ライフサイエンスコーパス: serine protease

1 ic activity of this unique membrane-anchored serine protease.

2 subunit of ClpP, an evolutionarily conserved serine protease.

3 otease 4 (HAT-L4) is a type II transmembrane serine protease.

4 ivary gland with the primary proteases being serine proteases.

5 m because it is actually a poor inhibitor of serine proteases.

6 n, a protease homologous to other allosteric serine proteases.

7 haracterizing the P2' specificity of various serine proteases.

8 emase (KPC), with no inhibition of mammalian serine proteases.

9 from the destructive activity of neutrophil serine proteases.

10 ates the activity of endogenous T. forsythia serine proteases.

11 oteolytic cleavage at their amino termini by serine proteases.

12 lectin complement pathway through associated serine proteases.

13 rolonged liquefaction due to the activity of serine proteases.

14 lly important property specific to leukocyte serine proteases.

15 kDa precursor though proteolytic cleavage by serine proteases.

16 nown to mostly act on potassium channels and serine proteases.

17 for generating target-tailored inhibitors of serine proteases.

18 , which regulate the proteolytic activity of serine proteases.

19 ants specifically inhibit different types of serine proteases.

20 atC without affecting those of elastase-like serine proteases.

21 ing lectin, mannan-binding lectin-associated serine proteases 1 and 2, and C4d in the lectin pathway.

22 king mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1) and MASP-3 contain zymogenic

23 Mannan-binding lectin-associated serine protease 2 (MASP-2) has been described as the ess

24 ative C3 by mannan-binding lectin-associated serine protease-2 bound to LP-activation complexes captu

25 ctor enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in a

26 LP-specific mannan-binding lectin-associated serine protease-2.

27 amma catalytic subunit (POLG1), due to HTRA3 serine protease accumulation in CS, but not in UV(s)S or

28 ing lectin, together with mannose-associated serine proteases, activates the lectin pathway of the co

29 rotease-like beta-barrel uses the degenerate serine protease active site to recognize blades 2, 3, an

30 Alternaria-specific serine protease activity causes rapid IL-33 release, whi

31 les, and syncytium formation, and endogenous serine protease activity did not contribute greatly to i

32 Serine protease activity in Aedes aegypti saliva augment

33 cleavage site, in agreement with the tryptic serine protease activity of FVIIa.

34 er common aeroallergens, possessed intrinsic serine protease activity that elicited the rapid release

35 challenged with Alternaria (with or without serine protease activity), and inflammation, remodeling,

36 hat a major Af allergen, Asp f13, which is a serine protease, alkaline protease 1 (Alp 1), promotes a

37 its interaction with proteases [most likely serine proteases] along the secretory pathway).

38 is proteolytically-activated by bloodstream serine proteases also involved in the formation of blood

39 se myeloid cell proteases, but not digestive serine proteases, also bind DNA strongly and localize to

40 d a murine model of occupational asthma to a serine protease and characterized the main molecular pat

41 owing the death of an insect host, while two serine protease and two metalloprotease genes had their

42 Serine proteases and caspases were differentially involv

43 tions sensitized viruses to entry-activating serine proteases and conferred more rapid entry kinetics

44 Although the role of selected serine proteases and matrix metalloproteases in chemokin

45 substrate specificity of cysteine proteases, serine proteases and metalloproteinases.

46 n-proteolytic functions of membrane-anchored serine proteases and provides unexpected new data on the

47 ase family, whose members are tetradecameric serine proteases and serve as regulators of several cell

48 gulation factor VIIa (FVIIa), a trypsin-like serine protease, and membrane-bound tissue factor (TF) i

49 -1, ficolin-2, and ficolin-3, the associated serine proteases, and complement activation products to

50 scle progenitor cell niche, which identified serine proteases, and especially neutrophil elastase, as

51 cellent selectivity against a panel of seven serine proteases, and FVII-deficient prothrombin time EC

52 The backbone dynamics of the coagulation serine protease, apo-thrombin (S195M-thrombin), were com

53 marrow, biosynthesis of CTSC and neutrophil serine proteases appeared normal along with initial proc

54 Serine proteases are critical for epidermal barrier home

55 ure immune cells and suggest that neutrophil serine proteases are dispensable for human immunoprotect

56 Although serine proteases are found ubiquitously in both eukaryot

57 HtrA serine proteases are highly conserved and essential ATP-

58 The granzyme family serine proteases are key effector molecules expressed by

59 Neutrophil serine proteases are specific regulators of the immune r

60 The NSPs, but not related serine proteases, are specifically blocked by the extrac

61 The barley TPPE was identified as a serine protease (BAJ93208) and expressed in Escherichia

62 se (uPA, urinary plasminogen activator) is a serine protease belonging to the peptidase S1 family.

