ライフサイエンスコーパス: serotonergic neuron

1 1B heteroreceptors (receptors located on non-serotonergic neurons).

2 stry for tryptophan hydroxylase (a marker of serotonergic neurones).

3 h is the only Pcdhalpha isoform expressed in serotonergic neurons.

4 it reduces serotonin synthesis and firing of serotonergic neurons.

5 ) from the synaptic cleft after release from serotonergic neurons.

6 s that distinguish physiological subtypes of serotonergic neurons.

7 ound within brainstem areas known to contain serotonergic neurons.

8 ionary changes in the number and presence of serotonergic neurons.

9 behavior of immunohistochemically identified serotonergic neurons.

10 can substitute for the role of OCR-2 only in serotonergic neurons.

11 in 2 has selective actions on a subset of DR serotonergic neurons.

12 crossed with Tph2-Cre mice expressing Cre in serotonergic neurons.

13 a branch specific for the differentiation of serotonergic neurons.

14 of both channel genes affects other types of serotonergic neurons.

15 thelium, but is excluded from the nucleus of serotonergic neurons.

16 ior segment of the eye, and dopaminergic and serotonergic neurons.

17 ncy by controlling the rate of firing of the serotonergic neurons.

18 rom a developmental abnormality of medullary serotonergic neurons.

19 y activate dorsal raphe but not median raphe serotonergic neurons.

20 dence for potential direct actions of CRF on serotonergic neurons.

21 heartless is expressed specifically in serotonergic neurons.

22 atric disorders attributed to dysfunction of serotonergic neurons.

23 re alpha4-containing nAChRs are expressed by serotonergic neurons.

24 ectopic dorsal clusters of dopaminergic and serotonergic neurons.

25 ption factors to successfully generate human serotonergic neurons.

26 partial agonist displayed an effect only in serotonergic neurons.

27 rfascicular dorsal raphe, both areas rich in serotonergic neurons.

28 rgic, glutamatergic and, at lower frequency, serotonergic neurons.

29 se line to permit translational profiling of serotonergic neurons.

30 pletion and could not be restored by grafted serotonergic neurons.

31 ion of neurons in the adult brain, including serotonergic neurons.

32 (SERT, SLC6A4) to the synaptic terminals of serotonergic neurons.

33 c excision of p38alpha MAPK selectively from serotonergic neurons.

34 e largely not direct postsynaptic targets of serotonergic neurons.

35 ned place aversion to pain via inhibition of serotonergic neurons.

36 relatively homogenous DA population with few serotonergic neurons.

37 ague-Dawley rat to measure the activation of serotonergic neurons: (1) determination ex vivo of accum

38 are involved in controlling the activity of serotonergic neurons, 5-HT1A knockout mice had normal le

39 In conclusion, RO serotonergic neurons activate breathing frequency and am

40 licited by direct optogenetic stimulation of serotonergic neurons activates HSF1 and upregulates mole

41 During noxious stimuli, serotonergic neurons activation was due to a suppression

42 We found three main features of serotonergic neuron activity: (1) a large fraction of se

43 of Caenorhabditis elegans tph-1 in a pair of serotonergic neurons ADF during an aversive experience w

44 In mice harboring Di-expressing serotonergic neurons, administration of the ligand cloza

45 Consequently, excitation of serotonergic neurons alone can suppress protein misfoldi

46 c excision of KOR from dopaminergic, but not serotonergic neurons, also blocked KOR-mediated disrupti

47 nduced tagged-5-HT(1A)R endocytosis in raphe serotonergic neurons and a portion of hippocampal neuron

48 xpressed in muscles that are postsynaptic to serotonergic neurons and are known to be required for th

49 mer's disease subjects showed markedly fewer serotonergic neurons and associated higher levels of neu

50 (3)ARs are coexpressed with SERT in midbrain serotonergic neurons and form a physical complex in A(3)

51 TN neurons are also activated by inputs from serotonergic neurons and hypothalamic neurons.

52 drives the differentiation of beta-cells and serotonergic neurons and imparts the shared ability to p

53 ysiological changes were driven by a loss of serotonergic neurons and reduced output as measured by h

54 oping mouse and chick neural tube, hindbrain serotonergic neurons and spinal glutamatergic V3 interne

55 ed facial motoneurons, catecholaminergic and serotonergic neurons and the ventral respiratory column

56 ntimate coordination between the activity of serotonergic neurons and their target cortical circuits.

