ライフサイエンスコーパス: systemic

1 nfidence interval [CI], 8.6-15.2; P < 0.001; systemic: 9.0 points; 95% CI, 5.6-12.3; P < 0.001; P = 0

2 3-Acetonyl-3-hydroxyoxindole (AHO) induces systemic acquired resistance (SAR) in Nicotiana.

3 no acid pipecolic acid (Pip) regulates plant systemic acquired resistance and basal immunity to bacte

4 We found that systemic acquired resistance induction in female inflore

5 Systemic administration in mice followed by local light-

6 of sustained weight reduction in response to systemic administration of a long-acting analog of the g

7 As we expected, systemic administration of anti-DC-STAMP-mAb downregulat

8 Systemic administration of CTDP-32476 alone produced a s

9 al phenotypes of ASD, to test the effects of systemic administration of insulin-like growth factor II

10 We find that systemic administration of MS0021570_1 attenuates anxiet

11 in counteracts the behavioral effects of the systemic administration of mu-opioid receptor (MOR) agon

12 Systemic administration of the MIF inhibitor ISO-1 signi

13 Upon systemic administration, exogenous Mn exhibited varying

14 ebo groups, and only grade 1 (mild) local or systemic adverse events occurred in both groups.

15 ected no significant differences in local or systemic adverse events or laboratory abnormalities betw

16 th ECD enabled treatment with a new-targeted systemic agent.

17 assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in chil

18 ucidate how skin barrier defects can lead to systemic allergen sensitization.

19 bination therapy using unmodified myxoma and systemic alphaPD1 antibodies.

20 able region (IGVL) genes among patients with systemic (ALS) and localized (ALL) amyloidosis and to as

21 These results suggest that systemic alterations in enterohepatic circulation, as we

22 kg 6c either simultaneously or 18 h prior to systemic AMPH administration reduced both AMPH-stimulate

23 The human systemic amyloid precursor protein transthyretin (TTR) i

24 diseases, type II diabetes, and a number of systemic amyloidoses.

25 cognized as one of the most common causes of systemic amyloidosis in North America.

26 tic use of this antibody in the treatment of systemic amyloidosis.

27 discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regul

28 ation of nitroglycerin causes changes in the systemic and coronary circulation that combine to reduce

29 Severe Perkinsea infections (SPI) were systemic and led to multiorganic failure and death.

30 e specificities, avidities, and functions of systemic and mucosal immune responses elicited by a vacc

31 These include fibrils associated with systemic and neurodegenerative diseases and cancer, func

32 Systemic and ocular treatment with the TR antagonists NH

33 tance to Plasmodium infections as well as to systemic and oral bacterial infections.

34 ated cirrhosis is characterized by disturbed systemic and splanchnic hemodynamics.

35 This study investigates accuracy of oral, systemic, and socioeconomic data on estimating periodont

36 Combination therapy of ISF35 with systemic anti-PD-1 generates greater antitumor activity

37 Both groups received a course of empirical systemic antibiotics (amoxicillin and clavulanic acid, 3

38 Exposure to systemic antibiotics destabilized the wound microbiota,

39 These results provide a proof of concept of systemic antitumor activity after intratumoral CD40 trig

40 Finally, we demonstrated that systemic application of antibiotics significantly improv

41 ssociation between post-TAVR blood pressure, systemic arterial load, and mortality.

42 enome editing could be applied to many other systemic as well as liver-restricted disorders which are

43 on renders this neutrophil functional defect systemic, associated with an increase in arterial LPS an

44 sease is considered to be a manifestation of systemic atherosclerosis with associated adverse cardiov

45 ith LAR, the potential conversion to AR with systemic atopy and the development of asthma during 10 y

46 Systemic sclerosis is an orphan, systemic autoimmune disease with no FDA-approved treatme

47 A as a novel type I IFN-independent model of systemic autoimmunity and implicate TLR-mediated NF-kapp

48 ines by eliciting local mucosal immunity and systemic B cell- and T cell-mediated memory responses.

