ライフサイエンスコーパス: toll

1 Toll-6 promotes cell survival via MyD88-NF-kappaB and ce

2 irus (BQCV) titers and lower expression of a Toll 7-like-receptor associated with autophagic viral de

3 The localized activation of Toll a few cell diameters from wound edges is reminiscen

4 Furthermore, the combinatorial activity of Toll and other signaling pathways in activating epiderma

5 otide-binding oligomerization domain (NOD)-, Toll-, and RIG1-like receptor pathways, was associated w

6 at the dorsal-ventral patterning function of Toll arose from the evolutionary cooption of a morphogen

7 Third, distinct adaptors downstream of Tolls can drive either apoptosis or cell survival.

8 Second, different Tolls can preferentially promote cell survival or death.

9 In this study, we show that DNTs and Tolls can switch from promoting cell survival to death i

10 n in sports has resulted in increased injury tolls due to shifts toward participation in competitive

11 explain why developmental activation of the Toll, ERK, or JNK pathways alone fail to activate wound

12 still present a time, money, and reputation toll for physicians.

13 yeloid differentiation response gene 88, and Toll-IL-1 receptor domain-containing adaptor-inducing in

14 n interferon-independent mechanism involving Toll-IL-1-receptor domain-containing adapter-inducing IF

15 Furthermore, we show that the intracellular Toll/IL-1 receptor (TIR) domain of Nv-TLR can interact w

16 to recruitment of the adaptor molecule TRIF (Toll/IL-1 resistance (TIR) domain-containing adapter-ind

17 ing of septic insult by targeting MyD88- and Toll/IL-1R domain-containing adaptor inducing IFN-beta-d

18 Microarray experiments indicated that the Toll/IL-1R domain-containing adaptor inducing IFN-beta/

19 These included components of the Toll, Imd and JAK/STAT pathways, consistent with interac

20 reater expression of genes involved in RNAi, Toll, Imd, and JAK-STAT pathways, but the majority of di

21 lators, few members of main immune pathways (Toll, Imd, and JAK/STAT), and immune effectors in P. xyl

22 edges is reminiscent of local activation of Toll in early embryonic ventral hypoderm, consistent wit

23 een unmoved by the relentlessly rising death toll in Syria suddenly appeared to care much more after

24 lting in widespread devastation with a death toll in the thousands.

25 Toll-interacting protein (TOLLIP) is a ubiquitin-binding

26 and activate downstream signaling via TIRAP (Toll-interleukin 1 receptor domain containing adaptor pr

27 typical multidomain structure: an N-terminal Toll-interleukin receptor (TIR) or coiled-coil (CC) doma

28 Here, we describe a Toll/interleukin 1 receptor (TIR) domain-containing prot

29 une responses by targeted degradation of the Toll/interleukin-1 receptor (TIR) domain-containing adap

30 ) results in dimerization of their cytosolic Toll/interleukin-1 receptor (TIR) domains and recruitmen

31 signaling adapter protein interactions with Toll/Interleukin-1 Receptor (TIR) domains present in sen

32 Analysis of Toll/interleukin-1 receptor (TIR) sequences indicated th

33 stal structures of MAL revealed a nontypical Toll/interleukin-1 receptor (TIR)-domain fold stabilized

34 his requires the P loops of each protein and Toll/interleukin-1 receptor (TIR)-domain-mediated hetero

35 In the Drosophila embryo, Toll is required to establish gene expression domains al

36 NA levels were assessed by real-time PCR and Toll like receptor 4 (TLR-4) protein expression by Weste

37 This activation is through the toll like receptor 4 (TLR4)/myeloid differentiation prim

38 R2-/- and TLR4-/- mice that are defective in toll like receptor signaling.

39 ing leucine-rich repeat (NLR) protein with a Toll-like interleukin-1 receptor (TIR) domain, which med

40 Toll-like receptor (Tlr) 13(-/-) BMDCs showed a weak res

41 In the present study, the roles of toll-like receptor (TLR) 2, TLR4 and MyD88, in exacerbat

42 Therefore, the role of Toll-like receptor (TLR) 2, TLR4, myeloid differentiatio

43 eversed the upregulation of calprotectin and Toll-like receptor (TLR) 4 in inflamed skin.

