ライフサイエンスコーパス: sphingosine-1-phosphate receptor

1 adenosine receptors, dopamine receptor, and sphingosine 1-phosphate receptor.

2 contrasting with the proposed access for the sphingosine 1-phosphate receptor.

3 from chemokine receptors, integrins, and the sphingosine-1-phosphate receptor.

4 of activation-induced cytidine deaminase and sphingosine-1-phosphate receptor.

5 s such as vasa, pumilio and piwi, as well as sphingosine-1-phosphate receptor.

6 d apoptosis was independent of activation of sphingosine 1-phosphate receptors.

7 n and mouse S1P(5) gene products as encoding sphingosine 1-phosphate receptors.

8 d maturation by activating G protein-coupled sphingosine 1-phosphate receptors.

9 er cell apoptosis in a manner independent of sphingosine-1-phosphate receptors.

10 extramedullary tissues into lymph depends on sphingosine-1-phosphate receptors.

11 ndent "transactivation" of G protein-coupled sphingosine-1-phosphate receptors.

12 ation of surface-expressed G protein-coupled sphingosine-1-phosphate receptors.

13 signals mediated by chemokine, integrin, and sphingosine-1-phosphate receptors.

14 to optimize the oral exposure of a series of sphingosine 1-phosphate receptor 1 (S1P(1)) antagonists

15 A series of subtype selective sphingosine 1-phosphate receptor 1 (S1P(1)) antagonists

16 Sphingosine 1-phosphate receptor 1 (S1P(1)) is a G prote

17 The sphingosine 1-phosphate receptor 1 (S1P(1)) promotes lym

18 Activation of the sphingosine 1-phosphate receptor 1 (S1P(1)R) protects ag

19 Sphingosine 1-phosphate receptor 1 (S1P1) plays a pivota

20 Sphingosine 1-phosphate receptor 1 (S1P1), a G protein-c

21 Whereas the role of sphingosine 1-phosphate receptor 1 (S1PR1) in T cell egr

22 targets, including the key migratory factor sphingosine 1-phosphate receptor 1 (S1PR1).

23 Endothelial cells were stimulated with sphingosine 1-phosphate receptor 1 agonists to determine

24 th sphingosine 1-phosphate, FTY720, or other sphingosine 1-phosphate receptor 1 agonists.

25 L/6 mice with bleomycin to assess effects of sphingosine 1-phosphate receptor 1 agonists.

26 ves a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-

27 red mice maintains significantly higher lung sphingosine 1-phosphate receptor 1 expression compared w

28 receptor 1 agonists to determine effects on sphingosine 1-phosphate receptor 1 expression.

29 ere, we present the crystal structure of the sphingosine 1-phosphate receptor 1 fused to T4-lysozyme

30 ave important implications for targeting the sphingosine 1-phosphate receptor 1 in solid organ transp

31 Agonism of sphingosine 1-phosphate receptor 1 inhibited the entry o

32 r-promoting agent that effectively maintains sphingosine 1-phosphate receptor 1 levels and improves o

33 Synthetic sphingosine 1-phosphate receptor 1 modulators constitute

34 FTY720 (S)-phosphonate maintains endothelial sphingosine 1-phosphate receptor 1 protein expression in

35 FTY720 is a high-affinity agonist at the sphingosine 1-phosphate receptor 1 that prevents lymphoc

36 e does not induce beta-arrestin recruitment, sphingosine 1-phosphate receptor 1 ubiquitination, and p

37 Reduction of sphingosine 1-phosphate receptor 1 with small interferen

38 ed these observations to confirm that S1PR1 (sphingosine 1-phosphate receptor 1) and integrin beta4 (

39 he cell surface and consequent activation of sphingosine 1-phosphate receptor 1, Src and Fyn tyrosine

40 pathway, and a downstream target of KLF2 is sphingosine 1-phosphate receptor 1.