49 However, systemic blockade of HCN channels produces cardiac effec

50 a coli cells both ex vivo and in vivo During systemic candidiasis, the absence of alphaXbeta2 resulte

51 Systemic capillary-leak syndrome is a very rare cause of

52 maternal body mass index (BMI) and offspring systemic cardio-metabolic profile are causal, via intrau

53 data suggest that exposure to PAHs may cause systemic changes during pregnancy that could lead to adv

54 erative responses in heart muscle induced by systemic chemical suppression of Wnt signaling.

55 ciation was independent of the use of modern systemic chemotherapy and remained in propensity score a

56 fin photodynamic therapy in combination with systemic chemotherapy therapies and oral corticosteroids

57 atment that includes surgery, radiation, and systemic chemotherapy.

58 to inform decisions on withholding adjuvant systemic chemotherapy.

59 to higher proportions of unconjugated BPA in systemic circulation.

60 mpanied by debilitating neuropsychiatric and systemic comorbidities; and carry a grave risk of mortal

61 ded that SSGA and MSGA, which performed more systemic comparisons and analyses of edge weights and ne

62 1029] vs 23.7% [278 of 1174], P < .001) and systemic complications (24.2% [249 of 1029] vs 31.2% [36

63 he complexity of hepatic responses and their systemic consequences in other organs.

64 Systemic corticosteroid therapy was not significantly as

65 An exacerbation was defined as a burst of systemic corticosteroids lasting 3 days or more.

66 severity does not influence the response to systemic corticosteroids.

67 o inhaled corticosteroids, but responsive to systemic corticosteroids.

68 sthma exacerbations requiring treatment with systemic corticosteroids.

69 Systemic cytokine responses may differentiate ECs from s

70 Systemic defence responses depend on the spread of signa

71 Finally, systemic deletion of Cldn14 completely rescued the hyper

72 Overall, systemic delivery of a bispecific molecule targeting an

73 Here we show that locoregional and systemic delivery of a rAAV2/8 vector expressing a canin

74 In this study, we sought to characterize systemic delivery of a rAAV2/9 vector as a non-invasive

75 Systemic delivery of anti-miR-181b in angiotensin II-inf

76 overexpression in colorectal cancer cells or systemic delivery of the conditioned medium from LOX-ove

77 : reducing acute toxicities that result from systemic diffusion of many soluble adjuvants, and delive

78 e investigated the role of PLA2 in local and systemic disease during S. pneumoniae infection.

79 his chemotherapy agent and allow for reduced systemic doses.

80 ist compound (SC-51322) to AGN 197727 in the systemic dosing regimen.

81 te an in vivo response, specifically whether systemic drug exposure is crucial for in vivo efficacy.

82 ment in a horned beetle species by combining systemic dsx knockdown, high-throughput sequencing of di

83 Interventions that attenuate or reverse systemic dysfunction associated with age therefore have

84 Pharmacodynamic assessment of the systemic effect of inhaled corticosteroids (ICSs) is oft

85 h the role of hepatocyte NAD levels from any systemic effects of NR, we generated mice overexpressing

86 expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in

87 f variable severity with little or no direct systemic effects.

88 reduce the risk of radiation-related adverse systemic effects.

89 k and severity, supporting the hypothesis of systemic elemental dysregulation in ASD.

90 We compared the rates of stroke/systemic embolism at 1 year according to diabetes status

91 ulation therapy for the prevention of stroke/systemic embolism in patients with atrial fibrillation.

92 l effectiveness end point of ischemic stroke/systemic embolism, no significant differences of the NOA

93 e of SCAF in those with a history of stroke, systemic embolism, or transient ischemic attack was 39.4

94 s: in vivo response of neutrophils evoked by systemic endotoxin challenge, the clonal response of leu

95 rates multiple metabolic pathways to warrant systemic energy homeostasis.

96 corticoids (GCs) are important regulators of systemic energy metabolism, and aberrant GC action is li

97 rt here that in rats at 24 h withdrawal from systemic ethanol administration (either by intraperitone

98 Systemic evolution of ligands by exponential enrichment

99 The systemic exposure of the free drug was much lower than t

100 To describe associations of ocular and systemic factors with retinal pigment epithelium (RPE)-B

101 ibited as water was ingested, suggesting pre-systemic feedback gating of drinking.

