ライフサイエンスコーパス: threonine kinase

1 epends on the RTKs activating the AKT serine/threonine kinase.

2 activating phosphorylation by Mst1, a serine/threonine kinase.

3 phytochromes are autophosphorylating serine/threonine kinases.

4 amino acid sequences of human protein-serine/threonine kinases.

5 segment conformation of tyrosine and serine/threonine kinases.

6 the protein kinase D (PKD) family of serine/threonine kinases.

7 rylation at Ser133 by various protein serine/threonine kinases.

8 APK)-related kinase, MAPK interacting serine/threonine kinase 1 (MKNK1), in viral entry.

9 ric inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK-1).

10 uired caspase-8, receptor-interacting serine/threonine kinase 1 (RIPK1), and Fas-associated death dom

11 -activated protein kinase interacting serine/threonine kinase 1 activation significantly suppresses T

12 educed levels of receptor-interacting serine-threonine kinase 1 and CRC cell necroptosis.

13 lower levels of receptor-interacting serine-threonine kinase 1 and shorter survival times of patient

14 ivated protein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as increa

15 Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) expression, and miR-155-5p inhibitio

16 in kinase) and MNK1 (MAPK-interacting serine/threonine kinase 1) signaling.

17 TBK1 (TANK-Binding Kinase 1)-AKT (AKT serine/threonine kinase 1)-IRF3 (interferon regulatory factor 3

18 ed levels of the receptor-interacting serine-threonine kinase 1, a mediator of necroptosis, in CRC ce

19 fibroblasts from receptor interacting serine/threonine kinase 1-knockout mice or their WT littermates

20 te-oriented kinase (LOK), also called serine threonine kinase 10 (STK10), is synthesized mainly in ly

21 The tumor suppressor serine/threonine kinase 11 (LKB1/STK11) is one of the most freq

22 The tumor suppressor serine/threonine kinase 11 (STK11 or LKB1) is mutated in 20-30%

23 Serine/threonine kinase 11 (STK11, also known as LKB1) function

24 (LKB1) tumor suppressor gene, Stk11 (serine threonine kinase 11), in the fetal Mullerian duct mesenc

25 Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor mutate

26 served interactions included those of serine/threonine kinase 16 (STK16), hippocalcin-like 1 (HPCAL1)

27 containing (Nod)/receptor-interacting serine-threonine kinase 2 (Ripk2) signals in DCs.

28 mediated through receptor-interacting serine/threonine kinase 2, and the transcriptional regulator CC

29 and in vivo by microtubule-associated serine/threonine kinase 3 (MAST3 kinase), an enzyme of previous

30 cally depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase doma

31 ice deficient in receptor-interacting serine-threonine kinase 3 (RIPK3).

32 We also validated that serine/threonine kinase 35 is a target of miR-377 using a dual

33 lin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation.

34 Among these genes, we identified serine/threonine kinase 40 (STK40), a negative regulator of NF-

35 We identified GCK-1, a conserved serine/threonine kinase [8], as a putative novel anillin intera

36 KD2) is a member of the PKD family of serine/threonine kinases, a subfamily of the CAMK super-family.

37 ng protein kinase (HIPK) 2, a nuclear serine/threonine kinase, activates CREB through Ser271 phosphor

38 cificity kinase and both tyrosine and serine/threonine kinase activities are required for its functio

39 It is an adaptor protein with serine/threonine kinase activity and has been shown to positive

40 Pak2 serine/threonine kinase activity is required for stromal-derive

41 terms protein kinase activity/protein serine threonine kinase activity, response to heat and reactive

42 The p.E80K mutation abolished serine/threonine kinase activity, resulting in altered ICK subc

43 the mutation blocks both tyrosine and serine/threonine kinase activity, whereas Y243 and Y250 are mor

44 , including the regulation of protein serine/threonine kinase activity.

