ライフサイエンスコーパス: theca cell

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1 rotein and mRNA levels are increased in PCOS theca cells.

2 pression and intrinsic abnormalities in PCOS theca cells.

3 ression profile that is distinct from normal theca cells.

4 rian surface epithelium, granulosa cells and theca cells.

5 NA when added to the medium of cultured PCOS theca cells.

6 defined a stable molecular phenotype of PCOS theca cells, 2) suggested new mechanisms for excess andr

7 strong mRNA labeling for BMP-4 and -7 in the theca cells and BMP receptor types IA, IB, and II in the

8 Oocyte growth is supported by theca cells and granulosa cells, which establish dynamic

9 he first genetic evidence for the origins of theca cells and reveal a multicellular interaction criti

10 n and insulin resistance persist in cultured theca cells and skin fibroblasts, respectively, from wom

11 g in the development and function of ovarian theca cells and the pathophysiologic effects of hyperins

12 anisms for excess androgen synthesis by PCOS theca cells, and 3) identified new candidate genes that

13 A hallmark of PCOS is excessive theca cell androgen secretion, which is directly linked

14 l interactions between ovarian granulosa and theca cells as an approach to cHRT.

15 Here we show that theca cells derive from two sources: Wt1(+) cells indige

16 r development by antagonizing the actions of theca cell-derived BMPs.

17 In this environment, theca cells form, oestrogen is produced and germ cells a

18 Our previous studies demonstrated that theca cells from PCOS ovaries maintained in long term cu

19 Our analysis revealed that PCOS theca cells have a gene expression profile that is disti

20 ved in excess androgen synthesis by the PCOS theca cells in order to identify candidate PCOS genes.

21 Using theca cells isolated and propagated from normal cycling

22 mutant stromal cells consist of a luteinized theca cell lineage at various differentiation stages inc

23 lls, the identification of mutant luteinized theca cells may add crucial evidence in understanding th

24 in expression to Leydig cells of the testis, theca cells of the ovary, and cells of the adrenal corte

25 ocytes and interstitial cells of the testis, theca cells of the ovary, cerebral cortical neurons, and

26 results suggest that GT198 mutant luteinized theca cells overexpressing CYP17 are common in ovarian c

27 in impaired granulosa cell proliferation and theca cell recruitment as well as fewer primordial folli

28 Knock-down of DENND1A.V2 in PCOS theca cells reduced androgen biosynthesis and CYP17A1 an

29 orced overexpression of DENND1A.V2 in normal theca cells resulted in a PCOS phenotype of augmented CY

30 overexpressing steroidogenic enzyme CYP17, a theca cell-specific marker.

31 ocated in the cytoplasm as well as nuclei of theca cells, suggesting a possible role in gene regulati

32 tly greater amounts of androgens than normal theca cells, suggesting an intrinsic abnormality.

33 is showing that treatment of cultured bovine theca cells (TC) with BMP6 significantly (>twofold; P <

34 Reelin, which is expressed in theca cells, triggers a signal in granulosa cells via ap

35 genes with increased mRNA abundance in PCOS theca cells were aldehyde dehydrogenase 6 and retinol de

36 Human granulosa and theca cells, which express endogenous SF-1, contained mo

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