ライフサイエンスコーパス: serine proteinase

1 that NS4A forms an integral part of the NS3 serine proteinase.

2 is a G protein-coupled receptor activated by serine proteinases.

3 a major physiological inhibitor of multiple serine proteinases.

4 n-coupled receptor activated by trypsin-like serine proteinases.

5 appeared to be an inhibitor of trypsin-like serine proteinases.

6 x that is the basis for serpin inhibition of serine proteinases.

7 rg, since P1 Arg also inhibits several other serine proteinases.

8 mited to the inhibition of chymotrypsin-like serine proteinases.

9 d mechanism, canonical protein inhibitors of serine proteinases.

10 eutrophil elastase, but not a range of other serine proteinases.

11 trypsin, thrombin, and several fibrinolytic serine proteinases.

12 s show that SCCA2 inhibits chymotrypsin-like serine proteinases.

13 physiologically important chymotrypsin-like serine proteinases.

14 bitor family, interacting with six different serine proteinases.

15 in common with that of the other families of serine proteinases.

16 mplementary to the active site cleft of many serine proteinases.

17 rophosphate, indicated that they were active serine proteinases.

18 activation of plasminogen and other complex serine proteinases.

19 t both papain-like cysteine and trypsin-like serine proteinases.

20 was an inhibitor of the S1 clan SA family of serine proteinases.

21 Enamel matrix serine proteinase 1 (EMSP1) is a proteolytic enzyme that

22 has been variously designated enamel matrix serine proteinase 1 (EMSP1), prostase, KLK4, and KLK-L1.

23 We designate this protein enamel matrix serine proteinase 1 or EMSP1.

24 78% identity with the porcine enamel matrix serine proteinase 1, an enzyme involved in enamel matrix

25 l as induce collagenase expression make this serine proteinase a key initiator and inducer of cartila

26 Serine proteinases activate the G protein-coupled recept

27 Of the serine proteinase activities detected, an enzyme of appr

28 MBP possesses endogenous serine proteinase activity and can undergo autocatalytic

29 Serine proteinase activity in liquid cultures was reduce

30 Each of the three serine proteinase activity-based probe-labelled enzymes

31 Transmural inflammation was associated with serine proteinase and MMP activity in overlying epitheli

32 eptides, phospholipase A(2), C-type lectins, serine proteinases and l-amino oxidases.

33 There is also a search for inhibitors of serine proteinases and matrix metalloproteinases to prev

34 ry activity toward PAPP-A2, but not selected serine proteinases and metalloproteinases.

35 ade activates latent MMP-1 and involves both serine proteinases and MMPs, particularly stromelysin 1

36 ns are structural modules found in arthropod serine proteinases and some proteolytically inactive hom

37 te the response, a cascade of mostly unknown serine proteinases, and phenoloxidase.

38 roteins (disintegrins, phospholipase A(2)'s, serine proteinases, and snake venom metalloproteases).

39 required for effective peptide inhibitors of serine proteinases, and will assist in the further desig

40 dopeptidases (thiorphan and phosphoramidon), serine proteinases (aprotinin), cysteine proteinases (le

41 This suggests that serine proteinases are involved in the activation cascad

42 Tests included cysteine proteinases, serine proteinases, aspartic proteinases, metallo protei

43 Standard mechanism protein inhibitors of serine proteinases bind as substrates and are cleaved by

44 ts that similar active site modifications of serine proteinases block the ability of serpins to form

45 specific labeling of the catalytic sites of serine proteinases but have not been widely used as prob

46 vity against any of the more common types of serine proteinases but is a potent cross-class inhibitor

47 ealed that SCCA2 inhibited chymotrypsin-like serine proteinases, but not papain-like cysteine protein

48 tive inhibitor of plasmin than several other serine proteinases, but the molecular basis for this spe

49 Inhibition of the serine proteinase by Streptomyces subtilisin inhibitor (

50 by thrombin or other heparin binding plasma serine proteinases by a similar mechanism.

51 ortance of this residue in the inhibition of serine proteinases by KD1.

52 Herpesviruses encode an essential serine proteinase called assemblin that is responsible f

53 A serine proteinase cascade in insect hemolymph mediates p

54 molymph phenoloxidase, a pathway involving a serine proteinase cascade.

