ライフサイエンスコーパス: systemically

1 functions locally, at the barrier level, and systemically.

2 concentrations locally and low side effects systemically.

3 originating either from neighboring cells or systemically.

4 rmation (C5b-9) locally and active TGF-beta1 systemically.

5 sleep neurons change physiology and behavior systemically.

6 communication, acting proximally as well as systemically.

7 eatening pulmonary infection that can spread systemically.

8 cell-to-cell communication both locally and systemically.

9 er time, while oral vancomycin was used more systemically.

10 siderin iron accumulation-both in tumors and systemically.

11 l inflammation and immunity both locally and systemically.

12 m, triggering hallmarks of premature ageing, systemically.

13 way and temporarily reducing pathogen levels systemically.

14 le is known about how this organism persists systemically.

15 50% lethal dose (LD50) when it was injected systemically.

16 nsplantation demonstrated no evidence of TLN systemically.

17 CA-induced pain in rodents when administered systemically.

18 ght chain (LC), which affects organ function systemically.

19 in the host both locally in the airways and systemically.

20 t binds phosphates and bile acids; it is not systemically absorbed.

21 ly monitor treatment response by visualizing systemically accessible EGFR with (111)In-cetuximab-F(ab

22 Identification of a systemically acting and universal small molecule therapy

23 iseases is still largely based on the use of systemically acting immunosuppressive drugs, which invar

24 Here, we describe the first class of systemically active agents that simultaneously inhibit F

25 Bone breakdown releases numerous systemically active cytokines and bone-sequestered toxin

26 Furthermore, discovery of a novel, systemically active M1 positive allosteric modulator (PA

27 c (PK) properties, allowing the discovery of systemically active mGlu2/3 PAMs.

28 Systemically administered actoxumab-bezlotoxumab prevent

29 ly relevant human monoclonal antibodies were systemically administered after acute SCI, and were dete

30 antibiotic resistance acquisition rates for systemically administered antibiotics were comparable be

31 lly (vaginally or rectally), orally or other systemically administered antiretroviral drugs to preven

32 Systemically administered antisense oligonucleotide (ASO

33 Thus, SCFAs, when systemically administered at levels higher than physiolo

34 design of drug delivery strategies based on systemically administered carriers.

35 Systemically administered chemotherapeutic drugs are oft

36 Although systemically administered CPT loaded nanoparticles slowe

37 mbined approach could be utilized to deliver systemically administered DNA-bearing BPN (DNA-BPN) acro

38 Systemically administered DNA-BPN delivered through the

39 Thus, clinically relevant, systemically administered drugs that attenuate Ras-ERK s

40 her using traditional pharmacotherapy (e.g., systemically administered drugs).

41 Systemically administered EDHB and its active metabolite

42 Systemically administered EDHB and its active metabolite

43 Immunohistochemical data show that a systemically administered fluorescent GLP-1R agonist acc

44 fect is mediated by GLP-1R, as the uptake of systemically administered fluorophore-tagged exendin-4 w

45 Further, because systemically administered fluoxetine increased aggressio

46 However, the delivery of systemically administered gene carriers to the CNS is hi

47 overcoming the low homing efficiency of MSCs systemically administered in inflammatory bowel diseases

48 Systemically administered melatonin significantly decrea

49 ngs reveal the respective sites of action of systemically administered MJN110 and AM251 in regulating

50 o CAQK increased injury site accumulation of systemically administered molecules ranging from a drug-

51 t report of an anti-inflammatory effect of a systemically administered NAAA inhibitor.

52 Understanding of the mechanisms by which systemically administered nanoparticles achieve delivery

53 Results indicate that systemically administered NBI-80713 dose-dependently dec

54 In this first in-human study of a systemically administered near-infrared (NIR) fluorescen

55 ve been developed to improve the delivery of systemically administered pharmaceuticals, which are sub

56 Systemically administered porphysomes accumulated in lun

57 e identified NMNAT2 positive-modulator, when systemically administered restored NMNAT2 expression in

58 ene silencing in injured brain parenchyma by systemically administered siRNA.