63 KT1) exhibited no inhibitory activity toward serine proteases but was a potent inhibitor of the major

64 onoclonal antibody targeting the CP-specific serine protease C1s, on CP activity induced by cold aggl

65 They have in common the production of a serine protease called Pic.

66 Minutes before egress, an essential parasite serine protease called SUB1 is discharged into the paras

67 me natural mutation in homologous pancreatic serine proteases can evolve a new physiological role or

68 rate-binding domain (N-betaGRP) and triggers serine protease cascades for the activation of prophenol

69 The serine protease cathepsin G recapitulated the effects of

70 proteolytic degradation by the endolysosomal serine protease cathepsin G.

71 D bronchoalveolar lavage fluid (BALF) due to serine protease cleavage, primarily by cathepsin G.

72 , and ELISA experiments revealed that myelin serine proteases cleave C3 to generate active fragments.

73 sin, a glycosylphosphatidylinositol-anchored serine protease, cleaved human PCI and mouse PCI (mPCI)

74 ctionated salivary gland extracts identified serine protease CLIPA3 as a putative cofactor, and short

75 Rhomboids are intramembrane serine proteases conserved in all kingdoms of life.

76 epsin C (CTSC), which processes a variety of serine proteases considered essential for antimicrobial

77 The chymotrypsin subfamily A of serine proteases consists primarily of eukaryotic protea

78 ein components of NETs, such as histones and serine proteases, contributes to coagulation and platele

79 osin, CAP, Profilin, Lipocalin, Trypsin-like serine protease, Cupin, BetV1, Expansin and Prolamin).

80 Despite serine protease-deficient immune cell populations, PLS p

81 We conclude that serine proteases derived from commensal bacteria can dir

82 present study demonstrates that two cellular serine proteases, DESC1 and MSPL, activate influenza vir

83 estigated neutrophil elastase (NE), a potent serine protease detected in vulnerable areas of human ca

84 tin plasma substitute or an inhibitor of the serine protease dipeptidyl peptidase 4.

85 ational analysis defines a chymotrypsin-like serine protease domain that mediates SltB autoproteolysi

86 Here, we show that the serine protease domains of C1r and C1s are located at th

87 A canonical model entails a C1r2s2 with its serine protease domains tightly packed together in the c

88 e to azurophil granules, including the major serine proteases, elastase, cathepsin G, and proteinase

89 Matriptase is a membrane-anchored serine protease encoded by suppression of tumorigenicity

90 Bacterial HtrAs are serine proteases engaged in extracytoplasmic protein qua

91 -specific serine protease (TSSP), a putative serine protease expressed by cortical thymic epithelial

92 Proteinase 3 (PR3) is a myeloid serine protease expressed in neutrophils, monocytes, and

93 The highly specific S1 serine protease factor D (FD) plays a central role in th

94 Tissue factor (TF) binds the serine protease factor VIIa (FVIIa) to form a proteolyti

95 blood coagulation as the pro-cofactor to the serine-protease Factor IXa (FIXa) in the FVIIIa-FIXa com

96 The S1 serine protease family is one of the largest and most bi

97 ptase, a member of the type II transmembrane serine protease family, in APP processing.

98 if, suggesting that PSDs belong to the D-H-S serine protease family.

99 to define the importance of these neutrophil serine proteases for antibacterial protection, granuloma

100 pecifically inhibits granzyme B, a cytotoxic serine protease found in the cytosolic granules of cytot

101 Together, these data indicate CTSC protects serine proteases from degradation in mature immune cells

102 h Temperature Requirement A (HtrA) family of serine proteases function in the periplasm to degrade da

103 Cysteine and serine proteases function via protease-activated and mas

104 e that LOXL2 is processed extracellularly by serine proteases, generating a 65-kDa form lacking the f

105 s also revealed, including the repression of serine-protease genes and the induction of protease-inhi

106 emonstration of the activation of a PAR by a serine protease GPI-linked to the cell surface.

