ライフサイエンスコーパス: translation initiation factor

1 S, a decapping pyrophosphatase, and eIF4E, a translation initiation factor.

2 on has not been previously described for any translation initiation factor.

3 of 4E-BP was dependent on its partner eIF4E translation initiation factor.

4 ependent translation by binding to the eIF4E translation initiation factor.

5 t of a 5' cap and some/all of the associated translation initiation factors.

6 coordinated interaction of a large number of translation initiation factors.

7 tress granule protein G3BP1, and a subset of translation initiation factors.

8 l and cellular mRNAs to compete for limiting translation initiation factors.

9 fold, which was not observed before in other translation initiation factors.

10 that the W73V mutant could not interact with translation initiation factors.

11 oskeletal organization, and the abundance of translation initiation factors.

12 Remarkably, Sui(-) mutations in eukaryotic translation initiation factor 1 (eIF1), eIF1A, and eIF2b

13 Extensive mutagenesis of the translation initiation factor-1 from Escherichia coli (E

14 Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimer

15 The eukaryotic translation initiation factor 2 (eIF2) is central to the

16 phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2alpha) in an AR-dep

17 d PERK specifically phosphorylate eukaryotic translation initiation factor 2 (eIF2alpha) on Ser51 to

18 nse in the liver, including alpha subunit of translation initiation factor 2 (eIF2alpha) phosphorylat

19 ntly increases phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) resulting in

20 Dephosphorylation of translation initiation factor 2 (eIF2alpha) terminates s

21 hosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) to activate

22 orylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), is an impor

23 osphorylates the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2alpha), resulting i

24 osphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), resulting i

25 ed dephosphorylation of the alpha subunit of translation initiation factor 2 (eIF2alpha).

26 Translation initiation factor 2 (IF2) promotes 30S initi

27 te (MMS), absence of the full-length form of Translation Initiation Factor 2 (IF2-1) or deficiency in

28 hat, translational control by the eukaryotic translation initiation factor 2 alpha (eIF2alpha) bidire

29 gulated inhibitor kinase (HRI), a eukaryotic translation initiation factor 2 alpha (eIF2alpha) kinase

30 kinase R (PKR) and its substrate eukaryotic translation initiation factor 2 alpha (eIF2alpha).

31 d activation (phosphorylation) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3,

32 hereas biallelic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF

33 result in phosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or

34 mmaTE treatment increased phosphorylation of translation initiation factor 2, IkappaBalpha, and JNK,

35 Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protei

36 Phosphorylation of eukaryotic translation initiation factor 2alpha (eiF2alpha) and exp

37 lum stress and phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) are ass

38 Phosphorylation of translation initiation factor 2alpha (eIF2alpha) attenua

39 In eukaryotes, phosphorylation of translation initiation factor 2alpha (eIF2alpha) by the

40 tein levels in the heme-regulated eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase

41 out (PERK-KO) or phosphodeficient eukaryotic translation initiation factor 2alpha (eIF2alpha) mouse e

42 As phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) on Ser5

43 Ppp1r15b, a regulatory subunit of eukaryotic translation initiation factor 2alpha (eIF2alpha) phospha

44 rated stress response mediated by eukaryotic translation initiation factor 2alpha (eIF2alpha) phospho

45 The eukaryotic translation initiation factor 2alpha (eIF2alpha) phospho

46 e the regulatory serine 51 of the eukaryotic translation initiation factor 2alpha (eIF2alpha) to inhi

47 se (UPR) associated with phosphorylation the translation initiation factor 2alpha (eIF2alpha), trigge

48 chment activates a canonical PERK-eukaryotic translation initiation factor 2alpha (eIF2alpha)-ATF4-CH

49 Ralpha and phosphorylation of the eukaryotic translation initiation factor 2alpha (eIF2alpha).

50 navirus encode a homologue of the eukaryotic translation initiation factor 2alpha (eIF2alpha).

51 edly increased phosphorylation of eukaryotic translation initiation factor 2alpha (p-eIF2alpha), an a

52 -dependent phosphorylation of the eukaryotic translation initiation factor 2alpha and enhanced transl

53 d that the PKR-like, ER-localized eukaryotic translation initiation factor 2alpha kinase branch of th

54 This increase in eukaryotic translation initiation factor 2alpha phosphorylation was

55 h activating pancreatic ER kinase/eukaryotic translation initiation factor 2alpha signaling.

56 inding protein and phosphorylated eukaryotic translation initiation factor 2alpha unchanged.

