ライフサイエンスコーパス: serine-threonine kinase

1 menon depends on the RTKs activating the AKT serine/threonine kinase.

2 its deactivating phosphorylation by Mst1, a serine/threonine kinase.

3 t plant phytochromes are autophosphorylating serine/threonine kinases.

4 sensus amino acid sequences of human protein-serine/threonine kinases.

5 ivation segment conformation of tyrosine and serine/threonine kinases.

6 Fs) and the protein kinase D (PKD) family of serine/threonine kinases.

7 phosphorylation at Ser133 by various protein serine/threonine kinases.

8 T and reduced levels of receptor-interacting serine-threonine kinase 1 and CRC cell necroptosis.

9 ed with lower levels of receptor-interacting serine-threonine kinase 1 and shorter survival times of

10 target Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) expression, and miR-155-5p in

11 T reduced levels of the receptor-interacting serine-threonine kinase 1, a mediator of necroptosis, in

12 nase (MAPK)-related kinase, MAPK interacting serine/threonine kinase 1 (MKNK1), in viral entry.

13 allosteric inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK-1).

14 opJ required caspase-8, receptor-interacting serine/threonine kinase 1 (RIPK1), and Fas-associated de

15 mitogen-activated protein kinase interacting serine/threonine kinase 1 activation significantly suppr

16 ate-activated protein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as

17 d protein kinase) and MNK1 (MAPK-interacting serine/threonine kinase 1) signaling.

18 stream TBK1 (TANK-Binding Kinase 1)-AKT (AKT serine/threonine kinase 1)-IRF3 (interferon regulatory f

19 ryonic fibroblasts from receptor interacting serine/threonine kinase 1-knockout mice or their WT litt

20 ymphocyte-oriented kinase (LOK), also called serine threonine kinase 10 (STK10), is synthesized mainl

21 nase B1 (LKB1) tumor suppressor gene, Stk11 (serine threonine kinase 11), in the fetal Mullerian duct

22 The tumor suppressor serine/threonine kinase 11 (LKB1/STK11) is one of the mo

23 The tumor suppressor serine/threonine kinase 11 (STK11 or LKB1) is mutated in

24 Serine/threonine kinase 11 (STK11, also known as LKB1) f

25 Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor

26 the conserved interactions included those of serine/threonine kinase 16 (STK16), hippocalcin-like 1 (

27 domain containing (Nod)/receptor-interacting serine-threonine kinase 2 (Ripk2) signals in DCs.

28 act is mediated through receptor-interacting serine/threonine kinase 2, and the transcriptional regul

29 t critically depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kina

30 em to mice deficient in receptor-interacting serine-threonine kinase 3 (RIPK3).

31 vitro and in vivo by microtubule-associated serine/threonine kinase 3 (MAST3 kinase), an enzyme of p

32 We also validated that serine/threonine kinase 35 is a target of miR-377 using

33 lakophilin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiat

34 Among these genes, we identified serine/threonine kinase 40 (STK40), a negative regulator

35 We identified GCK-1, a conserved serine/threonine kinase [8], as a putative novel anillin

36 e D2 (PKD2) is a member of the PKD family of serine/threonine kinases, a subfamily of the CAMK super-

37 teracting protein kinase (HIPK) 2, a nuclear serine/threonine kinase, activates CREB through Ser271 p

38 ual-specificity kinase and both tyrosine and serine/threonine kinase activities are required for its

39 of GO terms protein kinase activity/protein serine threonine kinase activity, response to heat and r

40 It is an adaptor protein with serine/threonine kinase activity and has been shown to p

41 Pak2 serine/threonine kinase activity is required for stromal

42 The p.E80K mutation abolished serine/threonine kinase activity, resulting in altered I

43 ant as the mutation blocks both tyrosine and serine/threonine kinase activity, whereas Y243 and Y250

44 athways, including the regulation of protein serine/threonine kinase activity.