107 8(+) T lymphocytes and can be cleaved by the serine protease granzyme B, one of the main components o

108 ies of regulatory B cells overexpressing the serine protease granzyme B.

109 Although trypsin-like serine proteases have flexible surface-exposed loops and

110 mice, we demonstrate that the membrane-bound serine protease hepsin is the enzyme responsible for the

111 Clip domain serine protease homologs (SPHs) are positive and negativ

112 these conditions the activity of neutrophil serine proteases, however, was not abolished in precurso

113 PARK13 is a neuroprotective serine protease; however, little is known about how PARK

114 nspeptidase (ggt), collagenase, the secreted serine protease htrA, and components of a type VI secret

115 Furthermore, this Alternaria serine protease-IL-33 axis triggered a rapid, augmented

116 llikrein-related peptidase 2 (KLK2) is a key serine protease in semen liquefaction and prostate cance

117 timulation and that this MBP cleaves L1 as a serine protease in the L1 extracellular domain at Arg(68

118 riptionally upregulated TFPI2, a Kunitz-type serine protease in the tissue factor pathway that inhibi

119 cmo and implicate neutrophils and neutrophil serine proteases in disease pathogenesis.

120 mational flexibility of uPA and trypsin-like serine proteases in general.

121 activates granule-associated proinflammatory serine proteases in hematopoietic precursor cells.

122 The serine proteases in saliva differ biochemically from try

123 gulate coagulation and inflammation, binding serine proteases in suicide-inhibitory complexes.

124 deficient mosquitoes showed a persistence of serine proteases in the midgut at 48 h after blood feedi

125 is driven by membrane-bound or extracellular serine proteases in the respiratory tract.

126 secretory vitamin K-dependent anticoagulant serine protease, inactivates factors Va/VIIIa.

127 d their potency against related trypsin-like serine proteases including trypsin itself could be furth

128 ansmembrane protein and inhibitor of several serine proteases, including hepatocyte growth factor act

129 ted via proteolytic cleavage by trypsin-like serine proteases, including kallikrein-5 (KLK5), or by t

130 nder conditions where CDCP1 was processed by serine proteases, indicating that FAK/PI3K/Akt pathway o

131 Killer lymphocyte granzyme (Gzm) serine proteases induce apoptosis of pathogen-infected c

132 ontaining protein-1 (CDCP1), by plasmin-like serine proteases induces outside-in signal transduction

133 A tradeoff between serine protease inhibition and growth as well as an indi

134 ta uncover a novel mechanism whereby loss of serine protease inhibition leads to lung lymphocyte accu

135 Many members of the serine protease inhibitor (serpin) family are activated

136 at secreted proteins Fibronectin 1 (FN1) and serine protease inhibitor (serpin) family E member 2 (SE

137 Deletion of the gene that encodes serine protease inhibitor 1 (SPI-1) of rabbitpox virus a

138 ajority of patients harbor a mutation in the serine protease inhibitor 1A (SERPINA1) gene leading to

139 The function of serine protease inhibitor 2A (Spi2A) was studied in mous

140 -c) and IgE-tp interact with polymers of the serine protease inhibitor alpha-1-antitrypsin (A1AT).

141 caused by the Z mutation (Glu342Lys) in the serine protease inhibitor alpha1-antitrypsin (alpha1AT),

142 i2A) was studied in mouse TH2 cells, and the serine protease inhibitor B3 (SERPINB3) and SERPINB4 gen

143 Protease nexin-1 (PN-1) is a serine protease inhibitor belonging to the serpin superf

144 A serine protease inhibitor blocked peptide and oligosacch

145 A serine protease inhibitor but not inhibitors of cysteine

146 eased the selectivity of ShPI-1, a versatile serine protease inhibitor from the sea anemone Stichodac

147 static associations between filaggrin (FLG), serine protease inhibitor Kazal-type 5 (SPINK5), and thy

148 These genes included that encoding the serine protease inhibitor Kunitz type 1 (Spint1), which

149 e inhibition of protease activity by using a serine protease inhibitor leupeptin or two structurally

150 eatments of C57/BL6J-betaENaC-Tg mice with a serine protease inhibitor ONO-3403, a derivative of camo

151 alpha1-Antitrypsin is a serine protease inhibitor produced in the liver that is