57 protein kinase-like ER kinase and eukaryotic translation initiation factor 2alpha, and the induction

58 he latter of which phosphorylates eukaryotic translation initiation factor-2alpha (eIF2alpha).

59 slation initiation factor complex eukaryotic translation initiation factor 2B (eIF2B) and the very-lo

60 ng disease caused by mutations in eukaryotic translation initiation factor 2B (eIF2B).

61 ons in genes encoding subunits of eukaryotic translation initiation factor 2B (eIF2B).

62 nce 03 (retr03), an allele of the eukaryotic translation initiation factor 2B-beta (eIF2Bbeta).

63 nitiation pathway, the 13-subunit eukaryotic translation initiation factor 3 (eIF3) controls access o

64 Eukaryotic translation initiation factor 3 (eIF3) is a central play

65 Eukaryotic translation initiation factor 3 (eIF3) plays a central r

66 We provide evidence that translation initiation factor 3 (IF3), an essential comp

67 nslation, a process that involved eukaryotic translation initiation factor 3 subunit b as a P311 bind

68 Two mutations were identified in eukaryotic translation initiation factor 3 subunit C (Eif3c).

69 addition, mTOR co-localised with Eukaryotic translation initiation factor 3 subunit F (eIF3F) at the

70 Eukaryotic translation initiation factor 3 subunit I (eIF3I) with t

71 t the protein translation factor, eukaryotic translation initiation factor 3, subunit a (eIF3a), bind

72 tease cleaves eIF3d, a subunit of eukaryotic translation initiation factor 3.

73 eIF3a (eukaryotic translation initiation factor 3a), one of the core subun

74 assembly of the mRNA cap protein, eukaryotic translation initiation factor 4 (eIF4)E, with activators

75 exerted at initiation through the eukaryotic translation initiation factor 4 F (eIF4F).

76 dase E (CPE) by inhibition of the eukaryotic translation initiation factor 4 gamma 1 translation init

77 s process facilitates IFN-induced eukaryotic translation initiation factor 4A (eIF4A) activity and bi

78 DEAD-box RNA helicases eukaryotic translation initiation factor 4A (eIF4A) and Ded1 promot

79 d4(157-469), a deletion mutant that binds to translation initiation factor 4A (eIF4A), sufficiently i

80 ha2(I) mRNAs, by interacting with eukaryotic translation initiation factor 4A (eIF4A).

81 -, beta-, and gamma-subunits) and eukaryotic translation initiation factor 4A (three isoforms), altho

82 Eukaryotic translation initiation factor 4A is an essential compone

83 In cells depleted of CDK12 or eukaryotic translation initiation factor 4A3 (eIF4A3) from the EJC,

84 ibodies to EJC components Y14 and eukaryotic translation initiation factor 4aIII (eIF4AIII).

85 rary profiling, we identified the eukaryotic translation initiation factor 4B (eIF4B) as a MELK-inter

86 We confirmed that Asp(563) in eukaryotic translation initiation factor 4B (eIF4B) is a cleavage s

87 Eukaryotic translation initiation factor 4B (eIF4B) is a cofactor f

88 e found that the protein level of eukaryotic translation initiation factor 4B (eIF4B), an integral co

89 ORF45 induced phosphorylation of eukaryotic translation initiation factor 4B (eIF4B), increased its

90 phorylation of the S6K1-dependent eukaryotic translation initiation factor 4B.

91 tion factor 4E-binding protein 1/ eukaryotic translation initiation factor 4E (4EBP1/eIF4E) cascades.

92 loid leukemia (AML) by regulating eukaryotic translation initiation factor 4E (eIF4E) activation.

93 d to be based on mutations in the eukaryotic translation initiation factor 4E (eIF4E) and its isoform

94 ing serine/threonine kinase (MNK)-eukaryotic translation initiation factor 4E (eIF4E) axis is overexp

95 Here, we show that eukaryotic translation initiation factor 4E (eIF4E) binding protein

96 The eukaryotic translation initiation factor 4E (eIF4E) binds to the 5'

97 ltaneous activation of mTORC1 and eukaryotic translation initiation factor 4E (eIF4E) by NS5A.

