ライフサイエンスコーパス: span

1 porally controlled strategies to extend life span.

2 ully, but experience a relatively short life span.

3 resonates continuously over a broad spectral span.

4 f recruitment and extended reproductive life span.

5 ary complications, resulting in shorter life-span.

6 is correlated with reduced survival and life span.

7 onsider developmental change across the life-span.

8 responsivity and anxiety throughout the life span.

9 nt number, power, duration, and/or frequency span.

10 and fibrinogen- varied across the adult age span.

11 hearts and showed significantly shorter life spans.

12 hase that largely determine their final life spans.

13 culated proton tunneling distances, r0, that span 0.719 to 1.244 A.

14 clusion criteria, with 816 usable MRI scans (spanning 1.0-11.2 years of the disease) available for an

15 The activation energies of the process span 135 kJ/mol to 226 kJ/mol, and 188 kJ/mol to 268 kJ/

16 majority of these families (21 of 27, 78%), spanning 16 genes, none of which is X-linked.

17 tified 24 candidate selection sweep regions, spanning 172 potentially novel and known genes, which ar

18 ome sequencing data from 5777 solid tumours, spanning 19 cancer types from The Cancer Genome Atlas.

19 years), and BMI repeatedly across adulthood, spanning 1966 to 2012.

20 ants (humans), sampled across the adult life span (20-89 years), to reveal that RSFC-based network or

21 aforesaid aza-heterocycles within short time spans (20-40 min).

22 tes socioeconomic characteristics of regions spanning 200 US cities by using 50 million images of str

23 used all live singleton births in California spanning 2005 to 2010 and estimated PTBs and other adver

24 (PFS) in CS patient samples with a follow-up spanning 234 months (mean: 57.6 months).

25 We used data from nine testing occasions spanning 28 y in the Swedish Adoption/Twin Study of Agin

26 nase using ancestral sequence reconstruction spanning 3 billion years of evolution.

27 y variation across 22 Caenorhabditis strains spanning 3 species, using multiple replicates collected

28 sured using stopped-flow kinetic techniques, spanned 4 orders of magnitude.

29 eterolytic cleavage of H2 can be controlled, spanning 4 orders of magnitude at 25 degrees C, from 2.1

30 Over the 10-y span, 56 US dental institutions received approximately $

31 3:1 mole ratio of Span 60:Tween 60, 4mg/ml of alpha-TOC and 25:12.5:2.5 mo

32 Sauce in the western Amazonian lowlands that spans 6900 years.

33 isomers of C6HnF(5-n)B(OH)2 with half-lives spanning 9 orders of magnitude: <3 ms to 6.5 months.

34 with at least four discrete eruptive events spanning 93 +/- 12 Ma (1416 +/- 7 Ma to 1322 +/- 10 Ma (

35 ined upon myristoylation and can be tuned to span a 30-60 degrees C.

36 laced under the control of 16 promoters that span a approximately 103-fold range of strengths, yieldi

37 that meiosis-specific HORMA domain proteins span a gap between cohesin complexes and the central reg

38 Local adaptation is common in species that span a range of environmental gradients (e.g., soils and

39 The experiments we review span a range of methodological techniques, including neu

40 should compare and integrate approaches that span a range of model complexity and spatial scale to ma

41 tains 7,192 successfully mapped markers that span a total of 2,811 cM, with an average marker interva

42 ion energy and its component parts, and they span a very broad range from 20 kBT to 150 kBT, dependin

43 Estimated fluxes span a wide range due to the range of diffusivity measur

44 ted genetic map containing 4,817 SNPs, which spanned a total of 4552.5 cM and covered an estimated 98

45 Specifically, we compared grasslands spanning a broad precipitation gradient ( approximately

46 and yield of co-blooming strawberry on farms spanning a gradient in cover of apple orchards in the la

47 nalyze data from three forest dynamics plots spanning a moisture gradient in Panama that have experie

48 ted over the course of ophthalmic follow-up, spanning a period of 20 years, beginning March 20, 1997,

49 t it provides structural distance restraints spanning a range of ca 3-60A while using the same sample

50 s of MG structures, derived from simulations spanning a range of compositions and quenching rates, we

51 rom four forests in the Brasil flux network, spanning a range of dry-season intensities and lengths,

52 available short side chain Aquivion ionomers spanning a range of equivalent weight (EW) suitable for

53 ned to bind in the minor groove of DNA while spanning a wide range of base strength from pKa 9.64 to

54 therapeutic window in a series of compounds spanning a wide range of signaling bias.