102 sk of adverse effects, including nephrogenic systemic fibrosis (NSF), the untreatable condition recen

103 None of the neonates developed nephrogenic systemic fibrosis.

104 ctious agents, such as acid-fast bacilli and systemic fungi, were revealed.

105 o investigate the contribution of chymase to systemic GBS infection and rates of preterm birth.

106 ling pathways in skeletal muscle to maintain systemic glucose homeostasis remains largely unexplored.

107 ts hepatic gluconeogenesis without affecting systemic glucose tolerance.

108 Systemic hemodynamics improved after SVR.

109 , rendering them competent to respond to the systemic hormone ecdysone.

110 Currently, systemic hormone replacement for cisgender adults requir

111 ce, displaying an unexpected increase in the systemic IgA responses.

112 esophagitis), suggesting both cutaneous and systemic immune activation.

113 oorer cognitive function, HIV infection, and systemic immune activation.

114 sponse of IL-1R1(-/-) mice did not reflect a systemic immune deficiency, because immunized IL-1R1(-/-

115 e studies demonstrate the critical impact of systemic immune responses that drive tumor rejection.

116 d breaks (DSB), apoptosis, and the local and systemic immune responses.

117 induce pathogen-specific SIgA in addition to systemic immunity achieved by injected vaccines.

118 commensal enteric fungi safeguard local and systemic immunity by providing tonic microbial stimulati

119 ecific immunity, enhance previously existing systemic immunity or re-target responses to the mucosae.

120 ized and nonrandomized studies on therapies (systemic immunomodulating therapies or supportive care)

121 the present study is to examine presence of systemic immunoreactivity to A. actionmycetemcomitans Lt

122 ant-associated materials have a local and/or systemic impact on the peri-implant soft and hard tissue

123 rhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial.

124 However, its systemic inactivation in adult mice induces T-cell acute

125 ), promotes acute pulmonary inflammation and systemic infection after lung challenge with S. pneumoni

126 Intrauterine and systemic infection and inflammation cause 30-40% of spon

127 C57BL/6J mice are extremely susceptible to systemic infection by Salmonella Typhimurium because of

128 Reasons for isolated enterectomy included systemic infection in 11, gastrointestinal bleeding in 1

129 During murine systemic infection, LipA suppresses pro-inflammatory mac

130 g allow us to use the eye as a window to the systemic infection.

131 issue damage in clinical scenarios of severe systemic infection.

132 Systemic infections are mainly with Pneumocystis jirovec

133 hat dietary Mn levels dictate the outcome of systemic infections caused by Staphylococcus aureus, a l

134 lbicans may spread to cause life-threatening systemic infections.

135 rols (n = 50), we measured parasite biomass, systemic inflammation (interleukin 6 [IL-6]), endothelia

136 Systemic inflammation and sarcopenia are easily evaluate

137 tand the effects of psoriasis medications on systemic inflammation associated with cardiovascular ris

138 cyte ratio (NLR) was used as an indicator of systemic inflammation before and after surgery.

139 Links between microbial alterations and systemic inflammation have been demonstrated in chronic

140 d support to a hypothesis implicating global systemic inflammation in HF with preserved ejection frac

141 nously, or per rectum; were on biomarkers of systemic inflammation in humans; and performed meta-anal

142 that plasmodial DNA is the primary driver of systemic inflammation in malaria, both within the phagol

143 hritis model and in IL-1beta- or LPS-induced systemic inflammation in vivo, IL-1R2(-/-) mice were cre

144 Systemic inflammation is increased in patients who devel

145 ecent findings suggest that an overexuberant systemic inflammation plays a primary role in ACLF progr

146 Systemic inflammation through persistent monocyte activa

147 d prior to Il1b detection in the brain, when systemic inflammation was minimal.

148 We statistically link early systemic inflammation with later local increases in infl

149 ng left ventricular and pulmonary pathology, systemic inflammation, and neurohormonal activation.