59 In comparison, a systemically administered TGF-beta mAb accumulated at lo

60 rupt the BBB, allowing localized delivery of systemically administered therapeutic agents as large as

61 cine is obtaining controlled distribution of systemically administered therapeutic agents within the

62 These results define systemically administered TLR5 agonists as organ-specifi

63 The antitumor activity of KOX/PEGbPHF systemically administered to a tumor xenograft model was

64 Finally, vectors were switched and systemically administered to the reciprocal group of ani

65 cles localize to solid tumors of humans when systemically administered.

66 drug but subject to low bioavailability when systemically administered.

67 In the present study, the role of systemically-administered CAR-DCN in AAA progression and

68 Here, we show that systemically administering a potent, long-acting PEGylat

69 nosine 3',5'-cyclic monophosphate (cGMP) and systemically affect plant salt and water balance and res

70 During this phase, nutrient status, by systemically affecting insulin/IGF-1 signalling, largely

71 The drugs were administered systemically after predetermination of their blood level

72 not affect protein synthesis, when delivered systemically after training or reactivation.

73 We systemically analysed chronological changes in biochemic

74 c cellular and humoral immune responses both systemically and at the oral and intestinal mucosa.

75 this study was to assess chitinase activity systemically and in the airways of patients with CF and

76 llenged mice markedly decreased ATX activity systemically and in the lung, without effect on pulmonar

77 markedly enhanced in betaArr1 knockout mice systemically and locally in various organs.

78 ese data demonstrate the efficiency of BMMC, systemically and noninvasively transplanted, in correcti

79 stemically healthy with CP (CP); and 6) both systemically and periodontally healthy (C).

80 als were split into four groups: 20 who were systemically and periodontally healthy (CTRL), 20 with t

81 KL, IL-6, and IL-8 were higher in TM than in systemically and periodontally healthy comparison groups

82 lly healthy individuals with CP (Cp), and 19 systemically and periodontally healthy controls (Ch).

83 oth groups at 6 months were compared with 25 systemically and periodontally healthy females (group A)

84 Subgingival plaque was collected from 44 systemically and periodontally healthy non-pregnant nons

85 n with GDM and healthy periodontium (Gh), 28 systemically and periodontally healthy women (Hh), and 3

86 women with PCOS and gingivitis (n = 35); 3) systemically and periodontally healthy women (n = 25); a

87 lower in healthy women with gingivitis than systemically and periodontally healthy women or women wi

88 Pmca4 deletion in mice, both systemically and specifically in fibroblasts, reduces th

89 inflammatory responses, but how they spread systemically and trigger inflammatory cascade is unclear

90 rst pass effect, limiting cytokine induction systemically, and demonstrated the potential for the imm

91 ry genes at the maternal-fetal interface and systemically, and rosiglitazone treatment partially atte

92 o follow and quantify the specific homing of systemically applied (64)Cu-labeled chicken ovalbumin (c

93 s that cumulatively deposit in the heart and systemically as amyloid.

94 ell responses, liver disease often manifests systemically as immunoglobulin (Ig)-related syndromes du

95 Tenapanor, a minimally systemically available inhibitor of the intestinal sodiu

96 to develop sign-tracking behavior if treated systemically before pavlovian conditioned approach train

97 opropane 5 (LY2934747), a novel, potent, and systemically bioavailable mGlu2/3 receptor agonist which

98 e were generated to determine the effects of systemically blocking interaction between p27 and Skp2/C

99 lls commonly enter the blood and disseminate systemically, but are highly inefficient at forming dist

100 (WT) and CD73(-/-) mice with T. gondii cysts systemically by the intraperitoneal (i.p.) route.

101 Nlrp6(-/-) and control mice systemically challenged with encephalomyocarditis virus

102 To systemically characterize circulating extracellular RNA

103 and pericytes, have a defective BBB in which systemically circulated tracer leaks into the brain pare

104 , avoiding many of the off-target effects of systemically circulating agents.

