Penicillin-binding-protein And Serine/Threonine kinase-Associated (PASTA) kinases is of

264 menon depends on the RTKs activating the AKT serine/threonine kinase.

265 mprise an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis

266 Dysregulated oncogenic serine/threonine kinases play a pathological role in div

267 e (smMLCK) is a member of a diverse group of serine/threonine kinases that feature cytoskeletal assoc

268 L-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in ini

269 The protein kinase D family of serine/threonine kinases, particularly PKD1, has been im

270 PAK4 is a member of the PAK family of serine/threonine kinases, which act as effectors for sev

271 Selective inhibitors for each serine/threonine phosphatase (PPP) are essential to inve

272 Surprisingly, this structure revealed a serine/threonine phosphatase fold that unexpectedly targ

273 Protein phosphatase-2A (PP2A) is an abundant serine/threonine phosphatase with anti-inflammatory acti

274 nd phosphatases modulate GPCR signaling, how serine/threonine phosphatases integrate with G protein s

275 e 2A (PP2A) is a member of the intracellular serine/threonine phosphatases.

276 ound that knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1) increased both

277 ath domain (TRADD), and receptor-interacting serine/threonine protein kinase 1 (RIPK1).

278 Polo-like kinase 1 (Plk1), a serine/threonine protein kinase normally expressed in mi

279 ological inhibition of either IKKbeta or the serine/threonine protein kinase TAK1 in monocytes blocke

280 Liver kinase B1 (LKB1) is a serine/threonine protein kinase ubiquitously expressed i

281 e PKM isoforms in A549 cells lacking LKB1, a serine/threonine protein kinase upstream of AMPK, failed

282 thioredoxin-fold-containing eukaryotic-like serine/threonine protein kinase, is a virulence factor i

283 rectly with the scaffolding A subunit of the serine/threonine protein phosphatase, PP2A, and that pho

284 report that a poxvirus kinase phosphorylates serine/threonine residues in the human small ribosomal s

285 the O-linkage of beta-N-acetylglucosamine to serine/threonine residues of membrane, cytosolic, and nu

286 ide bonds between proline and phosphorylated serine/threonine residues.

287 f PTPN12 by CDK2 impaired recruitment of the serine/threonine-protein kinase 1 (PAK1) to HER2, result

288 daptor proteins such as receptor-interacting serine/threonine-protein kinase 1 (RIPK1), receptor-inte

289 otein kinase 1 (RIPK1), receptor-interacting serine/threonine-protein kinase 3 (RIPK3), TIR-domain-co

290 estigated the functions of the Hippo pathway serine/threonine-protein kinases Lats1 and Lats2, which

291 Overexpression of the YBX1-S176A (serine-to-alanine) mutant in either HEK293 cells or colo

292 e in a loop within the PL-2 epitope due to a serine-to-proline mutation, locking the loop in a confor

293 ephalopathy and that their potentiation by D-serine treatment may underlie the associated clinical im

294 Notably, the naturally occurring coagonist D-serine was able to attenuate hypofunction of GluN2B(p.P5

295 D-serine was administered systemically to mice to evaluate

296 the respective enzymes with specificity for serine were missing.

297 ation requires the binding of a coagonist, D-serine, which is synthesized from L-serine by the neuron

298 and d-serine and that Alr2 bound to l- and d-serine with approximately 2-fold weaker affinity to that

299 s, mutation of four previously characterized serines within the Kv3.4 N-terminal inactivation domain

300 through a conserved four amino acid motif, (serine-X-isoleucine-proline) which exists within an intr