ライフサイエンスコーパス: striatum

1 ppocampus) and within the same brain region (striatum).

2 nucleus accumbens (but not the dorsolateral striatum).

3 n regions, ranging from 11% (insula) to 14% (striatum).

4 cess (old > new) effects may co-occur in the striatum.

5 location of dopamine cells projecting to the striatum.

6 receptor-expressing efferent pathways of the striatum.

7 lated neural activation in the anteroventral striatum.

8 adaptive coding in the midbrain and ventral striatum.

9 ex and the profit-sensitive region of dorsal striatum.

10 viously unknown function that is enriched in striatum.

11 t DA, both in solution and in the rat dorsal striatum.

12 mygdala, ventromedial prefrontal cortex, and striatum.

13 rotransmitter dysbalance on the level of the striatum.

14 ta (PDGFRbeta)-mediated endocytosis in mouse striatum.

15 diction error (RPE) signaling in the ventral striatum.

16 No differences were found in the striatum.

17 in both the ventral striatum and the dorsal striatum.

18 and adenosine A2A receptor signaling in the striatum.

19 aminergic control from the ventral to dorsal striatum.

20 FosB expression in the prefrontal cortex and striatum.

21 n the ventromedial prefrontal cortex/ventral striatum.

22 is how EAAC1 shapes synaptic function in the striatum.

23 munocytochemistry, and confocal imaging from striatum.

24 regulating dopamine availability/release in striatum.

25 ability was observed for SERT binding in the striatum.

26 ine morphology and phospho-CaMKIIbeta in the striatum.

27 inding at the D2 receptor selectively in the striatum.

28 in specific brain regions such as the dorsal striatum.

29 h is typical for a loss of DA release in the striatum.

30 ic interneurons (ChIs) acting locally in the striatum.

31 minantly to the rostral two-thirds of dorsal striatum.

32 ulation of CINs, contrary to core and dorsal striatum.

33 h the ventromedial prefrontal cortex/ventral striatum.

34 observed in dopaminergic axons in the dorsal striatum.

35 c connections between the cerebellum and the striatum.

36 in the ventral and dorsal territories of the striatum.

37 prefrontal cortex and reward PEs in ventral striatum.

38 ed when GPR88 expression was restored to the striatum.

39 iated with excessive dopamine release in the striatum.

40 he midbrain and dopaminoceptive areas of the striatum.

41 dopamine compared with acetylcholine in the striatum.

42 essed in the olfactory epithelium and in the striatum.

43 ate the connectivity between TPJ and ventral striatum.

44 zation of A2AR-CB1R heteromers in the dorsal striatum.

45 c cortex, while only JJ-3-42 decreased it in striatum.

46 he rat form WM fascicles embedded within the striatum.

47 irst-line treatment (Cohen's d=0.9191 (whole striatum), 0.7781 (associative striatum), 1.0344 (limbic

48 0.9191 (whole striatum), 0.7781 (associative striatum), 1.0344 (limbic striatum), and 1.0189 (sensori

49 assessment of chromatin accessibility in the striatum, a brain region central to reward and emotion.

50 Our findings show that, in the striatum, a brain region implicated with movement execut

51 EAAC1 is abundantly expressed in the striatum, a brain region that is hyperactive in OCD.

52 l-dependent activity was measured in ventral striatum, a dopamine target area known to represent RPEs

53 ed spine density on WD36 in the dorsolateral striatum, a region that is not implicated in incubation

54 Importantly, in dopamine-depleted striatum, a widespread population of iSPNs, which often

55 ABSTRACT: Synaptic plasticity in the striatum adjusts behaviour adaptively during skill learn

56 of the urea transporter SLC14A1 in the OVT73 striatum, along with other important osmotic regulators.

57 Reduced forebrain, hippocampus, striatum, amygdala, and cortical volume were also observ

58 ch observations, we construct a model of the striatum, an all-inhibitory circuit where sequential act

59 ohol increases Fgf2 expression in the dorsal striatum, an effect mediated via dopamine D2-like recept

60 ine biosynthesis genes enriched in the human striatum and absent in the nonhuman African ape neocorte

61 ulvinar input were those that project to the striatum and amygdala (76% responsive) or V1 (55%), wher

62 Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were

63 e the pulvinar also projects directly to the striatum and amygdala, these results establish the pulvi

64 of extrastriate neurons that project to the striatum and amygdala.