105 dipocytes sense systemic nutrient status and systemically communicate this information by releasing a

106 with hosts who were older, male, locally and systemically compromised, and healthcare and antibiotic

107 Although FH systemically controls complement activation, clinical ph

108 e circulation increase after O3 exposure and systemically convey signals of O3 exposure to the CNS.

109 n of reproductive aging and somatic aging is systemically coordinated by integrated nutrient-sensing

110 cine, that the ability of a strain to spread systemically correlated with reduced immunodominance.

111 When given systemically, curli-DNA composites triggered immune acti

112 In systemically deafened animals there was a negative corre

113 Collectively, our data show systemically decreased frequencies of MAIT cells likely

114 In conclusion, our data suggest that both systemically delivered and locally produced hepcidin pro

115 ning this area rendered animals resistant to systemically delivered anesthetics.

116 Remarkably, systemically delivered anti-ganglioside antibody in mice

117 ver is a key recipient of SMA therapies, and systemically delivered antisense treatment, completely r

118 Furthermore, systemically delivered cholesterol-modified agomiR-199a

119 atments of brain tumor associated edema with systemically delivered dexamethasone, the standard of ca

120 For the treatment of solid tumors, systemically delivered drug carriers face significant ch

121 is and was 10-fold more potent than the free systemically delivered drug in the lupus mouse models.

122 le of Pg expressed gingipain proteases using systemically delivered gingipain-deficient Pg mutants, w

123 lly contributes to the hypophagic effects of systemically delivered GLP-1R agonists by enhancing visc

124 n vivo porcine thigh model was used to study systemically delivered magnetically guided iron oxide (F

125 fundamentally important to the design of all systemically delivered nanoparticle nonviral gene delive

126 ated whether tumor priming is functional for systemically delivered siRNA via intravenous injection,

127 ts into an adeno-associated virus vector and systemically delivered them to mdx/Utr(+/-) neonates.

128 on, and narrows viable treatment regimes for systemically delivered therapeutics.

129 NP@mSiO2-ICG with sealed structures could be systemically delivered to brain vessels, with a long cir

130 , we note that, in vivo silencing of TTK, by systemically delivering TTK siRNAs to already tumor-bear

131 eveal for the first time that MAIT cells are systemically depleted in an AIDS virus infection.

132 ve motile coccobacilli were isolated from 15 systemically diseased African bullfrogs (Pyxicephalus ed

133 In nonvaccinated cattle, systemically disseminated virus was cleared from periphe

134 the nonlymphoid tissues, indicating that the systemically distributed host-protective cells have a co

135 verse ILC subsets are generated in situ from systemically distributed ILCPs in response to local envi

136 ra, indicating that ANXA1-containing EVs are systemically distributed in response to the inflammatory

137 mpared active versus passive brain uptake of systemically dosed antibodies (anti-transferrin receptor

138 e distinct immunological changes locally and systemically during acute exacerbation.

139 ction by CD4(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 rece

140 caled by nutrient-dependent signals that act systemically (e.g., Insulin-like peptides [ILPs] transdu

141 proconvulsant role of CCL2, we administered systemically either a CCL2 transcription inhibitor (bind

142 ngs are unique in that they were obtained in systemically euthyroid animals, revealing that brain D2

143 ection in Ifnar1-deficient mice is caused by systemically exacerbated levels of the proinflammatory c

144 ng various developmental stages has not been systemically examined.

145 In this study, we systemically explored possible kinetic mechanisms for DM

146 In addition, the surrogates can be systemically expressed and exhibit Wnt activity in vivo

147 1 by clinical antifungal drugs that are used systemically (fluconazole, voriconazole, ketoconazole, i

148 on the stem/culm, whereas SPs were observed systemically following damage to both stem/culm and leav

149 nitiation of RESV or placebo administration (systemically for 30 days) and was continued until the en

150 We administered VU0409551 systemically for 5 days to adult male wild-type C57BL/6

151 s cardiovascular outcomes, mice were treated systemically for 6 weeks with antibodies targeting IL-17

152 doses of various tau antibodies administered systemically for several months and have reported reduce

153 Viruses that spread systemically from a peripheral site of infection cause m

154 us that naturally infects the mouse, spreads systemically from the peripheral site of infection and r

155 ts with polycystic ovary syndrome (PCOS) and systemically healthy controls in the presence or absence

156 inety-five males (45 with prediabetes and 50 systemically healthy controls) were included.