45 caffolding protein essential for positioning serine-threonine kinases adjacent to target phosphorylat

46 (3)K (phosphatidylinositol-3-OH kinase), the serine-threonine kinase Akt and the metabolic checkpoint

47 The serine-threonine kinase Akt is a key regulator of cell p

48 Activation of the serine-threonine kinase Akt promotes the survival and pr

49 The serine-threonine kinase AKT regulates proliferation and

50 lic checkpoint kinase complex mTORC2 and the serine-threonine kinase Akt, and loss of this activity r

51 gering depends on the activation of PI3K and serine-threonine kinase Akt, and protein synthesis relie

52 al and activation-induced phosphorylation of serine-threonine kinases Akt and mechanistic target of r

53 aluate mice lacking specific isoforms of the serine/threonine kinase AKT and bone marrow chimeras, we

54 AKT3, a member of the serine/threonine kinase AKT family, is involved in a var

55 Here we demonstrate that the serine/threonine kinase Akt has a critical role in regul

56 Pharmacologic inhibition of the serine/threonine kinase Akt has recently been shown to p

57 Although the role of the key serine/threonine kinase Akt in promoting CNS myelination

58 Here we examined the role of the serine/threonine kinase Akt in the generation of protect

59 The serine/threonine kinase AKT is a key mediator of cancer

60 The serine/threonine kinase Akt, which regulates HTT functio

61 risphosphate (PIP3), and the activity of the serine/threonine kinase AKT.

62 Akt is a family of three serine-threonine kinases, Akt1, Akt2, and Akt3.

63 mutated kinases are tyrosine kinases, though serine/threonine kinases also play key roles in some mal

64 Here we explore how key serine-threonine kinases and their substrates mediate T

65 LKB1 is a serine/threonine kinase and a commonly mutated gene in l

66 expression of general control nonrepressed 2 serine/threonine kinase and increased expression of mamm

67 Expression of general control nonrepressed 2 serine/threonine kinase and mammalian target of rapamyci

68 w will focus on coordination of postsynaptic serine/threonine kinase and phosphatase signaling by sca

69 The liver kinase B1 (LKB1) is a serine/threonine kinase and tumor suppressor that couple

70 RATIONALE: LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regu

71 induce expression of the oncogenic PIM1/2/3 serine/threonine kinases, and as PIMs modulate transcrip

72 n complex comprises APC, Axin, beta-catenin, serine/threonine kinases, and other proteins.

73 We show that the apically localized serine/threonine kinase aPKC directly phosphorylates an

74 bers of the protein kinase D (PKD) family of serine/threonine kinases are major targets for tumor-pro

75 fied serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase, as an essential node downstream

76 e identify CDK5, a predominantly cytoplasmic serine/threonine kinase, as an important regulator of DL

77 homologous to penicillin-binding protein and serine/threonine kinase associated (PASTA) domains, and

78 extracellular penicillin-binding-protein and serine/threonine kinase-associated (PASTA) domains which

79 of bacterial Penicillin-binding-protein And Serine/Threonine kinase-Associated (PASTA) kinases is of

80 monovalent cations and contains a functional serine/threonine kinase at its carboxyl terminus.

81 , FBXO31 is phosphorylated by the DNA damage serine/threonine kinase ATM, resulting in increased leve

82 ession led to reduced phosphorylation of the serine/threonine kinases ATM and Chk2 and of histone H2A

83 ic aberrations in FA-complex genes or in ATM serine/threonine kinase (ATM) exhibited significantly lo

84 recruitment of ataxia-telangiectasia mutated serine/threonine kinase (ATM) to the damaged site, where

85 expression of Gene 33 triggers DDR in an ATM serine/threonine kinase (ATM)-dependent fashion and thro

86 dividual components is phosphorylated by the serine-threonine kinase, ATM.

87 characterized the activation process of the serine/threonine kinase Aurora-A by phosphorylation and

88 Classically defined as a serine/threonine kinase, BIK1 is shown here to possess t

89 Mutations in the serine/threonine kinase BRAF are found in more than 60%

90 tral element within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in develop

91 in which a constitutively active form of the serine/threonine kinase BRAF was expressed in neurons ga

92 The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequent

93 The protein kinase B-Raf proto-oncogene, serine/threonine kinase (BRAF) is an oncogenic driver an

94 te instability, and the B-Raf protooncogene, serine/threonine kinase (BRAF), mutation) in the Nurses'

95 es such as PLK1 (Polo-like kinase 1), C-MYC, serine-threonine kinase BUB1B and regulates their expres

96 eurin and protein phosphatase-1, as well the serine/threonine kinases CaMKII and PKA.

