ライフサイエンスコーパス: systemic administration

1 val in mice bearing PC micrometastases after systemic administration.

2 ption in a mouse model of visceral pain upon systemic administration.

3 n vivo, and antagonizes KOR in the CNS after systemic administration.

4 tic properties that render it unsuitable for systemic administration.

5 ies without the side effects associated with systemic administration.

6 uired FG7142-induced negative bias following systemic administration.

7 onic stress paradigms in rats within 24 h of systemic administration.

8 d unprecedented uptake by many tissues after systemic administration.

9 signal enhancement in tumor xenografts after systemic administration.

10 ity in mouse lungs and cerebral cortex after systemic administration.

11 inhibitors of HDAC6, brain bioavailable upon systemic administration.

12 mutation Ush1c c.216G > A following a single systemic administration.

13 ator (PAM) that exerts central effects after systemic administration.

14 e shown to cause pulmonary alterations after systemic administration.

15 apeutic payloads to metastatic lesions after systemic administration.

16 by inflammatory toxicities that result upon systemic administration.

17 hieving tumor specific gene expression after systemic administration.

18 cantly reducing local inflammation following systemic administration.

19 cation is limited by potential toxicity from systemic administration.

20 ctivity of drugs with payloads too toxic for systemic administration.

21 more than those reported following repeated systemic administration.

22 -30 min (drug-on) and 5-6 h (drug-off) after systemic administration.

23 ipheral tissues in severe SMA mice following systemic administration.

24 fts in real time after both intracranial and systemic administrations.

25 albumin-binding analog of CpG ODN, following systemic administration 3days after tumor irradiation.

26 After systemic administration, a 2-fold higher transduction in

27 After systemic administration, a 4-fold higher transduction in

28 mpted tumor-targeted delivery of miR-499 via systemic administration and evaluated the potency of thi

29 mouse hippocampi, appears in the brain after systemic administration and increases synaptic plasticit

30 xplored the potential of both inhibitors for systemic administration and performed pharmacokinetic ev

31 For the first time, safe systemic administration and systematic renal clearance w

32 l pain; however, insufficient efficacy after systemic administration and undesired effects preclude t

33 evokes profound antihyperalgesia also after systemic administration, but possible synergistic or ant

34 yma of mice in greater amounts in vivo after systemic administration compared with similar high-avidi

35 he same cancer with chemotherapy drugs after systemic administration due to individual biopharmaceuti

36 Upon systemic administration, exogenous Mn exhibited varying

37 Systemic administration had a more pronounced effect on

38 Systemic administration in mice followed by local light-

39 articles can reach the brain parenchyma from systemic administration in mice through a receptor-media

40 to target prostate carcinoma cells following systemic administration in mouse models.

41 duction and cytolytic activity in vitro Upon systemic administration in vivo, chNKG2D T cells migrate

42 Following systemic administration, laser irradiation enhances depo

43 Additionally, systemic administration may not lead to local drug conce

44 Systemic administration of 1.4 mg kg(-1) of mRNA into mi

45 Both natural fluctuations and systemic administration of 17beta-estradiol (E2) alter s

46 ffects of alcohol was confirmed, as both the systemic administration of 3-Cyano-N-(1,3-diphenyl-1H-py

47 Moreover, systemic administration of a 5-HT6 receptor inverse agon

48 Here, delayed systemic administration of a blood-brain barrier-permeab

49 Altogether, our data show that systemic administration of a brain-penetrant TrkB antago

50 Our study provides first-time evidence that systemic administration of a brain-penetrant TrkB antago

51 Whether repeated systemic administration of a CB2-preferring agonist enga

52 e development of integrated models that link systemic administration of a drug to the probability of

53 Previously, we showed that, systemic administration of a GABA reuptake blocker in ME

54 Subsequent experiments showed that systemic administration of a GABA(B)R antagonist, CGP558

55 Repeated systemic administration of a ghrelin receptor agonist en

56 tion correlated with FOS induction following systemic administration of a GLP-1 receptor agonist, exe

57 Moreover, we have demonstrated that systemic administration of a GLP-1R agonist (liraglutide

58 Systemic administration of a HIF-prolyl hydroxylase inhi

59 of sustained weight reduction in response to systemic administration of a long-acting analog of the g

60 the circulation during EAE induction through systemic administration of a mAb against PC/activated PC

61 After systemic administration of a MET kinase inhibitor, we pr

62 l spermine followed by a seeking test, or 3) systemic administration of a mGluR1 positive allosteric

63 Furthermore, systemic administration of a PKD inhibitor protects d-ga

64 e results of these studies clearly show that systemic administration of a selective NR2B NAM can caus

65 We further show that systemic administration of a single dose of dendrimer-N-

66 Our data suggest that systemic administration of AAT can be a promising therap

67 D from the cardiac troponin-T promoter after systemic administration of AAV9 provides significant pro

68 Systemic administration of AAV92YF-RdCVF improved cone f

69 Moreover, one-time systemic administration of Ac2-26 Col IV NPs accelerated

70 sed adrenal size and elevated CORT following systemic administration of adrenocorticotropic hormone.