55 and Toll pathway initiation) are mediated by serine proteinase cascades and regulated by serpins in h

56 in vertebrates and invertebrates to regulate serine proteinase cascades that mediate the host defense

57 K; and SCCA2 inhibits the chymotrypsin-like serine proteinases, catG and human mast cell chymase.

58 tored in azurophil granules along with other serine proteinases (cathepsin G, proteinase 3 and azuroc

59 in antichymotrypsin (ACT, I) reacts with the serine proteinase chymotrypsin (Chtr, E) to form an E*I*

60 alysis of the interactions between the human serine proteinases, chymotrypsin, cathepsin G, and elast

61 Several serine proteinases clearly influence vascular remodellin

62 we show that both human and mouse neutrophil serine proteinases cleave flagellin from Pseudomonas aer

63 er, our data suggest that neutrophil-derived serine proteinases cleave SP-D at sites of inflammation

64 in G, a member of the chymotrypsin family of serine proteinases, consistent with serpin activity.

65 PAP belongs to a family of arthropod serine proteinases containing a carboxyl-terminal protei

66 tion by elastolytic enzymes belonging to the serine proteinase, cysteine proteinase, and metallo-prot

67 d VLA-5 expression, and did so by inducing a serine proteinase-dependent proteolysis of this beta(1)

68 of West Nile virus (WNV) with an N-terminal serine proteinase domain and an RNA triphosphatase, an N

69 o terminus, a linker region, and a catalytic serine proteinase domain at the carboxyl terminus.

70 Molecular modeling of the serine proteinase domain of macrophage stimulating prote

71 n, whereas the 30-kDa light chain contains a serine proteinase domain, which was labeled by [(3)H]dii

72 respectively) and a lesser reduction of the serine proteinase, elastase (46%).

73 A serine proteinase encoded in the N-terminal 181 residues

74 sion in macrophages that increased following serine proteinase exposure.

75 minogen activator (tPA) is a highly specific serine proteinase expressed in the CNS during events tha

76 riety of molecules, including the neutrophil serine proteinases, extracellularly.

77 findings represent a novel mechanism whereby serine proteinases facilitate epithelial cell survival a

78 rombinase, an enzyme complex composed of the serine proteinase factor Xa and a cofactor protein, fact

79 complex (Xase) composed of the trypsin-like serine proteinase, factor VIIa, bound to tissue factor (

80 novel two-component viral proteinase of the serine proteinase family, NS2B/NS3(Pro), in the endoplas

81 e secretion of matrix metalloproteinases and serine proteinases for the extracellular degradation of

82 Tissue-type plasminogen activator (tPA) is a serine proteinase found in the intravascular space and t

83 As an example, we found that the serine proteinase from Staphylococcus aureus (SSP) had v

84 We have identified three different serine proteinases from the German cockroach that may, v

85 haracterization of TgSUB2, a subtilisin-like serine proteinase, from T. gondii.

86 Serine proteinase gene expression in femoral head cartil

87 mbled CrmA in that a stable complex with the serine proteinase granzyme B was detectable after sodium

88 ith selectivity against structurally related serine proteinases (>1000 times).

89 es of many protein inhibitors complexed with serine proteinases have revealed that the amide NH group

90 itional MC/B mediators or receptors, such as serine proteinases, histamine 4-receptor, 5-lipoxygenase

91 o prevented processing of pro-phenoloxidase, serine proteinase homolog (SPH) 1, and SPH2.

92 The serine proteinase homologs associate with a bacteria-bin

93 However, in the presence of two serine proteinase homologs, active phenoloxidase was gen

94 Furthermore, immulectin-2, serine proteinase homologs, proPO, PO, attacin-2, and a

95 the four kringle domains (K1 to K4) and the serine proteinase homology domain (SP) of HGF/SF individ

96 -strands b-c and d-a, whereas the C-terminal serine proteinase homology domain binds the opposite "b"

97 forms of the previously identified hemolymph serine proteinase, HP21.

98 tested whether neutrophil azurophil granule serine proteinases, human neutrophil elastase (NE), cath

99 We have identified more than 20 serine proteinases in hemolymph of the tobacco hornworm,

100 in regulating both exogenous and endogenous serine proteinases in hemolymph.

101 a central coordinator for activation of many serine proteinases in immune/inflammatory cells.

102 Serine proteinases in insect plasma have been implicated

103 evolutionary pathway of the dual clip-domain serine proteinases in M. sexta.

