ライフサイエンスコーパス: spinal cord

1 prion-like propagation of oligomeric SOD1 in spinal cord.

2 ociceptors have distinct morphologies in the spinal cord.

3 gral part of neural circuits for itch in the spinal cord.

4 Fos immunoreactivity pattern in the cervical spinal cord.

5 that governs axonal wiring of the zebrafish spinal cord.

6 thin band of tissue at the caudal end of the spinal cord.

7 erotonin innervation of motor neurons in the spinal cord.

8 time window for development of the brain and spinal cord.

9 ained excitation of neurons in slices of rat spinal cord.

10 ophage activation in the white matter of the spinal cord.

11 circuits and large diameter afferents in the spinal cord.

12 appears to occur to a lesser extent than in spinal cord.

13 synaptic afferents in the dorsal horn of the spinal cord.

14 ement and/or acute blood products within the spinal cord.

15 that this is controlled at the level of the spinal cord.

16 ytes in the demyelinated lesion of nude mice spinal cord.

17 te receptor with opioids at the level of the spinal cord.

18 per and lower motor neurons in the brain and spinal cord.

19 pathways and large diameter afferents in the spinal cord.

20 ntials if they were timed to converge in the spinal cord.

21 iately after complete transection of the rat spinal cord.

22 e regeneration of their central axons in the spinal cord.

23 axons growing across lesion epicenter in the spinal cord.

24 ctant for commissural axons in the embryonic spinal cord.

25 maturation of supraspinal projections to the spinal cord.

26 ling robust penetration of DR axons into the spinal cord.

27 s from the peripheral nervous system and the spinal cord.

28 ectedly profound pathology in the human INCL spinal cord.

29 , with no evidence of re-entry back into the spinal cord.

30 tly affecting the brainstem, cerebellum, and spinal cord.

31 interactions between cortex, brainstem, and spinal cord.

32 g from the hypothalamus to the brainstem and spinal cord.

33 remove netrin from different regions of the spinal cord.

34 cross five lumbosacral segments in the human spinal cord.

35 neurons project mostly to the hindbrain and spinal cord.

36 ectable in skeletal muscle, heart, brain and spinal cord.

37 by mechanosensory feedback in the vertebrate spinal cord.

38 several hundred micrometers of the zebrafish spinal cord.

39 , and importantly, also in the injured human spinal cord.

40 t architectures within these lineages in the spinal cord.

41 h as autonomic regions of the brain stem and spinal cord.

42 s (NSPCs) that contribute to the regenerated spinal cord.

43 in those sections from mechanically injured spinal cords.

44 the latter was only observed in regenerated spinal cords.

45 nistered by stereotaxic injection into mouse spinal cords.

46 of axons growing into a lesion epicenter in spinal cord after a concomitant dorsal column transectio

47 ying and tracking inflammatory damage in the spinal cord after TAR in a mouse model.

48 hen activating muscles, motor neurons in the spinal cord also activate Renshaw cells, which provide r

49 Targeting both the brain and spinal cord also produced dramatic and synergistic impro

50 l ganglionic eminence (MGE) into adult mouse spinal cord ameliorates mechanical and thermal hypersens

51 as an example of non-monotonic coding in the spinal cord and better explains observations in human ps

52 leptomeningeal disease and metastasis to the spinal cord and brain, resembling xenografts of human SH

53 as gamma-H2A.X positivity in neurons of the spinal cord and brain.

54 ch as estradiol, that are synthesized in the spinal cord and brainstem and act locally to influence p

55 cine corelease is particularly common in the spinal cord and brainstem, but its presence in the midbr

56 found that AAVrh10 transduces neurons in the spinal cord and dorsal root ganglia of immunodeficient m

57 of swelling, concomitant compression of the spinal cord and formation of post-traumatic cysts.

58 eral pain is a complex process involving the spinal cord and higher order brain structures.

59 uleus (LC) projects throughout the brain and spinal cord and is the major source of central noradrena

60 fulfilling dose-limiting constraints for the spinal cord and lungs.

61 rowth of embryos by contributing both to the spinal cord and mesoderm.