45 ing protein essential for positioning serine-threonine kinases adjacent to target phosphorylation sit

46 mice lacking specific isoforms of the serine/threonine kinase AKT and bone marrow chimeras, we found

47 hosphatidylinositol-3-OH kinase), the serine-threonine kinase Akt and the metabolic checkpoint kinase

48 AKT3, a member of the serine/threonine kinase AKT family, is involved in a variety of

49 Here we demonstrate that the serine/threonine kinase Akt has a critical role in regulating n

50 Pharmacologic inhibition of the serine/threonine kinase Akt has recently been shown to promote

51 Although the role of the key serine/threonine kinase Akt in promoting CNS myelination has be

52 Here we examined the role of the serine/threonine kinase Akt in the generation of protective imm

53 The serine/threonine kinase AKT is a key mediator of cancer cell su

54 The serine-threonine kinase Akt is a key regulator of cell prolifer

55 Activation of the serine-threonine kinase Akt promotes the survival and prolifera

56 The serine-threonine kinase AKT regulates proliferation and surviva

57 ckpoint kinase complex mTORC2 and the serine-threonine kinase Akt, and loss of this activity restores

58 depends on the activation of PI3K and serine-threonine kinase Akt, and protein synthesis relies on th

59 The serine/threonine kinase Akt, which regulates HTT function, resc

60 phate (PIP3), and the activity of the serine/threonine kinase AKT.

61 activation-induced phosphorylation of serine-threonine kinases Akt and mechanistic target of rapamyci

62 Akt is a family of three serine-threonine kinases, Akt1, Akt2, and Akt3.

63 kinases are tyrosine kinases, though serine/threonine kinases also play key roles in some malignanci

64 LKB1 is a serine/threonine kinase and a commonly mutated gene in lung ade

65 ion of general control nonrepressed 2 serine/threonine kinase and increased expression of mammalian t

66 ion of general control nonrepressed 2 serine/threonine kinase and mammalian target of rapamycin (both

67 focus on coordination of postsynaptic serine/threonine kinase and phosphatase signaling by scaffold p

68 The liver kinase B1 (LKB1) is a serine/threonine kinase and tumor suppressor that couples bioen

69 ATIONALE: LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regulates t

70 Here we explore how key serine-threonine kinases and their substrates mediate T cell si

71 expression of the oncogenic PIM1/2/3 serine/threonine kinases, and as PIMs modulate transcriptional

72 ex comprises APC, Axin, beta-catenin, serine/threonine kinases, and other proteins.

73 We show that the apically localized serine/threonine kinase aPKC directly phosphorylates an N-termi

74 the protein kinase D (PKD) family of serine/threonine kinases are major targets for tumor-promoting

75 rum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase, as an essential node downstream of IL-

76 ify CDK5, a predominantly cytoplasmic serine/threonine kinase, as an important regulator of DLC1 func

77 ous to penicillin-binding protein and serine/threonine kinase associated (PASTA) domains, and binds f

78 llular penicillin-binding-protein and serine/threonine kinase-associated (PASTA) domains which bind m

79 terial Penicillin-binding-protein And Serine/Threonine kinase-Associated (PASTA) kinases is of partic

80 ent cations and contains a functional serine/threonine kinase at its carboxyl terminus.

81 1 is phosphorylated by the DNA damage serine/threonine kinase ATM, resulting in increased levels of F

82 led to reduced phosphorylation of the serine/threonine kinases ATM and Chk2 and of histone H2AX after

83 rations in FA-complex genes or in ATM serine/threonine kinase (ATM) exhibited significantly longer tr

84 ment of ataxia-telangiectasia mutated serine/threonine kinase (ATM) to the damaged site, where it pla

85 ion of Gene 33 triggers DDR in an ATM serine/threonine kinase (ATM)-dependent fashion and through pat

86 l components is phosphorylated by the serine-threonine kinase, ATM.

87 terized the activation process of the serine/threonine kinase Aurora-A by phosphorylation and by its

88 Classically defined as a serine/threonine kinase, BIK1 is shown here to possess tyrosine

89 Mutations in the serine/threonine kinase BRAF are found in more than 60% of mela

90 ement within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in development an

91 h a constitutively active form of the serine/threonine kinase BRAF was expressed in neurons gated by

92 The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequently muta

93 protein kinase B-Raf proto-oncogene, serine/threonine kinase (BRAF) is an oncogenic driver and thera

94 ability, and the B-Raf protooncogene, serine/threonine kinase (BRAF), mutation) in the Nurses' Health

95 as PLK1 (Polo-like kinase 1), C-MYC, serine-threonine kinase BUB1B and regulates their expression.

96 nd protein phosphatase-1, as well the serine/threonine kinases CaMKII and PKA.

97 Here we report that the conserved serine/threonine kinase, casein kinase II (CK2), promotes miRIS

98 aining both an ion channel pore and a serine/threonine kinase (chanzyme).