152 A serine protease inhibitor reduced saliva-mediated enhanc

153 , we observed a compensatory increase in the serine protease inhibitor Serpina3n in mouse models of M

154 at alpha-1 antitrypsin (AAT; Prolastin-C), a serine protease inhibitor used for the treatment of AAT

155 otease TMPRSS2, but Zhou et al. found that a serine protease inhibitor was more protective than a cat

156 ng pathway and alpha1-antitrypsin protein (a serine protease inhibitor) expression and downregulation

157 carbamoyl triazole TCMDC-134379 (1), a known serine protease inhibitor, as an excellent starting poin

158 The reversible serine protease inhibitor, benzamidine, inhibited VesB a

159 The serine protease inhibitor, elafin, is a critical compone

160 The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene ar

161 The variant is located in the gene encoding serine protease inhibitor, low levels of which are assoc

162 translational processing is inhibited by the serine protease inhibitor, phenylmethylsulfonyl fluoride

163 SerpinA3N, a serine protease inhibitor, was upregulated in the dorsal

164 SLPI is a secreted serine protease inhibitor, which is overexpressed in a n

165 c alpha-amylase inhibitor CM2 (Tri a 29.02), serine protease inhibitor-like allergen (Tri a 39), and

166 ioactive peptide from the alpha1-antitrypsin serine protease inhibitor.

167 Trypsin was strongly inhibited by serine protease inhibitor.

168 odulating, and tissue-protective circulating serine-protease inhibitor, with levels that increase dur

169 neutrophil apoptosis and efferocytosis in a serine-protease inhibitor-sensitive manner.

170 in inhibition, which is in contrast to other serine protease inhibitors (camostat mesylate and aproti

171 Serine protease inhibitors (SPIs) regulate protease-medi

172 f the MBP cleavage site within L1 as well as serine protease inhibitors and an L1 peptide containing

173 essing resistance to inhibition by canonical serine protease inhibitors and in cleaving these inhibit

174 ultiple human and murine cell lines and that serine protease inhibitors block Xps-mediated rounding a

175 modulators of tumorigenesis/metastasis from serine protease inhibitors but also strengthens the func

176 nents of the Toll and JAK/STAT pathways, and serine protease inhibitors in both social and solitary b

177 Naturally-occurring serine protease inhibitors of the Bowman-Birk family exe

178 Elevated levels of the serine protease inhibitors SERPINB3 and SERPINB4 are see

179 on in the absence of the cognate Kunitz-type serine protease inhibitors, hepatocyte growth factor act

180 Serine protease inhibitors, or serpins, are paradigms fo

181 cular weight proteins classically defined as serine protease inhibitors.

182 e a large and functionally diverse family of serine protease inhibitors.

183 design templates for engineering reversible serine protease inhibitors.

184 phil response was sensitive to inhibition by serine protease inhibitors.

185 ng new avenues for a systematic discovery of serine protease inhibitors.

186 t protein A1 (HtrA1) is a primarily secreted serine protease involved in a variety of cellular proces

187 Granzyme B (GzmB) is a serine protease involved in cell-mediated cytotoxicity i

188 pider Cupiennius salei The chymotrypsin-like serine protease is a 28-kDa heterodimer with optimum act

189 The elevated level of chymases and other serine proteases is closely related to inflammatory and

190 protease-like activity factor), a Chlamydia serine protease, is activated via proximity-induced inte

191 was dependent on coagulation factor XIIa, a serine protease known to induce cleavage of high-molecul

192 focuses on human KLK1 and KLK5, 2 of the 15 serine proteases known as the kallikrein-related peptida

193 accharide hydrolysis by 18B7, and a putative serine protease-like active site was identified in the l

194 The MSPbeta serine protease-like beta-barrel uses the degenerate ser

195 on catalyzed by an adjacent His residue in a serine protease-like mechanism.

196 Staphylococcus aureus-derived serine protease-like protein (Spl) D and other closely r

197 We identified staphylococcal serine protease-like proteins (Spls) as dominant IgG4-bi

198 Granzymes (Grs) are serine proteases mainly produced by cytotoxic lymphocyte

199 s implicated the involvement of two putative serine proteases, MamE and MamO, during the early stages

200 complexes with the lectin complement pathway serine proteases MASP-1 and MASP-2.

201 associated protein (MAP) and MBL associated serine protease (MASP) are scarcely investigated.

