ライフサイエンスコーパス: switch

1 liquid gating, thereby forming a nonvolatile switch.

2 st density dependence to the lytic-lysogenic switch.

3 es during reversals akin to a spatial toggle switch.

4 had a manic switch or was hospitalized for a switch.

5 genesis or to trigger the tumoral angiogenic switch.

6 rol group and were completely resolved after switch.

7 f IF2 drive and regulate this conformational switch.

8 ructure of the prism faces accounts for this switch.

9 the role of miR-125a-5p in VSMCs phenotypic switch.

10 rain inputs activating the MLR like a dimmer switch.

11 inetics and energetics of the conformational switch.

12 rom increased cognitive load during language switches.

13 mental speed limit of the current electronic switches.

14 and subsequent bypass by error-free template switching.

15 es similarly to many types of effortful task switching.

16 ng logic gates through incoherent spintronic switching.

17 s to control food-regulated behavioral state switching.

18 mammals, enabling damage bypass by template switching.

19 which undergoes solvent-triggered tautomeric switching.

20 which revealed multiple episodes of capsular switching.

21 eries have suggested beneficial effects from switching.

22 switch, and then we discuss how this toggle switch accounts for the abrupt and irreversible nature o

23 atically revealed the behaviours of a toggle switch across scales from single-cell dynamics to popula

24 Ampaphos ligand triggers a regioselectivity switch, allowing both linear and branched isomers to be

25 the complex form, a conformation for domain switching, allows FIN219 to switch to its high-affinity

26 Protein switching also reshapes intrachromatin contacts to give

27 inding and single cell-based flagellar motor switching analyses.

28 evaluated clinical benefit from early taxane switch and circulating tumor cell (CTC) biomarkers to in

29 The structural basis of the switch and many of the pathways that RAS controls are we

30 accuracy of task-related information between switch and repeat trials.

31 Finally, vectors were switched and systemically administered to the reciprocal

32 points in the time-series, characterize the switches and filter the results with user input paramete

33 oelectronic applications such as NIR optical switches and photovoltaic devices.

34 g to rare intermittent forcing that precedes switching and bursting phenomena.

35 ential for active optics such as all-optical switching and light modulation.

36 ities such as thermal rectification, thermal switching and thermal cloaking.

37 o signals in the manner of a bistable toggle switch, and then we discuss how this toggle switch accou

38 ublications indicating problems with generic switches, and complaints to the US Food and Drug Adminis

39 led to the design and synthesis of shuttles, switches, and machines at the nanoscale.

40 evolutionary implications of symbiont gains, switches, and replacements, and identify future research

41 onal single-molecule devices such as diodes, switches, and wires are well studied, complex single-mol

42 ors, different modalities and definitions of switching, and available literature and recommendations

43 specific GC B cells, and high-affinity class-switched antibody production.

44 We further identified a role of APA in switching Araf protein isoforms during microglia activat

45 ayed accumulation of virus-specific, isotype-switched ASC requires CD19-dependent GC formation in CLN

46 he next generation of on-chip modulators and switches at THz frequencies.

47 t 3 weeks after the arrhythmic hamsters were switched back to ad libitum feeding.

48 This prey switching behavior attenuated an iconic predator-prey in

49 ith predefined qualitative features, such as switching behaviour, bistability or oscillations.

50 ich are Cdc42, Rac1, and RhoA, are molecular switches best known for regulating the actin cytoskeleto

51 w a polymer composed of a single protein can switch between different supercoiled states with high co

52 totrophs such as Rhodobacter sphaeroides can switch between heterotrophic and photosynthetic growth.

53 The dynamic polymer can reversibly switch between its "liquid" and "solid" properties in re

54 A strain with the ability to switch between multiple capsules was more competitive th

55 The ability of RbmA to switch between open and closed states is important for V

56 a as a major neural substrate regulating the switch between positive and negative affective states, w

57 The inability to switch between the oxidation of lipid and carbohydrate a

58 vations show that the N terminus affords the switch between transport modes.