41 Sphingosine-1 phosphate receptor 1 (S1P1) is critical fo

42 CD62L and beta7-integrin, yet expression of sphingosine-1 phosphate receptor 1 (which is a critical

43 The sphingosine-1-phosphate receptor 1 (S1P(1)) is expressed

44 Sphingosine-1-phosphate receptor 1 (S1P(1)) was recently

45 g a newly characterized potent and selective sphingosine-1-phosphate receptor 1 (S1P) agonist with ph

46 Activation of the GPCR sphingosine-1-phosphate receptor 1 (S1P1) by sphingosine

47 nic lymphocyte accumulation involved reduced sphingosine-1-phosphate receptor 1 (S1P1) expression and

48 Furthermore, deletion of the sphingosine-1-phosphate receptor 1 (S1P1) in these precu

49 ly activates the promoters of both CD62L and sphingosine-1-phosphate receptor 1 (S1P1), whose express

50 by utilizing the clinically important GPCR, sphingosine-1-phosphate receptor 1 (S1P1).

51 pability and increased surface expression of sphingosine-1-phosphate receptor 1 (S1P1).

52 phingosine-related therapeutics, agonists of sphingosine-1-phosphate receptor 1 (S1P1).

53 The sphingosine-1-phosphate receptor 1 (S1PR1) and beta1-adr

54 itical to this pathway was signaling through sphingosine-1-phosphate receptor 1 (S1PR1).

55 of thymus-exiting and skin-homing molecules sphingosine-1-phosphate receptor 1 and CCR10 and accumul

56 Teijaro et al. now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all

57 novel immunomodulator FTY720 down-modulates sphingosine-1-phosphate receptor 1 on lymphocytes at low

58 r Rac1 and Rac2 in transducing chemokine and sphingosine-1-phosphate receptor 1 signals leading to mo

59 S1P1 (sphingosine-1-phosphate receptor 1) agonists prevent lym

60 nanomolar concentrations, thereby inhibiting sphingosine-1-phosphate receptor 1-dependent egress of l

61 lipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.

62 enitor cells (NSCs) in vitro via a PAR1-PAR3-sphingosine-1-phosphate-receptor 1-Akt pathway, which su

63 m lymph nodes requires the G-protein-coupled sphingosine 1-phosphate receptor-1 (S1P(1)).

64 Lymphocyte egress requires sphingosine 1-phosphate receptor-1 (S1P1), and IFN-alpha

65 the beta2 adrenergic receptor (beta2AR), the sphingosine 1-phosphate receptor-1 (S1P1), or the kappa-

66 ed growth factor (PDGF)beta receptor and the sphingosine 1-phosphate receptor-1 (S1P1).

67 We showed that sphingosine 1-phosphate receptor-1 agonist FTY720 induce

68 SEW2871, a sphingosine 1-phosphate receptor-1 agonist that activate

69 An established role of sphingosine 1-phosphate receptor-1 in T cells is to guid

70 lial sphingosine 1-phosphate signals through sphingosine 1-phosphate receptor-1 to prevent mitochondr

71 use they down-regulate the expression of the sphingosine-1 phosphate receptor-1, which mediates the e

72 was required for effective transcription of sphingosine-1-phosphate receptor-1 (S1P(1)) and CD62L in

73 have identified cortical sinuses as sites of sphingosine-1-phosphate receptor-1 (S1P(1))-dependent T-

74 The mechanism by which sphingosine-1-phosphate receptor-1 (S1P1) acts to promot

75 We have shown that transgenic expression of sphingosine-1-phosphate receptor-1 (S1P1) in immature th

76 The expression of sphingosine-1-phosphate receptor-1 (S1PR1) and sphingosi

77 ible mouse model with a temporally disrupted sphingosine-1-phosphate receptor-1 (S1PR1) gene specific

78 We show that expression of sphingosine-1-phosphate receptor-1 (S1PR1), a G protein-

79 cular B-cell egress via the marginal zone is sphingosine-1-phosphate receptor-1 (S1PR1)-dependent.