65 aking, through interactions with the ventral striatum and amygdala.

66 ms of interval timing that take place in the striatum and are regulated by the amygdala.

67 vated the striatum, specifically the ventral striatum and caudate, striatal nodes implicated in motiv

68 ing dimensions of deep brain structures (the striatum and cerebellum), but not the cerebral cortex.

69 from patients with Huntington disease whose striatum and cerebral cortex develop inclusions associat

70 oform-A and -D is selectively reduced in the striatum and cortex of R6/2 HD mice as well as in the st

71 degenerative disease affecting predominantly striatum and cortex that results in motor and cognitive

72 lly in a number of brain areas-including the striatum and cortex-has been shown to encode elapsed tim

73 specialized brain structures, including the striatum and cortex.

74 oprotein (RNP) complexes in the hippocampus, striatum and cortex.

75 nects with associative regions of cortex and striatum and encodes salience (equal response to wins an

76 ventrolateral prefrontal cortex-sensorimotor striatum and fewer normalized streamlines in the right d

77 ng, molecularly distinct projections through striatum and globus pallidus to EP targets within epitha

78 ctroscopy (MRS) measures of glutamate in the striatum and hippocampus were obtained in the same subje

79 tiple neurons both in distant brain regions (striatum and hippocampus) and within the same brain regi

80 binoid system within the PFC, but not in the striatum and hippocampus, which was associated with enha

81 primary olfactory fibers was observed in the striatum and hypothalamus.

82 dorsolateral prefrontal cortex-sensorimotor striatum and in the left and right ventrolateral prefron

83 ventrolateral prefrontal cortex-associative striatum and left ventrolateral prefrontal cortex-sensor

84 inally reported, including expression in the striatum and medial prefrontal cortex (mPFC), and theref

85 ircuit involving cortical projections to the striatum and midbrain may underlie the striatal dopamine

86 ward-seeking behaviours, such as the ventral striatum and midline thalamus.

87 eas buprenorphine produced increased ventral striatum and motor cortex metabolism in females, and inc

88 large-scale extracellular recordings in the striatum and orbitofrontal cortex of mice that learned t

89 , we performed large-scale recordings in the striatum and orbitofrontal cortex of mice trained on a s

90 ance is mediated by connectivity between the striatum and prefrontal cortex; this connectivity select

91 ces of active control over threat engage the striatum and promote a shift from expression of innate d

92 terms of neurobiological alterations in the striatum and related clinical manifestations (i.e., crav

93 from medial prefrontal cortex to dorsomedial striatum and sensorimotor inputs from motor cortex to do

94 and directed connectivity within and between striatum and six cortical sites in each hemisphere of th

95 metabolism in females, and increased ventral striatum and somatosensory cortex metabolism in males.

96 -cre fate map, express Sox8 in the embryonic striatum and Sox8-EGFP BAC transgenic mice specifically

97 uced phasic dopamine release into the dorsal striatum and speech motor cortex exerts direct modulatio

98 or controls (P < 0.05 for all regions except striatum and thalamus at 1 h after injection).

99 ffected by experimental manipulations of the striatum and the anterior limb of the internal capsule.

100 psy studies have found pathology both in the striatum and the cerebellum, and functional disorganisat

101 is a unique structure that sits between the striatum and the cerebral cortex.

102 on-based infrared microspectroscopy that the striatum and the cortex of patients with Huntington dise

103 was also clearly present in both the ventral striatum and the dorsal striatum.

104 paminergic innervation, including the dorsal striatum and the globus pallidus, were also activated.

105 and elongated structure enclosed between the striatum and the insular cortex, with widespread recipro

106 functional connectivity between the ventral striatum and the medial prefrontal and parietal cortices

107 evealed a lack of tonic GlyR currents in the striatum and the PFC.

108 and parietal cortices and between the dorsal striatum and the somatosensory cortex.

109 ivity between the mid-insula and the ventral striatum and ventral pallidum.

110 d resting cerebral blood flow in the ventral striatum and ventromedial prefrontal cortex.

111 otropic glutamate receptors (mGluRIs) in the striatum and, by doing so, promotes D1 dopamine receptor

112 hallmark of HD is the loss of neurons in the striatum and, to a lesser extent, in the cortex.

113 .7781 (associative striatum), 1.0344 (limbic striatum), and 1.0189 (sensorimotor striatum) in line wi

114 atrophy in anterior cingulate, frontoinsula, striatum, and amygdala, indicating that degeneration of

115 d with dysfunction in the prefrontal cortex, striatum, and amygdala.

116 the ventromedial prefrontal cortex, ventral striatum, and other structures implicated in decision ma

117 course through a subcortical structure, the striatum, and share important organization principles wi

118 a major role for nigrostriatal dopamine, the striatum, and the external globus pallidus (GPe) in regu

119 p.) restricted these increases to the dorsal striatum, and the latter effect was blocked by the dopam

120 neurons in the nucleus accumbens and dorsal striatum, and their function in relation to stress and d

121 adaptive coding in both midbrain and ventral striatum, and was associated with a decrease in performa

122 s themselves; glutamatergic afferents to the striatum; and one of two dopamine-receptor-expressing ef

123 crossover study of DBS targeting the ventral striatum/anterior limb of the internal capsule (VS/ALIC)

124 subset of neural circuits within the dorsal striatum are preferentially vulnerable to HIV-1.SIGNIFIC

125 l cortical areas and the motor region of the striatum as a putative substrate for the observed behavi

126 dopamine release from multiple sites in the striatum as induced by behavioral performance and reward

127 ections into the IC and amygdala plus corpus striatum as well into the IC and auditory cortex did not

128 they place the caudate nucleus of the dorsal striatum at the center of the neural stimulus-control le

129 nk task, we tested the idea that the ventral striatum, because of its ability to modulate cortical in

130 modulate the impact of cortical input to the striatum between the direct and indirect pathways of the

131 creased serotonin transporter binding in the striatum, brainstem, and hypothalamus, possibly reflecti

132 extracellular dopamine levels in the dorsal striatum but lower levels in the mPFC; a pattern with si

133 lly and contain projections, not only to the striatum, but also to the thalamus and brainstem.

134 replicated by oxotremorine infusion into the striatum, but not into the cerebellum, indicating that d

135 , we used a common framework implicating the striatum, but not other parts of the mesolimbic system,

136 The highest average ICC values were in the striatum, but other regions were sensitive to measuremen

137 estingly, boosting dopamine signaling in the striatum by acute cocaine administration reveals that ab

138 f prediction error processing in the ventral striatum by the prefrontal cortex.

139 as voxel-based methods in both the DAT-rich striatum (caudate nucleus and putamen) and the SERT-rich

140 ease in viability upon implantation into rat striatum compared to neurons generated on 2D, consistent

141 on showed decreased activation in the dorsal striatum compared with healthy control individuals.

142 me sequencing of the postmortem human dorsal striatum comparing bipolar (18) and control (17) subject

143 ermine the extent of the association between striatum connectivity and individual differences in food

144 Dorsal striatum connectivity correlated with food craving and p

145 Particularly, the weaker intra-striatum connectivity was positively correlated with str

146 fort expectations were integrated in ventral striatum, consistent with a computation of an overall ne

147 that, although both areas encoded time, the striatum consistently outperformed the orbitofrontal cor

148 nding of D1 receptors and DAT throughout the striatum correlated negatively with age (D1 receptor: R(

149 Lower dopamine release in the associative striatum correlated with inattention and negative sympto

150 uggests that stress favors more rigid dorsal striatum-dependent habit memory, at the expense of flexi

151 Here, we studied the role of dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this in

152 Dorsal lateral striatum (DLS) is a highly associative structure that en

153 ministration had on firing in dorsal lateral striatum (DLS), a brain area known to be involved in hab

154 compartments restricted to the dorsolateral striatum (DLS), where less dopamine release was measured

155 hemic stroke was induced in the dorsolateral striatum (DLS).

156 The dorsomedial striatum (DMS) and midbrain areas of the nigrostriatal c

157 dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this incubation.

158 d Fgf2 expression selectively in dorsomedial striatum (DMS) of both mice and rats.

159 The dorsomedial striatum (DMS), a brain region critically involved in ad

160 hat associated changes include lower ventral striatum dopamine activity and lower cocaine operant sel

161 ate, orbitofrontal cortex, thalamus, ventral striatum, dorsal putamen, and anterior cingulate cortex.

162 shell (NAc(core) and NAc(shell)), and dorsal striatum (DS) following cocaine conditioning and EXT in

163 on errors; blunted activation of the ventral striatum during reward anticipation; blunted autonomic r

164 nvironment interactions were seen in ventral striatum during smoking abstinence when subjects perform

165 D2-MSNs), one of the major cell types in the striatum, during a food-seeking discrimination task.

166 inputs from ventral tegmental area (VTA) to striatum encode reward prediction errors and reinforce s

167 EADD-mediated inhibition of the dorsolateral striatum enhanced response-outcome conditioning, also in

168 verged to suggest early dysregulation in the striatum, especially in the rostral caudate, manifesting

169 etion males show increased activation in the striatum for ERK1, both at baseline and in response to s

170 Aberrant ventral striatum functional connectivity specifically predicts f

171 Here, we examined whether the ventral striatum, given its ability to modulate cortical informa

172 metabolic levodopa responses was seen in the striatum/globus pallidus (GP) of the lesioned hemisphere

173 e of this amygdala-CEA-DA neuron path to the striatum has been poorly characterized in primates.

174 els in the cortex (Hedge's g= 1.33, P<0.01), striatum (Hedge's g=0.57, P<0.05) and the nucleus accumb

175 from four brain regions (prefrontal cortex, striatum, hippocampus and cerebellum) from 41 schizophre

176 and endocannabinoid receptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabin

177 acity in the dorsal and ventral parts of the striatum in 13 pathological gamblers and 15 healthy cont

178 ventrolateral prefrontal cortex-sensorimotor striatum in chronic schizophrenia patients.

179 o examine the functional connectivity of the striatum in excess-weight versus normal-weight subjects

180 findings suggest a differential role for the striatum in human active avoidance versus extinction lea

181 ion of dopaminergic terminals throughout the striatum in individuals with Lewy body disease, and sero

182 ojections to the nucleus accumbens or dorsal striatum in mice.

183 jects to the basolateral amygdala and dorsal striatum in mice.

184 orsal putamen, and 17% higher in the ventral striatum in pathological gamblers compared with control

185 (limbic striatum), and 1.0189 (sensorimotor striatum) in line with the hypothesis that the dopaminer

186 nes located within the 16p11.2 region in the striatum, including the kinase extracellular-signal rela

187 rd the lesioned hemisphere (in particular to striatum) increased, most prominently during walking.

188 ion of recombinant FGF2 into the dorsomedial striatum increases alcohol consumption, whereas inhibiti

189 bcortical and cortical regions including the striatum, insula, lateral prefrontal cortex and anterior

190 mine neuron synaptic actions vary across the striatum, involving variations not only in dopamine rele

191 The striatum is a central part of the dopaminergic mesolimbi

192 The striatum is anatomically and behaviorally implicated in

193 The striatum is anatomically and functionally well placed to

194 IFICANCE STATEMENT: More than 90% of ventral striatum is composed of two cell types, those expressing

195 c regulation of dopaminergic inputs into the striatum is critical for normal basal ganglia (BG) funct

196 whether there are sex differences in how the striatum is impacted by genetic risk factors linked to n

197 We propose that GPR88 expression within the striatum is integral to efficient action-selection durin

198 the HD mutation to massive cell death in the striatum is the ability to characterize the subtle and e

199 The striatum is the major component of the basal ganglia and

200 Antagonism of D2R signaling in the striatum is thought to be the primary mode of action of

201 ion in the nucleus accumbens core and dorsal striatum, is also minimal in the shell in part due to el

202 interneurons are relatively scarce in rodent striatum, little is known about their molecular and othe

203 Months-long recordings from motor cortex and striatum made and analyzed with our system revealed rema

204 receptor 2 and adenosine receptor 2a in the striatum, markers of medium spiny neurons signaling via

205 Furthermore, value representations in the striatum may be inherited, to some extent, from the amyg

206 These results suggest that the ventral striatum may be part of a subcortical network that influ

207 hroughout multiple brain areas, but that the striatum may have a privileged role in timing because it

208 The striatum may, therefore, play less of a primary role in

209 rikarya were seen in the olfactory tubercle, striatum, medial septal nucleus, vertical and horizontal

210 characteristic of gene expression in dorsal striatum medium spiny neurons-unlike most other modules,

211 berrant, increased activation of the ventral striatum, midbrain, and other limbic regions for neutral

212 m rewards; blunted activation of the ventral striatum, midbrain, and other limbic regions for rewards

213 an/parafascicular thalalmic nucleus (PF) and striatum might underlie such deficits.