44 hma was induced in C57BL/6 J wild-type mice, Toll-like receptor (TLR) 4 knockout (Tlr4(-/-)) mice, an

45 sponse that was independent of both upstream Toll-like receptor (TLR) 4 signaling and downstream type

46 LPS binds Toll-like receptor (TLR) 4, which leads to the release o

47 Toll-like receptor (TLR) 5 binding was assessed with HEK

48 Small-molecule imidazoquinoline Toll-like receptor (TLR) 8 agonists robustly activate ne

49 Toll-like receptor (TLR) activation contributes to prema

50 Toll-like receptor (TLR) activation stimulates antiviral

51 The TIR domain is able to interact with the Toll-like receptor (TLR) adaptors TIRAP and MyD88, as we

52 zation and activation of the inflammasome by Toll-like receptor (TLR) agonism with bacterial lipopoly

53 Toll-like receptor (TLR) agonist adjuvant formulations h

54 nitric oxide synthase (iNOS) mRNA following Toll-like receptor (TLR) agonist treatment.

55 acrophages submitted to oxidative stress and toll-like receptor (TLR) agonist.

56 ons in combination with several Th1-inducing Toll-like receptor (TLR) agonists in vivo In mice, the T

57 cells, IL-10 can be produced in response to Toll-like receptor (TLR) agonists.

58 other types of dangers through their role in Toll-like receptor (TLR) and interleukin 1 receptor (IL-

59 Most members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-

60 onse gene 88 (MyD88), the common adaptor for toll-like receptor (TLR) and Interleukin-1 receptor sign

61 s, acting as a negative regulator of ILR and Toll-like receptor (TLR) downstream signalling pathways

62 r immune cell composition by flow cytometry, Toll-like receptor (TLR) expression by quantitative PCR,

63 ith the latter reflected in changes in local Toll-like receptor (TLR) expression.

64 TOLL-like receptor (TLR) ligands activate both innate an

65 cally relevant immune-agonists, specifically Toll-like receptor (TLR) ligands, using biodegradable, p

66 1-derived macrophages activated by different toll-like receptor (TLR) ligands.

67 Cross-regulation of Toll-like receptor (TLR) responses by cytokines is essen

68 Accumulating evidence indicates that Toll-like receptor (TLR) signaling adapter protein inter

69 ed kinase 1 (TAK1) is critical for mediating Toll-like receptor (TLR) signaling and subsequent activa

70 The role of Toll-like receptor (TLR) signaling in processing of SLE

71 We determined the function of Toll-like receptor (TLR) signaling on the progression of

72 ptor protein TRAF6 has a central function in Toll-like receptor (TLR) signalling, yet the molecular m

73 ues are phosphorylated both before and after Toll-like receptor (TLR) stimulation.

74 ns involved in signaling pathways, including Toll-like receptor (TLR), mitogen-activated protein kina

75 HCC because it has critical roles in virus-, Toll-like receptor (TLR)-, and IFN-induced signaling pat

76 Dysregulated Toll-like receptor (TLR)-4 activation is involved in acu

77 Escherichia coli lipopolysaccharide (LPS), a Toll-like receptor (TLR)-4 agonist.

78 Extracted monocytes were stimulated with the toll-like receptor (TLR)-4 ligand, lipopolysaccharide (L

79 ne chest wall mammary cancers with a topical toll-like receptor (TLR)-7 agonist, imiquimod.

80 ses to T-cell-independent antigens through a Toll-like receptor (TLR)-amplified pathway involving tra

81 Toll-like receptor (TLR)-mediated sensing of the microbi

82 ctivation, a host response also critical for Toll-like receptor (TLR)-mediated signaling.

83 of inflammation-associated genes, including toll-like receptor (TLR)2, the receptor for advanced gly

84 Expression of Toll-like receptor (TLR)2, TLR4, and nuclear factor (NF)

85 ot suppressed by inhibitors of intracellular toll-like receptor (TLR)9.