202 e serum of mannose-binding lectin-associated serine protease (MASP)-1/3(-/-) mice contains pro-FD and

203 recognition receptor complex, MBL-associated serine protease (MASP)-3/collectin-L1/K1 hetero-oligomer

204 d ficolins complexed with the MBL-associated serine proteases (MASP)-1 and MASP-2 cleave C4 and C2 to

205 with the MBL/ficolin/collectin-11-associated serine proteases (MASPs) in binding to MBL and the ficol

206 Membrane-anchored serine proteases (MASPs) play critical roles in the deve

207 the dynamic functional interplay between the serine protease matriptase and PDGF-D.

208 e autoactivation of the type 2 transmembrane serine protease matriptase and subsequent activation of

209 d that the membrane-anchored epithelial cell serine protease matriptase is critical in maintaining th

210 n IECs, and HAI-2 regulates the cell surface serine protease matriptase, a known modifier of intestin

211 he recently described hepcidin repressor-the serine protease matriptase-2 (encoded by Tmprss6)-is res

212 A powerful hepcidin inhibitor is the serine protease matriptase-2, encoded by TMPRSS6, whose

213 The membrane-anchored serine protease, matriptase, is consistently dysregulate

214 ed mannose-binding lectin-mannose-associated serine protease (MBL-MASP) functional activity in Crohn'

215 olymers in plasma protects the antibody from serine protease-mediated degradation, without affecting

216 tor HJV via inhibition of the membrane-bound serine protease MT-2.

217 lot, we discovered that granzyme A (GrmA), a serine protease not previously identified in human plate

218 viruses such as West Nile virus is the viral serine protease NS2B-NS3.

219 HCV serine protease NS3 represents an attractive drug target

220 Poorly controlled neutrophil serine protease (NSP) activity and complement activation

221 Neutrophil serine proteases (NSPs) are critical for the effective f

222 ne defenders against infection, express four serine proteases (NSPs) that play roles in the control o

223 Two similar neutrophil serine proteases (NSPs), cathepsin G and proteinase 3, c

224 cies, antimicrobial peptides, and neutrophil serine proteases (NSPs).

225 potently inhibits the activity of neutrophil serine proteases (NSPs): neutrophil elastase (NE), prote

226 monstrate that EatA, an immunogenic secreted serine protease of ETEC, contributes to virulence by deg

227 Neutrophil elastase (NE) is a serine protease of relevance in inflammatory diseases wh

228 selective towards thrombin than to the other serine proteases of the coagulation cascade.

229 s sufficient for the selective inhibition of serine proteases or whether other regions of a canonical

230 in hyperactivation, thereby leading to skin serine protease overexpression and disruption of skin ba

231 eas C. tropicalis hermaphrodites use a TRY-5 serine protease pathway.

232 (MAp)44, in regulating the composition of a serine protease-pattern recognition receptor complex, MB

233 e plasma by the liver, the proteinase K-like serine protease PCSK9 binds the low-density lipoprotein

234 od involves activation of plasminogen to the serine protease plasmin and facilitated cleavage of two

235 ssing FnBPB could be activated to the potent serine protease plasmin by staphylokinase and tissue pla

236 Plasminogen is the precursor of the serine protease plasmin, a central enzyme of the fibrino

237 Endogenous inhibitors of human neutrophil serine proteases preferentially inhibit HNE and to a les

238 ma kallikrein-kinin system (KKS) consists of serine proteases, prekallikrein (pKal) and factor XII (F

239 d prostate cancer, and proteinase 3 (PR3), a serine protease present in inflammatory neutrophils and

240 The membrane-anchored serine protease prostasin (CAP1/PRSS8) is part of a cell

241 glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin, which is a co-factor for matr

242 The membrane-anchored serine proteases prostasin (PRSS8) and matriptase (ST14)

243 nstead, caspase-3 activation was mediated by serine protease proteinase 3 (PR3), which is present in

244 G/IKr channel was selectively cleaved by the serine protease, proteinase K (PK).

245 Neutrophil serine proteases, proteinase 3 (PR3) and human neutrophi

246 Fibroblast activation protein (FAP) is a serine protease related to dipeptidyl peptidase IV (DPPI

247 We further show that trypsin, a serine protease released by pre-implantation embryos, el

248 Granzymes are serine proteases released by cytotoxic lymphocytes to in

249 resulting in neutrophils lacking elastase, a serine protease required for NET production.