57 ure, HA-5-HT(1B) receptors were expressed in serotonergic neurons and translocated to the forebrain.

58 Bulbospinal serotonergic neurons and two physiological classes of bu

59 3, possibly through their trophic effects on serotonergic neurons and/or motoneurons, may underlie se

60 xpressed in the ADF neurons but not in other serotonergic neurons, and act cell-autonomously to regul

61 nd eg: robo2/3 mutants lose Eg expression in serotonergic neurons, and robo2 and eg interact genetica

62 n the neocortex, modulatory dopaminergic and serotonergic neurons, and the striatal neurons that form

63 ockout mice (Lmx1bf/f/p), which lack central serotonergic neurons, and we report that opioid analgesi

64 s loss is specific to the HSN class as other serotonergic neurons appear to differentiate normally in

65 in states, and many of the known features of serotonergic neurons appear to match this function.

66 ventral midbrain where a relevant number of serotonergic neurons are generated.

67 Contacts of Kenyon cells with serotonergic neurons are heterogeneously distributed ove

68 Serotonergic neurons are ideally situated for sensing ar

69 gorously activated by CO(2) in vivo, whereas serotonergic neurons are not.

70 In Aplysia, serotonergic neurons are widely activated during sensiti

71 ha4-containing nAChRs, possibly expressed by serotonergic neurons, are involved in nicotinic-mediated

72 Our study revealed the cilium structure of serotonergic neurons as a trigger of regulated serotonin

73 ole in assessing the contribution of RTN and serotonergic neurons as well as glial cells to respirati

74 of putative chemosensitive glutamatergic and serotonergic neurons as well as marked astrocytic gliosi

75 The heterogeneity of serotonergic neuron behavior can also help to explain th

76 ute to the respiratory stimulation caused by serotonergic neurons, but serotonin seems without effect

77 erminal neuronal identity in four classes of serotonergic neurons, but that the development of the AD

78 %) incorporated into approximately 50% of RO serotonergic neurons by injecting AAV2 DIO ChR2-mCherry

79 promoter-driven excision of p38alpha MAPK in serotonergic neurons (by Slc6a4-Cre or ePet1-Cre) or ast

80 so demonstrate that changes in the number of serotonergic neurons change larval swimming behavior.

81 Thus, although serotonergic neurons comprise a minority of RVM neurons

82 ifferentiated in vitro into dopaminergic and serotonergic neurons, contractile cardiomyocyte-like cel

83 nucleus tractus solitarius (NTS) and caudal serotonergic neurons control the excitability of PBN neu

84 The spontaneous activity of serotonergic neurons correlates with dwelling behavior,

85 These effects of caudal MR serotonergic neurons could be at a chemoreceptor site, e

86 Paradoxically, the spiking activity of the serotonergic neurons decreased to a single burst at the

87 Serotonergic neurons derived from former rhombomere 2 dr

88 and roundabout3 (robo2/3) are necessary for serotonergic neuron differentiation and function indepen

89 f Robo2/3 is part of a signal that regulates serotonergic neuron differentiation and is transduced by

90 ctions, little is known about the process of serotonergic neuron differentiation.

91 In addition, a subset of serotonergic neurons displays a further increase in acti

92 tocadherin alpha (Pcdhalpha) gene cluster in serotonergic neurons disrupts local axonal tiling and gl

93 The early specification of dopaminergic and serotonergic neurons during vertebrate CNS development r

94 g the serotonin (5-HT) content of identified serotonergic neurons embedded in a simple motor circuit.

95 We recently showed that acute inhibition of serotonergic neurons en masse blunts the CO(2) chemorefl

96 populations, we applied RC::PFtox to silence serotonergic neurons, en masse or a subset defined combi

97 Here we report that a serotonergic neuron evokes two distinct neuromodulatory

98 As a group, presumed serotonergic neurons exhibited low tonic discharge rates

99 throughout the DR, and the vast majority of serotonergic neurons expressed both receptors.

100 Serotonergic neurons extended considerably longer neurit

101 the efficient generation of functional human serotonergic neurons from human fibroblasts as a novel t

102 and NGN2 directly and efficiently generated serotonergic neurons from human fibroblasts.