99 he LNAA leucine for activation of the serine-threonine kinase complex mTORC1 and for expression of th

100 tion of their primary sequences, many serine-threonine kinases display a significant preference for s

101 A key serine/threonine kinase distantly related to the MAPK family is

102 ate 1970s, is composed of at least 10 serine/threonine kinases, divided into three groups based on th

103 apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2; rs7594645-G) with better mem

104 ral and signaling motifs, including 2 serine/threonine kinase domains, SK1 and SK2, present at the CO

105 show that the kinase activity of the serine/threonine kinase encoded by TAOK2 is required for spine

106 The Escherichia coli eukaryote-like serine/threonine kinase, encoded by yeaG, is expressed in respo

107 , we find that phosphorylation of the serine/threonine kinase ERK (pERK) preferentially occurs in end

108 nally reported as an inhibitor of the serine/threonine kinase ERK, a kinase that is distinct in the s

109 well appreciated that eukaryotic-like serine/threonine kinases (eSTKs) control essential processes in

110 ber of the protein kinase C family of serine/threonine-kinases, expression varies during human megaka

111 sactivation of microtubule associated serine/threonine kinase family member 4 (MAST4).

112 cting NEK2, a member of the NIMA-like serine-threonine kinase family, in a patient with congenital he

113 The Fas-activated serine/threonine kinase (FASTK) family of proteins has recently

114 TOR, an atypical serine/threonine kinase, forms two distinct complexes TORC1 and

115 tein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated

116 arget of rapamycin complex 1 (mTORC1) serine/threonine kinase from the lysosomal membrane.

117 ein kinase (AMPK), a highly conserved serine/threonine kinase, functions as a critical metabolic sens

118 get of rapamycin (mTOR), an essential serine/threonine kinase, functions in biochemically distinct mu

119 Somatic inactivation of the serine/threonine kinase gene STK11/LKB1/PAR-4 occurs in a varie

120 in vitro functional studies, a novel serine/threonine kinase gene, unc-51-like kinase 4 (ULK4), as a

121 We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3alpha/b

122 Biallelic inactivation of LKB1, a serine/threonine kinase, has been detected in 30% of lung adeno

123 The serine/threonine kinase HIPK2 functions as a regulator of devel

124 53Ser46(P) by binding and stabilizing serine-threonine kinase HIPK2.

125 One of these binding partners is the serine/threonine kinase Hrr25p.

126 Serine/threonine kinase IKBKE is a newly identified oncogene; h

127 The serine/threonine kinase IL-1R-associated kinase (IRAK)4 is a cr

128 ibrain (Mnb; also known as Dyrk1A), a serine/threonine kinase implicated in autism spectrum disorder

129 (GSK-3, isoforms alpha and beta) is a serine-threonine kinase implicated in cellular processes.

130 kinase kinase kinase 4 (MAP4K4) is a serine/threonine kinase implicated in the regulation of many bi

131 Protein kinase C (PKC) is a family of serine/threonine kinases implicated in a variety of physiologic

132 e c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of vari

133 PKD) is a family of stress-responsive serine/threonine kinases implicated in the regulation of divers

134 the highly overexpressed genes of the serine/threonine kinase in CTCL.

135 point kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA damage.

136 ULK1/Atg1 is the only serine/threonine kinase in the core autophagy pathway and thus

137 ich encodes a type I activin receptor serine/threonine kinase, in 21% of DIPG samples.

138 , we identified PIM1, a non-essential serine-threonine kinase, in a synthetic lethal interaction with

139 a target of casein kinase 2 (CK2), a serine/threonine kinase, in proliferating myoblasts.

140 ycin (TOR), an evolutionary conserved serine/threonine kinase, in the plant defense response.

141 Enzastaurin is an oral serine/threonine kinase inhibitor antitumor agent.

142 mTOR is a serine/threonine kinase involved in a variety of cellular activ

143 rylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentiation an

144 e-3 (GSK3) are ubiquitously expressed serine-threonine kinases involved in a plethora of functions ra

145 an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis.