62 ish mutants in which OPCs migrate out of the spinal cord and myelinate peripheral motor axons, we ass

63 ich there is widespread demyelination of the spinal cord and optic nerves, we also show that thinly r

64 t neural stem cells, derived from the murine spinal cord and organized as neurospheres, can be trigge

65 hysiological effector systems, including the spinal cord and other peripheral organs.

66 n of BzATP resulted in ROS production in the spinal cord and oxidative DNA damage in dorsal horn neur

67 rom adrenomyeloneuropathy affecting only the spinal cord and peripheral nerves (Expanded Disability S

68 represent the direct cortical outputs to the spinal cord and play important roles in motor control ac

69 of the rodent nervous system, including the spinal cord and primary sensory neurons.

70 Bar(CRH) neurons project to the lumbosacral spinal cord and ramify extensively in two regions: the d

71 igrate extensively in the demyelinated mouse spinal cord and remyelinate axons.

72 including fever, viremia, and viral loads in spinal cord and testes-and increased mortality.

73 (HD)-within the various compartments of the spinal cord and their potential impact on the local vasc

74 s) that fuel embryo elongation by generating spinal cord and trunk mesoderm tissue.

75 logical analysis of the dorsal root ganglia, spinal cord, and cerebellum.

76 ulted in essentially no PPT1 activity in the spinal cord, and vice versa.

77 (CCS) is S-acylated in both human and mouse spinal cords, and in vitro in HEK293 cells.

78 A-binding protein TDP-43 in their brains and spinal cords, and rare mutations in the gene encoding TD

79 This foreshortened spinal cord appears to be related to anisotropic growth

80 Circuits in the sensorimotor system (e.g., spinal cord) are thought to be assembled sequentially [1

81 They support the concept of the state of the spinal cord as a negotiated equilibrium that reflects th

82 c stiffness of the injured rat neocortex and spinal cord at 1.5 and three weeks post-injury using ato

83 We aimed to investigate patterns of spinal cord atrophy and correlations with clinical marke

84 Quantitative measurements of spinal cord atrophy are important in fully characterizin

85 onal area in HAM/TSP and progressive MS show spinal cord atrophy.

86 The blood-spinal cord barrier (BSCB) plays significance roles in r

87 lls into symptomatic G93A mice towards blood-spinal cord barrier (BSCB) repair.

88 al impact on the local vasculature and blood-spinal cord barrier (BSCB).

89 ges, but not by the endothelium of the blood-spinal cord barrier.

90 NA encoding each gene primarily in brain and spinal cord, but also elsewhere.

91 ymphocytes from the blood into the brain and spinal cord by blocking the adhesion molecule alpha4-int

92 ration) that are specifically induced in the spinal cord by Th17 cells.

93 +ChABC treatment of the chronically contused spinal cord can provide a permissive substrate for the r

94 ses excitability in DRG neurons and leads to spinal cord central sensitization and neuropathic pain s

95 tomic regions when comparing astrocytes from spinal cord, cerebellum, cerebral cortex, and hippocampu

96 t is hardwired; but it is now clear that the spinal cord changes continually as new behaviors are acq

97 fective at inducing hyperexcitability within spinal cord circuits compared with skin afferents, which

98 g genetic approaches in the mouse to map the spinal cord circuits that transmit and gate the cutaneou

99 Neurobiotin retrograde transport from the spinal cord combined with immunofluorescence revealed sp

100 d events (SREs) such as pathologic fracture, spinal cord compression, or the necessity for radiation

101 related event (defined as clinical fracture, spinal cord compression, radiation to bone, or surgery i

102 native codon-derived DPRs in chick embryonic spinal cord confirmed in vitro data, revealing that each

103 hanisms for epigenetic regulation within the spinal cord constitute the starting point for handedness

104 We report that, after spinal cord contusion injury in adult female mice, the b

105 INTERPRETATION: Group average spinal cord cross-sectional area in HAM/TSP and progress

106 frequency (p = 0.04) correlate with T4 to T9 spinal cord cross-sectional area in HAM/TSP.

107 patients and correlated with representative spinal cord cross-sectional area regions at the C2 to C3

108 Spinal cord cross-sectional area was measured in individ

109 load (p = 0.01) was associated with thinner spinal cord cross-sectional area.