55 E degrees '(pH 5.5; alpha3FnY(O*/OH)) spans a range of 1040 +/- 3 mV to 1200 +/- 3 mV versus t

56 the flocculus, such that an optokinetic zone spans a ZII+/- pair: the HA zones span the P5+/- and P7+

57 increase by 31%) and shrinkage of the visual span (a decrease by 6.25 bits).

58 king, institutions that enable management to span across administrative boundaries, adaptive manageme

59 t assess efficacy in a specific disease that spans adult and pediatric populations.

60 E subfamilies by luciferase reporter assays, spanning all major TE classes, and showed that 95.6% of

61 spectral behavior, with a resulting palette spanning almost the entire visible range.

62 extensive medicinal chemistry endeavor that spans almost three decades.

63 avage produces a shorter N-terminal fragment spanning amino acids 1 to 193 (GSDMD1-193).

64 ey indicators of arthropathy across the life-span among participants with severe hemophilia A.

65 a(18)O) record from the South Atlantic Ocean spanning an interval between 30.1 My and 17.1 My ago.

66 Energy span and degree of TOF control analysis strongly support

67 ity that is in steady state at a longer time span and is less dependent on neurovascular coupling.

68 nd produced significant improvements in life span and motor function in Ppt1(-/-) mice.

69 Snow cover loss related mortality spans approximately 10 degrees latitude (half the native

70 omophores have a wide range of applications, spanning areas from biological imaging to solar energy c

71 We show that a region spanning AU-1 NSP2 gene nucleotides 784-820 is critical

72 d with performance on the Trails B and digit span backwards, mildly associated with Trails A performa

73 ed an alternative, dimensional approach that spans behavioural and language variants of frontotempora

74 -specific modifications to create a membrane-spanning beta-helical structure.

75 ignificant differences were observed in life span between genders, where females survived longer than

76 ttract interest for use in applications that span biomedicine to molecular electronics.

77 cting alone can ward off health threats that span borders, requiring international solutions.

78 on throughout the Tcrb recombination center, spanning both DbetaJbeta clusters.

79 dization sensors for Dengue virus detection, spanning both labeled and label-free transductions.

80 uplication and we observe fusion transcripts spanning both the 5' and 3' breakpoints.

81 tite complex is a transmembrane machine that spans both plasma membrane and outer membrane and active

82 r gamma oscillations across a 1.4 mm(2) grid spanned by 64 recording electrodes as male rats rested a

83 st, when analyzing a beam in a Hilbert space spanned by spatial modes - a critical task for spatial-m

84 o systematically search the structural space spanned by such compounds.

85 models of late-onset HPP with extended life spans by engineering a floxed Alpl allele, allowing for

86 N3 domain that is peripheral to the membrane-spanning C domain in the dodecameric secretin PulD, the

87 catalysts for (electro)chemical conversions spanning carbon, nitrogen, and oxygen chemistries.

88 uring seizure large-scale neural populations spanning centimetres of cortex coordinate with small neu

89 (1.2 x 1012GC), exhibited an increased life span, characterized by delayed weight loss and diminishe

90 inated the interdisciplinary research arenas spanning chemistry, material science, biological science

91 s the most comprehensive map of MEIs to date spanning chimpanzees, ancient hominids, and modern human

92 Cardiometabolic disease, spanning conditions such as obesity to type 2 diabetes m

93 ed a type of attachment to the reef and that spanned conventional location and use communities.

94 f cortex coordinate with small neural groups spanning cortical columns, and provide evidence that rap

95 The genomic regions spanning crossovers were significantly enriched with the

96 reased, leading to synchronized oscillations spanning d delta to beta frequencies; (2) the network ca

97 They have a range of functions spanning development, differentiation, growth, metabolis

98 , and testes, with common molecular features spanning different types.

99 This study spans different spatial scales from atoms to cells by co

100 s at 12 sandy beaches from four regions that spanned distances from 0.001 to 12,000 km.

101 y collected set of 278 primary colon cancers spanning diverse tumor stages and clinical outcomes.