97 Here we report that the conserved serine/threonine kinase, casein kinase II (CK2), promote

98 es containing both an ion channel pore and a serine/threonine kinase (chanzyme).

99 ke of the LNAA leucine for activation of the serine-threonine kinase complex mTORC1 and for expressio

100 inspection of their primary sequences, many serine-threonine kinases display a significant preferenc

101 A key serine/threonine kinase distantly related to the MAPK fa

102 n the late 1970s, is composed of at least 10 serine/threonine kinases, divided into three groups base

103 he pro-apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2; rs7594645-G) with bet

104 structural and signaling motifs, including 2 serine/threonine kinase domains, SK1 and SK2, present at

105 ere, we show that the kinase activity of the serine/threonine kinase encoded by TAOK2 is required for

106 The Escherichia coli eukaryote-like serine/threonine kinase, encoded by yeaG, is expressed i

107 studies, we find that phosphorylation of the serine/threonine kinase ERK (pERK) preferentially occurs

108 s originally reported as an inhibitor of the serine/threonine kinase ERK, a kinase that is distinct i

109 is now well appreciated that eukaryotic-like serine/threonine kinases (eSTKs) control essential proce

110 , a member of the protein kinase C family of serine/threonine-kinases, expression varies during human

111 on affecting NEK2, a member of the NIMA-like serine-threonine kinase family, in a patient with congen

112 CD transactivation of microtubule associated serine/threonine kinase family member 4 (MAST4).

113 The Fas-activated serine/threonine kinase (FASTK) family of proteins has r

114 TOR, an atypical serine/threonine kinase, forms two distinct complexes TO

115 Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and imp

116 alian target of rapamycin complex 1 (mTORC1) serine/threonine kinase from the lysosomal membrane.

117 ed protein kinase (AMPK), a highly conserved serine/threonine kinase, functions as a critical metabol

118 ian target of rapamycin (mTOR), an essential serine/threonine kinase, functions in biochemically dist

119 Somatic inactivation of the serine/threonine kinase gene STK11/LKB1/PAR-4 occurs in

120 tic and in vitro functional studies, a novel serine/threonine kinase gene, unc-51-like kinase 4 (ULK4

121 We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3

122 Biallelic inactivation of LKB1, a serine/threonine kinase, has been detected in 30% of lun

123 lates p53Ser46(P) by binding and stabilizing serine-threonine kinase HIPK2.

124 The serine/threonine kinase HIPK2 functions as a regulator o

125 One of these binding partners is the serine/threonine kinase Hrr25p.

126 Serine/threonine kinase IKBKE is a newly identified onco

127 The serine/threonine kinase IL-1R-associated kinase (IRAK)4

128 nase 3 (GSK-3, isoforms alpha and beta) is a serine-threonine kinase implicated in cellular processes

129 hat Minibrain (Mnb; also known as Dyrk1A), a serine/threonine kinase implicated in autism spectrum di

130 kinase kinase kinase kinase 4 (MAP4K4) is a serine/threonine kinase implicated in the regulation of

131 Protein kinase C (PKC) is a family of serine/threonine kinases implicated in a variety of phys

132 The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis

133 ase D (PKD) is a family of stress-responsive serine/threonine kinases implicated in the regulation of

134 one of the highly overexpressed genes of the serine/threonine kinase in CTCL.

135 Checkpoint kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA

136 ULK1/Atg1 is the only serine/threonine kinase in the core autophagy pathway an

137 kinome, we identified PIM1, a non-essential serine-threonine kinase, in a synthetic lethal interacti

138 ene, which encodes a type I activin receptor serine/threonine kinase, in 21% of DIPG samples.

139 is also a target of casein kinase 2 (CK2), a serine/threonine kinase, in proliferating myoblasts.

140 f rapamycin (TOR), an evolutionary conserved serine/threonine kinase, in the plant defense response.