110 ging applications for tissue regeneration is spinal cord damage.

111 dipine treatment attenuated clinical EAE and spinal cord degeneration and promoted remyelination.

112 Histopathological analysis of the spinal cord demonstrated a significant motoneurons loss,

113 opositivity, (2) myelitis attack and (3) MRI spinal cord demonstrating ring-enhancement.

114 tant in fully characterizing these and other spinal cord diseases.

115 (pC/EBPbeta) and its upstream pathway in the spinal cord dorsal horn (SCDH).

116 that many neurons in laminae I and V of the spinal cord dorsal horn and caudal spinal trigeminal nuc

117 cinergic inhibitory neurotransmission in the spinal cord dorsal horn gates nociceptive signaling, is

118 We found that ATP induces ROS production in spinal cord dorsal horn neurons, an effect eliminated by

119 athways that were changed in astrocytes from spinal cord during chronic EAE involved decreases in exp

120 e hypothesis that inducing plasticity in the spinal cord during chronic stroke could improve recovery

121 ar schwannomas), meninges (meningiomas), and spinal cord (ependymomas).

122 earch team has demonstrated that lumbosacral spinal cord epidural stimulation (scES) and activity-bas

123 POINTS: Pairing motor cortex stimulation and spinal cord epidural stimulation produced large augmenta

124 In spinal cords expressing ChR2, illumination increased mot

125 he prion-like seeding of SOD1 was assayed in spinal cord extracts of transgenic mice expressing a G85

126 gative, acylated SOD1 fibrils to organotypic spinal cord failed to produce the SOD1 inclusion patholo

127 ong transversal and longitudinal sections of spinal cord from control animals, but it strongly change

128 Spinal cords from EAE-challenged Plg(-) mice demonstrate

129 n and brainstem regions and project onto the spinal cord, have long been recognised as key links in t

130 Similarly, spinal cord immune responses between the sexes appeared

131 d RGS10 protein levels are suppressed in the spinal cord in a nerve injury-induced neuropathic pain m

132 increase in sensory axon regeneration in the spinal cord in comparison to wildtype C3(+/+) mice.

133 hage-specific mRNA directly from the injured spinal cord in mice and performed RNA sequencing to inve

134 es over motor cortex and the dorsal cervical spinal cord in rats; motor evoked potentials (MEPs) were

135 ia from the central canal (CC) lining of the spinal cord in rodents should occur in the embryonic per

136 defects in axon projection of DRG toward the spinal cord in vivo Furthermore, live-cell imaging of en

137 oth T and B cells were common infiltrates of spinal cords in diseased mice.

138 s within the ependymal layer of the original spinal cord include populations of neural stem/progenito

139 nimals and was associated with reduced acute spinal cord infiltration of Ly6C(hi) effector monocytes.

140 In lumbar spinal cord, inflammatory signaling is reduced in CX3CR1

141 udy participant was a 53-year-old man with a spinal cord injury (cervical level 4, American Spinal In

142 ied in 384 patients with clinically complete spinal cord injury (SCI) and consequent anejaculation.

143 Spasms after spinal cord injury (SCI) are debilitating involuntary mu

144 Traumatic spinal cord injury (SCI) causes a cascade of degenerativ

145 Acute spinal cord injury (SCI) causes systemic immunosuppressi

146 the loss of neuron-derived monoamines after spinal cord injury (SCI) in rats.

147 Spinal cord injury (SCI) induces a centralized fibrotic

148 STATEMENT Pain sensitization associated with spinal cord injury (SCI) involves poorly understood mala

149 NS trauma and disease.SIGNIFICANCE STATEMENT Spinal cord injury (SCI) leads to profound functional de

150 In this regard, spinal cord injury (SCI), Alzheimer's disease, and other

151 ays significance roles in recovery following spinal cord injury (SCI), and diabetes mellitus (DM) imp

152 Following spinal cord injury (SCI), astrocytes demonstrate long-la

153 Spontaneous remyelination occurs after spinal cord injury (SCI), but the extent of myelin repai

154 Spasticity, a common complication after spinal cord injury (SCI), is frequently accompanied by c

155 After spinal cord injury (SCI), meningeal ILC2s are activated

156 Following spinal cord injury (SCI), newly formed endothelial cells

157 Following spinal cord injury (SCI), the innate immune response of

158 influence many pathological processes after spinal cord injury (SCI), the intrinsic molecular mechan

159 Also, in rat T9-T10 hemisection spinal cord injury (SCI), we demonstrated that the tailo

160 esolution of inflammation is defective after spinal cord injury (SCI), which impairs tissue integrity

161 cytes that protect tissue and function after spinal cord injury (SCI).