80 the sphingosine kinase-1 inhibitor, and the sphingosine-1-phosphate receptor-1/-3 antagonist VPC2301

81 inhibit PP2A and that FTY720-P, acting as a sphingosine-1-phosphate-receptor-1 agonist, elicits sign

82 amily (expressed in HEK293 cells) identified sphingosine-1-phosphate receptor 2 (S1P(2) ) as being ac

83 neutralizing anti-S1P antibody (mAb) and the sphingosine-1-phosphate receptor 2 (S1PR2) antagonist JT

84 We identified sphingosine-1-phosphate receptor 2 (S1PR2) as a sex- and

85 We find that the sphingosine-1-phosphate receptor 2 (S1PR2) is repressed

86 act via HSPGs independently of its receptor, Sphingosine-1-Phosphate receptor 2 (S1PR2).

87 Work in mice showed that sphingosine-1-phosphate receptor-2 (S1PR2), a Galpha12 a

88 uencing revealed a Thr289Arg substitution in Sphingosine-1-Phosphate Receptor-2 (S1pr2).

89 ere more resistant but became dispersed when sphingosine-1-phosphate receptor-2 was also removed.

90 in the aPC pathway were fully compensated by sphingosine 1 phosphate receptor 3 (S1P3) deficiency or

91 We demonstrate here that local sphingosine 1-phosphate receptor 3 (S1P3) agonism recrui

92 Previously, we showed that levels of sphingosine-1 phosphate receptor 3 (S1PR3) are increased

93 Here we investigate the role of sphingosine-1-phosphate receptor 3 (S1PR3) in regulating

94 Notably, these cells express the sphingosine-1-phosphate receptor 3 (S1PR3), and stimulat

95 and this was attenuated by inhibition of the sphingosine-1-phosphate receptor 3 (S1PR3).

96 emokine receptors (CXCR1, CXCR2, and CXCR4), sphingosine 1-phosphate receptor-3 (S1P3), the melanocor

97 lls from lymph nodes in the mouse depends on sphingosine-1-phosphate receptor-3.

98 significantly upregulated the expression of sphingosine-1-phosphate receptor 4 on neutrophils, and t

99 Duane NK cells have a 30-fold deficiency in sphingosine-1-phosphate receptor 5 (S1P5) transcript lev

100 strongly support a cardioprotective role for sphingosine-1-phosphate receptor activation during MI.

101 We hypothesized that sphingosine-1-phosphate receptor activation with fingoli

102 Sphingosine-1-phosphate receptor activation with fingoli

103 Sphingosine 1-phosphate and the sphingosine 1-phosphate receptor agonist FTY720 did not

104 With this objective in mind, we used the sphingosine-1 phosphate receptor agonist fingolimod, a d

105 Since the new sphingosine-1-phosphate receptor agonist immunosuppressi

106 /HI administration of FTY720 (fingolimod), a sphingosine-1-phosphate receptor agonist that blocks lym

107 Mice lacking MZ B cells, or treated with a sphingosine-1-phosphate receptor agonist to dislocate th

108 eatment with sphingosine-1-phosphate or SEW (sphingosine-1-phosphate receptor agonist) remained effec

109 Fingolimod, a sphingosine-1-phosphate receptor agonist, is used for th

110 ral lymph nodes (LN) by direct activation of sphingosine 1-phosphate receptors, along with the partic

111 This pathway consists of cell-surface sphingosine-1-phosphate receptors, an intracellular casc

112 Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are

113 erized of a fourth, high affinity, rat brain sphingosine 1-phosphate receptor, Edg-8.

114 In mice deficient in sphingosine-1-phosphate receptor function, CB2 antagonis

115 that expression of CD69, by interfering with sphingosine-1-phosphate receptor function, is a critical

116 his comparative characterization of multiple sphingosine-1-phosphate receptor genes and their spatiot

117 Nevertheless, the role of individual sphingosine-1-phosphate receptors in the regulation of a

118 nase inhibitor N, N-dimethylsphingosine or a sphingosine 1 phosphate receptor inhibitor VPC23019 on i

119 oring in patients with multiple sclerosis on sphingosine 1-phosphate receptor modulating agents.