141 Enzastaurin is an oral serine/threonine kinase inhibitor antitumor agent.

142 e kinase-3 (GSK3) are ubiquitously expressed serine-threonine kinases involved in a plethora of funct

143 mTOR is a serine/threonine kinase involved in a variety of cellula

144 phosphorylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentia

145 mprise an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis

146 e previously determined that a transmembrane serine/threonine kinase (IreK) and its cognate phosphata

147 The Aurora family of serine/threonine kinases is essential for mitosis.

148 ound that casein kinase 1 alpha (Csnk1a1), a serine-threonine kinase, is essential for AML cell survi

149 que member of the polo-like kinase family of serine-threonine kinases, is a master regulator of centr

150 1alpha (CK1alpha), a ubiquitously expressed serine/threonine kinase, is a key negative regulator of

151 mTOR, a serine/threonine kinase, is a master regulator of cellul

152 Liver kinase B1 (LKB1), a serine/threonine kinase, is a tumor suppressor and metab

153 Protein kinase C (PKC) theta, a serine/threonine kinase, is involved in TH2 cell activat

154 Akt, a serine/threonine kinase, is known to increase cell survi

155 HPK1, a member of mammalian Ste20-like serine/threonine kinases, is lost in >95% pancreatic can

156 urs via the phosphorylation by WNKs of other serine-threonine kinases known as SPAK-OSR1.

157 n of apoptosis signal-regulating kinase 1, a serine/threonine kinase, leads to improvement in inflamm

158 atwall kinase (called microtubule-associated serine/threonine kinase like [Mastl] in mammals) is esse

159 In a previous study, we identified TRIB1, a serine-threonine kinase-like molecule, as a biomarker of

160 We found that the serine/threonine kinase LKB1 and one of its substrates,

161 The serine/threonine kinase LKB1 has been identified as a po

162 The serine/threonine kinase LKB1 is a tumor suppressor whose

163 We demonstrate that the serine/threonine kinase LKB1 regulates MCU expression, m

164 the activity of the evolutionarily conserved serine/threonine kinase mammalian target of rapamycin (m

165 The serine/threonine kinase mammalian/mechanistic target of

166 mitogen-activated protein kinase-interacting serine-threonine kinases MAP kinase-interacting kinase 1

167 In recent years, the serine/threonine kinase mechanistic target of rapamycin

168 ere, we show that the MAP kinase interacting serine/threonine kinase (MNK)-eukaryotic translation ini

169 licated the mechanistic target of rapamycin (serine/threonine kinase; MTOR) pathway in the regulation

170 we identify protein kinase C (PKC) gamma, a serine/threonine kinase mutated in the neurodegenerative

171 In this study, we show that the serine/threonine kinase Ndr2 controls integrin-dependent

172 PRL activates the serine/threonine kinase NEK3, which was reported to enha

173 the screen, we identified a mitotic-related serine/threonine kinase, NEK6, as a mediator of androgen

174 of noncanonical NF-kappaB signaling via the serine/threonine kinase NIK (NF-kappaB-inducing kinase)

175 s abrogated by the liver kinase B1 (LKB1), a serine-threonine kinase of the calcium calmodulin family

176 t was located within STK32C, which encodes a serine/threonine kinase, of unknown function.

177 Some of these binding partners include the serine/threonine kinases, p21-activated kinase 1 (PAK1),

178 ere, we determined that d-flow activated the serine/threonine kinase p90RSK, which subsequently phosp

179 Ovaries in flies mutant for the serine/threonine kinase Pak exhibit a novel phenotype, i

180 Serine/threonine kinase PAK1 is activated by estrogen an

181 The p21-activated serine-threonine kinase (PAK1) regulates cell motility a

182 We determine that the serine/threonine kinase Par1b defines lumen position in

183 The protein kinase D family of serine/threonine kinases, particularly PKD1, has been im

184 The hypoxia-inducible, pro-oncogenic, serine-threonine kinase PIM1 (Proviral Integration site

185 PKD is a family of three serine/threonine kinases (PKD-1, -2, and -3) involved in

186 We found that RhoA activated the serine-threonine kinases PKN1 and PKN2 that bind and pho

187 In eukaryotes, serine/threonine kinases play a central role in antivira

188 Dysregulated oncogenic serine/threonine kinases play a pathological role in div

189 IRAK4, a serine/threonine kinase, plays a key role in both inflam

190 The Akt protein, a serine/threonine kinase, plays important roles in cell s

191 The polo family serine threonine kinase Plk4 has been proposed as a ther

192 GSK3 is a pleiotropic serine-threonine kinase point of convergence of numerous

193 We have identified the serine/threonine kinase Polo-like kinase 1 (PLK1) as a h

194 ivotal role for the cell division regulating serine/threonine kinase polo-like kinase 2 (PLK2).