157 with gestational diabetes mellitus (GDM) and systemically healthy counterparts with different statuse

158 than those on medical treatment for PCOS and systemically healthy females.

159 <0.005) were higher in TM gingivitis than in systemically healthy gingivitis (P <0.001).

160 , PI scores, and biofluid parameters also in systemically healthy groups.

161 dative levels in patients with PS and PsA or systemically healthy individuals seems limited.

162 althy patients with hyperlipidemia (HLh), 19 systemically healthy individuals with CP (Cp), and 19 sy

163 PI) were monitored in gingivitis cases among systemically healthy patients (n = 60) or those with dia

164 serum MMP-9 levels and MMP-9/TIMP-1 ratio in systemically healthy patients (P <0.05).

165 y, 12 gingivitis, eight periodontitis] in 15 systemically healthy patients were investigated by immun

166 Twenty-eight systemically healthy volunteers with chronic periodontit

167 t2DM and periodontally healthy (DM-CTRL), 20 systemically healthy with CP (CP), and 20 with CP and t2

168 P); 4) PsA-periodontally healthy (PsA-C); 5) systemically healthy with CP (CP); and 6) both systemica

169 and periodontally healthy women (Hh), and 37 systemically healthy women with gingivitis (Hg) were eva

170 periodontally healthy women (n = 25); and 4) systemically healthy women with gingivitis (n = 20).

171 l as MMP-9/TIMP-1 ratios, were higher in the systemically healthy women with gingivitis compared with

172 ents are included in this study (TM, n = 29; systemically healthy, n = 48).

173 whole saliva, and plasma were obtained from systemically healthy, non-smoking individuals with gingi

174 To unravel this miRNA-dependent program, we systemically identified transcripts that were differenti

175 act of ultrafine jet-milling did however not systemically impact more TEAC values than cryo-milling.

176 ciated virus (AAV) 9-mbetagal vector infused systemically in adult GM1 mice (betaGal(-/-)) at 1 x 10(

177 are detected both locally in lung as well as systemically in bone marrow and spleen.

178 uced both in the tumour microenvironment and systemically in distant tissues.

179 Although bacterial products translocate systemically in human immunodeficiency virus (HIV)-infec

180 As GLP-1 mimetics are administered systemically in humans, we evaluated whether peripherall

181 that dexamethasone cannot be safely applied systemically in large concentrations.

182 Plant viruses move systemically in plants through the phloem.

183 When dosed systemically in swine, 13d provided a 15-fold enhanced C

184 ate across the intestinal epithelium, spread systemically in the circulation, and reach the fetoplace

185 raprolin-deficient macrophages and increased systemically in tristetraprolin-deficient mice.

186 defense pathways at the inoculation site and systemically in uninoculated tissues can help in the dev

187 sport vehicle for siRNAs in cell culture and systemically in vivo in mice.

188 In the present study, the Pdgfra gene was systemically inactivated in adult mouse (alpha-KO mouse)

189 XA1 expression was suppressed in the gut but systemically increased during early infection.

190 Chitinase activity was systemically increased in patients with CF compared with

191 ndicate that men and women spontaneously and systemically increased VTL and decreased F0 to imitate a

192 e(-/-)) have increased numbers of B-1b cells systemically, increased titers of oxidation-specific epi

193 ls (ILC2s) and regulatory T (Treg) cells are systemically induced by helminth infection but also sust

194 destruction of cytosolic constituents and is systemically induced by starvation.