146 ously determined that a transmembrane serine/threonine kinase (IreK) and its cognate phosphatase (Ire

147 The Aurora family of serine/threonine kinases is essential for mitosis.

148 (CK1alpha), a ubiquitously expressed serine/threonine kinase, is a key negative regulator of oncogen

149 mTOR, a serine/threonine kinase, is a master regulator of cellular meta

150 Liver kinase B1 (LKB1), a serine/threonine kinase, is a tumor suppressor and metabolic re

151 at casein kinase 1 alpha (Csnk1a1), a serine-threonine kinase, is essential for AML cell survival in

152 Protein kinase C (PKC) theta, a serine/threonine kinase, is involved in TH2 cell activation and

153 Akt, a serine/threonine kinase, is known to increase cell survival by

154 ber of the polo-like kinase family of serine-threonine kinases, is a master regulator of centriole du

155 PK1, a member of mammalian Ste20-like serine/threonine kinases, is lost in >95% pancreatic cancer thr

156 the phosphorylation by WNKs of other serine-threonine kinases known as SPAK-OSR1.

157 optosis signal-regulating kinase 1, a serine/threonine kinase, leads to improvement in inflammation a

158 kinase (called microtubule-associated serine/threonine kinase like [Mastl] in mammals) is essential f

159 revious study, we identified TRIB1, a serine-threonine kinase-like molecule, as a biomarker of chroni

160 We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK, r

161 The serine/threonine kinase LKB1 has been identified as a potent su

162 The serine/threonine kinase LKB1 is a tumor suppressor whose loss i

163 We demonstrate that the serine/threonine kinase LKB1 regulates MCU expression, mitochon

164 ivity of the evolutionarily conserved serine/threonine kinase mammalian target of rapamycin (mTOR).

165 The serine/threonine kinase mammalian/mechanistic target of rapamyc

166 -activated protein kinase-interacting serine-threonine kinases MAP kinase-interacting kinase 1 (Mnk1/

167 In recent years, the serine/threonine kinase mechanistic target of rapamycin (mTOR)

168 show that the MAP kinase interacting serine/threonine kinase (MNK)-eukaryotic translation initiation

169 the mechanistic target of rapamycin (serine/threonine kinase; MTOR) pathway in the regulation of neu

170 ntify protein kinase C (PKC) gamma, a serine/threonine kinase mutated in the neurodegenerative diseas

171 In this study, we show that the serine/threonine kinase Ndr2 controls integrin-dependent dendri

172 PRL activates the serine/threonine kinase NEK3, which was reported to enhance bre

173 reen, we identified a mitotic-related serine/threonine kinase, NEK6, as a mediator of androgen-indepe

174 canonical NF-kappaB signaling via the serine/threonine kinase NIK (NF-kappaB-inducing kinase) remains

175 ated by the liver kinase B1 (LKB1), a serine-threonine kinase of the calcium calmodulin family.

176 ocated within STK32C, which encodes a serine/threonine kinase, of unknown function.

177 of these binding partners include the serine/threonine kinases, p21-activated kinase 1 (PAK1), apopto

178 determined that d-flow activated the serine/threonine kinase p90RSK, which subsequently phosphorylat

179 Ovaries in flies mutant for the serine/threonine kinase Pak exhibit a novel phenotype, in which

180 Serine/threonine kinase PAK1 is activated by estrogen and plays

181 The p21-activated serine-threonine kinase (PAK1) regulates cell motility and adhe

182 We determine that the serine/threonine kinase Par1b defines lumen position in concert

183 The protein kinase D family of serine/threonine kinases, particularly PKD1, has been implicate

184 The hypoxia-inducible, pro-oncogenic, serine-threonine kinase PIM1 (Proviral Integration site for Mol

185 PKD is a family of three serine/threonine kinases (PKD-1, -2, and -3) involved in the re

186 We found that RhoA activated the serine-threonine kinases PKN1 and PKN2 that bind and phosphoryl

187 In eukaryotes, serine/threonine kinases play a central role in antiviral respo

188 Dysregulated oncogenic serine/threonine kinases play a pathological role in diverse fo

189 IRAK4, a serine/threonine kinase, plays a key role in both inflammation

190 The Akt protein, a serine/threonine kinase, plays important roles in cell survival

191 The polo family serine threonine kinase Plk4 has been proposed as a therapeutic

192 GSK3 is a pleiotropic serine-threonine kinase point of convergence of numerous cell-s

193 We have identified the serine/threonine kinase Polo-like kinase 1 (PLK1) as a host kin

194 role for the cell division regulating serine/threonine kinase polo-like kinase 2 (PLK2).

195 terphase of the cell cycle by NEK7, a serine-threonine kinase previously linked to mitosis.