150 All four had marked systemic inflammation, fever and fluctuating radiologic

151 evidence supports the active involvement of systemic inflammation, in addition to local brain inflam

152 In addition to systemic inflammation, local arterial inflammation, driv

153 on in the early phase after fracture reduced systemic inflammation, the recruitment of immune cells,

154 rate that deregulated necroptosis results in systemic inflammation, tissue fibrosis, and autoimmunity

155 ease in exercise performance observed during systemic inflammation.

156 infection-positive versus infection-negative systemic inflammation.

157 g the effect of prebiotics and synbiotics on systemic inflammation.

158 ficiencies in immune responses and increased systemic inflammation.

159 e actions of these statins on both joint and systemic inflammation.

160 in Apoe (-/-) mice by regulating lesion and systemic inflammation.

161 ted a significant decrease in >/=1 marker of systemic inflammation.

162 Concurrently, systemic inflammatory biomarkers, ex vivo blood tests on

163 contrast, afferent cVN activation amplifies systemic inflammatory processes, leading to activation o

164 Surgery launches a systemic inflammatory reaction that reaches the brain an

165 riteria, score discrimination was lowest for systemic inflammatory response syndrome (median area und

166 prospective identification of patients with systemic inflammatory response syndrome (SIRS) and sepsi

167 troduced quick SOFA (qSOFA), and removed the systemic inflammatory response syndrome (SIRS) criteria

168 The primary outcome was a composite of systemic inflammatory response syndrome and dysfunction

169 Systemic Inflammatory Response Syndrome and quick Sequen

170 psis-related Organ Failure Assessment score, systemic inflammatory response syndrome criteria, the Na

171 der the receiver operating characteristic of Systemic Inflammatory Response Syndrome for critical car

172 ic shock patients (defined: infection, >/= 2 systemic inflammatory response syndrome, and hypoperfusi

173 rotection from mortality in a mouse model of systemic inflammatory response syndrome.

174 Diagnosis is difficult due to the ongoing systemic inflammatory response.

175 ndependently involved in the pathogenesis of systemic inflammatory rheumatoid arthritis (RA) and AD.

176 The data support the emerging idea of a systemic influence to neurological disorders and point t

177 e role of specific cell types in the eye vs. systemic influences (e.g., serum) on the disease patholo

178 lsed focused ultrasound (pFUS) combined with systemic infusion of ultrasound contrast agent microbubb

179 bese dog model, suggesting the importance of systemic inhibition of DGAT1 for body weight control.

180 e of dietary exposure (e.g., via leaves) for systemic insecticides.

181 podocyte-selective injury but more likely by systemic insults, a humanized xenograft model of FSGS re

182 Systemic isotretinoin therapy has achieved nearly comple

183 h, or immediately following the cessation of systemic isotretinoin therapy.

184 laser are not recommended in the setting of systemic isotretinoin treatment.

185 When applied to systemic juvenile idiopathic arthritis (sJIA), an autoin

186 ow that in nitrate-fed mice there is reduced systemic leukocyte rolling and adherence, circulating ne

187 also significantly associated with increased systemic levels of A. actinomycetemcomitans-specific imm

188 with the IgA responses 30-fold greater than systemic levels.

189 Systemic lipopolysaccharide (LPS) is implicated in incre

190 Systemic lupus erythematosus (SLE) is a known risk facto

191 e population-based studies have been done on systemic lupus erythematosus (SLE) mortality trends in t

192 a with greater coagulant effects compared to systemic lupus erythematosus (SLE) non APS IgG.

193 with several autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren's syndrome,

194 d patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE).

195 ic variants are associated with the risk for systemic lupus erythematosus (SLE); however, it is uncle

196 Basophils from patients with systemic lupus erythematosus show an activated phenotype

197 In systemic lupus erythematosus, deposits of IgG-immune com

198 also in a diverse array of diseases such as systemic lupus erythematosus, diabetes, and cancer.

199 re associated with type I diabetes mellitus, systemic lupus erythematosus, RA, and celiac disease, th

200 uss the current and future impact of AMDs on systemic lupus erythematosus, rheumatoid arthritis, and

201 ular involvement, orbital lymphoma, or other systemic lymphoma.