86 s a macrophage immunosuppressant by reducing Toll-like receptor 1/2 (TLR1/2) activation by bacterial

87 Responses to all Toll-like receptor 1/2 (TLR1/2), TLR2/6, and TLR4 agonis

88 s trigger pro-inflammatory responses through Toll-like receptor 2 (TLR2) activation, and this whether

89 antibodies were used to dissect the role of Toll-like receptor 2 (TLR2) and programmed death-ligand

90 ed, albeit the recognition of lipoglycans by Toll-like receptor 2 (TLR2) appears to be important for

91 We examined the inflammatory role of Toll-like receptor 2 (TLR2) in age-related macular degen

92 Toll-like receptor 2 (TLR2) plays a critical role in hos

93 es in the proinflammatory markers TNF-alpha, toll-like receptor 2 (TLR2), and TLR4.

94 l" anti-inflammatory phenotype by activating Toll-like receptor 2 (TLR2), which regulates the inducti

95 he Brucella effector protein TcpB suppresses Toll-like receptor 2 (TLR2)- and TLR4-mediated innate im

96 n of macrophages derived from MyD88-, TRIF-, Toll-like receptor 2 (TLR2)-, TLR4-, and TLR2/4-deficien

97 stimulates the innate immune system through Toll-like receptor 2 (TLR2); however, the pathogen-assoc

98 Toll-like receptor 2 agonism activated luminal endotheli

99 eneration and elevated surface expression of toll-like receptor 2 and CD11b on monocytes and neutroph

100 with broad specificity that is dependent on Toll-like receptor 2 and interleukin 1beta.

101 IFN-kappa was significantly increased after toll-like receptor 2 and UVB treatment in lupus keratino

102 e skin microbiome is a rich source of LTA, a Toll-like receptor 2 ligand, we mimicked the GF microbio

103 ation factor, and lipoteichoic acid (LTA), a Toll-like receptor 2 ligand.

104 bed flow and of neutrophils, hyaluronan, and Toll-like receptor 2 ligation in superficial intimal inj

105 implicate flow disturbance, neutrophils, and Toll-like receptor 2 signaling as mechanisms that contri

106 h healthy control subjects after exposure to toll-like receptor 2, 3, or 4 agonists or exposure to UV

107 r membrane of A. muciniphila, interacts with Toll-like receptor 2, is stable at temperatures used for

108 olyinosine-polycytidylic acid (poly(I:C)), a Toll-like receptor 3 (TLR3) agonist used as a mimetic to

109 Defects in genes of the Toll-like receptor 3 (TLR3) pathway are associated with

110 merous interferon-regulated genes, including Toll-like receptor 3 (Tlr3), which encodes an innate imm

111 mal organization to the selective control of toll-like receptor 3 (TLR3)- and TLR4-mediated proinflam

112 Inhibition of BRD4 blocks Toll-like receptor 3 (TLR3)-dependent neutrophilia and R

113 Toll-like receptor 3, an innate pattern recognition rece

114 We sought to evaluate an inhibitory mAb to Toll-like receptor 3, CNTO3157, on experimental HRV-16 i

115 ary and sufficient to stimulate WIHN through toll-like receptor 3.

116 increase in TJ permeability was mediated by toll-like receptor 4 (TLR-4)/MyD88 signal-transduction p

117 e microbiota, hematopoietic cell deletion of Toll-like receptor 4 (TLR4) and inactivation of the IL-1

118 Here we identify endothelial Toll-like receptor 4 (TLR4) and the gut microbiome as cr

119 ntigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in p

120 further implicate the innate immune receptor toll-like receptor 4 (TLR4) as an underlying mechanism m

121 Stimulation of Toll-like receptor 4 (TLR4) by bacterial lipopolysacchar

122 Similarly, Toll-like receptor 4 (TLR4) has been implicated in breas

123 Ps) induced NF-kappaB activation mediated by Toll-like receptor 4 (TLR4) in a glycoprotein (GP)-depen

124 LPS-mediated activation of Toll-like receptor 4 (TLR4) in macrophages results in th

125 Toll-like receptor 4 (TLR4) is a critical component of i

126 SIGNIFICANCE STATEMENT: Toll-like receptor 4 (TLR4) is a key mediator of innate

127 Toll-like receptor 4 (TLR4) is a pattern recognition mol

128 morphine binds to the innate immune receptor toll-like receptor 4 (TLR4) localized primarily on micro

129 Here, we show that Toll-like receptor 4 (TLR4) mediates cancer-induced musc

130 To test the hypothesis that toll-like receptor 4 (TLR4) mediates proinflammatory pol

131 rs of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells.

