ライフサイエンスコーパス: serine palmitoyltransferase

1 pe that was corrected by transformation with serine palmitoyltransferase.

2 hesis of complex sphingolipids downstream of serine palmitoyltransferase.

3 imiting enzyme in sphingolipid biosynthesis, serine palmitoyltransferase.

4 but unlike myriocin FTY720 does not inhibit serine palmitoyltransferase.

5 the activities of both ceramide synthase and serine palmitoyltransferase.

6 s and knockdowns affecting either subunit of serine palmitoyltransferase, a key enzyme in ceramide an

7 Inactivation of serine palmitoyltransferase, a key enzyme in generating

8 ntial substrate specificity of virus-encoded serine palmitoyltransferase, a key enzyme of sphingolipi

9 sphingolipids, apparently via modulation of serine palmitoyltransferase, a rate-limiting enzyme in d

10 were protected from diet-induced increase in serine palmitoyltransferase, acid sphingomyelinase, and

11 tion that associates with increased monocyte serine palmitoyltransferase activity and chemotaxis towa

12 These mutations are dominant and decrease serine palmitoyltransferase activity by 50% when the wil

13 h after ultraviolet B irradiation), whereas serine palmitoyltransferase activity did not change.

14 l-Cycloserine, an inhibitor that blocks serine palmitoyltransferase activity, lowered both sphin

15 The tsc3 mutant cells have severely reduced serine palmitoyltransferase activity.

16 ation of Tyr(164) to Phe in SPTLC1 increased serine palmitoyltransferase activity.

17 hingomyelin) are reduced secondary to absent serine palmitoyltransferase activity.

18 LCB1 gene of Saccharomyces cerevisiae reduce serine palmitoyltransferase activity.

19 alpha-oxoamine synthase family required for serine palmitoyltransferase activity.

20 n, isolation, and analyses of the Toxoplasma serine palmitoyltransferase, an enzyme catalyzing the fi

21 ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the in

22 ion of [(3)H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into

23 ation of [3H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into

24 isin B1, specific inhibitors of key enzymes (serine palmitoyltransferase and dihydroceramide synthase

25 thase activity (over 2-fold, p = 0.01); both serine palmitoyltransferase and glucosylceramide synthas

26 hytosphingosine bypasses the requirement for serine palmitoyltransferase and restores proteolysis.

27 generation through the de novo pathway (e.g. serine palmitoyltransferase) and via the hydrolysis of s

28 hingolipid biosynthetic pathway (mediated by serine palmitoyltransferase), and at least regulated, de

29 These results implicate serine palmitoyltransferase as the enzyme controlling de

30 zymes known as the alpha-oxoamine synthases, serine palmitoyltransferase catalyzes the committed step

31 Serine palmitoyltransferase catalyzes the first step of

32 cycloserine, and 4-HPR transiently activated serine palmitoyltransferase, demonstrating that 4-HPR in

33 is work demonstrates that one subunit of the serine palmitoyltransferase enzyme, SPTLC1, but not subu

34 or angiogenic responses in mice with reduced serine palmitoyltransferase expression.

35 ace of L-serine, the mutant HSAN1-associated serine palmitoyltransferase generates deoxysphingolipids

36 While the putative homologues of giardial serine palmitoyltransferase (gSPT) subunit genes (gspt-1

37 two isoforms of the small subunits of human serine palmitoyltransferase (hssSPTs) that activate the

38 as evolutionarily related to the prokaryotic serine palmitoyltransferase, identified in the Sphingomo

39 A-stimulated RAW264.7 cells (and mutation of serine palmitoyltransferase in CHO-LYB cells); furthermo

40 e for de novo sphingoid base biosynthesis by serine palmitoyltransferase in the transient G0/G1 arres

41 we1 kinase renders mutant cells sensitive to serine palmitoyltransferase inhibition due to impaired s

42 esis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show st

43 The serine palmitoyltransferase inhibitor myriocin reversed

44 In all eukaryotes analyzed to date, serine palmitoyltransferase is a highly conserved hetero

45 oamine synthases are soluble homodimers, but serine palmitoyltransferase is a membrane-associated enz

46 We also show that serine palmitoyltransferase is an Lcb1p small middle dot

47 Modeling studies suggest that serine palmitoyltransferase is likely to have a single a

48 ort here that the gene encoding a subunit of serine palmitoyltransferase is located within the HSN1 l

49 This result suggests that the activation of serine palmitoyltransferase is the event responsible for

50 1-100, which harbors a temperature-sensitive serine palmitoyltransferase, lacked increased de novo ge

51 n orthologue to be a functional, homodimeric serine palmitoyltransferase localized to the endoplasmic

52 f ceramide, through the rate-limiting enzyme serine palmitoyltransferase long chain (Sptlc)-2, is req

53 onstrated that the ER-resident human protein serine palmitoyltransferase long chain-1 (SPTLC1), which

54 itary neuropathies are dominant mutations in serine palmitoyltransferase, long chain base subunit 1 (

55 the gene was identified as SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1.

56 d an increase in the message and activity of serine palmitoyltransferase (P < 0.05).

57 ysical interaction between Orm1 and Orm2 and serine palmitoyltransferase, responsible for the first c

58 ynthase, and ISP-1, myriocin an inhibitor of serine palmitoyltransferase, significantly attenuated th

59 The relationship between serine palmitoyltransferase (SPT) activity and ORMDL reg

60 Serine palmitoyltransferase (SPT) catalyzes the first co

61 Serine palmitoyltransferase (SPT) catalyzes the first st

62 Serine palmitoyltransferase (SPT) catalyzes the first st

63 Serine palmitoyltransferase (SPT) catalyzes the first st

64 The enzyme serine palmitoyltransferase (SPT) catalyzes the formatio

65 Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT) cause an adult-onset,

66 a sensory neuropathy due to mutations in the serine palmitoyltransferase (SPT) enzyme.

67 Serine palmitoyltransferase (SPT) is a key enzyme in the

68 Serine palmitoyltransferase (SPT) is the first and rate-

69 Serine palmitoyltransferase (SPT) is the first rate-limi

70 Serine palmitoyltransferase (SPT) is the key enzyme in S

71 The LCB chain length is determined by serine palmitoyltransferase (SPT) isoenzymes, which are

72 volved, we utilized two models: heterozygous serine palmitoyltransferase (SPT) subunit 2 (Sptlc2) gen

73 yridoxal-5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) which is a promising t

74 ndensation of alanine with palmitoyl-CoA via serine palmitoyltransferase (SPT), as indicated by incor

75 n SPTLC1 gene, encoding the Lcb1p subunit of serine palmitoyltransferase (SPT), cause hereditary sens

76 Serine palmitoyltransferase (SPT), composed of LCB1 and

77 s with either L-cycloserine, an inhibitor of serine palmitoyltransferase (SPT), or fumonisin B(1), an

78 ere labeled with [14C]serine, a substrate of serine palmitoyltransferase (SPT), the enzyme catalyzing

79 -chain base 1 (LCB1), one of two subunits of serine palmitoyltransferase (SPT), the enzyme catalyzing

80 not directly alter the in vitro activity of serine palmitoyltransferase (SPT), the enzyme responsibl

81 apid decrease in LCB levels, indicating that serine palmitoyltransferase (SPT), the first and rate-li

82 nesis, the ehv050 gene predicted to encode a serine palmitoyltransferase (SPT), the first and rate-li

83 ot associated with changes in mRNA levels of serine palmitoyltransferase (SPT), the rate-limiting enz

84 SPTLC1 encodes one subunit of serine palmitoyltransferase (SPT), the rate-limiting enz

85 osynthesis in Leishmania, we have focused on serine palmitoyltransferase (SPT), which catalyses the f

86 We therefore semiquantified mRNA of serine palmitoyltransferase (SPT), which catalyzes the f

87 proteins are claimed to be inhibitors of the serine palmitoyltransferase (SPT).

88 sphingolipids are 2-amino, 1,3-diols made by serine palmitoyltransferase (SPT).

89 ep in sphingolipid synthesis is catalyzed by serine palmitoyltransferase (SPT).

90 s encoding 2 of the 3 subunits of the enzyme serine palmitoyltransferase (SPT).

91 esults from mutations in the LCB1 subunit of serine palmitoyltransferase (SPT).

92 yl-CoA catalyzed by the PLP-dependent enzyme serine palmitoyltransferase (SPT).

93 novo synthesis of sphingolipids catalyzed by serine palmitoyltransferase (SPT).

94 and committed biosynthetic step catalyzed by serine palmitoyltransferase (SPT, EC 2.3.1.50).

95 ion is catalysed by the PLP-dependent enzyme serine palmitoyltransferase (SPT; EC 2.3.1.50), which is

96 of the Lcb1p subunit of yeast and mammalian serine palmitoyltransferases (SPT) were investigated.

97 rotoxic sphingolipids that are formed by the serine-palmitoyltransferase (SPT).

98 trypanosomatid protozoan Leishmania lacking serine palmitoyltransferase (spt2-) and SLs grow well, a

99 etion of the key de novo biosynthetic enzyme serine palmitoyltransferase subunit 2 (SPT2).

100 th myriocin (50 nm), a specific inhibitor of serine palmitoyltransferase (the first step in de novo s

101 n of Sptlc1 Sptlc1 is an obligate subunit of serine palmitoyltransferase, the enzyme responsible for

102 synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting

103 is, increase the activity and mRNA levels of serine palmitoyltransferase, the first committed step in

104 rtially reduced by myriocin, an inhibitor of serine palmitoyltransferase, the first committed step in

105 We therefore inactivated serine palmitoyltransferase, the first enzyme in the sph

106 treated with myriocin, a potent inhibitor of serine palmitoyltransferase, the rate-limiting enzyme in

107 investigation using a labeled substrate for serine palmitoyltransferase, the rate-limiting enzyme in

108 Nogo-B inhibits serine palmitoyltransferase, the rate-limiting enzyme of

109 synthase, but not by ISP-1, an inhibitor of serine palmitoyltransferase, the rate-limiting step in t

110 xysphingolipids are produced when the enzyme serine palmitoyltransferase uses l-alanine instead of l-

111 cted a deletion mutant of BF2461, a putative serine palmitoyltransferase whose yeast homolog catalyze

112 AT2 receptor activated serine palmitoyltransferase with a maximum time of 24 h

113 t lack Nogo-B, pharmacological inhibition of serine palmitoyltransferase with myriocin reinstates end