162 he recovery of hand motor function following spinal cord injury (SCI).

163 rious neurological pathologies and following spinal cord injury (SCI).

164 and impaired wound healing, as occurs after spinal cord injury (SCI).

165 y associated with persistent pain induced by spinal cord injury (SCI).

166 examine their therapeutic potential to treat spinal cord injury (SCI).

167 hand dexterity increased in individuals with spinal cord injury after the I-wave protocol.

168 an reveal early inflammation associated with spinal cord injury after thoracic aortic ischemia-reperf

169 individuals with chronic incomplete cervical spinal cord injury and 17 uninjured participants.

170 -cost portable BMI for survivors of cervical spinal cord injury and investigated it as a means to sup

171 at motor evoked potentials size increased in spinal cord injury and uninjured participants after the

172 c remodeling and involves netrin-1 signaling.Spinal cord injury can induce synaptic reorganization an

173 receptor, promotes recovery after traumatic spinal cord injury in mice, a benefit achieved in part b

174 Therapeutic development for spinal cord injury is hindered by the difficulty in cond

175 of rehabilitation strategies in humans with spinal cord injury is to strengthen transmission in spar

176 cystic cavities in a clinically relevant rat spinal cord injury model.

177 After paralyzing spinal cord injury the adult nervous system has little a

178 f an individual with traumatic high-cervical spinal cord injury who coordinated reaching and grasping

179 th chronic tetraplegia, due to high-cervical spinal cord injury, can regain limb movements through co

180 veral neurological disorders such as stroke, spinal cord injury, multiple sclerosis, amyotrophic late

181 s neurological conditions, such as stroke or spinal cord injury, result in an impaired control of the

182 s system to restore motor function following spinal cord injury, the role of cortical targets remain

183 ipate in neuronal development, angiogenesis, spinal cord injury, viral invasion, and immune response.

184 ecruitment of spinal motor neurons following spinal cord injury.

185 ion in conditions such as cerebral palsy and spinal cord injury.

186 ote axonal regeneration and plasticity after spinal cord injury.

187 nassisted hindlimb locomotion after complete spinal cord injury.

188 migration and reversed astroglial fate after spinal cord injury.

189 sticity that improves breathing in models of spinal cord injury.

190 ion in conditions such as cerebral palsy and spinal cord injury.SIGNIFICANCE STATEMENT Acquisition of

191 or stimulating axonal regeneration following spinal cord injury.SIGNIFICANCE STATEMENT Injury of peri

192 least one to three LTMR classes, as well as spinal cord interneurons and corticospinal neurons.

193 of myelinating Schwann cells in the injured spinal cord; invasion of peripheral myelinating (P0+) Sc

194 Two distinct MRI patterns of spinal cord involvement were described according to T2-w

195 that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in cen

196 that develops following injuries to brain or spinal cord is a major obstacle.

197 ABSTRACT: The dorsal horn (DH) of the spinal cord is an important site for modality-specific p

198 lipid molecular order of myelin in the mouse spinal cord is significantly reduced throughout the prog

199 enesis of brain disease, but its role in the spinal cord is unclear.

200 (whole brain and gray matter), and cervical spinal cord lesions (T2LV) and atrophy.

201 idges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients.

202 Ring-enhancing spinal cord lesions were more common in NMOSD than other

203 d on highly specific molecular features from spinal cord level to the terminal nerves at wrist level.