196 coupled receptor kinase 5 (GRK5) is a serine/threonine kinase previously shown to mediate polymicrobi

197 RIPK1 and RIPK3, a pair of homologous serine/threonine kinases previously implicated in the regulatio

198 horylated by the MST1 (Hippo homolog) serine-threonine kinase, previously shown to be an AR repressor

199 echanistic target of rapamycin (mTOR) serine/threonine kinase promotes myelination, but factors that

200 A bioinformatic screen identified the serine-threonine kinase protein kinase D2 (PRKD2) as a potentia

201 the expression of the Golgi-localized serine-threonine kinase protein kinase D3 (PKD3) is elevated in

202 dually suppressed RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK signaling through the intera

203 ike kinase 1 (ALK1) is an endothelial serine-threonine kinase receptor for bone morphogenetic protein

204 and both protein-tyrosine kinase and serine/threonine kinase receptor transactivation concomitantly

205 In contrast, serine/threonine kinase receptor transactivation is mediated by

206 Here, we show that serine-threonine kinase receptor-associated protein (STRAP) is

207 Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wide spec

208 ediate signals via transactivation of serine/threonine kinase receptors, most notably the transformin

209 The RAF serine/threonine kinases regulate cell growth through the MAPK

210 n synthase kinase-3 (GSK-3) family of serine/threonine kinases regulates several of these pathways, b

211 ng protein kinase (Hipk), a conserved serine-threonine kinase, regulates numerous factors during tiss

212 cell polarity protein Par-1 (MARK), a serine-threonine kinase, regulates the localization and activat

213 a B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (A

214 c approach identified PKCtheta as the serine/threonine kinase responsible for alphaPIX serine phospho

215 P-dependent protein kinase (PKA) is a serine/threonine kinase responsible for most of the effects of

216 siRNA-mediated inhibition of various serine/threonine kinases revealed ERK1/2 as a positive regulato

217 RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochond

218 The serine/threonine kinase RIPK1 is recruited to TNFR1 to mediate

219 Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Protein K

220 e translocation and activation of the serine/threonine kinase ROCK1, a downstream target of the RhoA

221 ORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic r

222 ess downregulates the activity of the serine/threonine kinase Shaggy (Sgg; also known as GSK-3).

223 fibrosis-relevant tyrosine kinase and serine/threonine kinase signaling pathways.

224 d by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding partner

225 d by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding partner

226 Silencing the serine/threonine kinase STK11 (also known as LKB1) in HT-29 cel

227 kers, one (rs10937625) located in the serine/threonine kinase STK32B and one (rs17590046) in the tran

228 YAP1 is under the control of a serine-threonine kinase, STK4.

229 o interferes with the activity of the serine/threonine kinase StkP, the central regulator of pneumoco

230 In plants and algae, the serine/threonine kinase STN7/STT7, orthologous protein kinases

231 Trans-membrane signaling involving a serine/threonine kinase (Stt7 in Chlamydomonas reinhardtii) dir

232 ranscription factor NF-kappaB via the serine/threonine kinase TAK1.

233 dentifying degrader hits based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) and have g

234 enerated Taok3(-/-) mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects

235 that shRNA-mediated knockdown of the serine/threonine kinases TESK1 or LIMK2 promoted mesenchymal-to

236 mTOR is a serine/threonine kinase that acts as a central cellular censor

237 LKB1 is a multi-functional serine/threonine kinase that associates with actin at the cellu

238 MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 family o

239 istic target of rapamycin (mTOR) is a serine-threonine kinase that coordinates nutrient and growth fa

240 et of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions

241 et of rapamycin (mTOR) is a conserved serine/threonine kinase that forms two complexes, mTORC1 and mT

242 protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in development and tumor

243 Integrin-linked kinase (ILK) is a serine/threonine kinase that has been linked to human and exper

244 LKB1 encodes a serine/threonine kinase that has critical roles in cell growth,

245 eta1 (LKB1, also known as STK11) is a serine/threonine kinase that has multiple cellular functions in

246 GSK-3 is a serine/threonine kinase that has numerous substrates.

247 Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth and induces p

248 eptor-interacting protein (RIP1) is a serine/threonine kinase that integrates inflammatory and necrop

249 Specifically, we show that NLK, a serine/threonine kinase that interacts with ATXN1, modulates di

250 AMPK is a serine/threonine kinase that is activated by upstream kinases L

251 t cyclin-dependent kinase 5 (Cdk5), a serine-threonine kinase that is highly active in postmitotic ne