59 tivation is not analogous to a simple binary switch between two defined conformations, but the activa

60 ean network modelling identifies a mandatory switch between two stable states (stem and differentiate

61 al sensorimotor area while monkeys naturally switched between exploring and exploiting rewarding opti

62 a result, 45%, 49%, and 50% of all subjects switched between tertiles of sodium intake when the 1-,

63 with intestinal bacteria in mice undergoing switches between high-fat, high-sugar (HFHSD) and low-fa

64 food availability controls behavioral state switching between active (roaming) and sedentary (dwelli

65 At the group level, switching between active and passive modes is uncorrelat

66 ultiplexed cell culture system, we find that switching between certain combinations of antibiotics co

67 Our results also suggest how switching between different harmonin isoforms can regula

68 k agents, characterized by a higher level of switching between different social activities than expec

69 vidual colicinogenic cells showed stochastic switching between expressers and non-expressers.

70 FC temporal similarity together with altered switching between FC states.

71 available literature and recommendations for switching between P2Y12 inhibitors.

72 geometries during the lifetime of a complex, switching between states of opposing prochirality in the

73 are approximately a factor of 10 different, switching between the different images modes may be done

74 Switching between these metabolic modes requires a rapid

75 beads at low stiffness of restraint revealed switching between two states: frictional coupling to ret

76 first implements the G-quadruplex structure-switching biosensing principle in graphene nanoelectroni

77 An unprecedented solvent-directed "switch" both in helical pattern and handedness was obser

78 tion vectors decorrelated rapidly after each switch, but did not develop anticorrelated firing patter

79 APA site usage frequencies of 42 genes were switched by auxin, suggesting that auxin affects the cho

80 method to predict potential phosphorylation switches by mapping phosphorylation sites to protein-pro

81 fectors YAP/TAZ act as on-off mechanosensing switches by sensing modifications in extracellular matri

82 imer in which a metal-induced conformational switch can occur independently in the two monomers.

83 This optically induced charge switching can lead to charge-state fluctuations but can

84 LVD switched cardiac MSCs toward an inflammatory phenotype,

85 gle CLCb-expressing NSCLC cells, as well as "switched" cells that predominantly express CLCb, exhibit

86 ng the filament to the atomic scale, current switching characteristics are observed that are distinct

87 Multiple cycles of switching, controllable in real time, are possible.

88 hway that involves ERF74 acting as an on-off switch controlling an RbohD-dependent mechanism in respo

89 e the prefrontal cortex or elicit behavioral switch costs.

90 facilities within two weeks of the national switch date, removing any tOPV vials found.

91 tatory-to-inhibitory gamma-aminobutyric acid switch; defects in this switch have been unequivocally l

92 Patchy switching describes a change in the state of a network w

93 In production, voluntary switching did not engage the prefrontal cortex or elicit

94 control regions, whereas natural, voluntary switching did not.

95 Persistent currents in non-molecular rings switch direction as a function of the magnetic flux pass

96 are clearly observed when the magnetization switches direction in the GaMnAs layer, but are negligib

97 versely, we observed a myogenic-to-lipogenic switch during fibrosis resolution.

98 We compared the effect of switching efavirenz (EFV) to raltegravir (RAL) on hepati

99 ates deletional CSR and inhibits inversional switching events remains unknown.

100 resents a multistable, epigenetic anatomical switch: experimental reversals of bioelectric state rese

101 orectal cancer cells, as well as a metabolic switch favoring glutamine consumption through IGF1 recep

102 /- 220 mum at baseline to 419 +/- 212 mum at switch follow-up (p = 0.86), but decreased significantly

103 It utilizes an sxRNA switch for detection of miRNA-mRNA interactions combined

104 rent EPFs, thus functioning as a specificity switch for the regulation of the activities of ERfs.

105 te that distinct MMPs might act as molecular switches for specific types of LTP.

106 denced by reduced T-cell proliferation and a switch from a Th1 to a Th2 phenotype.

107 c chemostat cultures to demonstrate that the switch from aerobic to anaerobic metabolism is brought a

108 secreted by BM stromal cells and involved a switch from BCL2 to BCLXL-dependent cell survival.

109 ons are predisposed to an activity-dependent switch from GABA-mediated inhibition to excitation.

110 rator-activated receptor signaling-dependent switch from glycolysis to fatty acid oxidation.

111 n ring aromaticity/antiaromaticity, with the switch from ground-state singlet ions to triplet-favored

112 also be the result of an age-related subunit switch from high affinity beta2-containing nAChRs to low

113 s whereby IL-13Ralpha2 serves as a molecular switch from invasion to proliferation, and suggest that

114 Previous studies suggested that the KSHV switch from latency to lytic replication is primarily co

115 nges of reconfiguring the system fluidics to switch from one probe to another.

116 liest stages of plant development and on the switch from pluripotency to differentiation in different

117 lates STAT3 and TBK1 signaling, triggering a switch from proinflammatory to anti-inflammatory respons

118 he authors show that beta-cells in zebrafish switch from proliferative to functional states with incr

119 ntrosome and somal migration, as well as the switch from tangential to radial migration.

120 role in biofilm development by enabling the switch from the planktonic to the biofilm mode of growth

121 In many ways, the experience with the global switch from trivalent OPV (tOPV) to bivalent OPV (bOPV)

122 n stimulus, the tweezers can be mechanically switched from an open "W"-shaped conformation to a close

123 harmful nanoparticles by a third, as drivers switched from ethanol to cheaper gasoline, showing a ben

124 to sleep in a manner that is known to cause switches from depression to mania.

125 lates movement initiation and execution, and switches from one state to another.

126 ctivity, an increase in current density when switching from a Ca(2+)-containing solution to a divalen

127 Switching from bevacizumab to either aflibercept, or ran

128 n adenine dinucleotide(FAD), and prompts VVD switching from Dark state to Light state with significan

129 o CPPase, with product selectivity gradually switching from FPP to GPP, until replacement of the fina

130 We aimed to assess glycaemic outcomes when switching from multiple daily injections (MDI) to CSII i

131 ctance difference of 7.3 is observed for the switching from the highest conducting state to second-hi

132 Switching from the standard Xpert cartridge to the Xpert

133 s therapeutic targets due to their molecular switch function in turning gene expression on or off and

134 lso show that optix simultaneously acts as a switch gene for blue structural iridescence in some butt

135 embrane-bound glycolytic enzymes and in turn switches glucose flux towards glycolysis relative to the

136 ring enzyme 1alpha (IRE1alpha) as a critical switch governing M1-M2 macrophage polarization and energ

137 Genotyping suggests that capsular switching has occurred between MDR vaccine serotypes bel

138 ht, so-called all-optical helicity dependent switching, has renewed interest in the physics that gove

139 ma-aminobutyric acid switch; defects in this switch have been unequivocally linked to diseases such a

140 All-optical switches have been considered as a promising solution to

141 The three-way junction and the P1 switch helix of the two apo conformers are notably diffe

142 Unexpectedly, the switch I mutations had only modest effects on GTP bindin

143 In an attempt to rationalize this switch in absolute configuration an investigation of the

144 ults suggests that UBP684 binding may induce switch in conformation similar to glutamate LBD locked s

145 reporter to directly monitor the phenotypic switch in drug-resistant bacteria with temporal resoluti

146 This dramatic switch in favored electronic states can be ascribed to c

147 1 proteins of S. pyogenes show a dichotomous switch in ligand binding between human tissue and blood

148 anges in axonal projection morphology, and a switch in neuronal function.

149 yte-enriched microRNA-211, a known metabolic switch in nonpigmented melanoma cells, was severely down

150 f, soft, or suspension, induced a phenotypic switch in prostate cancer cells via mechanotransduction.

151 ch a mechanotransduction-mediated phenotypic switch in prostate cancer cells was accompanied by decre

152 that this modification leads to a phenotypic switch in the bacterial colonizers.

153 ence, dopamine signalling mediates an energy switch in the mushroom body that controls long-term memo

154 ed supernatant fluid can reproduce the EndMT switch in vitro.

155 for detecting significant transcript isoform switches in time-series data.

156 n, permitting the optimization of azobenzene switching in new as well as indirect ways.

157 ferroelectric polarization and polarization switching in prototypical BaTiO3 of tetragonal symmetry.

158 Switching in the Saccharomycotina originated in the comm

159 This intermediate filament subtype switching induced dysregulation of the actin cytoskeleto

160 r invariant natural killer T (iNKT) cells in switching inflammation to tissue repair in an interlukin

161 odel of aromatic amino acid side chains) can switch inherent dynamical tendencies for competing modes

162 This switch involves production of either the anti-migratory

163 ur theoretical calculations suggest that the switch is due to the change in the energy level alignmen

164 This hypersensitive regulatory switch is entirely dependent on the unique flexibility a

165 This switch is rate-limiting for deubiquitination and strongl

166 Each switch is turned on and off sequentially to distribute a

167 Moisture-powered potential switching is achieved by establishing ion channels and a

168 Orientation switching is long-time stable and can be induced by appl

169 Full laser switching is performed by electrostatic gating of the me

170 language sentences ("Find the dog!") than in switched-language sentences ("Find the chien!").

171 k, operating on a longer time scale, changes switch-like behavior into oscillations having a period o

172 Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ ne

173 S, which leads to bistability and allows for switch-like responses to inputs, is nested within a nega

174 The functionally important switch loop of the trimeric multidrug transporter AcrB s

175 een in topologically associating domains, as switching markedly favors local (short-range) contacts o

176 tes an unanticipated lagging-strand template-switch mechanism during replication.

177 We describe a switching mechanism that senses proton binding by marked

178 controls revealed that frequencies of class-switched memory B cells were increased in the patients,

179 These methods reveal that conformational switches modulate normal and abnormal information transf

180 of a gene regulatory network and of a toggle-switch network.

181 Most switches occurred within the first 5 weeks of treatment.

182 n different states and that a conformational switch of aromatic side-chains fine-tunes sequence speci

183 ing a neuronal proliferation/differentiation switch of ID-bHLH factors.

184 st that, by regulating DCC, miR-218 may be a switch of susceptibility versus resilience to stress-rel

185 tients with compartmental samples, whereas a switch of the major HCMV population was observed in 6 in

186 An induced switch of the T reg cell TCR repertoire to a random repe

187 significant expansion, retention, and class-switching of autoreactive B cells in GCs under condition

188 Thus, thermally induced conformational switching of benenodin-1 may also be relevant to the bio

189 With this "Gel-PTH", we demonstrate switching of controlled radical polymerization reactions

190 This new concept of switching of excited-state configuration should pave the

191 Recent observations of switching of magnetic domains in ferromagnetic metals by

192 dal analysis leads to discovery of a general switching of polyhedral distortions at symmetry-disallow

193 sequence-specific oligomer synthesis and the switching of product chirality, a photo-responsive host

194 system genes in the same operon ensures that switching of tetrapyrrole metabolism toward bacteriochlo

195 ed and reduced states, leading to reversible switching of the DNA conductance between two discrete le

196 In addition, a 'twin toggle switch' of Phe200(3.36) and Trp356(6.48) (superscripts d

197 When <10 rewarded trials separated goal switches, OFC population vectors decorrelated rapidly af

198 alpha-methylisoserine-derived sulfamidates, switching off and on the nucleophilic ring-opening in a

199 uminescence would be better interpreted as a switching off of the promoter, or where an increase in b

200 d (2) switching on the expression of PYY and switching off the expression of certain other hormones i

201 st importantly, the computational ability to switch on and off hydrogen bonds permitted us to identif

202 ntiating into enteroendocrine cells, and (2) switching on the expression of PYY and switching off the

203 cular smooth muscle cells (VSMCs) phenotypic switch, one of the main events responsible for bare meta

204 lidean lattice in particular, hysteresis and switching only occur in an extremely narrow region of th

205 20% were atrial baffling procedures (atrial switch operation) or 2-stage repairs (pulmonary artery b

206 (pulmonary artery band followed by arterial switch operation).