98 Here, we show that mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosp

99 ow that a functional reduction of eukaryotic translation initiation factor 4E (eIF4E) in Drosophila s

100 etically increasing the levels of eukaryotic translation initiation factor 4E (eIF4E) in mice results

101 translation, and indicate that activation of translation initiation factor 4E (eIF4E) is involved in

102 Eukaryotic translation initiation factor 4E (eIF4E) is overexpresse

103 Activation of the translation initiation factor 4E (eIF4E) promotes malign

104 Eukaryotic translation initiation factor 4E (eIF4E) promotes transl

105 kappaB alpha (IkappaB-alpha) S32, eukaryotic translation initiation factor 4E (eIF4E) S209, Smad2 S46

106 Importantly, either MYC or eukaryotic translation initiation factor 4E (eIF4E) was required to

107 Association of eukaryotic translation initiation factor 4E (eIF4E) with eIF4E-bind

108 iation of the cap-binding protein eukaryotic translation initiation factor 4E (eIF4E) with eIF4G is a

109 Here, we focus on eukaryotic translation initiation factor 4E (eIF4E), a prooncogenic

110 somal protein S6 kinase 1 (S6K1), eukaryotic translation initiation factor 4E (eIF4E), and autophagy,

111 Phosphorylation and activation of eukaryotic translation initiation factor 4E (eIF4E), eIF4E-binding

112 lated or minimally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing bin

113 o Mnk1 lead to phosphorylation of eukaryotic translation initiation factor 4E (eIF4E), which has been

114 imiting factor for translation is eukaryotic translation initiation factor 4E (eIF4E), which is negat

115 e analogues were bound tightly to eukaryotic translation initiation factor 4E (eIF4E), with CCl2-subs

116 o target a specific oncogene, the eukaryotic translation initiation factor 4E (eIF4E), with its inhib

117 ed expression of the translational repressor translation initiation factor 4E (eIF4E)-binding protein

118 d translation of MTFP1, which is mediated by translation initiation factor 4E (eIF4E)-binding protein

119 inhibited phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E)-binding protein

120 t Eap1p, which is a member of the eukaryotic translation initiation factor 4E (eIF4E)-binding protein

121 mice, we investigated the role of eukaryotic translation initiation factor 4E (eIF4E)-eIF4G interacti

122 ignaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-d

123 ain, which displays similarity to eukaryotic translation initiation factor 4E (eIF4E).

124 on is dependent on mTORC1 and the eukaryotic translation initiation factor 4E (eIF4E).

125 eIF4E1b, closely related to the canonical translation initiation factor 4E (eIF4E1a), cap-binding

126 ockade of its downstream effector eukaryotic translation initiation factor 4E activity equally reduce

127 achinery, decreases expression of eukaryotic translation initiation factor 4E and cyclin D1, and indu

128 tion, 4E binding protein 1 (4E-BP1) binds to translation initiation factor 4E and inhibits cap-depend

129 ate the importance of the p38-MNK-eukaryotic translation initiation factor 4E axis in TNF production

130 otein S6, S6 kinase 1 (S6K1), and eukaryotic translation initiation factor 4E binding protein 1 (4E-B

131 TOR)-dependent phosphorylation of eukaryotic translation initiation factor 4E binding protein-1 (4EBP

132 d even under conditions of inhibition of the translation initiation factor 4E function mediated by LY

133 educe the level of phosphorylated eukaryotic translation initiation factor 4E in the tumor tissues.

134 lates the alternative splicing of eukaryotic translation initiation factor 4E nuclear import factor 1

135 ammalian target of rapamycin, and eukaryotic translation initiation factor 4E phosphorylation seen in

136 A trend for an increase of eukaryotic translation initiation factor 4E phosphorylation was obs

137 r 1 (Eif4enif1), which encodes an eukaryotic translation initiation factor 4E transporter (4E-T) prot

138 rget of rapamycin, phosphorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-bind

139 APK-interacting kinase (MNK), and eukaryotic translation initiation factor 4E, which is a critical re

140 A-RNA interaction and an adjacent eukaryotic translation initiation factor 4E-binding 3'CITE.

141 p T-shaped structure (kl-TSS) and eukaryotic translation initiation factor 4E-binding Panicum mosaic

142 mTORC1 activation inhibits eukaryotic translation initiation factor 4E-binding protein (4E-BP)

143 malian target of rapamycin (mTOR)/eukaryotic translation initiation factor 4E-binding protein (4E-BP)

144 OR) signaling pathway to preserve eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

145 ribosomal protein S6 kinase 1 (S6K1) and the translation initiation factor 4E-binding protein 1 (4E-B

146 serine 345 (S345), Chk 2 S33/35, eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

147 rget of rapamycin (mTOR)-directed eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

148 revealed hyperphosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

149 first, it preferentially targets eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

150 Eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

151 ibosomal protein S6 kinase 1, and eukaryotic translation initiation factor 4E-binding protein 1 durin

152 K/ribosomal protein S6 (RPS6) and eukaryotic translation initiation factor 4E-binding protein 1/ euka

153 Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-B

154 l-cycle regulators via the mTORC1/eukaryotic translation initiation factor 4E-binding protein pathway

155 the translation repressor, 4E-BP (eukaryotic translation initiation factor 4E-binding protein).