214 dorsolateral prefrontal cortex-sensorimotor striatum negatively correlated with Trail-Making Test, P

215 o demonstrate a critical role of dorsomedial striatum neuronal ensembles in this new form of incubati

216 Increased left ventral striatum node strength predicted increased risk for futu

217 The ventral striatum (nucleus accumbens) and its role in mood, rewar

218 er, no study examined Slc6a15 in the ventral striatum [nucleus accumbens (NAc)] in depression.

219 ted pathology was observed in the cortex and striatum of all cases studied.

220 late cortex and confirmed in blocks from the striatum of cases with dementia with Lewy bodies.

221 een D1 and D2 receptor binding in the dorsal striatum of control subjects (R(2)=0.31, p<0.05) that wa

222 s, we recorded unit activities in the dorsal striatum of dopamine-intact and dopamine-depleted rats d

223 and cortex of R6/2 HD mice as well as in the striatum of HD patients.

224 y, injection of astrocytic exosomes into the striatum of HD140Q KI mice reduces the density of mHtt a

225 epigenetic impairments were detected in the striatum of heroin self-administering rats.

226 7 glioblastoma cells were implanted into the striatum of immunodeficient RNU rats.

227 this mode to activate dorsal versus ventral striatum of individual mice and reveal different effects

228 dose- and age-dependent manner in cortex and striatum of mice.

229 es was oxytocin in the NAc and CARTpt in the striatum of SR rats.

230 While the striatum of the grafted Huntington's disease patient rev

231 tors as well as loss of PDE10A enzyme in the striatum of zQ175 mice as compared with WT animals, in a

232 regulated in prefrontal cortex (PFC) but not striatum or hippocampus where CK2alpha is also ablated.

233 cal or biochemical evidence of injury in the striatum or prefrontal cortex, respectively.

234 ion of the thalamus (P = 0.0003), and in the striatum (P = 0.0042).

235 CD had significantly lower DeltaBPND in the striatum (P=0.002, effect size (ES)=1.48), including the

236 t size (ES)=1.48), including the associative striatum (P=0.003, ES=1.39), sensorimotor striatum (P=0.

237 ve striatum (P=0.003, ES=1.39), sensorimotor striatum (P=0.003, ES=1.41) and the pallidus (P=0.012, E

238 trolled neurons in the posterior dorsomedial striatum (pDMS) are critical for interlacing new and exi

239 ptor ([(3)H]sulpiride) binding in the dorsal striatum postmortem from matched suicides and controls.

240 l regions of the adolescent mouse forebrain (striatum, prefrontal cortex, hippocampus, amygdala, and

241 (DA) decline affecting neural processing in striatum, prefrontal cortex, or both.

242 ubregional DGLalpha deletion from the dorsal striatum produced deficits in social interaction, wherea

243 The striatum receives segregated and integrative white matte

244 opamine during electrical stimulation of the striatum region.

245 ining the functions of ERK/MAPK signaling in striatum-related neurophysiology and behavior is lacking

246 w value is represented and maintained in the striatum remains unclear since decision-making in these

247 teraction, whereas deletion from the ventral striatum resulted in repetitive grooming.

248 vely correlated with striatal atrophy, while striatum-retrosplenial cortex connectivity is negatively

249 In the primate striatum, Scgn co-expression also identified a topograph

250 nucleus accumbens core, but not dorsolateral striatum, selectively reduced cue-controlled sucrose see

251 The striatum shapes the activity of the CSTC pathway through

252 the function of dopamine transporters in the striatum.SIGNIFICANCE STATEMENT Delivery of ectopic glia

253 -down control of cognitive processing in the striatum.SIGNIFICANCE STATEMENT The ability to guide act

254 c rat temperatures in the rectum, cortex and striatum significantly (P < 0.01) faster than hypothermi

255 reward-network nodes, only the left ventral striatum significantly predicted depression.