103 , noradrenergic neurons cease discharge, and serotonergic neurons greatly reduce activity.

104 he i5HT neurons expressed markers for mature serotonergic neurons, had Ca(2+)-dependent 5HT release a

105 precise circuit connectivity that regulates serotonergic neurons has not been well defined.

106 Serotonergic neurons have a powerful stimulatory effect

107 Central serotonergic neurons have been implicated in numerous an

108 y programs that control the specification of serotonergic neurons have been investigated by genetic m

109 The dorsal raphe (DR) serotonergic neurons have long been implicated in the pr

110 provide a comprehensive map of the inputs to serotonergic neurons, highlighting the complexity and di

111 enteric nervous systems, SERT is located in serotonergic neurons; however, these neurons are not pre

112 ponded to 5-HT in a manner characteristic of serotonergic neurons (i.e., with activation of an inward

113 reased c-Fos expression in subpopulations of serotonergic neurons identified by either tryptophan hyd

114 RO serotonergic neurons, identified by their entrainment to

115 te to the dysregulation of noradrenergic and serotonergic neurons implicated in the pathogenesis of M

116 Serotonergic neurones in the mammalian medullary raphe r

117 directs a subset of these cells to generate serotonergic neurons in a particular location is unresol

118 eurons during development and maintenance of serotonergic neurons in adults.

119 selectively stimulating raphe obscurus (RO) serotonergic neurons in anesthetized mice and to test wh

120 as been observing the activity of identified serotonergic neurons in animals engaged in behavioral ta

121 han hydroxylase, we found that a majority of serotonergic neurons in both dorsal and caudal raphe cel

122 The activity of brain serotonergic neurons in both the pontine-mesencephalic a

123 terogeneity within the MR of the function of serotonergic neurons in breathing.

124 vironment and underscores neuroplasticity of serotonergic neurons in C. elegans under stress and stre

125 f the two molecules was confirmed in primary serotonergic neurons in culture.

126 tudies have examined pathological changes in serotonergic neurons in depression, particularly in elde

127 duced KOR-mediated GIRK currents recorded in serotonergic neurons in DRN postsynaptically, without si

128 a method for obtaining dopaminergic (DA) and serotonergic neurons in high yield from mouse ES cells i

129 To query brain serotonergic neurons in homeostasis, we used a neuronal

130 ntity, projection patterns, and functions of serotonergic neurons in juvenile and adult Aplysia are r

131 c and noradrenergic neurons or PET1-positive serotonergic neurons in mice decreased corresponding neu

132 osure is thought to selectively activate DRN serotonergic neurons in such a way as to render them tra

133 istry, we found changes in the activation of serotonergic neurons in the brainstem as well as evidenc

134 itch sensation, whereas mice lacking 5-HT or serotonergic neurons in the brainstem exhibit markedly r

135 Serotonergic neurons in the brainstem raphe nuclei dense

136 e present study examines the distribution of serotonergic neurons in the caudal raphe involved in the

137 Non-serotonergic neurons in the caudal raphe nuclei also pro

138 e neuronal density and neuritic pathology in serotonergic neurons in the dorsal raphe nuclei of elder

139 diated via the CRF type 2 (CRF2) receptor on serotonergic neurons in the dorsal raphe nucleus (DR).

140 ollable stress depend on hypersensitivity of serotonergic neurons in the dorsal raphe nucleus (DRN),

141 he expression of alpha4-containing nAChRs by serotonergic neurons in the dorsal raphe offered a means

142 Although the serotonergic neurons in the dorsal raphe project through

143 Birds also have serotonergic neurons in the dorsal raphe, suggesting tha

144 ssion within the basolateral amygdala and in serotonergic neurons in the dorsal, ventrolateral, cauda

145 e if CRF2 receptor activation has effects on serotonergic neurons in the DR in conscious behaving rat

146 Serotonergic neurons in the DRN have been theorized to e

147 ents were the predominant tonic influence on serotonergic neurons in the DRN.

148 ntrollable stressors preferentially activate serotonergic neurons in the DRN.

149 There are approximately 100 serotonergic neurons in the Drosophila nervous system, a

150 ined the organization and development of its serotonergic neurons in the leopard frog.