132 ow that GOS is recognized by and upregulates Toll-like receptor 4 (TLR4) on RAW264.7 macrophages, fol

133 entiation revealed that binding of S100A9 to Toll-like receptor 4 (TLR4) promotes activation of p38 m

134 emonstrate that hRetn binds the LPS receptor Toll-like receptor 4 (TLR4) through its N terminal and m

135 ent of Gram-negative bacteria that activates Toll-like receptor 4 (TLR4) to trigger proinflammatory r

136 Binding of MfP to Toll-like receptor 4 (TLR4) was determined by co-immunop

137 WD-fed Toll-like receptor 4 (TLR4)(-/-) mice did not exhibit my

138 o found to bind TRAM, an adaptor protein for Toll-like receptor 4 (TLR4), and thereby impact both vir

139 In the ALHS, we tested for a gene [Toll-like Receptor 4 (TLR4), encoding the endotoxin rece

140 ytoplasm and downregulated the expression of toll-like receptor 4 (TLR4), receptor for advanced glyca

141 gle study revealed a new complex composed of Toll-like receptor 4 (TLR4), TLR6, and CD36 induced by f

142 del of PHH, we demonstrate that IVH causes a Toll-like receptor 4 (TLR4)- and NF-kappaB-dependent inf

143 Disease was linked to a Toll-like receptor 4 (TLR4)-dependent mechanism of IAP d

144 EL induced PTX3 expression by activating the Toll-like receptor 4 (TLR4)-dependent pathway via nuclea

145 ct ligations or sham surgeries on C57BL/6 or toll-like receptor 4 (TLR4)-knockout mice to induce live

146 ages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX)

147 f opioids, and we recently demonstrated that Toll-like receptor 4 (TLR4)-mediated neuroinflammation i

148 Toll-like receptor 4 (TLR4)-mediated signaling was asses

149 ue damage and expressed by tumors, activates toll-like receptor 4 (TLR4)-mediated sterile inflammatio

150 ated predominantly via the membrane receptor Toll-like receptor 4 (TLR4).

151 s in cultured myenteric neurons that express Toll-like receptor 4 (TLR4).

152 reduced lipopolysaccharide activation of the toll-like receptor 4 and increased survival times compar

153 n end products (RAGE) messenger RNA, but not toll-like receptor 4 in hippocampal microglia.

154 amplified platelet response to the agonists; Toll-like receptor 4 inhibitor blunted this effect.

155 primes the cell for an enhanced response to toll-like receptor 4 ligands.

156 In the brain, levels of RAGE and Toll-like receptor 4, glial fibrillary acidic protein an

157 also attenuated proinflammatory signaling by Toll-like receptor 4, which has a central role in Ad pat

158 nd SseK3 suppress TNF-alpha-induced, but not Toll-like receptor 4- or interleukin-induced, NF-kappaB

159 rass pollen or mite allergens to enhance the Toll-like receptor 4-mediated proallergic properties of

160 s blunted by incubation with an inhibitor of Toll-like receptor 4.

161 s, an event triggered by the innate receptor Toll-like receptor 4.

162 eta1 integrin and the innate immune receptor toll-like receptor 4.

163 ury triggering the macrophage activation via Toll-like receptor 4.

164 Additionally, we found a significant toll-like receptor 4/alpha4beta1-dependent enrichment in

165 Toll-like receptor 5 (TLR5) is considered an attractive

166 Toll-like receptor 5 (TLR5) recognition of flagellin ins

167 ellin:allergen fusion protein containing the Toll-like receptor 5 ligand flagellin A from Listeria mo

168 Fusion proteins incorporating the Toll-like receptor 5 ligand flagellin are currently unde

169 n of bacterial flagellins that interact with Toll-like receptor 5.

170 Toll-like receptor 7 (TLR7) mediates autoantigen and vir

171 Toll-like receptor 7 (TLR7) stimulation in the airways m

172 The induction of toll-like receptor 7 (TLR7)-dependent type I interferons

173 cognition of intracellular Y. pestis by host Toll-like receptor 7 (TLR7).

174 On treatment with the toll-like receptor 7 agonist imquimod (IMQ), Trim32 knoc

175 e isolated from whole blood, stimulated with Toll-like receptor 7 agonist, and analyzed by means of e

176 application of Aldara cream, containing the Toll-like receptor 7/8 agonist Imiquimod, is a widely us

177 Activation of Toll-like receptor 7/8 by means of topical application o

178 We show that activation of pDCs through Toll-like receptor 7/8 suppresses ILC2-mediated AHR and

179 on by the pattern-recognition receptor (PRR) Toll-like receptor 8 (TLR8).

180 rich in unmethylated CG motifs (CpGs) engage Toll-Like Receptor 9 (TLR-9) in endosomes and are well d

181 re cultured with CD40 ligand (CD40L) and the Toll-like receptor 9 (TLR9) agonist cytidine-phosphate-g

182 thesized that a single drug molecule-a novel Toll-like receptor 9 (TLR9) agonist, MGN1703-could funct

183 ly, we identify parasite DNA-sensing through Toll-like receptor 9 (TLR9) along with inflammatory cyto

184 a key role in recognition, as highlighted by Toll-like receptor 9 (TLR9) in the endosomal compartment

185 We investigated the ability of the Toll-like receptor 9 (TLR9) ligand CpG to modulate estab

186 responsiveness of paired lung fibroblasts to Toll-like receptor 9 (TLR9) stimulation by CpG-oligodeox

187 Toll-like receptor 9 (TLR9)-deficient (TLR9(-/-)) mice a

188 In this study, we report that the Toll-like receptor 9 (TLR9)-MyD88 pattern-recognition re

189 a defective response to ligation of BCR and Toll-like receptor 9 (TLR9).

190 wed that stimulation of innate immunity with Toll-like receptor 9 agonist, class B CpG (cytosine-phos

191 Breg cells obtained by Toll-like receptor 9 and CD40 activation of B cells prev

192 stem and microglia/macrophage activation via Toll-like receptor 9 using CpG (cytosine-phosphate-guani

193 -kappaB-->ZEB1 signaling represses the TLR9 (toll-like receptor 9), IFNG, MCP-1 (monocyte chemoattrac

194 CD40 ligand- and Toll-like receptor 9-mediated signaling were less strong

195 Toll-like receptor agonists are potent enhancers of inna

196 hypersensitivity accompanied by increases in Toll-like receptor and cytokine gene expression in the s

197 mmune response, leading to activation of the Toll-like receptor and NF-kappaB pathways.

198 ally upregulated by ligands of IL-1 receptor/Toll-like receptor family members via the activation of

199 25 plus IL-33 (IL-25/IL-33), or a mixture of Toll-like receptor ligands to evaluate their ability to

200 s whereas exposure to innate stimuli such as Toll-like receptor ligands was not sufficient.

201 Activation of this reporter, using Toll-like receptor ligands, resulted in GFP expression,

202 cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ marked

203 tor of interferon genes (STING), but not the Toll-like receptor or the mitochondrial antiviral-signal

204 Moreover, the toll-like receptor signaling adaptor protein TRIF (TIR-d

205 In contrast, stimulating Toll-like receptor signaling in medaka enhanced immune c

206 ve low-dose naltrexone influencing opioid or toll-like receptor signaling to improve calcium mobiliza

207 ession is not driven by adaptive immunity or toll-like receptor signaling, and that BabA may have oth

208 regulates innate immune responses, including Toll-like receptor signaling, which initiate adaptive im

209 ccompanied by elevated activation of TCR and Toll-like receptor signaling-related proteins.