120 However, administration of FTY720, a sphingosine 1-phosphate receptor modulator that induces

121 Fingolimod, an oral sphingosine 1-phosphate receptor modulator, is effective

122 Fingolimod (FTY720), a sphingosine-1-phosphate-receptor modulator that prevents

123 onist or antagonist effects on select LPA or sphingosine 1-phosphate receptors, nor did they inhibit

124 matory sites by decreasing expression of the sphingosine-1 phosphate receptor normally required for e

125 IVIg or F(ab')2 fragments decrease the sphingosine-1 phosphate receptor on CD4 cells, thus sequ

126 After Tyro3 ligation, PS activated sphingosine 1-phosphate receptor (S1P(1)), resulting in

127 rapid recruitment (5 minutes) to CEMs of the sphingosine 1-phosphate receptor (S1P(1)), the serine/th

128 urn to the marginal zone was promoted by the sphingosine 1-phosphate receptors S1P1 and S1P3.

129 th the transcriptional downregulation of the sphingosine-1-phosphate receptor S1P1.

130 ed phosphorylation of, the barrier-promoting sphingosine 1-phosphate receptor (S1P1) within caveolin-

131 phate (S1P) is the endogenous ligand for the sphingosine 1-phosphate receptors (S1P1-5) and evokes a

132 Here, we show that the sphingosine 1-phosphate receptor (S1PR) modulator fingol

133 m, fingolimod-phosphate (fingolimod-P), is a sphingosine 1-phosphate receptor (S1PR) modulator that i

134 Sphingosine 1-phosphate receptor (S1PR)1 stimulation con

135 as 5-fold greater selectivity for binding to sphingosine-1-phosphate receptor (S1PR) 1 (S1PR(1)) vers

136 cent data have demonstrated the potential of sphingosine-1-phosphate receptor (S1PR) agonism in the t

137 termine the impact of fingolimod (FTY720), a sphingosine-1-phosphate receptor (S1PR) agonist, on 2 mo

138 Agonists of the sphingosine-1-phosphate receptor (S1PR) attenuate kidney

139 iated through S1P binding to specific GPCRs [sphingosine-1-phosphate receptor (S1PR)1-5] and some oth

140 thymus through transcriptional activation of sphingosine-1-phosphate receptor S1pr1 as well as for na

141 he adenosine A(2A) receptor (AA2AR), and the sphingosine 1-phosphate receptor (S1PR1).

142 The sphingosine-1-phosphate receptors (S1PRs) are a well-stu

143 ific protease activated receptors (PARs) and sphingosine-1-phosphate receptors (S1PRs), in that siRNA

144 S1P(2) sphingosine 1-phosphate receptor signaling can regulate

145 The sphingosine 1-phosphate receptor-signaling pathway is be

146 These results indicate that FTY720- and sphingosine 1-phosphate receptor-stimulated T cell migra

147 in-mediated cell growth and survival via the sphingosine 1-phosphate receptor subtype 2 (S1P2) follow

148 in a straightforward total synthesis of the sphingosine 1-phosphate receptor-subtype 1 (S1P(1)) agon

149 Ozanimod (RPC1063) is an oral agonist of the sphingosine-1-phosphate receptor subtypes 1 and 5 that i

150 ta demonstrate that Edg-8 is a high affinity sphingosine 1-phosphate receptor that couples to G(i/o)a

151 The capacity of drugs that act on type 1 sphingosine 1-phosphate receptors to suppress organ graf

152 alphabeta T cells require sphingosine 1-phosphate receptor type 1 (S1P(1)) and CD6

153 T cells deficient in sphingosine 1-phosphate receptor type 1 probed the sinus

154 us probing is followed by entry dependent on sphingosine 1-phosphate receptor type 1, capture of cell

155 Mice deficient in sphingosine 1-phosphate receptor type 2 (S1P(2)) develop