151 Spinally-projecting serotonergic neurons in the LH have not been identified,

152 Single unit activity of presumed serotonergic neurons in the medulla [n. raphe obscurus (

153 Serotonergic neurons in the medulla are central respirat

154 Serotonergic neurons in the mesencephalic median raphe n

155 Here we show that serotonergic neurons in the midbrain of rats are also hi

156 Serotonergic neurons in the MnR were destroyed by the di

157 ic afferents had a strong tonic influence on serotonergic neurons in the MRN.

158 Putative serotonergic neurons in the NRM, a medullary nucleus pro

159 There was a severe depletion of serotonergic neurons in the nucleus raphe magnus, raphe

160 their differentiation into dopaminergic and serotonergic neurons in the presence of mitogen and spec

161 Serotonergic neurons in the raphe nuclei associated with

162 le, randomly presented sound pulses activate serotonergic neurons in the rat median raphe but not dor

163 suggesting that the LH innervates brainstem serotonergic neurons in the rostral ventromedial medulla

164 This removes the tonic inhibition of GABA on serotonergic neurons in the RVM, and activation of these

165 glutamatergic neurons in the spinal cord and serotonergic neurons in the RVM.

166 d a specific projection from NPVF neurons to serotonergic neurons in the ventral raphe nucleus (vRN).

167 sed the firing frequency of dopaminergic and serotonergic neurons in the ventral tegmental area and t

168 ty of cell types, including dopaminergic and serotonergic neurons in vitro and germ cells in vivo.

169 Phox2b was not detected in serotonergic neurons, in the A5, A6, and A7 noradrenergi

170 d laser photostimulation of ChR2-transfected serotonergic neurons increased respiratory frequency (fR

171 both short- and long-term activation of DRN serotonergic neurons induce antidepressant-like behavior

172 erm activation of dorsal raphe nucleus (DRN) serotonergic neurons induces robust behavioral responses

173 neurons in the RVM, and activation of these serotonergic neurons inhibits pain.

174 ls within RTN confirmed that lower medullary serotonergic neurons innervate RTN.

175 The dorsal swim interneurons (DSIs) are serotonergic neurons intrinsic to the central pattern ge

176 expression and regulation of these genes in serotonergic neurons invites speculation that they may m

177 e immune system on a specific group of brain serotonergic neurons involved in the pathophysiology of

178 ter example: the neuromodulatory effect of a serotonergic neuron is dependent on the interval between

179 neurons, but that the development of the ADF serotonergic neurons is regulated by an UNC-86-independe

180 Induced serotonergic neurons (iSNs) showed increased expression

181 Using the serotonergic neuron-like CA77 cell line, we have demonst

182 Chemosensitive glutamatergic and serotonergic neurons located just beneath the ventral me

183 es have suggested that activation of KORs on serotonergic neurons may be sufficient to mediate aversi

184 Depletion of serotonergic neurons may contribute to impaired control

185 To test whether serotonergic neurons mediate opioid analgesia, morphine

186 Here we show for the first time that serotonergic neurons migrate by somal translocation medi

187 gic neuron activity: (1) a large fraction of serotonergic neurons modulated their tonic firing rates

188 er the DeltapH(i)/DeltapH(o) of 0.75 for non-serotonergic neurones (most of which are not chemosensit

189 Serotonergic neurons (n = 16) were identified, as previo

190 Serotonergic neurons not activated by hemorrhage were lo

191 assium transient current I(A) for a presumed serotonergic neuron of the rat dorsal raphe nucleus (DRN

192 Thus, the serotonergic neurones of the developing midline raphe sy

193 Serotonergic neurones of the raphenucleus and the trochl

194 The serotonergic neurons of the dorsal raphe (DR) nucleus in

195 These findings reveal that serotonergic neurons of the dorsal raphe have a state-de

196 Serotonergic neurons of the dorsal raphe nucleus (DRN) c

197 duced p38alpha MAPK signaling cascade within serotonergic neurons of the dorsal raphe nucleus that me

198 ty after flow revealed increased activity in serotonergic neurons of the dorsal raphe.

199 Serotonergic neurons of the DRN are involved in the cont

200 We conclude that MCH reduces the activity of serotonergic neurons of the DRN.

201 We have previously shown that serotonergic neurons of the medulla are strongly stimula

202 The serotonergic neurons of the ML, though known to be activ

203 ity is initiated by a driver population, the serotonergic neurons of the nascent raphe.