204 ticospinal tract axons in the contralesional spinal cord makes a significant contribution to sensorim

205 e motor cortex is functionally linked to the spinal cord, making it more likely that spinal gene expr

206 blood-cerebrospinal fluid barrier and of the spinal cord meninges, but not by the endothelium of the

207 We assessed spinal cord microglia in humans and mice with AMN and in

208 onstrate that endogenous RGS10 is present in spinal cord microglia, and RGS10 protein levels are supp

209 end-feet astrocytes were also determined in spinal cords, mostly in high-cell-dose mice.

210 romuscular disorder characterized by loss of spinal cord motor neurons, muscle atrophy and infantile

211 Brain and spinal cord MRI and optic nerve assessments from patient

212 urological examination, a baseline brain and spinal cord MRI scan obtained less than 3 months from cl

213 In the developing dorsal spinal cord, multiple BMPs are required to specify senso

214 eolytic targets of calpain in Xenopus laevis spinal cord neurons both in vivo and in vitro Inhibition

215 se and approaches for recording signals from spinal cord neurons with a focus on motoneurons.

216 s the EphB-NMDAR interaction in cortical and spinal cord neurons.

217 DM13 that are critical for specifying dorsal spinal cord neurons.

218 5 in the tonsil and intestine, as well as in spinal cord neurons.

219 FT most closely resembles that of the adult spinal cord niche.

220 eviously characterized in both the brain and spinal cord of adult animals.

221 ecifically up-regulated in the thoracolumbar spinal cord of colitis-affected mice.

222 her (64)Cu-rituximab uptake in the brain and spinal cord of huCD20tg EAE, and B220 immunostaining ver

223 n, particularly of minor U12 introns, in the spinal cord of mice 30 d after SMA induction, which was

224 mp activity regulate locomotor output in the spinal cord of neonatal mice.

225 activity regulate locomotor networks in the spinal cord of neonatal mice.

226 In the spinal cord of patients with ALS, but not Con, AD or CJD

227 cal changes also occur at every level of the spinal cord of PPT1-deficient (Ppt1(-/-) ) mice before t

228 eposition around demyelinated lesions in the spinal cord of Theiler's murine encephalomyelitis virus-

229 ier in the optic nerve, corpus callosum, and spinal cord of young adult mice or rats.

230 sex difference in the IMS-UPRmt, because the spinal cords of female, but not male, G93A-SOD1 mice sho

231 vent in patients with multifocal or isolated spinal cord or optic neuritis involvement at onset in co

232 s; 81%) was inflammation of meninges, brain, spinal cord, or all 3 (meningoencephalomyelitis).

233 ates the use of lgals-1(-/-) mice to develop spinal cord- or traumatic brain injury models for the ev

234 ted, matured, and integrated into the rodent spinal cords over a time frame that aligned with the nor

235 ncer, deep vein thrombosis, major procedure, spinal cord paralysis, venous injury, lower extremity fr

236 These data show that spinal cord pathology significantly contributes to the c

237 Lumbar spinal cord PET signal was significantly higher in EAE m

238 They are integral to brain and spinal-cord physiology and perform many functions import

239 Dopaminergic modulation of spinal cord plasticity has long been recognized, but cir

240 man reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression

241 Using a novel ex vivo spinal cord preparation, here we identify the functional

242 orsal horn and RVM neurons to uncover an RVM-spinal cord-primary afferent circuit controlling pain th

243 oncept introduces.SIGNIFICANCE STATEMENT The spinal cord provides a reliable final common pathway for

244 We propose that spinal cord regeneration in geckos represents a truncati

245 e deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshol

246 subunits to AMPAR-mediated signaling in the spinal cord remains unclear.

247 subunits to AMPAR-mediated signaling in the spinal cord remains unclear.

248 stiffness properties that are well suited to spinal cord repair by supporting cell growth mechano-bio

249 original, regenerating and fully regenerate spinal cord represent a heterogeneous population.

250 Spinal cord ring-enhancement accompanies one-third of NM

251 detected in cytoplasm of spinal neurons, and spinal cord samples were positive for ZIKV RNA.

252 mRNA was down-regulated in the KO embryonic spinal cord (SC) and kidneys.