252 osal and the activation of Akt/PKB, a serine/threonine kinase that is obligate for insulin-stimulated

253 osphatidylinositol 3-kinase-dependent serine/threonine kinase that is rapidly induced in response to

254 Cdc7 is a serine-threonine kinase that phosphorylates components of the p

255 F2K), a Ca(2)(+)/calmodulin dependent serine/threonine kinase that phosphorylates eEF2 and regulates

256 1-like kinase 1 (ULK1) is a conserved serine-threonine kinase that plays a central role in the initia

257 p21-activated kinase-1 (Pak1) is a serine/threonine kinase that plays a key role in mediating anti

258 uiring enzyme 1alpha (IRE1alpha) is a serine-threonine kinase that plays crucial roles in activating

259 is a highly conserved and pleiotropic serine/threonine kinase that promotes many prosurvival and proi

260 re we identify Stk2, a staphylococcal serine/threonine kinase that provides efficient immunity agains

261 alian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a diverse array of cellu

262 e A (PKA) is a ubiquitously expressed serine/threonine kinase that regulates a variety of cellular fu

263 alian target of rapamycin (mTOR) is a serine/threonine kinase that regulates processes including mRNA

264 Tumor progression locus 2 (Tpl2) is a serine-threonine kinase that regulates Th1 differentiation, sec

265 Integrin-linked kinase (ILK) is a serine-threonine kinase that transduces extracellular matrix-re

266 ed kinases (PAKs) are a family of six serine/threonine kinases that act as key effectors of RHO famil

267 OCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associated with

268 Serine-threonine kinases that activate NKCC2 have been identifi

269 The p21-activated kinases (Paks) are serine/threonine kinases that are major effectors of the Rho gu

270 LegK1-4 proteins are eukaryotic-like serine/threonine kinases that are translocated by the Dot/Icm t

271 CK) is a member of a diverse group of serine/threonine kinases that feature cytoskeletal association.

272 NEK family kinases are serine/threonine kinases that have been functionally implicated

273 nase catalytic subunit (DNA-PKcs) are serine-threonine kinases that orchestrate the cellular response

274 ceptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating

275 ho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key downstream effectors

276 repeats, a transmembrane domain and a serine/threonine kinase, the rice (Oryza sativa) protein XA21 c

277 gnaling pathway consists of conserved serine/threonine kinases to maintain optimal organ sizes.

278 The translocation of Akt, a serine/threonine kinase, to the plasma membrane is a critical s

279 The serine-threonine kinase TOR, the Target of Rapamycin, is an imp

280 The testis-specific serine/threonine kinases (TSSKs) comprise a family of post-meio

281 The serine/threonine kinase tumor progression locus 2 (Tpl2, also k

282 through binding and activation of the serine/threonine kinase type II TGF-beta receptor (TbetaRII), w

283 n of the MTOR complex 1 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncogene hom

284 TSSK1, -2, -4, and -6 (small serine/threonine kinase) were all found to associate with HSP90

285 pe II (TbetaRII) and type I (TbetaRI) serine/threonine kinases, whereby Smad2 and Smad3 are phosphory

286 kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous s

287 CASK (a calcium/calmodulin-activated serine/threonine kinase), which binds to neurexins, and mutatio

288 interacts with calmodulin-associated serine/threonine kinase, which is implicated in X-linked mental

289 PAK4 is a member of the PAK family of serine/threonine kinases, which act as effectors for several sm

290 AMPK is a conserved serine/threonine kinase whose activity maintains cellular energ

291 se II (CaMKII) is a calcium-regulated serine threonine kinase whose functions include regulation of s

292 protein kinase (AMPK) is a conserved serine/threonine kinase with a critical function in the regulat

293 ied MAST205 (a microtubule-associated serine/threonine kinase with a molecular mass of 205 kDa) as a

294 coupled receptor kinase 2 (GRK2) is a serine/threonine kinase with an important function in the desen

295 racting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necroptosis.

296 eting oncogenic mutations in the BRAF serine/threonine kinase with small molecule inhibitors can lead

297 polo-like kinases (PLK), a family of serine/threonine kinases with well-known roles in cell cycle re

298 Two of these genes encode the serine-threonine kinases WNK1 and WNK4.

299 Serine threonine kinase WNK4 (With No K = lysine member 4) and

300 One such protein, the serine/threonine kinase YopO (YpkA in Yersinia pestis), uses mo