71 Although chronic systemic administration of aducanumab in 22-month-old mi

72 This can be achieved by systemic administration of Ag-specific Treg cells, which

73 No safety concerns were identified after systemic administration of AKB-9778 for 4 weeks in patie

74 or D2R MSNs, we show that repeated cycles of systemic administration of alcohol or alcohol consumptio

75 We show that intranasal but not systemic administration of alpha-GalCer to piglets infec

76 Antiallodynic efficacy of systemic administration of AM1710 was absent in CB2KO mi

77 Furthermore, we show that systemic administration of an agonist Notch3 antibody pr

78 he work described herein was to test whether systemic administration of an antagonist of miR-467 woul

79 Neutrophil depletion by systemic administration of an anti-Gr1 antibody improved

80 Here, we show in rats that systemic administration of an aromatase (estrogen syntha

81 Notably, systemic administration of an EGFL6-neutralizing antibod

82 Systemic administration of an HDAC inhibitor rescues the

83 Also, systemic administration of an MAP kinase kinase inhibito

84 cue-induced craving are high, we found that systemic administration of an mGluR1 PAM attenuated the

85 First, we studied the effects of systemic administration of an OT receptor (OTR) antagoni

86 Systemic administration of anti-C5- or anti-C5a-blocking

87 This article will focus on the systemic administration of anti-cancer agents and their

88 These data indicate that systemic administration of anti-CD40Ab may be particular

89 As we expected, systemic administration of anti-DC-STAMP-mAb downregulat

90 nsection (L5SNT; modified Chung's model) and systemic administration of anti-ganglioside Abs.

91 d that blocking of interleukin 11 (IL-11) by systemic administration of anti-IL-11 antibodies attenua

92 r than 20% intratumoral accumulation and (b) systemic administration of anti-MG1 HNPs can enlarge a t

93 ts in intestinal mucosal wound repair, while systemic administration of ANXA1 promoted wound recovery

94 of dopamine receptor signaling in vivo with systemic administration of apomorphine, amphetamine, and

95 In Nrf2 wild-type mice, systemic administration of artemisitene strongly inhibit

96 nsection (to remove sympathetic influences), systemic administration of atropine increased left ventr

97 e agonist NMDA) or inflammation in vivo (via systemic administration of bacterial lipopolysaccharides

98 The systemic administration of BB-94 alone at the same dose

99 In most patients, systemic administration of biological therapies with cyt

100 notable recovery in function observed after systemic administration of BMSCs to MCAO rats is likely

101 n the release of inflammatory mediators; the systemic administration of Boc2, a formylated peptide re

102 Local and systemic administration of both dexamethasone and cedira

103 We found that the systemic administration of brain lipid rafts induced a m

104 Either intrarenal or systemic administration of C-21 prevented Ang II-mediate

105 type directly and specifically responding to systemic administration of CBLB502 but not to that of th

106 s with periodontitis compared to serum after systemic administration of clarithromycin.

107 al suppression of macrophage infiltration by systemic administration of clodronate-incorporated lipos

108 e glutamate levels following intracranial or systemic administration of clozapine N-oxide (CNO) and t

109 Systemic administration of CNO inhibited cue-induced rei

110 Systemic administration of CNO suppresses focal seizures

111 Systemic administration of cocaine is thought to decreas

112 confirmed VTA DA neurons that is excited by systemic administration of cocaine.

113 Moreover, systemic administration of collagen IV targeted Ac2-26 N

114 Systemic administration of compounds that block the acti

115 at are notoriously difficult to eliminate by systemic administration of conventional antifungal agent

116 tricular leptin infusion was not impacted by systemic administration of corticosterone at a dose that

117 A drug delivery system suitable for systemic administration of CPA is needed before CPA can

118 used for the treatment of psoriasis; however systemic administration of CsA is potentially life threa