253 Here, using cultured spinal cord (SC) neurons grown using a compartmented pla

254 Blockade (NMB) and another undergoing lumbar spinal cord (SC) transection, both serving as controls.

255 In sum, when a new behavior changes the spinal cord, sensory feedback to the brain guides furthe

256 The spinal cord showed architectural distortion, severe neur

257 We utilized ex vivo spinal cord slice cultures (SCSC) to demonstrate that an

258 king of Slack channels also occurs in intact spinal cord slices and that it is carried out by adaptor

259 INs using targeted patch-clamp recording in spinal cord slices from adult transgenic mice that expre

260 In spinal cord slices, clonidine reduced the frequency of c

261 ed current in mouse dorsal horn neurons from spinal cord slices.

262 ed from large lamina I neurons in horizontal spinal cord slices.

263 Repeated pairing of motor cortex and spinal cord stimulation caused lasting increases in evok

264 modulation of cortical evoked potentials by spinal cord stimulation was largest when the spinal elec

265 ology components for injured adult mammalian spinal cord that are different from those involved in no

266 dings suggest that there exists a pathway in spinal cord that ascends from periphery to mesolimbic re

267 re traditionally viewed as the output of the spinal cord that do not influence locomotor rhythmogenes

268 on the mechanisms of axonal guidance in the spinal cord that provide for a discussion of the current

269 ject directly to nuclei in the brainstem and spinal cord that regulate parasympathetic and sympatheti

270 the transcriptome of both the cerebellum and spinal cord that was consistent with glial activation an

271 At the lesion epicenter (mid-thoracic spinal cord), the microenvironment created by CX3CR1(-/-

272 physiological studies about reflexes in the spinal cord, the contribution of mechanosensory feedback

273 In the spinal cord, the expression of other proteins identifies

274 This new variant is undetectable in brain or spinal cord, the only and most abundant known sources of

275 Previous work measures spinal cord thinning in chronic progressive myelopathies

276 Spinal cord tissue from heterozygous (ARQ/VRQ or ARH/ARQ

277 de-dependent TDP-43 aggregates in cortex and spinal cord tissue.

278 iated viral vectors, serotype-9 (scAAV-9) in spinal cord tissues after intraspinal injection of mouse

279 neurons, human cells and C9orf72 ALS patient spinal cord tissues.

280 he central canal of the brain ventricles and spinal cord to circulate the cerebral spinal fluid (CSF)

281 hundred fifty thousand axons emerge from the spinal cord to innervate the human upper limb, of which

282 nomic estrogen signaling within the cervical spinal cord to recover respiratory neuroplasticity in di

283 Renshaw cells (RCs) is disrupted by thoracic spinal cord transection at postnatal day 5 (P5TX).

284 rvivors.SIGNIFICANCE STATEMENT The brain and spinal cord undergo adaptive rewiring ("plasticity") fol

285 By selectively ablating microglia in the spinal cord using a saporin-conjugated antibody to Mac1,

286 Targeting the spinal cord via intrathecal administration of an adeno-a

287 aluated for motor impairment, mortality, and spinal cord viral load.

288 ced paralysis in infected mice and decreased spinal cord viral loads.

289 most completely absent in both the brain and spinal cord when intracranial and intrathecal injections

290 mutant SOD1 protein in the disease-affected spinal cord, where concomitant increases in copper and S

291 significantly increased in the injured mouse spinal cord, where it is predominantly found in astrocyt

292 ing between prefrontal areas, brainstem, and spinal cord, which might represent a flexible mechanism

293 The second derived feature is the very short spinal cord, which terminates midway along the thoracic

294 receptor and cytokine gene expression in the spinal cord, which were normalized by postnatal coloniza

295 that lacked CCR7 were retained in brain and spinal cord while wild type DC migrated to cervical lymp

296 The replacement tail includes a regenerated spinal cord with a simple morphology: an ependymal layer

297 Na](+) adducts was observed in samples from spinal cord with demyelination, while the intensity of t

298 direct and trans-synaptic infection from the spinal cord with rabies viruses that carry glycoproteins

299 form to the circumvolutions of the brain and spinal cord without damaging neural tissues or triggerin

300 ing stimulation of motor cortex and cervical spinal cord would strengthen motor responses through the

301 despite implantation into the injured rodent spinal cord, yet they support delayed functional recover