156 lls through the activation of the eukaryotic translation initiation factor 4E/MAPK-interacting kinase

157 Disrupting the eukaryotic translation initiation factor 4F (eIF4F) complex offers

158 Eukaryotic translation initiation factor 4F (eIF4F), comprising the

159 (eIF4G), the scaffold subunit of eukaryotic translation initiation factor 4F (eIF4F), preferentially

160 are required for formation of the eukaryotic translation initiation factor 4F complex (eIF4F) and ini

161 MNK binds eukaryotic translation initiation factor 4G (eIF4G) and phosphoryla

162 Ser-rich segment (RS1 domain) of eukaryotic translation initiation factor 4G (eIF4G) and the Lys-ric

163 Remarkably, depleting eukaryotic translation initiation factor 4G (eIF4G), the scaffold s

164 on initiation by interaction with eukaryotic translation initiation factor 4G (eIF4G), we investigate

165 nding partners containing a middle domain of translation initiation factor 4G (MIF4G) are emerging as

166 to bind the poly(A) tail of mRNA, as well as translation initiation factor 4G and eukaryotic release

167 protein synthesis and levels of eukaryotic (translation) initiation factor 4G1 (eIF4G1).

168 Eukaryotic translation initiation factor 4h (Eif4h) encodes a prote

169 ionine decarboxylase 1 (AMD1) and eukaryotic translation initiation factor 5A (eIF5A), two genes asso

170 for deoxyhypusine modification of eukaryotic translation initiation factor 5A (eIF5A).

171 rently known hypusinated protein, eukaryotic translation initiation factor 5A.

172 Two of these proteins, are eukaryotic translation initiation factor 5A1 (eIF5A1) that is invol

173 ta reveal a transient increase of eukaryotic translation initiation factor 5B (eIF5B), the eukaryotic

174 anslation initiation via an interaction with translation initiation factor 5B (eIF5B).

175 ng is controlled by the G-protein eukaryotic translation initiation factor 5B (eIF5B).

176 nduced protein kinase R (PKR) and eukaryotic translation initiation factor alpha (eIF2alpha) phosphor

177 doplasmic reticulum kinase (PERK)-eukaryotic translation initiation factor alpha (eIF2alpha)-CEBP hom

178 omitant with elevated phosphorylation of the translation initiation factor alpha subunit of eukaryoti

179 acids led to significant down-regulation in translation initiation factors, amino acid metabolism, a

180 onucleoprotein (mRNP) aggregates composed of translation initiation factors and mRNAs that appear whe

181 g mRNA-binding proteins, ribosomal proteins, translation initiation factors and translation elongatio

182 election by 5' upstream open reading frames, translation initiation factors, and primary and secondar

183 ing proteins (PABPs) link mRNA 3' termini to translation initiation factors, but they also play key r

184 f eukaryotic initiation factor 2 (eIF2alpha) translation initiation factor by a variety of cellular s

185 udies suggest that the reduced activity of a translation initiation factor called eIF2alpha might be

186 tion between the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmar

187 assays, we show the Saccharomyces cerevisiae translation initiation factor complex eukaryotic transla

188 to identify the components of the norovirus translation initiation factor complex.

189 demonstrates that viruses can increase host translation initiation factor concentration to foster th

190 Deregulation of translation initiation factors contributes to many patho

191 ed in the MIF4G domain of CBP80/20-dependent translation initiation factor (CTIF).

192 Yet, no signals specifically targeting translation initiation factors during mitosis have been

193 factors such as ribosomal protein RPS-1 and translation initiation factor EIF-3.J to reduce infectio

194 SG formation is triggered by both eukaryotic translation initiation factor (eIF) 2alpha phosphorylati

195 thways convergently signal to the eukaryotic translation initiation factor (eIF) 4F complex to regula

196 The eukaryotic translation initiation factor (eIF) 4G is a scaffold pro

197 The eukaryotic translation initiation factor (eIF) 4G is required durin

198 or remained putative for decades: eukaryotic translation initiation factor (eIF) 5A.

199 Here we report that translation initiation factor eIF1A directly interacts w

200 phosphorylation of the alpha subunit of the translation initiation factor eIF2 (eIF2alpha) can promo

201 hosphorylates and in end-effect inhibits the translation initiation factor eIF2 (eukaryotic initiatio

202 ase (OAS), which respectively inactivate the translation initiation factor eIF2 and stimulate RNA cle

203 The general translation initiation factor eIF2 is a major translatio

204 eIF2B GEF activity toward its substrate, the translation initiation factor eIF2, in vitro.

205 orylates the alpha subunit of the eukaryotic translation initiation factor eIF2, leading to global do

206 orylation of the alpha-subunit of eukaryotic translation initiation factor, eIF2.

207 nslational control by phosphorylation of the translation initiation factor eIF2alpha (p-eIF2alpha) ac

208 gene product, phosphorylates the eukaryotic translation initiation factor eIF2alpha and causes trans

209 riggered by increased phosphorylation of the translation initiation factor eIF2alpha and the protein

210 induces Perk-mediated phosphorylation of the translation initiation factor eif2alpha causing selectiv

211 PKR activation leads to phosphorylation of translation initiation factor eIF2alpha inhibition of pr

212 host response to virus infection mediated by translation initiation factor eIF2alpha phosphorylation.

213 study, we found that reduced activity of the translation initiation factor eIF2alpha underlies the hy

214 PKR inactivates the translation initiation factor eIF2alpha via phosphorylat

215 evels, an extensive dephosphorylation of the translation initiation factor eIF2alpha was observed dur

216 ted by the stress-induced phosphorylation of translation initiation factor eIF2alpha, and this inhibi

217 tivation by PACT leads to phosphorylation of translation initiation factor eIF2alpha, inhibition of p

218 s (MRV) infection induces phosphorylation of translation initiation factor eIF2alpha, which promotes

219 lar stress responses, by phosphorylating the translation initiation factor eIF2alpha.

220 that are mediated via phosphorylation of the translation initiation factor eIF2alpha.

221 otein translation via phosphorylation of the translation initiation factor eIF2alpha.

222 atase activity, dephosphorylating eukaryotic translation initiation factor (eIF2alpha), and derepress

223 s MITF via ATF4 in response to inhibition of translation initiation factor eIF2B.

224 , we show that the mRNAs encoding eukaryotic translation initiation factors eIF2B2 and eIF4G2 are pre

225 ng the local protein synthesis of eukaryotic translation initiation factors eIF2B2 and eIF4G2 in the

226 nection between the structure of the central translation initiation factor eIF3 and recognition of th

227 By interacting with the translation initiation factor eIF3, Cpeb4 represses the

228 teracts directly with the pivotal eukaryotic translation initiation factor eIF3.

229 the gene encoding eIF3e, the p48 subunit of translation initiation factor eIF3.

230 oaded onto capped mRNAs via the multisubunit translation initiation factors eIF3 and eIF4F.

231 motif (SBM) in two additional proteins: the translation initiation factor eIF3g and the mRNA-export

232 Moreover, overexpression of translation initiation factor eIF4A, a helicase, enhance

233 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its heli

234 was associated with increased expression of translation initiation factors eIF4A and eIF4GI, and red

235 wding on structure and function of the human translation initiation factors eIF4A, a two-domain DEAD-

236 e regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppress

237 The principal translation initiation factor eIF4AI displays helicase a

238 Eukaryotic translation initiation factor eIF4AI, the founding membe

239 d activity of mTORC1 and its downstream mRNA translation initiation factors eIF4B and 4EBP1, as well

240 through the phosphorylation of a eukaryotic translation initiation factor, eIF4B.

241 UTR, which is controlled by the oncogene and translation initiation factor eIF4E downstream Myc activ

242 of mTOR despite hypoxia involves release of translation initiation factor eIF4E from its repressor p

243 Overexpression of the rate-limiting translation initiation factor eIF4E induced Rae1 and ULB

244 The translation initiation factor eIF4E is an oncogene that

245 Translation initiation factor eIF4E mediates normal cell

246 The interaction of the eukaryotic translation initiation factor eIF4E with the initiation

247 Eukaryotic translation initiation factor eIF4E, an essential compon

248 We show that the eukaryotic translation initiation factor eIF4E, an oncoprotein, dri

249 in part, by elevated levels of the activated translation initiation factor eIF4E, overexpression of w

250 d the calcineurin regulator Rcn2, the 4E-BP (translation initiation factor eIF4E-binding protein) tra

251 ltiple ribosome biogenesis genes and the key translation initiation factor eIF4E.

