ライフサイエンスコーパス: serum protein

1 d aspartate aminotransferase, AST) and total serum protein.

2 ted in the corresponding lysine of the human serum protein.

3 proteolysis when tethered to the long-lived serum protein.

4 alpha-trypsin inhibitor (IaI) is an abundant serum protein.

5 gen activator, plasminogen, or any prominent serum protein.

6 a model biomolecule against a background of serum protein.

7 otein at the level of 4.0 fmol of ospA/mg of serum protein.

8 tors assessed in splenic gene expression and serum proteins.

9 ed by correlating the skin transcriptome and serum proteins.

10 that these are ligands stabilizing the major serum proteins.

11 ce the production of abnormally glycosylated serum proteins.

12 the presence of high salt concentrations and serum proteins.

13 ell as in casein micelles separated from the serum proteins.

14 ies of more than two dozen membrane-bound or serum proteins.

15 onto live cell membranes in the presence of serum proteins.

16 to IFN-gamma in the presence of overabundant serum proteins.

17 ia, remains a mystery due to the plethora of serum proteins.

18 in factor H (FH) and additional unidentified serum proteins.

19 that some bacteria mask their surfaces with serum proteins.

20 n interaction through their interaction with serum proteins.

21 urement of the binding of small molecules to serum proteins.

22 g injury, such as surfactant, proteases, and serum proteins.

23 nes are adjacent and express closely related serum proteins.

24 citation, and asymptomatic elevations of two serum proteins.

25 to competitive adsorption of surface active serum proteins.

26 ficant interference from other cytokines and serum proteins.

27 were significantly altered as CBLG bound to serum proteins.

28 le resilience to the non-specific binding of serum proteins.

29 bs) not previously tested for cross-reacting serum proteins.

30 adsorption surface coverage of crude bovine serum proteins.

31 rs-of-magnitude lower than the most abundant serum proteins.

32 sensor surface with considerable amounts of serum proteins.

33 ell attachment and binding and inhibition of serum proteins.

34 ve been identified, including GDF-associated serum protein-1 (GASP-1) and GASP-2, which are capable o

35 growth and differentiation factor-associated serum protein-1) as a novel downstream target of PPARbet

36 Tubular epithelial cells exposed to serum proteins adopted phenotypic and functional charact

37 protein adsorbers effectively competed with serum protein adsorbers for the hydroxyapatite surface.

38 icles to exhibit not only high resistance to serum protein adsorption but also pH-dependent adsorptio

39 Variations in serum protein adsorption correlate with differences in t

40 n in purified DNA samples due to nonspecific serum protein adsorption onto the sensing surface.

41 e of size and surface chemistry in mediating serum protein adsorption to gold nanoparticles and their

42 Nonspecific serum protein adsorption was minimized with effective su

43 ve biological environment due to nonspecific serum protein adsorption.

44 ves supported cell adhesion independently of serum protein adsorption.

45 rface resistance to both nonspecific DNA and serum protein adsorption.

46 e respiratory distress syndrome in which the serum protein albumin adsorbs to an air-liquid interface

47 iers by leveraging the long-lived endogenous serum protein albumin as an siRNA carrier.

48 transcriptional changes were induced by the serum protein albumin via TGFbeta signaling in primary a

49 f phospholipid-bound vesicles containing the serum proteins albumin, fetuin-A, and apolipoprotein A1;

50 A number of prominent serum proteins (albumin and IgG) were detected in the vi

51 mpared directly, 34 differentially expressed serum proteins allowed the separation of these two patie

52 albumin, constituting more than 50% of total serum proteins, allows increased protein loads on immobi

53 ugh it has previously been reported that the serum protein alpha(2)-macroglobulin is unable to inhibi

54 filing, provided insights into the nature of serum-protein alterations in pancreatic cancer patients,

55 sibly occurs as a result of competition with serum proteins, although our data seem to rule out a dir

56 ement procedure development of low abundance serum protein analytes.

57 irectly correlated with the intensity of the serum protein and indirectly with the tryptic peptides m

58 rognostic and predictive strategies based on serum protein and messenger RNA biomarkers can identify

59 tions and examined correlations between this serum protein and the antibiotic treatment outcomes of p

60 -specific binding to cells, interaction with serum proteins and cell adhesion molecules and can lead

61 ate analysis of these markers, together with serum proteins and cytokines, revealed a general signatu

62 ion, several co-linear relationships between serum proteins and DTI measures reported in healthy cont

63 Serum proteins and extracellular matrix (ECM) markers we

64 sis of small molecules in samples containing serum proteins and for the measurement of the binding of

65 esis and storage of nutrients, production of serum proteins and hormones, and breakdown of toxins and

66 ading to edema, excitotoxicity, and entry of serum proteins and inflammatory cells.

67 rkable binding resistance to a wide range of serum proteins and nucleic acids.

68 order to minimize nonspecific adsorption of serum proteins and other biomolecules, and (ii) a signal

69 A/(ng/ml), with negligible interference from serum proteins and other cytokines.

70 unique interactions of FhbA with individual serum proteins and provide support for the hypothesis th

71 akdown associated with brain accumulation of serum proteins and several vasculotoxic and/or neurotoxi

72 We examined 171 serum proteins and small molecules measured in 1,676 par

73 presses an unexpected dependence of Nodal on serum proteins and that it is critically required for no

74 s are the major barrier to the filtration of serum proteins, and altered podocyte function and/or red

75 drug can enhance its half-life by binding to serum proteins, and be targeted to bacterial membranes.

76 some of its natural inhibitors, nonspecific serum proteins, and diluted plasma.

77 ulation frequencies, cytokine responses, and serum proteins, and found that 77% of these are dominate

78 aphy, blocked blood-brain barrier leakage of serum proteins, and increased the number of endothelial

79 and mucin type O-glycosylation was found on serum proteins, and reduced metabolic labeling of sialic

80 ss the strength of association between these serum proteins, and to determine group sizes needed for

81 The interaction of 1 with the serum proteins apotransferrin (apoTf) and human serum al

82 ealed significant binding of (177)Lu-cm09 to serum proteins ( approximately 91%) in plasma, compared

83 nt differences in the levels of CFH or other serum proteins are detected.

84 spectrometry, we find that over 70 different serum proteins are heterogeneously adsorbed to the surfa

85 Although serum proteins are implicated in the activity of Ti(IV)

86 Serum proteins are known to assist in this complex proce

87 ular the effect on this of the adsorption of serum proteins, are directly examined by measuring the f

88 Second, the extravasation of serum proteins as a result of brain microvascular diseas

89 on the use of the nonspecific adsorption of serum proteins as an additional layer of surface passiva

90 ptors or indirectly by exploiting matrix and serum proteins as molecular bridges.

91 tient subgroups were performed to assess the serum proteins associated with anti-Jo-1 antibody-positi

92 1831 corresponded to approximately 100 known serum proteins, based on MS/MS analysis of one run each

93 ith collagen IV, fibronectin, laminin-332 or serum proteins before seeding with 125 mouse islets.

94 ogous to the target antigen of antiCl on the serum protein beta-2 glycoprotein-I (beta2GPI) and thus

95 Taken together, these data suggest that the serum protein beta2-GPI initiates the IR-induced intesti

96 lipid alterations that are recognized by the serum protein, beta2-glycoprotein I (beta2-GPI).

97 We investigated the role of the serum protein, beta2-glycoprotein I as an initiating Ag

98 evious studies indicated that binding of the serum protein, beta2-glycoprotein I, to the endothelium

99 roperties upon disassembly, we observed that serum proteins bind to and interact with the polymeric a

100 re, were employed to produce models of human serum protein binding (% bound) on a data set of 1008 ex

101 ide engineering strategy that incorporates a serum protein binding motif onto a covalent side-chain s

102 ledge, this data is the largest set on human serum protein binding reported for QSAR modeling.

103 compromised targeting owing to non-specific serum protein binding, and hindered tumor penetration.

104 n of clinical, radiographic, functional, and serum protein biomarker assessments, this study was aime

105 strated that combinations of these and other serum protein biomarkers can distinguish these disease s

106 trometry (SELDI-TOF MS) to identify multiple serum protein biomarkers for detection of liver disease

107 It is expected that serum protein biomarkers in Duchenne muscular dystrophy

108 Serum protein biomarkers were identified by stability se

109 We also find that the serum protein-bound form of NY is photoacoustically well

110 to normalize the basal metabolic rate and/or serum protein-bound iodine level, but thyrotoxic adverse

111 ve been designed to limit steroid binding to serum proteins, but there is evidence that binding to se

112 ling of peptides has been measured for a few serum proteins, but this approach awaits full validation

113 his study, we report the prefractionation of serum proteins by batch anion exchange chromatography in

114 e proteins can be separated from the bulk of serum proteins by high-speed centrifugation causing subs

115 We explored cord blood serum proteins by profiling a UCB pool of 12 neonates wi

116 vidence further supported the replacement of serum proteins by salivary proteins.

117 It is demonstrated how serum protein can be efficiently, cost-effectively, and

118 The accumulation of serum proteins can block targeting functionalities and a

119 sis of changes in the heat capacity of blood serum proteins can provide an insight into patient respo

120 These data indicate that host and pathogen serum proteins can serve as reliable biomarkers for trac

121 ransduction occurs via an unidentified mouse serum protein capable of bridging HAdV-5 to CAR.IMPORTAN

122 Four serum proteins-carcinoembryonic antigen, retinol binding

123 Human breast cancer cells (MCF-7) grown on serum protein-coated gold sensors were placed in dynamic

124 rated that ERFE messenger RNA expression and serum protein concentration increase in mice subjected t

125 into the underlying genetic architecture of serum protein concentrations and their association with

126 repair of DNA strand breaks improves, as do serum protein concentrations that are associated with th

127 expression of olfactomedin-4 messenger RNA, serum protein concentrations, and percentage of neutroph

128 Many disorders are associated with altered serum protein concentrations, including malnutrition, ca

129 Apolipoprotein L1 (ApoL1) is a human serum protein conferring resistance to African trypanoso

130 ter alpha inhibitor (IalphaI) is an abundant serum protein consisting of three polypeptides: two heav

131 the profiling of hepatic gene expression and serum protein content in patients with different subtype

132 nsideration to modulate the formation of the serum protein corona (PC) and the resultant immune respo

133 We find that the presence of a serum protein corona on the tip strongly modifies the in

134 tration in particular, of T cells as well as serum proteins correlate with lupus disease activity.

135 scanning calorimetry (DSC) analysis of blood serum proteins could reveal the patient response to the

136 Albumin, the most abundant serum protein, did not interfere in the detection of the

137 Fortified human blood serum, protein digest and fractions collected after prot

138 yelin status, lesion activity, astrocytosis, serum protein distribution, axonal area, and axonal loss

139 distributed, obstructed amines) rapidly bind serum proteins, diverse cells types in vitro, and endoth

140 If chemotherapy is effective, serum proteins DSC curve of non-small cellular lung canc

141 Serum protein electrophoresis (SPEP) demonstrated a 3.5

142 Appropriate evaluation including serum protein electrophoresis and hematology consultatio

143 (90%, 95% confidence interval, 74%-97%); by serum protein electrophoresis and/or immunofixation elec

144 erapeutic antibodies with immunofixation and serum protein electrophoresis assays may lead to underes

145 s of sFLC, SRM data was more consistent with serum protein electrophoresis than nephelometric data an

146 Serum protein electrophoresis with immunofixation and se

147 ve metabolic panel, vitamin B12 measurement, serum protein electrophoresis with immunofixation, fasti

148 of differential scanning calorimetry (DSC), serum protein electrophoresis, and free light chain assa

149 Serum protein electrophoresis, immunofixation electropho

150 Blood samples were collected for serum protein electrophoresis.

151 Its interaction with serum proteins, elemental distribution, and coordination

152 e S. epidermidis 0-47 or with biotin-labeled serum proteins eluted from the surface of bacteria grown

153 conclusion, although significant numbers of serum proteins emanate from the gingival sulcus, their a

154 FLD and NASH and demonstrates key changes in serum protein expression levels between control subjects

155 The serum proteins factor H (FH), consisting of 20 complemen

156 ions provide evidence that the uptake of the serum protein fetuin-A by VSMC is a key event in the inh

157 and renders them resistant to disassembly by serum proteins for >24 h.

158 emoglobin could be completely substituted by serum proteins for the provision of amino-acids in vitel

159 We initially assayed six serum proteins, four discovered by proteomics and two pr

160 spE paralogs bound factor H and unidentified serum proteins from a subset of animals, while OspF and

161 glomerular filtration barrier prevents large serum proteins from being lost into the urine.

162 A rank comparison of undepleted serum proteins from common bottlenose dolphins (Tursiops

163 H/factor H-like protein 1 (FHL-1) and other serum proteins from different animals was assessed.

164 of the counterflow used with TGF to exclude serum proteins from the analysis channel while small mol

165 ns-junction protein, resulting in leakage of serum proteins from the damaged barrier.

166 f hemoglobin in comparison with glycation of serum proteins (fructosamine), the glycation gap.

167 were the first to report that a bifunctional serum protein, Gas6, bridges envelope phosphatidylserine

168 Welding was associated with increases in serum protein, GPx, aconitase, TAS, and isoprostane leve

169 riteria (a ratio of pleural fluid protein to serum protein >0.5, a ratio of pleural fluid LDH to seru

170 comprehensive human plasma proteome, 5 of 11 serum proteins had a differential rank greater than 200.

171 The results demonstrated that serum proteins had significant interactions with Mg-base

172 far prevented comprehensive measurements of serum protein half-lives.

173 This serum protein, HIV-1 enhancing serum protein (HESP), might promote viral transcription

174 This serum protein, HIV-1 enhancing serum protein (HESP), mig

175 ood colourant tartrazine with two homologous serum proteins, HSA and BSA, were investigated, employin

176 ce-response patterns were obtained from five serum proteins (human serum albumin, immunoglobulin G, t

177 A number of serum proteins identified by this immunoproteomic study

178 ated with glucose and lipid metabolism, e.g. serum protein Igfbp1 and lipoprotein lipase.

179 Additionally, the serum protein, IgG, was observed to leak from capillarie

180 actors, such as glucose, ascorbic acid human serum protein, immunoglobulin G, and immunoglobulin M),

181 lts suggest the potential benefit of using a serum protein in a non-covalent manner in conjunction wi

182 Factor VIII (fVIII) is a serum protein in the coagulation cascade that nucleates

183 es, which also did not adsorb any detectable serum protein in undiluted FBS.

184 levels of 190 multiplex immunoassay profiled serum proteins in 149 schizophrenia patients and 198 mat

185 nstrated a robust overexpression of multiple serum proteins in SSc patients, particularly those with

186 onolayer reduces the nonspecific signal from serum proteins in such a manner that short exposure of t

187 , several CFH-binding proteins, and abundant serum proteins in the retinal pigmented epithelium (RPE)

188 ies have emphasized the likely role of human serum proteins in the transportation and accumulation of

189 The presence of serum proteins in the vitreous was detected by Coomassie

190 These serum proteins include vitellogenins, which are egg yolk

191 evaluating the stabilizing effect of several serum proteins including albumin and immunoglobulin G.

192 g fever in North America, binds host-derived serum proteins including factor H (FH), plasminogen, and

193 nosis interactions were identified for eight serum proteins including Factor-VII[rs555212], Alpha-1-A

194 Serum proteins, including CD14 and LPS-binding protein,

195 is subfamily of proteins degrade a number of serum proteins, including circulating complement, provid

196 ells become exposed to ultrafiltrate-derived serum proteins, including complement factors.

197 g to the quantification of a large number of serum proteins, including those with an abundance of 10(

198 Folate receptor (FR), a serum protein indicative of various cancers, was chosen

199 nt of heavy chains that are derived from the serum protein inter-alpha-inhibitor (IalphaI), a process

200 m absorption to secretion; increased leak of serum protein into the intestinal lumen; and altered tig

201 of brain microvascular disease is leakage of serum proteins into the brain extracellular space, in a

202 e leakage of a fluorescent tracer as well as serum proteins into the developing brain and reduced the

203 utrophilic inflammation, vascular leakage of serum proteins into the lung tissue, and exudation of pr

204 Turnover of blood serum proteins is a vital function in mammals, but techn

205 and selectivity over other sugars and human serum proteins is demonstrated as a proof of concept.

206 the interactions of nanoparticles (NPs) with serum proteins is necessary for the rational development

207 This panel of four serum proteins is valuable in suggesting the diagnosis o

208 ximately 10(7) lower in abundance than major serum proteins, is feasible.

209 mmunoaffinity depletion of the most abundant serum proteins, isobaric tags for relative and absolute

210 minidase that removes sialic acid from human serum proteins; it is required for T.denticola to grow i

211 ins is greatly enhanced by two lipid-binding serum proteins known as lipopolysaccharide-binding prote

212 polymorphism and pSS and found an increased serum protein level of IL-12p70 in patients with pSS car

213 th mutant AAT mRNA in the liver and defected serum protein level were inhibited by 95%, whereas liver

214 0.03 g/dl (95% CI 0.008-0.05; p < 0.009) in serum protein level.

215 or gene expression by RNA sequencing and for serum protein levels by Luminex and enzyme-linked immuno

216 Serum protein levels for these candidates were measured

217 Serum protein levels improved significantly over time.

218 ycoprotein (AGP) hepatic mRNA expression and serum protein levels.

219 ing was not correlated with the standard HCC serum protein marker alpha fetoprotein (P = 0.57).

220 ranslational application, S-glutathionylated serum proteins may be useful as biomarkers in individual

221 The adsorption of even a single serum protein molecule on a gold nanosphere used in biom

222 ofiling, measuring the concentrations of 182 serum proteins obtained from acute HAV- (18), HBV- (18),

223 icants is often affected by their binding to serum proteins, of which the most abundant in humans is

224 The adsorption of serum protein on the unmodified sensing membrane led to

225 potency between compounds and the effects of serum proteins on the metabolic stability of compounds d

226 phagocytosis assay, we studied the effect of serum proteins on this phagocytic process.

227 self-assembled monolayers and adsorption of serum protein onto the formed layer can be measured cont

228 c resistance to inactivating agents, such as serum proteins or meconium.

229 tial biomarker candidates, we determined the serum proteins overlapping with the retinal proteins kno

230 oresis/mass spectrometry identified specific serum proteins oxidized under cardiotoxic conditions.

231 L-13 as potential upstream regulators of the serum protein patterns in the sera of patients with diff

232 tested bound to unknown approximately 60-kDa serum proteins produced by different mammals.

233 Serum protein profiles measured by an antibody array con

234 Serum protein profiles obtained by antibody arrays repre

235 Transthyretin (TTR) is a largely beta-sheet serum protein responsible for transporting thyroxine and

236 INTERPRETATION: We have identified serum proteins secreted from metaplastic epithelium that

237 Cell viability and serum protein secretion functions were assessed.

238 The PERSEVERE biomarkers are serum proteins selected from among the proteins directly

239 Candidate serum protein septic acute kidney injury biomarkers were

240 Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive pro

241 s spiked into the complex matrix of digested serum protein solution where ion suppression effects and

242 lly, cytokine expression was examined in the serum (protein), spleen, and hypothalamus (mRNA).

243 Interestingly, some of the serum proteins such as Serum amyloid A, Apolipoprotein A

244 In addition, serum proteins, such as c-met, that were top ranked at i

245 they also degrade via removal of the iron by serum proteins, such as transferrin, over a period of se

246 ER-B with proteomic techniques allowed human serum proteins susceptible to oxidative damage to be det

247 ve protein (CRP) is a classical, acute phase serum protein synthesized by the liver in response to in

248 An established multivariate serum protein test can be used to classify patients acco

249 nce of a significant interaction between the serum protein test classification and treatment.

250 ing history, centre, and masked pretreatment serum protein test classification, and randomly assigned

251 Our findings indicate that serum protein test status is predictive of differential

252 ighly induced protein was DPP4, a measurable serum protein that has well-described roles in cancer pr

253 th the sera of mice deficient in fetuin-A, a serum protein that inhibits calcification, and the sera

254 annose-binding lectin (MBL) is a circulating serum protein that is sequestered to sites of inflammati

255 Mannose-binding lectin (MBL) is a serum protein that plays an important role in host defen

256 etween RBP4 and transthyretin (TTR), another serum protein that protects RBP4 from renal clearance.

257 MBL is an oligomeric serum protein that recognizes carbohydrates decorating a

258 Retinol binding protein 4 (RBP4) is a serum protein that serves as the major transport protein

259 sorption of albumin and other surface-active serum proteins that are present in the lung during acute

260 e studied the identity and quantity of human serum proteins that bind to spherical nucleic acid (SNA)

261 urfaces close to the gingival sulcus contact serum proteins that emanate via this sulcus, which may i

262 kidney mineral nanoparticles contain several serum proteins that inhibit ectopic calcification in bod

263 ctor H-like protein 1 (FH/FHL-1) are soluble serum proteins that negatively regulate the alternative

264 -based proteomics analyses, we identified 24 serum proteins that were significantly variant between t

265 Complement factors are serum proteins that work through a cascade of proteolyti

266 Our goal was to identify a combination of serum proteins that would provide a biological measure f

267 For antibodies, like many other serum proteins, the folding and assembly steps involve t

268 tion of the capacity for a large, endogenous serum protein to gain unobstructed access to the transie

269 t sufficiently distinguish between these two serum proteins to allow it to hijack the regulator alone

270 n caused many of the differentially abundant serum proteins to be restored towards wild-type levels.

271 dhesion of human endothelial cells and human serum proteins to bioceramics of different compositions,

272 (SDS) denaturation and chemical reduction of serum proteins to dissociate ADA-drug bindings, followed

273 nanocrystal-based formulation stabilized by serum protein transferrin in a non-covalent manner.

274 The serum protein transferrin was selected for use after eva

275 and Bruch's membrane and, together with the serum proteins transferrin and albumin, elevated in BM/C

276 n and partial monomer unfolding of the human serum protein transthyretin, resulting in aggregation an

277 weight loss along with serum levels of total serum protein (TSP), albumin, C-reactive protein, and le

278 The secreted serum protein TXNDC16 is bound in circulating immune com

279 This serum protein undergoes intensive posttranslational modi

280 yses were conducted for adiponectin mRNA and serum protein using a maximum likelihood-based variance

281 imization of the nonspecific signal from the serum protein was achieved by immobilizing the antibody

282 s of infected, apoptotic cellular debris and serum protein was consistently observed.

283 selectivity for venomous PLA2 over abundant serum proteins, was not cytotoxic, and showed substantia

284 rom several glycoprotein standards and human serum proteins, we demonstrated that the Y1 ion triggere

285 affinities of linear PFOS and PFOA to total serum protein were confirmed when both calf serum and hu

286 and a second membrane strip containing human serum proteins were coincubated with a ssDNA library con

287 ity, stability up to 260 min, and binding to serum proteins were determined.

288 The total serum proteins were digested with trypsin at 50 degrees

289 Interferences from serum proteins were first significantly reduced by prote

290 Using this method, a series of serum proteins were identified to have weak, but specifi

291 To study competition, saliva and serum proteins were labeled with CyDyes, mixed in variou

292 xpression levels of 7 IRGs and IFN-inducible serum proteins were monitored as potential biomarkers fo

293 tive and integrin-selective binding of human serum proteins, whereas the binding and adhesion of huma

294 ral organic coatings prevented adsorption of serum proteins, which otherwise increased hydrodynamic d

295 C-reactive protein (CRP) is an acute-phase serum protein with binding reactivity to nuclear autoant

296 of the patients, we identified a monoclonal serum protein with the same heavy- and light-chain isoty

297 etry-based approach we identified over 1,700 serum proteins with a peptide identification (ID) confid

298 arrays to probe the associations of multiple serum proteins with pancreatic cancer and to explore the

299 ment of either human serum or isolated human serum proteins with various oxidizing agents, damaged, b

300 FEPR = [serum creatinine x urine protein] / [serum protein x urine creatinine], %) and PCR ([urinary