202 deficiency, exhibit a small eye defect, and systemic malformations including hydrocephaly and cardia

203 Patients with systemic mastocytosis (SM) may suffer from mast cell (MC

204 ular understanding of the pathophysiology of systemic mastocytosis have provided new therapeutic cons

205 by a range of modifications to the local and systemic maternal immune system.

206 ysteine therapy, delivered using a targeted, systemic, maternal, dendrimer nanoparticle (DNAC), in a

207 ed understanding of the associations between systemic medication use and intraocular pressure (IOP) i

208 Several systemic medications for low back pain are associated wi

209 ls that reported pain, function, or harms of systemic medications versus placebo or another intervent

210 TLR trafficking and signaling in xenobiotic systemic mercury-induced autoimmunity (HgIA).

211 nnate type 2 immunity, and also to integrate systemic metabolic and thermogenic responses.

212 onship between loss of CB1 in adipocytes and systemic metabolic changes.

213 oluntary) adipose tissue loss as well as its systemic metabolic consequences are far less understood.

214 t takes up and burns lipids and is linked to systemic metabolic homeostasis, we hypothesized that the

215 Therapy with systemic methotrexate did not suffice, as all the patien

216 iRNAs than the wild type and showed enhanced systemic movement of PTGS to grafted shoots.

217 Systemic muscimol or baclofen are antipruritic against b

218 is was considered the most prevalent endemic systemic mycosis in the Americas, but this situation mig

219 Systemic neutrophil depletion was found to render wild-t

220 taneous monitoring of anti-tumor potency and systemic off-tumor toxicity, micromolar affinity CAR T c

221 The effects of systemic or centrally administered orexin receptor (OXR)

222 ion of the epitope specificities, locations (systemic or mucosal), and effector functions of antibodi

223 The aim of this study was to establish if systemic oxidative status in POAG patients was elevated

224 ed energy metabolism, which further leads to systemic oxidative stress and inflammation.

225 bacterial dissemination, and intestinal and systemic pathology of wild-type and CCR7-/- mice were as

226 The use of systemic prednisolone in eyes with vasculitis was associ

227 Furthermore, while both cultivars developed systemic priming of chitosan-induced callose after singl

228 vulnerable populations is representative of systemic problems plaguing the regulation of chemicals i

229 However, systemic processes such as inflammation, as well as cell

230 form of meat allergy characterized by severe systemic reactions 3-7 h after consumption of red meat.

231 at the injection site, and the most frequent systemic reactogenic events were fatigue (29 [43%]), hea

232 Local and systemic reactogenicity was transient and self-limiting.

233 inin (HA) protein substantially affected the systemic replication and pathogenicity of these H5N1 inf

234 This raises the question of the ecosystem's systemic resilience and its ability to rebound after lar

235 creasing current knowledge regarding induced systemic resistance (ISR) to pathogens and pests in whit

236 r iron with soil-borne pathogens or induce a systemic resistance that shares early signaling componen

237 This systemic response was coordinated across tissues and req

238 iew, the long-distance signals implicated in systemic responses to various environmental cues are dis

239 Worsening systemic RV function and tricuspid regurgitation may dev

240 To evaluate the efficacy and ocular and systemic safety of netarsudil 0.02% ophthalmic solution,

241 No ocular or systemic safety signals were observed during the long-te

242 The primary endpoint was ocular and systemic safety, but exploratory data including BCVA, re

243 Here, we review the clinical features of systemic sclerosis and describe the best practice approa

244 Systemic sclerosis is an autoimmune disease characterize

245 Systemic sclerosis is an orphan, systemic autoimmune dis

246 Skin biopsy-derived RNAs from 14 early systemic sclerosis patients and six healthy individuals

247 oding RNAs are deregulated in skin tissue of systemic sclerosis patients suggesting a novel class of

248 y of proteins not previously associated with systemic sclerosis that provide insight into pathogenesi

249 l class of genes involved in pathogenesis of systemic sclerosis.