195 d to interphase of the cell cycle by NEK7, a serine-threonine kinase previously linked to mitosis.

196 rotein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase previously shown to mediate poly

197 le for RIPK1 and RIPK3, a pair of homologous serine/threonine kinases previously implicated in the re

198 s phosphorylated by the MST1 (Hippo homolog) serine-threonine kinase, previously shown to be an AR re

199 y the mechanistic target of rapamycin (mTOR) serine/threonine kinase promotes myelination, but factor

200 A bioinformatic screen identified the serine-threonine kinase protein kinase D2 (PRKD2) as a p

201 w that the expression of the Golgi-localized serine-threonine kinase protein kinase D3 (PKD3) is elev

202 urn gradually suppressed RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK signaling through the

203 eptor-like kinase 1 (ALK1) is an endothelial serine-threonine kinase receptor for bone morphogenetic

204 Here, we show that serine-threonine kinase receptor-associated protein (STR

205 system, and both protein-tyrosine kinase and serine/threonine kinase receptor transactivation concomi

206 In contrast, serine/threonine kinase receptor transactivation is medi

207 Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wi

208 also mediate signals via transactivation of serine/threonine kinase receptors, most notably the tran

209 The RAF serine/threonine kinases regulate cell growth through th

210 glycogen synthase kinase-3 (GSK-3) family of serine/threonine kinases regulates several of these path

211 teracting protein kinase (Hipk), a conserved serine-threonine kinase, regulates numerous factors duri

212 at the cell polarity protein Par-1 (MARK), a serine-threonine kinase, regulates the localization and

213 , Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mit

214 genetic approach identified PKCtheta as the serine/threonine kinase responsible for alphaPIX serine

215 of cAMP-dependent protein kinase (PKA) is a serine/threonine kinase responsible for most of the effe

216 cal and siRNA-mediated inhibition of various serine/threonine kinases revealed ERK1/2 as a positive r

217 randed RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mi

218 The serine/threonine kinase RIPK1 is recruited to TNFR1 to m

219 Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Pr

220 membrane translocation and activation of the serine/threonine kinase ROCK1, a downstream target of th

221 how mTORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at ge

222 Wingless downregulates the activity of the serine/threonine kinase Shaggy (Sgg; also known as GSK-3

223 ion of fibrosis-relevant tyrosine kinase and serine/threonine kinase signaling pathways.

224 followed by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding p

225 followed by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding p

226 Silencing the serine/threonine kinase STK11 (also known as LKB1) in HT

227 two markers, one (rs10937625) located in the serine/threonine kinase STK32B and one (rs17590046) in t

228 YAP1 is under the control of a serine-threonine kinase, STK4.

229 nce also interferes with the activity of the serine/threonine kinase StkP, the central regulator of p

230 In plants and algae, the serine/threonine kinase STN7/STT7, orthologous protein k

231 Trans-membrane signaling involving a serine/threonine kinase (Stt7 in Chlamydomonas reinhardt

232 lular-transcription factor NF-kappaB via the serine/threonine kinase TAK1.

233 s for identifying degrader hits based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) and

234 We generated Taok3(-/-) mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic

235 e found that shRNA-mediated knockdown of the serine/threonine kinases TESK1 or LIMK2 promoted mesench

236 Mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that coordinates nutrient and gr

237 HipA of Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth and in

238 how that cyclin-dependent kinase 5 (Cdk5), a serine-threonine kinase that is highly active in postmit

239 Cdc7 is a serine-threonine kinase that phosphorylates components o

240 Unc-51-like kinase 1 (ULK1) is a conserved serine-threonine kinase that plays a central role in the

241 tol-requiring enzyme 1alpha (IRE1alpha) is a serine-threonine kinase that plays crucial roles in acti

242 Tumor progression locus 2 (Tpl2) is a serine-threonine kinase that regulates Th1 differentiati

243 Integrin-linked kinase (ILK) is a serine-threonine kinase that transduces extracellular ma

244 Serine-threonine kinases that activate NKCC2 have been i

245 tein kinase catalytic subunit (DNA-PKcs) are serine-threonine kinases that orchestrate the cellular r

246 The Rho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key downstream ef

247 mTOR is a serine/threonine kinase that acts as a central cellular

248 LKB1 is a multi-functional serine/threonine kinase that associates with actin at th

249 MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 f

250 ic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular fu

251 an target of rapamycin (mTOR) is a conserved serine/threonine kinase that forms two complexes, mTORC1