204 ic neurons of the A7 and A5 cell groups, and serotonergic neurons of the nucleus raphe magnus (NRM).

205 gered internalization of tagged 5-HT(1A)R in serotonergic neurons only.

206 The study found no evidence of a loss of serotonergic neurons or of neuritic pathology in the dor

207 nd saporin (anti-SERT-SAP; 1 microm) to kill serotonergic neurones, or (c) SP-SAP and anti-SERT-SAP t

208 the larva forms an anterior concentration of serotonergic neurons, or apical organ.

209 As in serotonergic neurons, Pet1 expression in islets required

210 es whose expression is characteristic of the serotonergic neuron phenotype.

211 Serotonergic neurons positive for GAD mRNAwere found in

212 Serotonergic neurons possess an enhanced ability to rege

213 rates of a subpopulation (19 of 70, 27%) of serotonergic neurons predominantly located in the ventra

214 We propose that DR serotonergic neurons preempt reward delays at the decisi

215 DRN serotonergic neurons project broadly throughout the brai

216 Serotonergic neurons project their axons pervasively thr

217 Serotonergic neurons project widely throughout the CNS a

218 is, in part, under the inhibitory control of serotonergic neurons projecting from the dorsal raphe nu

219 n neuronal than EC cell serotonin; moreover, serotonergic neurons promote development/survival of som

220 ency, inactivation of the leptin receptor in serotonergic neurons recapitulates them fully.

221 perpolarized the great majority (81%) of non-serotonergic neurons recorded extra- and intracellularly

222 This work establishes that serotonergic neurons regulate life-sustaining respirator

223 1877-1893), who show that serotonergic neurons regulate the growth of peripheral t

224 r, the subsequent differentiation of central serotonergic neurons required both the suppression of VM

225 Restoring NS3 to only 106 serotonergic neurons rescued global growth defects.

226 -like episodes correlated with the number of serotonergic neurons restored with orexin receptor expre

227 Activation of median raphe serotonergic neurons results in the desynchronization of

228 saicin-induced activation of dopaminergic or serotonergic neurons reversibly alters both physiologica

229 n the metazoan central nervous system (CNS), serotonergic neurons send projections throughout the syn

230 with the known arousal-dependent activity of serotonergic neurons, show that these receptors may medi

231 Electrophysiologically, female serotonergic neurons showed blunted membrane excitabilit

232 BS-NSC graft-derived catecholaminergic and serotonergic neurons showed remarkable long-distance axo

233 These results suggest that serotonergic neurons signal information about reward and

234 Transgenic mouse serotonergic neurons specifically labeled by enhanced ye

235 -Fos expression was greatly increased in DRN serotonergic neurons suggesting that OFF DRN-projecting

236 mbryoids also produced neuron-like cells and serotonergic neurons, suggesting that mesomeres are auto

237 Its differential occurrence in serotonergic neurons supports the idea that 5-HT(1A)R in

238 s exclusion from GABAergic, cholinergic, and serotonergic neurons supports the notion that DNPI/VGLUT

239 pical plate and pharyngeal endoderm, and 4-6 serotonergic neurons that are confined to the apical pla

240 dicate that the BF shift can be modulated by serotonergic neurons that augment or reduce the BF shift

241 However, it remains unknown how serotonergic neurons that innervate the first olfactory

242 We examined the sole pair of serotonergic neurons that innervates the Drosophila ante

243 us is a major limbic target of the brainstem serotonergic neurons that modulate fear, anxiety, and le

244 he DRN are responsible for the inhibition of serotonergic neurons that occurs during natural AS.

245 r the genetic inactivation of Tph2 in caudal serotonergic neurons that project to the NTS protects ag

246 ns, egg laying, which is driven by a pair of serotonergic neurons, the hermaphrodite-specific neurons

247 To investigate afferent influences on serotonergic neurons, this study compared the role of en

248 ophila ventral nerve cord (VNC), each of two serotonergic neurons tiles distinct innervation patterns

249 odulatory actions at one synapse may allow a serotonergic neuron to play distinct roles at different

250 These SONs activate serotonergic neurons to inhibit nociceptor-to-SON transm

251 The findings suggest that NS3 acts in serotonergic neurons to regulate insulin signaling and t

252 the hypothesis that the capacity of midbrain serotonergic neurons to release 5-HT at the MH is reduce

253 This increased ability of serotonergic neurons to robustly grow on high amounts of

254 ), a specific marker of early differentiated serotonergic neurons, to study their migration via immun

255 amined how visceral motor neurons (VMNs) and serotonergic neurons, two neuronal subtypes, are sequent

256 ifferentiation of an embryonically generated serotonergic neuron type.