250 ethylome in primary T cells of patients with systemic sclerosis.

251 the absence of large differences in risk of systemic serious adverse events between these two anti-V

252 the blood-brain-barrier (BBB) and eliminates systemic side effects.

253 e model and that A-SAA could be an important systemic signal of O3 exposure to the CNS.

254 rates, and amino acids, as well as governing systemic signaling networks.

255 typically ambulatory on presentation without systemic signs of infection.

256 Systemic small molecule Gbetagamma-GRK2 inhibition initi

257 and cerebrospinal fluid without evidence of systemic spread.

258 index, smoking, hypertension, diabetes, and systemic steroid use.

259 ory symptoms requiring either antibiotics or systemic steroids, and severe events by the need for hos

260 T is effective in reducing severe subsequent systemic sting reactions and in improving disease-specif

261 -effective in those at high risk of repeated systemic sting reactions and/or impaired quality of life

262 and local treatment or by a therapeutic and systemic strategy, abolished IL-1beta- and GLAST-depende

263 The ability of systemic stress-level corticosterone treatment to potent

264 VHL-related juxtapapillary RCH treated with systemic sunitinib malate.

265 s followed routinely every 4 months while on systemic sunitinib prescribed by her oncologist for meta

266 n and improved muscle strength, suggesting a systemic supply of FKRP protein acting as glycosyltransf

267 Available systemic therapies for CTCL may variably decrease tumor

268 Use of systemic therapies for moderate to severe psoriasis in c

269 As systemic therapies improve, patients with lung cancer li

270 parison with a cohort receiving non-biologic systemic therapies in a propensity score-weighted Cox pr

271 The pipeline of more targeted topical and systemic therapies is expanding based on our growing und

272 linicians when choosing between non-biologic systemic therapies, etanercept, adalimumab, and ustekinu

273 vival, particularly in patients treated with systemic therapies.

274 assessment of tumor response to neoadjuvant systemic therapy (NST) in patients with breast cancer an

275 wed by adjuvant systemic therapy relative to systemic therapy alone for patients with breast cancer l

276 nd stratified according to duration of prior systemic therapy and presence of liver metastases.

277 Purpose Systemic Therapy for Advanced or Metastatic Prostate Can

278 Twenty patients received systemic therapy for widely disseminated disease.

279 ness of liver resection followed by adjuvant systemic therapy relative to systemic therapy alone for

280 ans for treatment (surgery, radiotherapy, or systemic therapy) within 90 d for lung and 180 d for pro

281 estrogen-receptor status, type and timing of systemic therapy, menopausal status, statin use, and tre

282 uable disease, who had not received previous systemic therapy.

283 e NSCLC tumors that had been resected before systemic therapy.

284 teen patients were using a self-administered systemic therapy; 22.4% were classified as "non-adherent

285 clinical studies have in part described this systemic-to-brain signaling pathway, we lack information

286 The safety profile and risk of systemic toxic effects when brimonidine is used topicall

287 ut its use to treat GBM is limited by severe systemic toxicity and inefficient penetration of brain t

288 No systemic toxicity was noted with the expanders and histo

289 ic syndrome and dyslipidemia, while avoiding systemic toxicity.

290 Systemic treatment of rats with 6 mg/kg 6c either simult

291 INTERPRETATION: Regorafenib is the only systemic treatment shown to provide survival benefit in

292 In a proof-of-concept setting systemic treatment with ustekinumab diminished imiquimod

293 e current era, with long-term survival after systemic treatment, there is a need for a timely diagnos

294 mors highlight the need to develop effective systemic treatments for this disease.

295 has changed due to the introduction of novel systemic treatments that can result in long-term surviva

296 l for priming of CD8(+) T cells that mediate systemic tumour rejection (abscopal effect) in the conte

297 may be a surrogate biomarker of cerebral and systemic vascular risk in patients with OSA requiring fu

298 e of clinical complications of pulmonary and systemic vasculopathy, including pulmonary hypertension,

299 sm that controls osmotic water transport and systemic water balance in mammals.

300 so the ability of prosystemin to trigger the systemic wound response in vivo.