210 o-inflammatory priming with phorbol ester or Toll-like receptor stimulation.

211 Western diet or by applying topical TLR7/8 (Toll-like receptor) agonists.

212 RNAs are estrogen responsive and target TLR (toll-like receptor) signaling pathways.

213 atum orchestrates a molecular network of the Toll-like receptor, microRNAs, and autophagy to clinical

214 e 1/2 MAP kinase signaling pathway following Toll-like receptor, TNFR1, and IL-1R stimulation.

215 his article, we show that germ-free (GF) and Toll-like receptor-2 (Tlr2)-deficient mice have reduced

216 igh-iron conditions had reduced responses to Toll-like receptor-2, -3, and -4 agonists, which associa

217 Toll-like receptor-3 (TLR3), a member of the pathogen re

218 livery system, and simultaneously, activated Toll-Like Receptor-4 (TLR-4) on APCs to release chemokin

219 In this work, human Toll-Like Receptor-4 (TLR-4), a protein responsible for

220 innate immune signaling components including Toll-like receptor-4 and type I IFNs.

221 so improved the level of HA receptors (CD44, Toll-like receptor-4, and receptor for HA-mediated motil

222 highly conserved cysteine residue (Cys98) on Toll-like receptor-7.

223 or prostate cancer cells stably adorned with Toll-like receptor-9 ligand-loaded particles using strep

224 thway activation in SS through activation of Toll-like receptor-dependent and -independent pathways.

225 Although C-type lectin receptor- and Toll-like receptor-induced signaling pathways are key ac

226 at wild-type pigs display both a basal and a Toll-like receptor-mediated ASL secretory response to th

227 Toll-like receptors (TLR) are conserved immune sensors m

228 nterpart, has been achieved using hybridized toll-like receptors (TLR) combining TLR1 and TLR2 onto a

229 Inflammatory mediators binding to Toll-Like receptors (TLR) induce an influx of superoxide

230 survival defect after engagement of CD40 or Toll-like receptors (TLR), despite paradoxically enhance

231 A unifying feature for the two components is Toll-like receptors (TLR), which are key regulators of t

232 Given the fundamental role of Toll-like receptors (TLRs) and complement in inflammatio

233 le of rescuing gp96 client proteins, such as Toll-like receptors (TLRs) and integrins, in a gp96-defi

234 Recent work has identified Toll-like receptors (TLRs) and type I interferon (IFN) s

235 vital to rapidly responding to pathogens and Toll-like receptors (TLRs) are a critical component of t

236 Toll-like receptors (TLRs) are innate immune receptors f

237 Toll-like receptors (TLRs) are major players of the inna

238 In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detector

239 RAK4 or MYD88, which mediate the function of Toll-like receptors (TLRs) except TLR3, contained VH4-34

240 Endosomal Toll-like receptors (TLRs) have been shown to be crucial

241 te innate immune activation through specific toll-like receptors (TLRs) in epidermal keratinocytes, a

242 The retention of intracellular Toll-like receptors (TLRs) in the endoplasmic reticulum

243 Therapies based on activation of multiple Toll-like receptors (TLRs) may offer superior therapeuti

244 Toll-like receptors (TLRs) play an important role in B c

245 Toll-like receptors (TLRs) play an important role in imm

246 Ligand binding to Toll-like receptors (TLRs) results in dimerization of th

247 als are sensed and acted upon acutely by the Toll-like receptors (TLRs) to halt proliferation and act

248 critical role in innate immune signaling by Toll-like receptors (TLRs), and loss of IRAK4 activity i

249 tain nucleic acids that can be recognized by Toll-like receptors (TLRs), engulfment of ACs does not i

250 e immunity, involved in signaling by several Toll-like receptors (TLRs), key pattern recognition rece

251 When activated through toll-like receptors (TLRs), macrophages generate IL-33,

252 Pathogen-activated Toll-like receptors (TLRs), such as TLR2 and TLR4, dimer

253 Several microglia-related molecules, such as Toll-like receptors (TLRs), the complement system, cytok

254 One such family is the Toll-like receptors (TLRs).

255 oxidase pathway modulators and inhibitors of Toll-like receptors (TLRs).