207 Most (80%) were single-stage arterial switch operations, but 20% were atrial baffling procedur

208 No patient had a manic switch or was hospitalized for a switch.

209 subsets to generate IgE(+) PCs and the class switching pathways involved.

210 TnC, followed by cTnC binding the troponin I switch peptide (TnISW).

211 rces reportedly used in each sampled unit by switch phase.

212 steps of TSIS are to search for the isoform switch points in the time-series, characterize the switc

213 e broken) statistical system and uncover how switching policy affects oscillatory trends and the spee

214 inal dynorphin/KOR signaling, functions as a switch, preventing or promoting, respectively, spinal EM

215 ial anatomy (ie, Fontan palliation or atrial switch procedure).

216 into the kinetics and thermodynamics of the switching process.

217 Neurotransmitter switching produces up or down reversals of behavior.

218 ed to exhibit very clean on/off fluorescence switching properties for polar volatile organic compound

219 The switching properties of the hydrazones in both toluene a

220 16-residue "target region" of the flagellar switch protein, FliM, leads to easily measurable changes

221 at PufQ governs the haem/bacteriochlorophyll switch; pufQ is found within the oxygen-regulated pufQBA

222 Loss of Hippo switches Ras activation from promoting cellular differen

223 een the typical cluster size and the protein switching rate.

224 to two orders of magnitude higher resistance-switching ratio at 300 K, which is attributed to the int

225 ytidine deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutation (SH

226 In B cells, Ig class switch recombination (CSR) is initiated by activation-in

227 nd the somatic hypermutation (SHM) and class switch recombination (CSR) pipeline.

228 We find that AhR negatively regulates class-switch recombination ex vivo by altering activation-indu

229 n NP, and there was evidence for local class switch recombination in NP.

230 rates mimicking the mammalian immunoglobulin switch regions are particularly good AID substrates in v

231 5hmU is enriched in strand switch regions, telomeric regions, and intergenic region

232 resented with increased microhomology use at switched regions.

233 an visual acuity over the 3 months after the switching rules were met, although all patients continue

234 Using these switching rules, we identified a 3-month and a 6-month c

235 y intrachromosomal recombination between two switch (S) regions upstream of each C region gene.

236 o DNA double-strand breaks (DSBs) within IgH switch (S) regions.

237 lobal, or local, pH-dependent conformational switch should be possible.

238 riability in temperature to transduce a fate-switching signal within this biological system.

239 A hierarchical switching state-space model was used to identify transit

240 hybrid transcription factor SS18:SSX alters SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remod

241 Visible-light-responsive reversible color-switching systems are attractive to many applications be

242 Possible solutions including micro-RNA switch technologies that purify target cell types are al

243 Thus, PAI-1 is a molecular switch that controls the cardiac TGF-beta axis and its e

244 plays a key role in controlling a molecular switch that dictates cell fate following exposure to adv

245 Here we identify a lysosomal switch that enhances germline proteostasis before fertil

246 dy reveals a GbetaL-ubiquitination-dependent switch that fine-tunes the dynamic organization and acti

247 rain sites under the control of a PBel(CGRP) switch that is necessary to arouse animals from hypercap

248 The only exception is the AUG to UUG switch that is strongly selected against among start cod

249 mediated dephosphorylation provide a phospho-switch that regulates the cellular activity of ATG4B to

250 angl2-Dvl interaction as a key bi-functional switch that underlies the central logic of PCP signaling

251 rae biofilm formation, as RbmA variants with switches that are locked in either of the two states lea

252 ling elicits context-dependent transcription switches that determine normal development and oncogenes

253 Moriarty et al. now suggest that the pH switching that occurs between different cellular environ

254 der the peak of the gain spectrum curve) and switch the lasing action to another mode.