195 terized by a strong transcriptional response systemically induced in the foliage that prepares plants

196 We find that systemically induced memory T cells are restricted to th

197 In response, systemically induced resistance in plants is common and

198 Potato virus X (PVX) does not systemically infect Arabidopsis thaliana Columbia-0, but

199 more infectious to naive animals than their systemically infected counterparts and that transmission

200 sis was performed using the first and second systemically infected leaves (termed 1 SL and 2 SL, resp

201 In contrast, RAGE(-/-) mice systemically infected with A. baumannii exhibit increase

202 Moreover, IL-27R (WSX-1)-deficient mice systemically infected with C. parapsilosis displayed enh

203 ine-specific neutralizing anti-IL-6 mAbs and systemically infused mAbs into fetal sheep at 126 days o

204 currently under investigation or development systemically inhibit the complement system, but since co

205 osslinked to the surface of Ad, generating a systemically injectable hybrid system, oAd/DCN/LRP-PEG-N

206 Although systemically injected 17beta-estradiol (E2) increases CA

207 Both systemically injected and topically applied antibodies t

208 evidenced by their ability to interact with systemically injected antibodies and form localized immu

209 ith sciatic nerve crush were immediately and systemically injected BMMC through the caudal artery.

210 binds to injured mouse and human brain, and systemically injected CAQK specifically homes to sites o

211 Systemically injected drug delivery systems distribute i

212 These macrophages were then systemically injected into mice with fluorescent human t

213 However, over 90% of systemically injected nanocarriers typically accumulate

214 ts pointed out a significant accumulation of systemically injected nanoparticles in the skin.

215 We reviewed results from recent studies of systemically injected PAMs and NAMs of mGluRs in rodents

216 rats that were subjected to PPI after being systemically injected with PCP or saline.

217 Such approaches miss the opportunity to systemically integrate the phenome-wide data available f

218 s visualization of biological processes with systemically introduced contrast agents.

219 molecular interaction map, allowing users to systemically investigate network-dependent effects of a

220 mnifera and the present study is designed to systemically investigate the anti-HCC efficacy of WA.

221 study we employed a degradomics approach to systemically investigate the endogenous substrates of KL

222 138511 individuals of European ancestry and systemically investigated pleiotropy between PD and type

223 In the present study, we systemically investigated the associations of the 6 SNPs

224 We systemically investigated the stability of BCM in serum

225 NF and AAV.Ntf3, on guinea pig ears deafened systemically (kanamycin and furosemide) or locally (neom

226 d lipid oxidation in the lung can spill over systemically, leading to metabolic dysfunction and weigh

227 Systemically low levels of survival motor neuron-1 (SMN1

228 hereas conventional NK (cNK) cells circulate systemically, many NK cells reside in tissues where they

229 utant HTT is ubiquitously expressed and acts systemically, meaning blood, which is readily available

230 critically ill patients without the need to systemically monitor ionized calcium.

231 rindividual epigenetic variation that occurs systemically must be established prior to gastrulation i

232 sis that this region contains the CoV FP, we systemically mutated every residue in the pFP of Middle

233 cond, we report that exogenous leptin, given systemically or directly into the ventral tegmental area

234 ature responses in 5-CSRTT when administered systemically or directly into VTA.

235 al inhibitor, we found that inhibiting Egln1 systemically or in skeletal muscles protects mice agains

236 The JAK2 inhibitor AG490 given systemically or into the OFC at the time of ketamine inj

237 In contrast, only memantine, administered systemically or intra-PLmPFC, interacted with prior alco

238 he CB2 antagonist AM630, administered either systemically or intrathecally.

239 rent delivery methods are carried out either systemically or locally into diseased areas, both of whi

240 Mice lacking Nogo-B either systemically or specifically in endothelial cells are hy

241 Exogenous B2M injected systemically, or locally in the hippocampus, impairs hip

242 Consequently, using the latter would systemically overestimate PNDC by 22%.

243 (P = 0.004) occurred locally (P = 0.003) and systemically (P = 0.01).

244 Despite its inability to spread systemically, PA14::hepP formed perivascular cuffs aroun

245 When administered systemically, PHF1 has been shown to modestly reduce tau

246 hat can have direct effects on attackers, or systemically prime distant plant parts for enhanced defe

247 HT into naive mice, either subcutaneously or systemically, promoted collagen deposition in the skin a

248 ics datasets, and functional perturbation to systemically reconstruct regulatory networks underlying

249 unction arising during mental processes that systemically reduce hippocampal activity.