119 Systemic administration of CTDP-32476 alone produced a s

120 Both local and systemic administration of CTLA4(apt)-STAT3 siRNA dramat

121 Notably, systemic administration of CYM51010 induced antinocicept

122 Systemic administration of DAR decreases hepatic ischemi

123 Either systemic administration of DCs loaded with allogeneic-Ig

124 Strikingly, systemic administration of Del-1-Fc ameliorated clinical

125 We hypothesized that systemic administration of DHA-derived SPMs [resolvin D2

126 After systemic administration of diaCEST liposomes to mice bea

127 repopulating HSCs and progenitor cells, and systemic administration of Dkk1 to irradiated mice incre

128 , while inactivating the VTA or the combined systemic administration of dopamine D1 and D2 antagonist

129 Systemic administration of drugs that improve respirator

130 reason for functional impairment of BSEP is systemic administration of drugs, which as a side effect

131 xpressed functional EGF receptor (EGFR), and systemic administration of EGF promoted the recovery of

132 We demonstrated that systemic administration of endogenous nitric oxide donor

133 In rodents, systemic administration of endogenous or synthetic neuro

134 Weekly systemic administration of ESTA-MSV/STAT3 siRNA signific

135 Systemic administration of Etanercept inhibited MHC-I(hi

136 In vivo systemic administration of F. major sphingolipids change

137 In this study, we showed that systemic administration of FK506 (1.5 mg kg(-1) day(-1))

138 ansgene into the hippocampus and reversed by systemic administration of fluoxetine.

139 Further, we show that either intra-LA or systemic administration of garcinol within a narrow wind

140 ipulation, when tested pharmacologically via systemic administration of group III mGluR antagonists,

141 To determine whether the systemic administration of HER2-specific chimeric antige

142 Current treatment strategies are based on systemic administration of high doses of antibiotics, wh

143 Following systemic administration of HPPH liposomes, near infrared

144 These findings suggest that high-dose systemic administration of human cultured MSCs can resto

145 t while local infusion of HSA or saline, and systemic administration of human PRP lysate, compared to

146 We discovered that systemic administration of human recombinant CSF1 amelio

147 MRI of the TNBC xenograft tumor after systemic administration of ICAM-IONPs, coupled with iron

148 weights, both transgenic overexpression and systemic administration of IGF-1 combined with Bax-inhib

149 Treatment of tumor bearing mice with systemic administration of IL-12 in combination with int

150 potentially lethal toxicity associated with systemic administration of IL-12 precludes its clinical

151 Systemic administration of IL-12p70 has demonstrated cli

152 ph nodes, both of which could be reversed by systemic administration of IL-1R antagonist (anakinra).

153 Systemic administration of insulin delays the death of c

154 Interestingly, systemic administration of insulin has been shown to del

155 al phenotypes of ASD, to test the effects of systemic administration of insulin-like growth factor II

156 In a murine periodontitis model, systemic administration of JQ1 significantly inhibited i

157 Systemic administration of JWH133 attenuated these marke

158 Systemic administration of JWH133, a highly selective CB

159 mottled-brindled (mo-br), we tested whether systemic administration of L-threo-dihydroxyphenylserine

160 Interestingly, systemic administration of LiCl in a critical time windo

161 atty liver is partially recapitulated by the systemic administration of low-dose carboxyatractyloside

162 Additional systemic administration of low-dose PMO25 at 2-week inte

163 revent symptoms and suggests that subsequent systemic administration of low-dose PMO25 in SMA mice ca

164 Systemic administration of macrophages transfected ex vi

165 A single systemic administration of MDSC markedly prolonged survi

166 rathecal injection of an NMDAR antagonist or systemic administration of memantine effectively reverse

167 Systemic administration of methylxantines improves respi

168 Systemic administration of micelles carrying paclitaxel

169 Both systemic administration of miR-124 or adoptive miR-124-t

170 r knowledge, this is the first report of the systemic administration of mRNA for delivery to the lung

171 We find that systemic administration of MS0021570_1 attenuates anxiet

172 target dormant breast cancer cells based on systemic administration of MSC loaded with antagomiR-222

173 in counteracts the behavioral effects of the systemic administration of mu-opioid receptor (MOR) agon

174 Behavioral studies show that systemic administration of muscarinic acetylcholine rece

175 Using systemic administration of nanoparticle-formulated miRNA

176 Systemic administration of neutralizing Abs to either TN

177 ease of B cells in the spleen in response to systemic administration of Nod1 agonists in a TNF-alpha-

178 Systemic administration of NRG demonstrated efficacy in

179 Furthermore, systemic administration of oAd/DCN/LRP-PEG-NT significan

180 Allergen sensitization by either systemic administration of OVA with aluminum hydroxide o

181 After systemic administration of oxotremorine, an unselective

182 animals reduces muscle regeneration, whereas systemic administration of oxytocin rapidly improves mus

183 duced epilepsy: intrahippocampal kainate and systemic administration of paraoxon.

184 The chosen systemic administration of PEA stabilized the amplitude

185 In rats, systemic administration of PF-04859989 dose-dependently

186 In the context of inflammatory disorders, systemic administration of pharmacological doses of synt

187 This study examined if systemic administration of Piribedil, a dopamine agonist

188 Here, we found that systemic administration of pleiotrophin (PTN), a protein

189 We tested the hypothesis that systemic administration of porphyrin precursors to zebra

190 Acute systemic administration of pregabalin in vivo also selec

191 I (DW-MRI) in wild-type (WT) mice, the acute systemic administration of pregabalin increased the thre

192 ced changes in mPFC firing were mitigated by systemic administration of propranolol (10 mg/kg, i.p.),

193 Systemic administration of PTH(1-34) augmented bone volu

194 t migration and mineralization in vitro, and systemic administration of PTHrP1-17 augments ectopic bo

195 was noticed over periods of months after the systemic administration of QDs.

196 In rats, systemic administration of R-MOD alone (10-30 mg/kg i.p.

197 Importantly, we found that systemic administration of recombinant FGF2 (rFGF2) in m

198 7 was more effective than either LL-IL-10 or systemic administration of recombinant IL-27 in reducing

199 Finally, systemic administration of recombinant IL-27 in Treg-spe

200 Systemic administration of recombinant MK completely res

201 inergic neurons and either local infusion or systemic administration of retigabine normalized neurona

202 The effects of systemic administration of rimonabant on anxiety-like be

203 Systemic administration of rimonabant precipitated anxie

204 Systemic administration of RT53 inhibited the growth of

205 a within-subjects design, of male rats given systemic administration of saline or lipopolysaccharide

206 We found systemic administration of SB-334867 (0, 7.5, 15, 30 mg/

207 Performance was assessed following systemic administration of selective D(2), D(3), and D(4

208 We show that systemic administration of siMGMT-SNAs via single tail v

209 atform may afford the specificity lacking in systemic administration of small-molecule inhibitors.

210 Systemic administration of sodium 4-phenylbutyrate (PBA)

211 We examined the effects of local and systemic administration of sodium nitrite on the radial

212 m load, which was significantly decreased by systemic administration of specific blockers of the angi

213 immunosuppressive signals can be achieved by systemic administration of supporting adjuvant drugs suc

214 Previous research showed that systemic administration of TAAR1 agonists could attenuat

215 Our recent studies showed that systemic administration of TAAR1 agonists decreased abus

216 motor hyperactivity was attenuated following systemic administration of TAT-C24WT but not TAT-C24Scr.

217 ilocarpine model of status epilepticus (SE), systemic administration of TG6-10-1 completely recapitul

218 We found that systemic administration of the 4-1BB aptamer-raptor siRN

219 exibility on this task is improved following systemic administration of the 5-HT reuptake inhibitor c

220 f unfavorable outcomes were tested following systemic administration of the 5-HT1A receptor agonist,

221 Systemic administration of the alpha2-AR agonists dexmed

222 The systemic administration of the anti-Kras nanobeacons res

223 Systemic administration of the AROM inhibitor letrozole

224 d female monkeys were severely attenuated by systemic administration of the aromatase inhibitor, letr

225 Simultaneous systemic administration of the bioorthogonal IONPs in tu

226 Systemic administration of the bispecific DVD-Ig or the

227 asthma in C57BL/6 mice, we demonstrate that systemic administration of the BK channel agonist rottle

228 Systemic administration of the BMP antagonist LDN-193189

229 Importantly, systemic administration of the CaMKII inhibitor tatCN21

230 Systemic administration of the CB2 receptor agonist JWH1

231 Systemic administration of the CCR3 antagonists GW766994

232 onists, we examined the cognitive effects of systemic administration of the CRF1 receptor selective a

233 Finally, we show that systemic administration of the CRMP-2 inhibitor lacosami

234 Following systemic administration of the Cy5-labeled dendrimer (D-

235 and that this disruption was reversed by the systemic administration of the dopamine D2/D3 receptor a

236 to the dose-limiting side effects following systemic administration of the drugs.

237 the neuroinflammatory response produced by a systemic administration of the Escherichia coli lipopoly

238 reinstated cocaine seeking was prevented by systemic administration of the group II metabotropic glu

239 Systemic administration of the growth factor FLT3L follo

240 Systemic administration of the Hcrtr-1 antagonist SB3348

241 In conclusion, systemic administration of the heme precursors PP-IX or

242 Systemic administration of the high-affinity Sig1R ligan

243 Systemic administration of the KOR agonist U69,593 inhib

244 mouse intranasal virus challenge study, and systemic administration of the mAb markedly reduced vira

245 Finally, systemic administration of the mGlu2/3 agonist LY379268

246 Systemic administration of the MIF inhibitor ISO-1 signi

247 The data show that systemic administration of the miR-467 antagonist could

248 ed on rats bearing melanoma xenografts after systemic administration of the N-cadherin antagonist, AD

249 Systemic administration of the N/OFQ receptor (NOP) anta

250 Systemic administration of the nAChRa7 agonist PNU-28298

251 We now report that systemic administration of the novel mGlu5 positive allo

252 Systemic administration of the opiate antagonist, naloxo

253 Systemic administration of the orexin-1 receptor (OX1R)

254 in the DLS, as well as intra-DLS infusion or systemic administration of the p75NTR modulator, LM11A-3

255 pha4beta2* nicotinic ACh receptors (nAChRs), systemic administration of the partial nAChR agonist ABT

256 , and repetitive behaviors, we report that a systemic administration of the polypeptide insulin-like

257 RNAs against HuR with FA-3DNA and found that systemic administration of the resultant FA-3DNA-siHuR c

258 Noteworthy, systemic administration of the S1PR1 modulator FTY720 (F

259 DOX and TMZ microcapsules are compared with systemic administration of the same treatments in a rode

260 Systemic administration of the selective cyclin-dependen

261 gnal mediator Smoothened (Smo) as well as by systemic administration of the Smo inhibitor vismodegib,

262 sion of follistatin in skeletal muscle or by systemic administration of the soluble form of the activ

263 Acute systemic administration of the TAT-4BB reversed M3G-indu

264 2-specific antibody (REGN910) is reversed by systemic administration of the Tie2 agonist Ang1.

265 refrontal cortex of the Met68BDNF mice or by systemic administration of the tropomyosin receptor kina

266 Furthermore, systemic administration of the vectors results in widesp

267 Third, the systemic administration of the water-soluble CoQ10 analo

268 Systemic administration of these agonists to monkeys per

269 Systemic administration of this probe to mice bearing S.

270 Knockdown of vascular DHCR24 and HO-1 and systemic administration of tin-protoporphyrin-IX, an HO

271 Systemic administration of TNF antagonists for radiculop

272 Systemic administration of TP-10 (3.2 mg/kg) robustly in

273 Systemic administration of TRAILPEG after disease onset

274 present a tumor-detection strategy based on systemic administration of tumor-activatable minicircles

275 Here we find that the systemic administration of typhoid toxin, a unique virul

276 al enhancement of endocannabinoid levels via systemic administration of URB597, an inhibitor of endoc

277 was applied on the back of mice, followed by systemic administration of vehicle or ARA290 at 1, 12, a

278 Systemic administration of vitamin D during regeneration

279 earing metastatic colon tumors compared with systemic administration of wild-type VSV alone.

280 Systemic administration of Y4 effectively inhibits growt

281 At the cognitive level, systemic administration of young blood plasma into aged

282 ns were made selectively zolpidem-sensitive, systemic administration of zolpidem shortened sleep late

283 plant, this work analyzed the effect of BMMC systemic administration on nerve repair and pain behavio

284 After systemic administration, optical imaging suggests that t

285 High-dose systemic administration or local injection of recombinan

286 Microdialysis studies revealed that either systemic administration or local intranigral perfusion o

287 premature responses; motor impulsivity) upon systemic administration or microinfusion directly into t

288 only alcohol-heightened aggression, whereas systemic administration reduced both alcohol-heightened

289 In mice, systemic administration resulted in the specific co-loca

290 o mimic the in vivo experience of LNPs after systemic administration, such as interactions with serum

291 27853 and no nephrotoxicity was found after systemic administration, suggesting it to be a potential

292 n cerebrospinal fluid (110+/-30 pg/ml) after systemic administration, suggesting that it crosses the

293 Upon systemic administration to mice bearing uPA-overexpressi

294 Systemic administration to mice of the TLR9 agonist CpG

295 ralizes TNF-alpha and is used principally by systemic administration to treat many inflammatory disor

296 Central mGluR1 target engagement after systemic administration was demonstrated by a dose-depen

297 After systemic administration we demonstrate a robust ability

298 e it bypasses the challenges associated with systemic administration which suffers from enzymatic deg

299 s, co-solvent delivery is required for their systemic administration, which is usually associated wit

300 valuable cell tropisms to allow efficacious systemic administration, yet basic aspects of AAV cellul