257 reproducible and accurate method to profile serotonergic neurons under a variety of conditions and s

258 (Ucn 2) increases c-Fos expression in rat DR serotonergic neurons via actions on CRF2 receptors, we g

259 omically and functionally distinct subset of serotonergic neurons via activation of CRF2 receptors.

260 directly modulate gene expression in select serotonergic neurons via ER alpha and PR in female and m

261 ession of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia-inducible tran

262 laevis larvae modulates the specification of serotonergic neurons via regulation of expression of the

263 a mitogen-activated protein kinase (MAPK) in serotonergic neurons was found to be a critical mediator

264 A small percentage of spinally projecting serotonergic neurons was immunoreactive for the alpha3 s

265 lla, but the number of catecholaminergic and serotonergic neurons was not significantly reduced.

266 e with Fos and markers for noradrenergic and serotonergic neurons was used to examine if an intraplan

267 chniques and a novel lentiviral reporter for serotonergic neurons, we identified and overexpressed ke

268 l role of GLUA1-containing AMPA receptors in serotonergic neurons, we used the Cre-ERT2/loxP-system f

269 tro, and into mature-appearing pyramidal and serotonergic neurons weeks after being injected into the

270 in 1 receptor-positive neurons or descending serotonergic neurons were ablated before hyperalgesic pr

271 We sought to determine whether medullary serotonergic neurons were affected in multiple system at

272 Putative serotonergic and non-serotonergic neurons were distinguished from one another

273 Aergic and glutamatergic cells projecting on serotonergic neurons were found in the DRN and the adjac

274 In contrast, serotonergic neurons were immunoreactive for the alpha3

275 Grasshopper serotonergic neurons were microinjected with a fluoresce

276 the floor plate, including dopaminergic and serotonergic neurons, were greatly reduced in number or

277 F DRN-projecting RGCs predominately activate serotonergic neurons whereas ON DRN-projecting RGCs main

278 o regions receive a very small input from ML serotonergic neurons which, instead, heavily innervate t

279 d that the DeltapH(i)/DeltapH(o) of 0.69 for serotonergic neurones (which are stimulated by acidosis)

280 rominent at locations that contain medullary serotonergic neurones, which are chemosensitive in vitro

281 Serotonergic neurons, which are born early from TC proge

282 We tested hypotheses that serotonergic neurons, which arise early, affect developm

283 in contrast to activity in noradrenergic and serotonergic neurons, which is more tightly coupled to t

284 o long-term increases in the excitability of serotonergic neurons, which may represent a mechanism un

285 lls also activate dorsal raphe nucleus (DRN) serotonergic neurons, which project to the vicinity of t

286 Pet1 neurons may act downstream of Egr2-Pet1 serotonergic neurons, which were previously established

287 ntly augmented or reduced the activity of DR serotonergic neurons, while mice decided between differe

288 t with a loosely organized arousal system of serotonergic neurons whose components can be generally o

289 Destruction of serotonergic neurons with 5,7-DHT resulted in fragmented

290 lularly under voltage clamp, were induced in serotonergic neurons with bath and microiontophoretic ap

291 Inhibition of caudal MR serotonergic neurons with the 5-HT(1A) receptor agonist

292 We 'tagged' serotonergic neurons with the light-sensitive protein ch

293 We conclude that serotonergic neurons within the caudal MR provide a non-

294 stimuli via actions on a specific subset of serotonergic neurons within the dorsal raphe nucleus.

295 topographically organized subpopulations of serotonergic neurons within the DR.

296 In this study, we use a pair of identified serotonergic neurons within the Drosophila olfactory sys

297 ation of Egr2-neurons thus may stem from non-serotonergic neurons within the Egr2 domain.

298 provide further support for the presence of serotonergic neurons within the median raphe nucleus tha

299 Furthermore, the basic branching pattern of serotonergic neurons within the neuropil remains unchang

300 greater neurofibrillary pathology and fewer serotonergic neurons would be found in the dorsal raphe