252 s via a direct interaction with the cellular translation initiation factor eIF4E.

253 s its association with and inhibition of the translation initiation factor eIF4E.

254 A translation initiation by sequestering the translation initiation factor eIF4E.

255 The eukaryotic translation-initiation factor eIF4E is a rate-limiting f

256 utcomes and include targeting the eukaryotic translation initiation factor (eIF4E) with its inhibitor

257 tance to asTORi by downregulating eukaryotic translation initiation factor (eIF4E)-binding proteins (

258 phosphate mRNA cap analogues with eukaryotic translation initiation factor (eIF4E).

259 e based on mutations in the plant eukaryotic translation initiation factors, eIF4E and eIF4G or their

260 The eIF4E translation initiation factors, eIF4E1, eIF4E2, and eIF4

261 Translation initiation factor eIF4F (eukaryotic initiati

262 clude the ability to bind a component of the translation initiation factor eIF4F complex and to engag

263 It relies on its ability to compete with the translation initiation factor eIF4F to specifically reco

264 translation by binding the eIF4G subunit of translation initiation factor eIF4F with high affinity.

265 he ability of infected cells to assemble the translation initiation factor eIF4F, promoting viral pro

266 ciated with the 4F subunit of the eukaryotic translation initiation factor (eIF4F) complex in infecte

267 ated in splicing, interacts with the general translation initiation factor eIF4G and promotes transla

268 on factor 4A (eIF4A) activity and binding to translation initiation factor eIF4G to promote mRNA tran

269 gnition, the poly(A) binding protein and the translation initiation factor eIF4G.

270 f from the viral polyprotein and cleaves the translation initiation factor eIF4G.

271 untranslated region that interacts with host translation initiation factor eIF4G.

272 mRNA translation mediated by high levels of translation initiation factor eIF4G1 (eukaryotic initiat

273 trate that calpain-mediated degradation of a translation initiation factor, eIF4G1, is a cause of bot

274 Vhs binds the translation initiation factors eIF4H, eIF4AI, and eIF4AI

275 carcinoma (PDAC), mutant KRAS stimulates the translation initiation factor eIF5A and upregulates the

276 ch to investigate the role of the eukaryotic translation initiation factor eIF5A in human cervical ca

277 Eukaryotic translation initiation factor eIF5A promotes protein syn

278 DOHH) catalyzes the activation of eukaryotic translation initiation factor (eIF5A), a protein essenti

279 The process is mediated by eukaryotic translation initiation factors (eIFs) in conjunction wit

280 nt with a decrease in phosphorylation of the translation initiation factor eukaryotic initiation fact

281 Global translation is regulated through the translation initiation factor eukaryotic initiation fact

282 osphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation fac

283 uded ribosomal proteins, nucleolar proteins, translation initiation factors, helicases, and hnRNPs.

284 ely to the poorly characterized domain II of translation initiation factor IF2 and prevented the bind

285 Bacterial translation initiation factor IF2 promotes ribosomal sub

286 element (ARE)-binding protein that recruits translation initiation factors, molecular chaperones, an

287 mes postinfection and contains TIA but lacks translation initiation factors, mRNA binding proteins, a

288 By commandeering cellular translation initiation factors, or destroying those disp

289 ity, induced oxidative stress, or stimulated translation initiation factor phosphorylation significan

290 l-restricted intracellular antigen 1 (TIA1), translation initiation factors, RNA binding proteins, an

291 protein expression in adipose tissue of the translation initiation factor serine-kinase-6-1, which i

292 SPONSE TO DEHYDRATION14, AUXIN RESISTANT1, a translation initiation factor SUI1 family protein, and t

293 These results identify Ded1 as a translation initiation factor that assembles and remodel

294 A1 and its highly related isoform eIF5A2 are translation initiation factors that have been implicated

295 which serves as a scaffold to recruit other translation initiation factors that ultimately assemble

296 arrest mediated by the phosphorylation of a translation initiation factor, the alpha subunit of euka

297 tion either by sterically blocking access of translation initiation factors to the 5'-cap or by activ

298 he ASOs appear to improve the recruitment of translation initiation factors to the target mRNA.

299 es the eukaryotic initiation factor 2 (eIF2) translation initiation factor upon binding to viral doub

300 s that relies on the interaction of cellular translation initiation factors with the virus genome-enc

301 mechanism that relies on the interaction of translation initiation factors with the virus-encoded VP