104 Increasing evidence implicates serine proteinases in pathologic tissue turnover.

105 Increasing evidence implicates serine proteinases in the proteolytic cascades leading t

106 inalis is a potent protein inhibitor of many serine proteinases including chymotrypsin and subtilisin

107 iants were active as inhibitors of microbial serine proteinases, including subtilisin Carlsberg, prot

108 oforms of AbetaPP that contain a Kunitz-type serine proteinase inhibitor (KPI) domain are expressed i

109 therton disease (SPINK5) encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed i

110 ane and thus was named myoepithelium-derived serine proteinase inhibitor (MEPI).

111 Serine proteinase inhibitor (PI)-9 with a reactive cente

112 d efficacy of a novel nontoxic viral-derived serine proteinase inhibitor (SERP-1) in preventing posta

113 en (PSA) and its SDS-stable complex with the serine proteinase inhibitor (serpin) alpha(1)-antichymot

114 Kallistatin is a unique serine proteinase inhibitor (serpin) and a heparin-bindi

115 rch showed that GCET1 has a highly conserved serine proteinase inhibitor (SERPIN) domain and is locat

116 ion of proteinase activity by members of the serine proteinase inhibitor (serpin) family is a critica

117 Members of the serine proteinase inhibitor (serpin) family play importa

118 C1 inhibitor (C1INH), a member of the serine proteinase inhibitor (serpin) family, is an inhib

119 a(1)-antichymotrypsin (ACT), a member of the serine proteinase inhibitor (serpin) family.

120 ibitory members of the high-molecular-weight serine proteinase inhibitor (serpin) family.

121 We report here that the serine proteinase inhibitor (serpin) PI-9 accounts for t

122 The activity of the serine proteinase inhibitor (serpin) plasminogen activat

123 ation levels of kallistatin, a member of the serine proteinase inhibitor (SERPIN) superfamily with an

124 metazoan member of the high molecular weight serine proteinase inhibitor (serpin) superfamily, we ini

125 Kallistatin is a serine proteinase inhibitor (serpin) that specifically i

126 Headpin is a novel serine proteinase inhibitor (serpin) with constitutive m

127 An amyloid-associated serine proteinase inhibitor (serpin), alpha(1)-antichymo

128 Kallistatin, a serine proteinase inhibitor (serpin), is expressed in th

129 A cDNA clone for the serine proteinase inhibitor (serpin), neuroserpin, was i

130 Kallistatin is a heparin-binding serine proteinase inhibitor (serpin), which specifically

131 The serine proteinase inhibitor (SPI-3) gene expression is t

132 nd hence named trespin (TGF-beta-repressible serine proteinase inhibitor (trespin).

133 nhibitor 9 (PI-9), or the murine orthologue, serine proteinase inhibitor 6 (SPI-6), confers resistanc

134 r 9 (PI-9/serpinB9) and the murine ortholog, serine proteinase inhibitor 6 (SPI-6/serpinb9) are membe

135 have demonstrated that administration of the serine proteinase inhibitor alpha1-antitrypsin (AAT) pre

136 trix of type I collagen and the ability of a serine proteinase inhibitor and all-trans-retinoic acid

137 uman LEKTI gene encodes a putative 15-domain serine proteinase inhibitor and has been linked to the i

138 es in, and the functional activation of, the serine proteinase inhibitor antithrombin.

139 icating that the RRHR motif is not a general serine proteinase inhibitor binding site.

140 ed peptidylarginine deiminases, kallikreins, serine proteinase inhibitor family members, Kruppel-like

141 adly expressed multifunctional member of the serine proteinase inhibitor family.

142 Inter-alpha-inhibitor (IalphaI) is a serine proteinase inhibitor found in high concentrations

143 A Beta vulgaris serine proteinase inhibitor gene (BvSTI) was fused to th

144 The abundant serine proteinase inhibitor heparin cofactor II (HCII) h

145 vator inhibitor type 2 (PAI-2) is an unusual serine proteinase inhibitor in that it is largely retain

146 The sugar beet serine proteinase inhibitor may be more effective for in

147 sue-type plasminogen activator (tPA) and the serine proteinase inhibitor neuroserpin are both express

148 -Antitrypsin is the archetypal member of the serine proteinase inhibitor or serpin superfamily.