252 acting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in development an

253 Integrin-linked kinase (ILK) is a serine/threonine kinase that has been linked to human an

254 LKB1 encodes a serine/threonine kinase that has critical roles in cell

255 inase beta1 (LKB1, also known as STK11) is a serine/threonine kinase that has multiple cellular funct

256 GSK-3 is a serine/threonine kinase that has numerous substrates.

257 Receptor-interacting protein (RIP1) is a serine/threonine kinase that integrates inflammatory and

258 Specifically, we show that NLK, a serine/threonine kinase that interacts with ATXN1, modul

259 AMPK is a serine/threonine kinase that is activated by upstream ki

260 or disposal and the activation of Akt/PKB, a serine/threonine kinase that is obligate for insulin-sti

261 es a phosphatidylinositol 3-kinase-dependent serine/threonine kinase that is rapidly induced in respo

262 ase (eEF2K), a Ca(2)(+)/calmodulin dependent serine/threonine kinase that phosphorylates eEF2 and reg

263 p21-activated kinase-1 (Pak1) is a serine/threonine kinase that plays a key role in mediati

264 CK2 is a highly conserved and pleiotropic serine/threonine kinase that promotes many prosurvival a

265 Here we identify Stk2, a staphylococcal serine/threonine kinase that provides efficient immunity

266 Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a diverse array o

267 n kinase A (PKA) is a ubiquitously expressed serine/threonine kinase that regulates a variety of cell

268 Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates processes includi

269 activated kinases (PAKs) are a family of six serine/threonine kinases that act as key effectors of RH

270 ases (ROCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associat

271 The p21-activated kinases (Paks) are serine/threonine kinases that are major effectors of the

272 LegK1-4 proteins are eukaryotic-like serine/threonine kinases that are translocated by the Do

273 e (smMLCK) is a member of a diverse group of serine/threonine kinases that feature cytoskeletal assoc

274 NEK family kinases are serine/threonine kinases that have been functionally imp

275 L-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in ini

276 e-rich repeats, a transmembrane domain and a serine/threonine kinase, the rice (Oryza sativa) protein

277 ippo signaling pathway consists of conserved serine/threonine kinases to maintain optimal organ sizes

278 The translocation of Akt, a serine/threonine kinase, to the plasma membrane is a cri

279 The serine-threonine kinase TOR, the Target of Rapamycin, is

280 The testis-specific serine/threonine kinases (TSSKs) comprise a family of po

281 The serine/threonine kinase tumor progression locus 2 (Tpl2,

282 brosis through binding and activation of the serine/threonine kinase type II TGF-beta receptor (Tbeta

283 protein of the MTOR complex 1 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncog

284 TSSK1, -2, -4, and -6 (small serine/threonine kinase) were all found to associate wit

285 ptor type II (TbetaRII) and type I (TbetaRI) serine/threonine kinases, whereby Smad2 and Smad3 are ph

286 endent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the ne

287 protein CASK (a calcium/calmodulin-activated serine/threonine kinase), which binds to neurexins, and

288 TSPYL2 interacts with calmodulin-associated serine/threonine kinase, which is implicated in X-linked

289 PAK4 is a member of the PAK family of serine/threonine kinases, which act as effectors for sev

290 nt Kinase II (CaMKII) is a calcium-regulated serine threonine kinase whose functions include regulati

291 AMPK is a conserved serine/threonine kinase whose activity maintains cellula

292 tivated protein kinase (AMPK) is a conserved serine/threonine kinase with a critical function in the

293 identified MAST205 (a microtubule-associated serine/threonine kinase with a molecular mass of 205 kDa

294 rotein-coupled receptor kinase 2 (GRK2) is a serine/threonine kinase with an important function in th

295 or-interacting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necro

296 gh targeting oncogenic mutations in the BRAF serine/threonine kinase with small molecule inhibitors c

297 of the polo-like kinases (PLK), a family of serine/threonine kinases with well-known roles in cell c

298 Two of these genes encode the serine-threonine kinases WNK1 and WNK4.

299 Serine threonine kinase WNK4 (With No K = lysine member

300 One such protein, the serine/threonine kinase YopO (YpkA in Yersinia pestis),