255 emical (EC) gate voltage to the molecule, we switch the redox group between the oxidized and reduced

256 dimers bind to a myriad of genomic sites and switch the targeted genes on or off with precision.

257 In women (n = 10), intragastric DB switched the origin of phase III contractions from the s

258 c responses are dynamically controllable via switching the folding state of Miura-ori split-ring reso

259 -2, Hbalpha-3.2, and Hbbeta-3.1, effectively switching the predominantly expressed isoforms.

260 ng the participants who met the criteria for switching, the CATT participants were a mean (SD) of 79.

261 nesis to produce astroglia and interneurons, switch their fate and generate granule neurons in mice.

262 ypic plasticity, as they have the ability to switch their functional phenotypes during inflammation a

263 d to a reduced foraging payoff, 49% of birds switched their behavior to a higher-payoff foraging tech

264 al, we demonstrate that matrix degradability switches three-dimensional endothelial cell invasion bet

265 be reinforced by the elevated costs of prey switching, thus promoting the process of resource specia

266 intensity at 355 nm tune the characteristic switching time over several orders of magnitude, from le

267 6 weeks, 1 hospital was randomly assigned to switch to "HEART care," during which physicians calculat

268 in a particular perceptual interpretation or switch to another.

269 Thus, Vasorin acts as a switch to augment Notch signaling under hypoxic conditio

270 Patients who were economically motivated to switch to clopidogrel had (compared with patients who co

271 Flint is located) was directly linked to the switch to corrosive Flint River water from noncorrosive

272 a sialylation, ST6Gal-I acts as a functional switch to divert signaling toward survival.

273 ation for domain switching, allows FIN219 to switch to its high-affinity mode and thereby enhances JA

274 maintenance of KSHV latent infection and the switch to lytic replication.

275 ontinue risperidone for 16 weeks followed by switch to placebo for 16 weeks, or to receive placebo fo

276 yoff information subjects are less likely to switch to pro-cooperative heuristics.

277 atio [HR] 2.6, 95% CI 2.5-2.8; p<0.0001) and switch to second-line ART (HR 5.2, 4.4-6.1; p<0.0001]) c

278 Patients were randomly assigned (2:1) to switch to the open-label study regimen or continue the c

279 set, 2 of 9 (22.2%) ERBB2/HER2-negative BrCa switched to ERBB2/HER2-positive with 1 BrM acquiring ERB

280 of the 35 patients in ACOSOG Z1031B who were switched to neoadjuvant chemotherapy experienced a pCR (

281 lacebo [62%, including early escape patients switched to sirukumab at week 18] of 294; 194 [66%] of 2

282 quality of care improved after the hospitals switched to this integration model.

283 per TB death averted, if standard Xpert were switched to Xpert Ultra.

284 gh affinity while also generating functional switches to drive vectorial cellular processes.

285 We investigated the efficacy and safety of switching to a single-tablet regimen of darunavir, cobic

286 studies have established that a strategy of switching to an aromatase inhibitor after 2 to 3 years o

287 conversion, no association was found between switching to an employment model and improvement in any

288 Switching to dual therapy was associated with a signific

289 falling close to the threshold required for switching to IgE production.

290 INTERPRETATION: Switching to rilpivirine, emtricitabine, and tenofovir a

291 te the efficacy, safety, and tolerability of switching to this regimen compared with remaining on cof

292 t nitrate induces PGC1alpha expression and a switch toward type I and IIa fibers in rat muscle and my

293 mines language control networks' engagement: switching under external constraints heavily recruited p

294 Our results indicate that the benefits of switching virologically suppressed NVP-exposed HIV-infec

295 urther suppress the on-state current and the switching voltage.

296 ents in enhancer regions occurred before the switch was completed, but not after.

297 y networks that control this differentiation switch, we employed a high-throughput microfluidic imagi

298 Both kill switches were shown to maintain functionality in vitro f

299 icular, the C terminus functions as a toggle switch, which affects access of the NADPH substrate to t

300 Moreover, Coop-seq uncovers a nucleotide switch within the POU half-site when spacing is altered,