149 ent study was to investigate the role of the serine proteinase inhibitor plasminogen activator inhibi

150 ve "canonical conformation" typical of small serine proteinase inhibitor proteins, which explains why

151 le the interaction with other members of the serine proteinase inhibitor superfamily, protein nexin 1

152 or pathway inhibitor (TFPI) is a Kunitz-type serine proteinase inhibitor that down-regulates tissue f

153 ima phloem serpin-1 (CmPS-1), a novel 42-kDa serine proteinase inhibitor that is developmentally regu

154 (TFPI-2), which encodes for a broad-spectrum serine proteinase inhibitor that negatively regulates th

155 We report here that the serine proteinase inhibitor tissue factor pathway inhibi

156 Kallistatin is a serine proteinase inhibitor which binds to tissue kallik

157 e inhibitor of the Wnt pathway, SERPINA3K, a serine proteinase inhibitor with anti-inflammatory and a

158 igment epithelium-derived factor (PEDF) is a serine proteinase inhibitor with antiangiogenic activiti

159 Members of the serpin (serine proteinase inhibitor) superfamily play a central

160 ocyte proteinase inhibitor (SLPI) is a major serine proteinase inhibitor, a potent antibiotic, and th

161 SERPINA3K is a serine proteinase inhibitor, and its levels were decreas

162 ve shown that retinal levels of SERPINA3K, a serine proteinase inhibitor, are decreased in an animal

163 Serine proteinase inhibitor, clade E, member 2 (SERPINE2

164 Labeling of these polypeptides with a serine proteinase inhibitor, diisopropyl fluorophosphate

165 nes including DEFB4 (defensin B4), SERPINB3 (serine proteinase inhibitor, member 3), STAT1 (signal tr

166 alpha(1)-Antichymotrypsin is a member of the serine proteinase inhibitor, or serpin, family that typi

167 Addition of the broad-spectrum serine proteinase inhibitor, p-aminobenzamidine, or the

168 show that sodium dodecyl sulfate induces the serine proteinase inhibitor, plasminogen activator inhib

169 The serine proteinase inhibitor, plasminogen activator inhib

170 s, whereas levels of mRNA encoding a related serine proteinase inhibitor, proteinase inhibitor 8, wer

171 op-active site interaction characteristic of serine proteinase inhibitor-serine proteinase pairs.

172 is a secreted myxoma virus anti-inflammatory serine proteinase inhibitor.

173 ium-derived factor (PEDF), a multifunctional serine proteinase inhibitor.

174 In addition, CPAMD8 has a Kazal-type serine proteinase inhibitor/follistatin-like domain at t

175 ecular mechanism of action of this family of serine proteinase inhibitors (I77).

176 The high-molecular-weight serine proteinase inhibitors (serpins) are restricted, g

177 Serine proteinase inhibitors (serpins) form enzymaticall

178 Serine proteinase inhibitors (serpins) play a vital regu

179 High-molecular-weight serine proteinase inhibitors (serpins) regulate a divers

180 a distinct substrate specificity, targeting serine proteinase inhibitors (serpins), which regulate c

181 kin-18-binding protein, semaphorin, and five serine proteinase inhibitors (serpins).

182 protein polymerization in the superfamily of serine proteinase inhibitors (serpins).

183 genes that encode two high-molecular-weight serine proteinase inhibitors (serpins).

184 b9) are members of a family of intracellular serine proteinase inhibitors (serpins).

185 rypsin inhibitor-like (TIL) domains of small serine proteinase inhibitors (smapins).

186 Pretreatment of CM with serine proteinase inhibitors 4-(2-aminoethyl)benzenesulf

187 ents but was inhibited by specific synthetic serine proteinase inhibitors and the aminopeptidase inhi

188 Proteinaceous serine proteinase inhibitors are widespread throughout t

189 ) is distinct from those of other classes of serine proteinase inhibitors except in the inhibitor loo

190 The serpin-type serine proteinase inhibitors have a flexible reactive si

191 Serine proteinase inhibitors have been reported to block

192 The serpin family of serine proteinase inhibitors is a mechanistically unique

193 Many serine proteinase inhibitors of the serpin superfamily h

194 Serpins are a superfamily of serine proteinase inhibitors which function to regulate

195 The serpins (SERine Proteinase INhibitors) are a family of proteins w

196 ration/spermiogenesis (metalloproteinase and serine proteinase inhibitors), and steroidogenesis (CYP2

197 Serpins, serine proteinase inhibitors, form enzymatically inactiv

198 Serine proteinase inhibitors, including plasminogen acti

199 de precursors is believed to be regulated by serine proteinase inhibitors, or serpins.

200 a-lytic proteinase by two standard mechanism serine proteinase inhibitors, turkey ovomucoid third dom

201 05 that members of the serpin superfamily of serine proteinase inhibitors, which are best recognized

202 PI) is a member of the serpin superfamily of serine proteinase inhibitors, which function in maintain

203 age was inhibited with synthetic and natural serine proteinase inhibitors.

204 upplemented with any one or all of the above serine proteinase inhibitors.

205 n-reactive loop of the Bowman-Birk family of serine proteinase inhibitors.

206 high molecular weight serpin superfamily of serine proteinase inhibitors.

207 P-mediated Abeta degradation is inhibited by serine proteinase inhibitors.

208 r bracovirus encodes the Egf family of small serine proteinase inhibitors.

209 rd mechanism canonical protein inhibitors of serine proteinases, inserts into the S1 primary specific

210 SDS-resistant ACT complex, suggesting an ACT-serine proteinase interaction.

211 a manner similar to that observed for serpin-serine proteinase interactions.

212 similar to that observed for typical serpin-serine proteinase interactions.

213 einase inhibitor that regulates a variety of serine proteinases involved in coagulation and fibrinoly

214 demonstrate that a catalytically active NS3 serine proteinase is essential for pestivirus replicatio

215 mily of protein inhibitors with six selected serine proteinases is described.

216 in-cleaving enzyme (APCE), a prolyl-specific serine proteinase, is essentially identical to membrane-

217 n-coupled receptor activated by trypsin-like serine proteinases, is expressed on intestinal epithelia

218 , a G-protein-coupled Receptor, activated by serine proteinases, is reported to have both protective

219 ously reported that expression of a panel of serine proteinase kallikreins (KLK 5, 7, 8, and 10) is c

220 Serine proteinase levels increased in colitic tissue, wi

221 own for its inhibition of the action of many serine proteinases like trypsin and chymotrypsin.

222 was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in

223 Most importantly, we show that serine proteinase MMP-12 regulation in macrophages occur

224 d to form SDS-stable complexes with inactive serine proteinases modified at the catalytic serine with

225 Serine proteinases modulate the interaction of tumor cel

226 tructures confirms the "universality" of the serine proteinase motif and reveals a difference at resi

227 bond in the complexes of OMTKY3 with several serine proteinases, native chemical ligation was used fo

228 of P. aeruginosa flagellin by the neutrophil serine proteinases neutrophil elastase and cathepsin G r

229 FNf also induced monocytes to release a serine proteinase, nominally identified as proteinase-3,

230 d the hypothesis that the neutrophil-derived serine proteinases (NSPs): neutrophil elastase, proteina

231 Because the serine proteinase of the natural anticoagulant pathway,

232 development of inhibitors of human and viral serine proteinases of clinical relevance.

233 the reagents can be employed for labeling of serine proteinases of diverse substrate specificity.

234 ence showed significant identity with fungal serine proteinases of the subtilisin family, indicating

235 lt of nucleophilic attack by Ser(195) of the serine proteinase on the P1 residue within the RCL of th

236 The specific action of serine proteinases on protein substrates is a hallmark o

237 operative aprotinin, an inhibitor of several serine proteinases, or placebo.

238 elevant results from studies of other serpin-serine proteinase pairs.

239 haracteristic of serine proteinase inhibitor-serine proteinase pairs.

240 A serine proteinase pathway in insect hemolymph leads to p

241 l point in cartilage collagen breakdown, and serine proteinase pathways activate MMPs.

242 We examined the role of the serine proteinase plasmin in regulating fibroblast-media

243 The serine proteinases plasmin and thrombin convert proenzym

244 rLEKTI inhibited the serine proteinases plasmin, subtilisin A, cathepsin G, h

245 onfirm the identity of, and to quantify, the serine proteinase, plasmin.

246 plasminogen, by the proteolytic action of a serine proteinase, plasminogen activator (PA).

247 Although the VSMC-derived serine proteinases, plasminogen activator and plasminoge

248 suited to bind high concentrations of active serine proteinases released from degranulating PMN.

249 d the secretion of the metalloproteinase and serine proteinases, respectively.

250 n of the NS3 protein, is a chymotrypsin-like serine proteinase responsible for processing of the nons

251 The prohormone convertases (PCs) are serine proteinases responsible for the processing of sec

252 teraction of this class of inhibitors with a serine proteinase results in the formation of a stable a

253 in, SCCA2 (an inhibitor of chymotrypsin-like serine proteinases), reversed their target specificities

254 Chymases are chymotrypsin-like serine proteinases secreted by mast cells.

255 istic of the prolyl oligopeptidase family of serine proteinases (Ser-Asp-His).

256 or (BPTI), a well-known inhibitor of various serine proteinase (SerP) enzymes.

257 Standard mechanism protein inhibitors of serine proteinases share a common mechanism of interacti

258 eveloped for immobilizing thrombin and other serine proteinases specifically (>/=92%) through their a

259 The A. bisporus serine proteinase SPR1 is induced by humic acids and is

260 The propeptides of subtilisin-like serine proteinases (subtilases, SBTs) serve dual functio

261 Transforming growth factor-beta (TGF-beta), serine proteinases such as trypsin, and proteinase-activ

262 plasminogen activator inhibitor-1 (PAI-1) to serine proteinases, such as tissue-type plasminogen acti

263 contained increased levels of several active serine proteinases, suggesting that MP24.15 activates on

264 lin is susceptible to cleavage by neutrophil serine proteinases suggests a novel role for these enzym

265 Members of the Flaviviridae encode a serine proteinase termed NS3 that is responsible for pro

266 Although 12 of the 13 serine proteinases tested in our laboratory for inhibiti

267 d two complementary approaches to identify a serine proteinase that activates proPAP3.

268 from the tobacco hornworm, Manduca sexta, a serine proteinase that activates proPO, and have cloned

269 f the tobacco hornworm, Manduca sexta, a new serine proteinase that cleaves prophenoloxidase.

270 Tissue-type plasminogen activator (tPA) is a serine proteinase that is found in the intravascular spa

271 autoantigen in Wegener's granulomatosis is a serine proteinase that is normally stored intracellularl

272 kinase-type plasminogen activator (uPA) is a serine proteinase that upon binding to the urokinase-typ

273 kinase-type plasminogen activator (uPA) is a serine proteinase that, upon binding to its receptor (uP

274 a-defensins are converted to active forms by serine proteinases that co-localize in azurophil granule

275 rypsin-like elastases (CELAs) are pancreatic serine proteinases that digest dietary proteins.

276 terocyclic mechanism-based inhibitors of the serine proteinases that embody in their structure a nove

277 ite loop (RSL) to bait and trap their target serine proteinases, the mechanism by which they inactiva

278 sumed to be a physiological inhibitor of the serine proteinase thrombin.

279 The serine proteinase tissue kallikrein has been previously

280 The serine proteinase tissue-type plasminogen activator (tPA

281 Type II transmembrane serine proteinase (TMPRSS6) antagonizes hepcidin inducti

282 demonstrated that the type II transmembrane serine proteinase (TTSP) matriptase acts as a novel init

283 family member, interacting with the same six serine proteinases under the same conditions.

284 ester analog interacting with a panel of six serine proteinases, we have determined that the P1 NH-->

285 Serine proteinases were detected by casein substrate zym

286 zymography, one metalloproteinase and three serine proteinases were detected in the conditioned medi

287 A panel of mammalian serine proteinases were screened and Bm-SPN-2 protein wa

288 are directed against proteinase-3 (PR-3), a serine proteinase which is located in azurophilic granul

289 of stable mechanism-based inhibitors of the serine proteinases which can be readily synthesized usin

290 expression of matrix metalloproteinases and serine proteinases, while others induce apoptosis throug

291 Neutrophil elastase (NE) is a potent serine proteinase whose expression is limited to a narro

292 This proteinase was a serine proteinase, whose identity is not known.

293 A serine proteinase with a broad band around 180 kDa was f

294 ten-containing medium from which an alkaline serine proteinase with a molecular mass of 28.7 kDa was

295 rophil elastase (NE) is a neutrophil-derived serine proteinase with broad substrate specificity.

296 Granzyme B, a serine proteinase with substrate specificity similar to

297 f these variants with six well characterized serine proteinases with hydrophobic S1, cavities.

298 Seven of the variants inhibited mammalian serine proteinases, with association rate constants comp

299 y inducing non-proteolytic activation of the serine proteinase zymogen, plasminogen (Pg), in the SK.P

300 tic activation mechanism of trypsinogen-like serine proteinase zymogens, insertion of the first 2 res