250 Inhibition of serine proteases restored physiological POLG1 levels in

251 ds on IL-21-mediated death and activation of serine protease(s).

252 Subtilisin-like serine proteases (SBTs) are extracellular proteases that

253 t addition of subtilisin (50 nm to 2 mum), a serine protease secreted by the non-pathogenic bacterium

254 We found that serine proteases secreted by activated mast cells (chyma

255 ing genetic analysis, we determined that the serine proteases StmPr1 and StmPr2, which were confirmed

256 Here, we report that a third serine protease, StmPr3, is also secreted in an Xps-depe

257 ontrolling maturation of the subtilisin-like serine protease SUB1 in exoneme secretory vesicles.

258 Because usage of the serine protease subtilisin in the detergent industry res

259 Serine proteases such as trypsin and mast cell tryptase

260 Neutrophil serine proteases, such as cathepsin G (CG) and neutrophi

261 of oxidants and granule proteins, including serine proteases, support the microbial killing in phago

262 her the zymogen (prekallikrein) or any other serine protease tested.

263 Corin is a serine protease that activates the natriuretic peptides,

264 e is an epithelia-specific membrane-anchored serine protease that has received considerable attention

265 t, Mycoplasma Ig protease (MIP), is a 97-kDa serine protease that is able to cleave off the VH domain

266 atriptase-2 (MT2) is a type II transmembrane serine protease that is predominantly expressed in hepat

267 VesB, a newly identified serine protease that is secreted by the type II secretio

268 Testisin is a unique trypsin-like serine protease that is tethered to the extracellular me

269 hat the L. pneumophila effector Lpg1137 is a serine protease that targets the mitochondria and their

270 ent protease A (HtrA) represents a family of serine proteases that play important roles in microbial

271 Their secretory products contain serine proteases that suppress excitability via activati

272 e of activated platelets are degraded by the serine protease thrombin and release the urokinase plasm

273 Activation of platelets by the serine protease thrombin is a critical event in haemosta

274 ity with respect to the related trypsin-like serine proteases (thrombin, tPA, FXa, plasmin, plasma ka

275 led receptors that are activated by multiple serine proteases through specific N-terminal proteolytic

276 at our approach may also be applied to other serine proteases, thus opening new avenues for a systema

277 his study, we show how the membrane-anchored serine protease TMPRSS2 stimulates a proteolytic cascade

278 than on the cell surface acid pH-independent serine protease TMPRSS2, but Zhou et al. found that a se

279 We recently identified the StmPr1 and StmPr2 serine proteases to be the substrates of the Xps type II

280 cused on the potential for membrane-anchored serine proteases to regulate PAR activation.

281 on but conferred potent activity against the serine protease trypsin (Ki = 1.5 nm).

282 The serine protease trypsin I can activate ENaC in vitro but

283 ee ligands with different affinities for the serine protease trypsin.

284 optimize microviridin variants targeting the serine proteases trypsin and subtilisin.

285 Thymus-specific serine protease (TSSP) is expressed by thymic epithelial

286 vious studies suggested that thymus-specific serine protease (TSSP), a putative serine protease expre

287 S13 is a member of the type II transmembrane serine protease (TTSP) family.

288 The type II transmembrane serine protease (TTSP) TMPRSS2 cleaves and activates the

289 n protein (FAP) is a cell surface-associated serine protease up-regulated in the lungs of patients wi

290 The autoactivation of an initiating serine protease upon binding of pattern recognition prot

291 The trypsin-like serine protease, urokinase-type plasminogen activator (u

292 subsequently, upon nuclease activity, active serine proteases, which proteolytically degrade NET-asso

293 ying special attention to neutrophil-derived serine proteases, which subsequently induce inflammation

294 Activation Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in ac

295 ein-related peptidases (KLKs) are a group of serine proteases widely expressed in various tissues and

296 Factor D is a trypsin-like serine protease with a narrow specificity for arginine i

297 tivated protein C (APC) is a multifunctional serine protease with anticoagulant, cytoprotective, and

298 nan-binding protein 2) is a Ca(2+)-dependent serine protease with putative roles in blood coagulation

299 Prostasin, a membrane-anchored serine protease with trypsin-like substrate specificity

300 tion of proteolytic activity of plasmin-like serine proteases with aprotinin prevented beta1 integrin