256 production of membrane-associated mucins and Toll-like receptors (TLRs).

257 ls of pattern recognition receptors, such as Toll-like receptors 1 and 2, dectin 1, and dendritic cel

258 HMGB1 functions as a ligand of Toll-like receptors 2 and 4 on macrophages, leading to a

259 her, it is critical for activating endosomal toll-like receptors and antiviral humoral immunity.

260 Expression of Toll-like receptors and cellular adhesion molecules were

261 (MyD88) is an adaptor protein that mediates Toll-like receptors and interleukin-1 receptor signaling

262 tivated kinase 1 (TAK1) is a key mediator of toll-like receptors and pro-inflammatory cytokine signal

263 associated with its antagonistic effects on Toll-like receptors and suppression of RhoA GTPase signa

264 These pathways include Toll-like receptors and the recently described cGAS-STIN

265 Toll-like receptors in alveolar macrophages (AMPhi) reco

266 tection of circulating microbial products by Toll-like receptors on T cells, and this regulation is c

267 Toll-like receptors play a central role in the initiatio

268 ficient mice, by which microbiota signal via Toll-like receptors to elicit IgD CSR.

269 ) mice) and mice defective in trafficking of Toll-like receptors to the endosome (Unc93b1(-/-) mice).

270 es for proinflammatory cytokines and various toll-like receptors were overexpressed in SAH neutrophil

271 (myeloid differentiation factor 88) or TLRs (Toll-like receptors), we demonstrate that TLR2 and TLR6

272 d by the induction of chemokines, cytokines, Toll-like receptors, antimicrobial peptides, monocytoid

273 Indeed, Toll-like receptors, G-protein-coupled receptors, integr

274 tivation of innate immune components such as Toll-like receptors, IL-1 receptor-associated kinase/tum

275 flammatory disease through the activation of toll-like receptors.

276 ell receptor (BCR), Fc receptors (FcRs), and toll-like receptors.

277 a regulatory network where co-activation of Toll/NF-kappaB and EGFR signaling by ROS levels in the P

278 Here, we establish that Toll/NF-kappaB pathway activation in the PSC in response

279 this paper we explore the involvement of the Toll/NF-kappaB pathway in the localized activation of wo

280 istance (R) genes as a case study of how the toll of defense can be generated and ameliorated.

281 e eye, a fact underscored by the devastating toll of excessive inflammation at the cornea - blindness

282 ensitivity analysis suggests that the actual toll of killings and kidnappings may be underestimated i

283 To obtain the overall toll of killings and kidnappings, those probabilities we

284 other non-communicable diseases puts a heavy toll on health systems in tropical countries.

285 tions continue to take an unacceptably heavy toll on the most disadvantaged living with HIV-AIDS, and

286 uced transcription from ple and Ddc requires Toll pathway components ranging from the extracellular l

287 f the Drosophila immune deficiency (IMD) and Toll pathway components, an AMP gene expression profile

288 se mutants also exhibit dysregulation of the Toll pathway target transcripts Drosomycin (Drs) and Imm

289 survival pathways, respectively, by binding Toll receptor family members, which then recruit distinc

290 We also show that active Toll receptors are limiting in wild-type embryos, which

291 Drosophila NTs (DNTs) bind Toll receptors instead to promote neuronal survival, but

292 Toll signaling on the ventral side breaks the Dorsal/Cac

293 These are characteristics of defects in Toll signaling, and consistent with this, we demonstrate

294 A forms affected by pathogens that stimulate Toll signaling.

295 Dorsal nuclear localization ventrally, where Toll signals are high.

296 Here, we investigate how cactus modulates Toll signals through its effects on the Dorsal gradient

297 gests that this ability of Cactus to enhance Toll stems from the mobilization of a free Cactus pool i

298 therapeutics that could help ameliorate the toll that infections take during the treatment of cancer

299 Whereas IS undoubtedly exerts a cumulative toll, there is concern that insufficient or no IS may co

300 revent or reduce SSIs, prompted by the heavy toll they take on patients and health care budgets.