ライフサイエンスコーパス: sphingosine-1-phosphate lyase

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1 ibly degraded by the highly conserved enzyme sphingosine-1-phosphate lyase.

2 and demonstrate that inhibiting the enzyme, sphingosine-1-phosphate lyase 1 (SPL), has neuroprotecti

3 he expression of sphingosine kinase 1 and 2, sphingosine-1-phosphate lyase 1, and sphingosine-1-phosp

4 otein kinase type I-beta regulatory subunit, sphingosine-1-phosphate lyase 1, centaurin beta 1, prote

5 hingosine-1-phosphate receptor-1 (S1PR1) and sphingosine-1-phosphate lyase-1 (SPL1) in splenocytes wa

6 Conversely, FTY720 inhibited sphingosine-1-phosphate lyase activity in vitro.

7 eatment of mice with FTY720 inhibited tissue sphingosine-1-phosphate lyase activity within 12 h, wher

8 The absence of sphingosine-1-phosphate lyase affects multiple stages th

9 This identifies sphingosine-1-phosphate lyase as a dual modulator of sph

10 Sphingosine-1-phosphate lyase catalyzes the conversion o

11 osphate was stable in the presence of active sphingosine-1-phosphate lyase, demonstrating that the ly

12 iotropic effect, which is due to the loss of sphingosine-1-phosphate lyase, establishes sphingolipids

13 Recent studies have suggested that sphingosine-1-phosphate lyase expression affects animal

14 ese studies demonstrate that ELT-2 regulates sphingosine-1-phosphate lyase expression in vivo.

15 ian cell fate decisions, a recombinant human sphingosine-1-phosphate lyase fused to green fluorescent

16 We report the cloning of the Drosophila sphingosine-1-phosphate lyase gene (Sply) and demonstrat

17 In this study, regulation of sphingosine-1-phosphate lyase gene expression was invest

18 Additionally, we demonstrate that the human sphingosine-1-phosphate lyase gene is regulated by a GAT

19 isruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the en

20 To investigate whether sphingosine-1-phosphate lyase influences mammalian cell

21 Sphingosine-1-phosphate lyase is a widely expressed enzy

22 neumophila translocates the effector protein sphingosine-1 phosphate lyase (LpSpl) to target the host

23 ffects of FTY720 on immune function and that sphingosine-1-phosphate lyase may be a potential target

24 Thus, sphingosine-1-phosphate lyase overexpression in HEK293 c

25 er gene as well as an increase in endogenous sphingosine-1-phosphate lyase protein.

26 ial role, mechanisms affecting expression of sphingosine-1-phosphate lyase remain poorly understood.

27 Sphingosine 1-phosphate lyase (S1P lyase) irreversibly c

28 Sphingosine 1-phosphate lyase (S1PL) has been characteri

29 phingosine signaling pathways, we identified sphingosine-1-phosphate lyase (S1PL) as a drug target fo

30 iant, we describe the novel interaction with sphingosine 1-phosphate lyase (SGPL1)-a key enzyme for t

31 rome caused by loss-of-function mutations in sphingosine-1-phosphate lyase (SGPL1).

32 d (SL) mutant lacking the degradatory enzyme sphingosine 1-phosphate lyase (spl-).

33 ctions between FTY720, FTY720-phosphate, and sphingosine-1-phosphate lyase, the enzyme responsible fo

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