102 GFP demonstrate that the N-terminal membrane-spanning domain flanked by a few positively charged or n

103 in sexual function during an individual life span driven by environmental cues - is an exceedingly ra

104 ted through a multiscale tomography workflow spanning eight orders of magnitude, combining X-ray comp

105 erived from a full developmental time course spanning embryogenesis through to adulthood.

106 iple layers of the lobula, and each dendrite spans enough columns to sample 75 degrees of visual spac

107 e longest living rodent, with a maximum life span exceeding 30 years, and found that injury responses

108 analysis identified a deletion in a patient spanning exon 35 as a result of a recombination event be

109 bacteria from young donors resulted in life span extension and delayed behavioral decline.

110 was not associated with performance on digit span forwards.

111 sequenced the mitogenomes of 89 House Crows spanning four native and five invasive populations.

112 A multigenic locus at 3p13-14, spanning FOXP1 to SHQ1, is commonly deleted in prostate

113 time series from Taiwan tree cellulose that span from 1190 AD to 2007 AD.

114 he mass range of the mini-CIT detector could span from m/z 75 to 681.

115 The adaptation time scales span from milliseconds to days, involving different regu

116 ardiovascular disease are multifactorial and span from the individual level to the social environment

117 octanol) values (log P(XCF2H) - log P(XCH3)) spanned from -0.1 to +0.4.

118 Protein content spanned from 20% to 35%, fat from 4% to 7%, and starch f

119 rimental generation of a 6.8 muJ laser pulse spanning from 1.8 to 4.2 mum from cascaded second-order

120 icles was 1.1 (0.57/1.8) x 10(-2) m(2) g(-1) spanning from 83 femtograms (fg) to 517 fg (500 nm </= m

121 This makes for a rich research field spanning from biochemistry and cell biology into nutriti

122 ly from lightweight organic electronics, now spanning from displays to logics, because of the vital i

123 oxy from South America for this time period, spanning from the Last Glacial Maximum (LGM) to the mid-

124 nanodroplet formation for many applications, spanning from the preparation of pharmaceutical polymeri

125 a exhibits increased conformational dynamics spanning from the trimerization interface to the regions

126 atistical features in different Nino regions spanning from the western to the eastern Pacific are cap

127 ytical performance, with a linear range that spans from 1microM to 10mM and limit of detection of 10(

128 ransmembrane helices constituting a membrane-spanning furrow that provides a path for lipids in scram

129 ith low particle valence form stable, volume-spanning gels at low density, whereas central regions wi

130 In particular, we found selection sweeps spanning genes and/or pathways associated with metabolis

131 n medicine, requires new infrastructure that spans geography, institutional boundaries, and the divid

132 find a significant association of rs10463311 spanning GPX3-TNIP1 with ALS (p = 1.3 x 10(-8)), with re

133 ne T1D subject was detected at repeat visits spanning >15 mo, demonstrating clonotype stability.

134 Much research spanning >20 years shows a strong association between mi

135 pulation sizes to historical data from sites spanning >400 km.

136 pic membrane proteins with a single membrane-spanning helix play a plethora of vital roles in the cel

137 RNA sequencing (RNA-seq) experiments now span hundreds to thousands of samples.

138 precision alignment of key climate data sets spanning iceberg-rafted debris event Heinrich 3 and Gree

139 The space-spanning immobile particles, whose population is sensiti

140 less than expected based on the 20 degrees C span in high-temperature extremes across the globe.

141 we show that RAGE exhibits an extended life span in lung epithelia (t(1/2) 6 h), is monoubiquitinate

142 expression of shared target genes, and whose span in many cases coincides with topologically associat

143 tebrates, and usually result in shorter life spans in the larger sex, although the underlying mechani

144 Alaska, USA, populations over a 37-year time span indicated that survival is highest during low snowf

145 on length that is associated with the system-spanning instabilities (also known as shear bands), whic

146 4.8) across a median 10.0-year iterated life span (IQR, 4.1-16.7).

147 Wide-field amacrine cells span large segments of the retina, making them uniquely

148 ows robust responses to a 2.2 degrees object spanning less than half of one facet of the compound eye

149 osine kinases that are activated by membrane-spanning ligands called ephrins.

150 Three scientific visualizations are shown, spanning macroscopic to nanoscopic length scales.

151 d domains in phase-separated continuous pore-spanning membranes (PSMs).

152 100 data points each), with stoichiometries spanning more than 2 orders of magnitude and requiring o

153 of N2 binding across three oxidation states spans more than 37 kcal mol(-1).

154 We apply this method to two examples that span movement networks that vary considerably in size an

155 nctional protein complex and physical forces spanning multicellular clusters, which further promotes

156 ughout the lifetime of the organism, or even span multiple generations.

157 other platforms to generate trimers that now span multiple subtypes.

158 hed for long-range genomic interactions that spanned multiple TADs.

159 A haplotype spanning multiple beta-defensin genes and containing 94

160 to become a 60-nm-wide achromatic resonance spanning multiple cavity free-spectral-ranges.

161 ng fused to create multimodal nanomaterials (spanning multiple different physical imaging modalities

162 Overall, expression spans multiple brain regions, structures, and cell types

163 s for the extensive Russian Siberian Arctic, spanning nearly half of the circum-Arctic.

164 ed in axons and exists extensively in axons, spanning nearly the entire axonal shaft of mature neuron

165 System spanning networks can also form without a condensation o

166 ron bunch in a plasma wakefield accelerator, spanning nonlinear to quasi-linear regimes, and unveil t

167 to 84% of Carnot cycle COP at a temperature span of 41 K, which cannot be obtained using an AMR with

168 ugh to kill 10(5)CFUmL(-1) in the small time span of 5 minutes.

169 on patterns of 376 million users over a time span of 6 y (January 2010 to December 2015).

170 2,000 years, to multiple tsunamis within the span of a century.

171 MHC-class I on recipient DCs during the life span of a skin graft.

172 At low dose exposure, the life span of affected organisms is barely shortened, enabling

173 causes a severe decline of replicative life span of daughter cells.

174 of mammalian CD59 genes to identify the only span of genomic DNA in C. porcellus that is homologous t

175 stasis of MDA-MB-231 cells and prolongs life span of mice injected with these cells.

176 We capitalized on wide geographic span of our sampling to address intriguing question abou

177 forebrain than the hindbrain across the life span of the Tg mice, suggesting that sortilin, at least

178 ust model systems that recapitulate the full span of thymopoiesis, from hematopoietic stem and progen

179 ntrast, dCMP+dTMP+THU therapy decreased life span of Tk2(-/-) animals compared to dCMP+dTMP.

180 dC+dT delayed disease onset, prolonged life span of Tk2-deficient mice and restored mtDNA copy numbe

181 Notably, mature taste cells have life spans of only 5-20 days and, consequently, are constantl

182 ly unfold and refold on time scales that can span orders of magnitude for different proteins.

183 pportunities to attack complex problems that span orders of magnitude in length and time scale, which

184 blood cells (RBCs) display a range of sizes, spanning orders of magnitude in volume in different clad

185 pecific stiffness, and stiffness values that span over an order of magnitude.

186 rovided a set of constitutive promoters that span over four logs of strength without detectable fitne

187 ng of electron transport, as reported values span over three orders of magnitude.

188 These abstracts spanned over 1467 cancer cell lines and 4373 genes repre

189 skilled and innovative surgeon whose career spanned over 4 decades of patient care, clinical investi

190 change connectivity among a network of MPAs spanning over 1000 km of coastline off the coast of east

191 Here we show for a wildfire chronosequence spanning over more than 5000 years in boreal forest in n

192 reated a continuous mechanical gradient that spans over a 200-fold difference in stiffness, approachi

193 h are associated with a longer maternal life span (P 1.4 x 10-3).

194 g are associated with a longer parental life span (P 6.2 x 10-6 for fathers and P 2.0 x 10-3 for moth

195 hydration water is its equilibrium dynamics spanning picosecond to nanosecond time scales.

196 s disrupt cell integrity by forming membrane-spanning pores that ultimately lead to their death.

197 pping the interaction sites between membrane-spanning proteins is a key challenge in structural biolo

198 HmAb 5J7 binds to a complex, 3-monomer spanning quaternary epitope in the DENV3 envelope (E) pr

199 cale sequencing of family samples, 215 genes spanning rare and replication copy number variations, 99

200 We conclude that the hinge-spanning region of the 5J7 quaternary epitope is a targe

201 ading to efficient labelling of the membrane-spanning regions of the protein upon irradiation at 349

202 r except that some helical segments in apoE4 spanning residues 12 to 20 and 204 to 210 are unfolded.

203 strikingly broad range of local stiffnesses, spanning roughly two decades.

204 near-transfer WM tests (Digit-Span, Spatial-Span), self-reported executive functioning, and function

205 ight-time warming across an aridity gradient spanning seven European shrublands using indices of C as

206 ngs of objects ranging from atoms to grains, spanning seven orders of magnitude in diameter and 13 or

207 ies (size, shape, density and porosity) that span several spatial scales.

208 three distinct catalyst states with activity spanning several orders of magnitude.

209 ded Zn(2+) sensors at a range of time points spanning several seconds and subsequently sort a mixed-c

210 We recently identified a risk haplotype spanning SLC16A11 that explains approximately 20% of the

211 anifest through mechanisms and features that span spatial and temporal scales.

212 Nontrained near-transfer WM tests (Digit-Span, Spatial-Span), self-reported executive functioning

213 is an assembly of eight single-pass membrane-spanning subunits on the surface of T lymphocytes that i

214 of the past decade, a review of literature, spanning surgery, and implementation science, was conduc

215 Cognition was measured by the Letter Number Span test and scales from the California Verbal Learning

216 of 22 genes across five organs, over a time span that encompassed the development of autonomic nervo

217 tructed sequential deletions in regions that span the 530 bps.

218 and ZF11 are not visible, while ZF8 and ZF9 span the backbone of the DNA duplex, conferring no seque

219 ese pumps form multi-protein assemblies that span the cell envelope.

220 otaxane fluorophores whose emission profiles span the color range from green to near-infrared.

221 mbinant fragments (60-79 aa), which together span the entire length of tropomyosin, were weak secreta

222 of the nucleoskeleton and cytoskeleton) that span the entire NE and mediate nuclear positioning [10-1

223 nce from task-irrelevant information)], that span the lateral prefrontal cortex (dorsolateral prefron

224 by the acidic microenvironment to insert and span the membranes of tumor cells.

225 unable metal and chalcogen compositions that span the MoSe2-WSe2 and WS2-WSe2 solid solutions, respec

226 netic zone spans a ZII+/- pair: the HA zones span the P5+/- and P7+/- ZII stripe pairs, whereas the V

227 PqiB create channels of sufficient length to span the periplasmic space.

228 erize the maturation kinetics of 50 FPs that span the visible spectrum at two different temperatures

229 include high-resolution marine records that span the YD.

230 Juno's capture orbit spanned the jovian magnetosphere from bow shock to the p

231 uring their long evolutionary history, which spanned the Jurassic and the Cretaceous (201 to 66 Ma),

232 The categories chosen spanned the range of 0-Dimensional (0D) objects such as

233 romedial gradient of low to high frequencies spanned the two regions.

234 irectly radiocarbon dated to a time transect spanning the 7(th)-11(th) centuries CE) yielded sufficie

235 onnected to an extended coil-coiled platform spanning the bacterial periplasm.

236 HSA targets key Abeta self-recognition sites spanning the beta strands found in cross-beta protofibri

237 a panel of antibodies specific for peptides spanning the CD23 surface, both binding and inhibition a

238 ect of magnetotelluric geophysical soundings spanning the central TAM was acquired.

239 ing a new database of individual rain events spanning the contiguous United States.

240 t wildtype Cyp c 1, and overlapping peptides spanning the Cyp c 1 sequence.

241 from embryonic development to three months, spanning the duration over which numerous sensory and ne

242 Using five antibodies spanning the dysferlin protein, we identified a highly r

243 tions each crossed to tetraploid populations spanning the geographic and phylogenetic range of the Ca

244 the DNA sequence of a 1.75-Mb genomic region spanning the Gli-2 locus was analyzed in the diploid gra

245 using non-linear exposure-response functions spanning the global range of exposure.

246 sealing of culverts in the railroad causeway spanning the Great Salt Lake in late 2013 documented dra

247 plitudes and pulse widths, for 21 cell types spanning the inner two layers of the rabbit retina.

248 h water (AIW) temperatures and sea-ice cover spanning the last 1.5 million years (Ma) of orbitally-

249 (1989-2005 CE) and Holocene fossil specimens spanning the last c.

250 e quantified savanna woody vegetation change spanning the last century.

251 iments deposited over the past 500,000 y and spanning the last five glacial-interglacial periods.

252 roach for 891 terrestrial vertebrate species spanning the late Permian through Early Jurassic.

253 nication) were imparted by protein nanopores spanning the lipid bilayer formed at the interface of th

254 sults from a 1.5 year-long InSAR time series spanning the March, 2015 extreme precipitation event in

255 lithic to the Late Neolithic and two samples spanning the Mesolithic-Neolithic boundary from the Dnie

256 rates the versatility of a hiPSC-based panel spanning the mutational heterogeneity within a single di

257 omain for the 'pole' and four helical 'ribs' spanning the N-terminal TRPM homology regions (MHRs), th

258 horus abundances in marine sedimentary rocks spanning the past 3.5 billion years.

259 mbase, and CENTRAL and did also a new search spanning the period Jan 1, 1975, until Feb 1, 2016.

260 to disrupt developmental events in organisms spanning the phylogenetic scale.

261 for a wide range of CB2R reference ligands, spanning the range of full, partial, and inverse agonist

262 er hand, the meridional temperature gradient spanning the Sahel has increased in recent decades, cons

263 high-spatial-resolution RNA sequencing data spanning the secondary phloem, vascular cambium, and woo

264 , which included over 40 starting structures spanning the spectrum from the extended unfolded state t

265 onology over the past approximately 11,000 y spanning the transition to maize-based food production.

266 aged with a multispectral imaging instrument spanning the UV, visible and NIR regions (19 wavelengths

267 estimated the n2 in a large wavelength range spanning the visible to the mid-IR region.

268 ontologically structured, model centric, and spans the breadth of AMR drug classes and resistance mec

269 onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese.

270 y a approximately 60 nucleotide element that spans the initiating AUG and by codon and amino acid fre

271 ology characterized by a vertical stalk that spans the retina and branches in each retinal layer.

272 ate upstream of the podocyte glycocalyx that spans the slit, but none are observed upstream of the sl

273 ion of sources of nutrients, the slime mould spans the sources with networks of its protoplasmic tube

274 This domain arrangement spans the two DNA gyres of the nucleosome and bridges bo

275 n is restricted to RF subregions, inhibition spans the width of simple cell RFs.

276 A synthetic peptide spanning this sequence forms amyloid-like fibrils in vit

277 raphic distribution of migratory species can span thousands of kilometers.

278 nt signal (p=1.12 x 10(-10)) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2.

279 216 000 world-wide observations of Fabaceae, spanning three orders of magnitude in seed size and incl

280 x clusters of dynamic modes, with timescales spanning three orders of magnitude.

281 Median iterated life span (timespan across which modifications occurred after

282 reover, we find that the lncRNA and promoter-spanning transcript interaction are based on a combinati

283 ract first with a 5' UTR-containing promoter-spanning transcript, which is then followed by the recru

284 eighted and binary graph, as well as minimum spanning tree (MST).

285 A maximum spanning tree approach revealed the centrality of the oc

286 ncluding principal component analysis (PCA); spanning-tree progression analysis of density-normalized

287 growing/coalescing to form a subcritical gap-spanning tube, which then must grow to cross the barrier

288 are generally within a factor of 2 of values spanning two orders of magnitude.

289 s at the cytosolic interface of the membrane spanning type III secretion 'injectisome'.

290 ion R p, driven with meteorological forcings spanning uncertainty across climate change models.

291 hmarking on a set of RNAs with complex folds spanning up to 56 nucleotides in length yields structura

292 ds, broadleaf forests and needleleaf forests spanning up to 65 years, during which time the frequency

293 Using social network data spanning up to half of the median adult lifespan in a gr

294 Ss1 dominates in the centromeric regions and spans up to 500 kb.

295 tandem arrays of alpha-satellite DNA, which spans up to several megabases.

296 Performance was evaluated on data sets spanning various lengths of time to understand the adapt

297 ogical descriptor related to molecular size (SPAN) was isolated next to a descriptor related to the a

298 Further studies across the life span will determine progression of cardiac dysfunction.

299 tant knockin LRRK2 mice over half their life span, with observable and measurable phenotype, is inval

300 actions of space and number through the life span, yet propose a theory with several weaknesses.