256 jects showed increased activation of ventral striatum specifically for cues predicting erotic picture

257 mily types, coparental stimuli activated the striatum, specifically the ventral striatum and caudate,

258 synaptic compartment of cerebral cortex and striatum strongly supports our approach for accurately o

259 on errors correlate with activity in ventral striatum/subgenual anterior cingulate cortex, while upda

260 dorsal anterior cingulate cortex and ventral striatum, such that the normal (vs. slow) genotype indiv

261 sphorylated to a high basal stoichiometry in striatum, suggestive of basal inhibition of PP2A in stri

262 rewarding behavior and motor actions through striatum-targeting efferents from ventral tegmental area

263 ndent activity patterns of the vmPFC and the striatum that coexist with value signals.

264 in the forebrain was observed in the dorsal striatum that is not traditionally associated with VTA d

265 sduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransm

266 minergic input to the brain, projects to the striatum (the primary locus of action for antipsychotic

267 d number of glia is normal in B6.Htt(Q111/+) striatum, the most vulnerable brain region in HD, up to

268 The striatum then encodes value representations that drive d

269 project via the nigrostriatal pathway to the striatum to regulate voluntary movement.

270 functional connectivity of bilateral ventral striatum to right anterior ventromedial subthalamic nucl

271 hat dopamine axons continue to grow from the striatum to the PFC during adolescence.

272 'VS dopamine') and the posterior tail of the striatum ('TS dopamine').

273 anterior limb of the ventral capsule/ventral striatum (VC/VS).

274 nally, we used transcriptome analysis of the striatum via messenger RNA sequencing to identify the pr

275 -of-function of D2-MSNs within ventrolateral striatum (VLS) is sufficient to reduce goal-directed beh

276 The ventral striatum (VS) is a key brain center regulating reward-or

277 performance of rhesus macaques with ventral striatum (VS) lesions on a two-arm bandit task that had

278 Reinforcement learning models of the ventral striatum (VS) often assume that it maintains an estimate

279 We focused on the ventral striatum (VS), due to its association with incentive mot

280 ctivation of presynaptic KORs in the ventral striatum (VS).

281 mics in dopamine axon signals in the ventral striatum ('VS dopamine') and the posterior tail of the s

282 ) recorded from the human and rodent ventral striatum (vStr) exhibit prominent, behaviorally relevant

283 bic areas.SIGNIFICANCE STATEMENT The ventral striatum (vStr) is an area of anatomical convergence in

284 At 6 mo of age, the BPND in the striatum was lower in zQ175 than WT animals by 40% for (

285 tor inputs from motor cortex to dorsolateral striatum, we show that associative and sensorimotor inpu

286 t and the nucleus accumbens (NAc) and dorsal striatum were collected to measure gene expression with

287 Functional connectivity maps of the striatum were generated and examined in relation to DUP

288 responses, connected more strongly with the striatum when subjects successfully overrode the decoy e

289 In the striatum, where D2 receptors are abundant, antipsychotic

290 he frontoparietal control network and dorsal striatum, whereas default mode regions depicted increase

291 n showed increased activation in the ventral striatum, whereas individuals with gambling addiction sh

292 r reduction of D1, D2, and 5-HT2ABPND in the striatum, whereas PDE10A reached a plateau.

293 erations in synaptic transmission within the striatum, which has key roles in controlling actions and

294 the well established role of dopamine in the striatum, which is known to redistribute cortical input

295 ocaine challenge induced WAVE1 activation in striatum, which was assessed by dephosphorylation.

296 iation of TSPO levels in the hippocampus and striatum with alcohol dependence severity (P<0.035).

297 crosstalk between the hippocampus and dorsal striatum with the amygdala, a key structure in emotional

298 nds to both D1- and D2-type receptors in the striatum, with downstream effects on cortical activity.

299 o as neurochemically identified zones in the striatum, yet technical hurdles have hampered the study

300 ucleus located between the neocortex and the striatum, yet the functions of corticoclaustral and clau