250 These data indicate that GDF11 systemically regulates muscle aging and may be therapeut

251 We demonstrate the generation of systemically releasable anti-cancer drugs from multilaye

252 ant KRAS bearing tumour cells upregulate and systemically release chemokine ligand 2 (CCL2) into the

253 Activated mast cells systemically released heparin, which provided a negative

254 unological tone of tissues, both locally and systemically, requires tonic sensing of microbes and com

255 l deliveries led to trafficking of mRNA-LNPs systemically resulting in active translation of the mRNA

256 ction, murine cytomegalovirus (MCMV) spreads systemically, resulting in virus replication and patholo

257 We applied the "PICKY" software to systemically screen the HBV genome, then used hydrodynam

258 We systemically searched and selected all studies on melano

259 We postulate that tumor cells locally and systemically share molecules carried by EVs in vivo and

260 mune activation was evident in the tumor and systemically shortly after effective therapy was adminis

261 siology methods, we found that administering systemically SMN-restoring antisense oligonucleotides (A

262 onventional CD4(+)CD25(+) regulatory T cells systemically suppressed anti-FIX responses.

263 ted in vivo in head and neck cancer cells by systemically targeting tumours with gold colloids and lo

264 Systemically, the metabolic syndrome, including dyslipid

265 Systemically, the proportion of activated CD4(+)-T cells

266 Because most miRNA-based therapies act systemically, this may preclude widespread clinical use.

267 Systemically, this production resulted in highly elevate

268 components of the florigenic signal and move systemically through the phloem to reach the shoot apica

269 ations that are required locally in tissues, systemically throughout the body, and at the interface w

270 targeted against this virus does not spread systemically throughout the organism and cannot be passe

271 raarterially (ipsilateral femoral artery) or systemically to 8 CD IGS rats just before blood sampling

272 y, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose int

273 wer dose than the unconjugated drug injected systemically to effectively induce respiratory recovery

274 m-negative bacteria were able to disseminate systemically to induce immunoglobulin G (IgG) response,

275 Administration of rIL-22 systemically to infected wild-type mice decreased bacter

276 ptake of fluorescently loaded ECVs delivered systemically to mice before and after administration of

277 D-serine was administered systemically to mice to evaluate its effect on fear exti

278 When administered systemically to mice, HTiO2 NPs effectively suppressed t

279 cy and efficacy in vitro, but when delivered systemically to mice, the 5-phosphate is removed within

280 are released from tissues and act locally or systemically to promote insulin sensitivity and glucose

281 the anti-solTNF peptide, XPro1595, injected systemically, to normalize morphine-induced CNS neuroinf

282 this system in the controlled expression of systemically toxic cytokine IL-12.

283 activation with C-21, both intrarenally and systemically, translocated AT2Rs from intracellular site

284 =1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 a

285 gs, which were either left untreated or were systemically treated with either dexamethasone, aminophy

286 This should be considered when systemically treating cancer patients with heparanase in

287 CAR-DCN or vehicle was administrated systemically until day 15.

288 osine stress imaging protocols have not been systemically validated for absolute myocardial perfusion

289 mounts as well as ultrasound parameters were systemically varied.

290 erations in the microenvironment, as well as systemically via circulating metabolic and inflammatory

291 the gastrointestinal tract and disseminates systemically via hematogenous or neural routes.

292 of axillary buds into branches is regulated systemically via plant hormones and the demand of growin

293 antiviral immune protection both locally and systemically via stimulation of CD8 cellular immune resp

294 d freezing, using dexamethasone administered systemically which is known to result in suppression of

295 umans; however, wild-type (WT) mice infected systemically with conventional doses of Brucella do not

296 brain phenotype, we treated 5XFAD/Tg197 mice systemically with infliximab, an anti-huTNF-alpha antibo

297 Brain ischemia inhibits immune function systemically, with resulting infectious complications.

298 lycans in mice, the ability to image glycans systemically within a live organism has remained elusive

299 synthesis and attenuated jasmonate responses systemically within the plant.

300 can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism.