ライフサイエンスコーパス: serine racemase

1 te the conversion of l-serine to d-serine by serine racemase.

2 porin 4, actin, and glutamine synthetase and serine racemase.

3 nd is created by conversion from L-serine by serine racemase.

4 zation of L- to D-serine by a membrane-bound serine racemase.

5 Serine racemase activity was also detected in membrane p

6 lacking the predicted transmembrane domain, serine racemase activity was detected in the cytoplasm.

7 n was overexpressed in Escherichia coli, and serine racemase activity was detected in the membrane bu

8 The serine racemase activity was partially (64%) inhibited b

9 the astrocytic d-serine-synthesizing enzyme serine racemase after CCI injury improved synaptic plast

10 We now report cloning and expression of serine racemase, an enzyme catalyzing the formation of D

11 -8)), whereas a variant in SRR (that encodes serine racemase and is associated with schizophrenia) co

12 oxyaspartate follow this trend, with both WT serine racemase and the S84N mutant being competitively

13 urial components of rat spinal nerve contain serine racemase, and western blot analysis detected the

14 tions of D-serine and it biosynthetic enzyme serine racemase approximate the distribution of NMDA rec

15 5.1.1.13, and 41% identical to the mammalian serine racemase, EC 5.1.1.18.

16 and fibroblasts, and both cell types showed serine racemase expression by immunofluorescence and Wes

17 d modulate neuronal activity in the CNS, but serine racemase expression in the PNS has not been repor

18 Purified serine racemase has a molecular mass of 37 kDa and requi

19 two genetically modified mouse strains: the serine racemase homozygous knockout (SR-/-) and glycine

20 fication of slow binding inhibitors of human serine racemase (hSR).

21 Occurrence of serine racemase in the brain demonstrates the conservati

22 tected d-serine and its synthesizing enzyme, serine racemase, in the retinas of several vertebrate sp

23 Serine racemase is a protein representing an additional

24 enzymatically depleting D-serine or by using serine racemase knock-out (SR-KO) mice, confirming its s

25 We utilized two genetic mouse models, the serine racemase knockout (SR-/-) and the glycine transpo

26 Serine racemase knockout (SR-/-) mice, which lack D-seri

27 In this study, we utilize a serine racemase knockout (SRKO) mouse to explore the con

28 O-Lys(114) hydrogen-bonding network in human serine racemase lowers the pKa of the Ser(84)re-face bas

29 These expression patterns of serine racemase may indicate roles for D-serine in perip

30 olymerase chain reaction, further confirming serine racemase mRNA in Schwann cells and fibroblasts.

31 ptor (NMDAR) hypofunction, and thus used the serine racemase-null mutant mouse (SR(-/-)), which has l

32 e enzyme responsible for D-serine synthesis (serine racemase) or blocking NMDA receptor glycine coago

33 Serine racemase (SR) generates D-serine, a coagonist wit

34 Serine racemase (SR) is the enzyme that converts L-serin

35 D-Serine, formed from L-serine by serine racemase (SR), is a physiologic coagonist at NMDA

36 ow that the biosynthetic enzyme of d-serine, serine racemase (SR), is expressed almost entirely by ne

37 Serine racemase (SR), localized to astrocytic glia that

38 DISC1 binds to and stabilizes serine racemase (SR), the enzyme that generates D-serine

39 ale genome-wide association study identified serine racemase (SR), the enzyme that produces the NMDAR

40 We show that serine racemase (SR), which generates D-serine from L-se

41 hesized from L-serine by the neuronal enzyme serine racemase (SR).

42 duced by glycine, a competitive inhibitor of serine racemase (SR).

43 ession quantitative trait locus of the human serine racemase (SRR) gene, was associated with fear-rel

44 NMDARs generated from l-serine by the enzyme serine racemase (Srr).

45 Serine racemase, the D-serine-synthesizing enzyme, is ex

46 There is currently great interest in human serine racemase, the enzyme responsible for producing th

47 Whereas l-serine is not transported, serine racemase, the synthesizing enzyme for d-serine, i

48 D-Serine is formed by serine racemase, which directly converts L-serine to D-s