ライフサイエンスコーパス: translation termination

1 n recognition during both tRNA selection and translation termination.

2 as identified that suppresses nonsense codon translation termination.

3 onsense mutations) typically cause premature translation termination.

4 RNA binding site (A-site) during inefficient translation termination.

5 of eRF3a which itself has an active role in translation termination.

6 nition and peptide release during eukaryotic translation termination.

7 lowed the established rules for hierarchy of translation termination.

8 haracterized-for example, those required for translation termination.

9 portant role in ester bond hydrolysis during translation termination.

10 t lead to splicing aberrations and premature translation termination.

11 lation elongation or a reduced efficiency of translation termination.

12 ystem, we show that PABP directly stimulates translation termination.

13 and suggests involvement of L27 in bacterial translation termination.

14 ng a critical role in peptide release during translation termination.

15 between the G1093 region and helix 73 during translation termination.

16 ribosome pauses at stop codons during normal translation termination.

17 egion has an adaptive function separate from translation termination.

18 ribosomal proteins and a yeast suppressor of translation termination.

19 reinitiate on AUG codons 5' to the point of translation termination.

20 next downstream AUG, resulting in premature translation termination.

21 op codon because of ribosomal pausing during translation termination.

22 A clones) resulted in a frameshift and early translation termination.

23 nt whose function is likely to be related to translation termination.

24 on the mechanisms of canonical and premature translation termination.

25 ribosomal particles due to a dysfunction in translation termination.

26 f thousands of genes without manipulation of translation termination.

27 pid ribosome exchange into the cytosol after translation termination.

28 he degradation of mRNAs undergoing premature translation termination.

29 , essential gene in eukaryotes implicated in translation termination.

30 One potential source of DRiPs is premature translation termination.

31 UGA codon as selenocysteine (Sec) instead of translation termination.

32 ear mRNA export, translation initiation, and translation termination.

33 various fates of ribosomes that pause during translation termination.

34 ex set of molecular functions in addition to translation termination.

35 ents of RF1 and RF2 are critical to accurate translation termination.

36 ular basis for stop codon recognition during translation termination.

37 ATPase activity during both mRNA export and translation termination.

38 ctional importance of individual residues in translation termination.

39 Gle1, and IP(6) are also required for proper translation termination.

40 e cleavage of stop codons during inefficient translation termination.

41 A decay, we have been studying how premature translation termination accelerates the degradation of m

42 The C-terminal region provides translation termination activity.

43 (M-)domain; and a C-terminal domain with the translation termination activity.

44 eracts with the release factors, (ii) delays translation termination and (iii) dissociates post-termi

45 in a transient increase in the efficiency of translation termination and a loss of the [PSI+] phenoty

46 mRNA decay (NMD) pathway monitors premature translation termination and degrades aberrant mRNAs.

47 a nascent peptide motif that interferes with translation termination and elicits tmRNA.SmpB activity.

48 Rat8p also functions in translation termination and has been implicated in funct

49 om complete loss of RFC protein due to early translation termination and increased turnover of a muta

50 ion involved the introduction of overlapping translation termination and initiation codons in-frame i

51 demonstrate that yeast eRF1 plays a role in translation termination and is functionally equivalent t

52 [PSI+] is a prion of Sup35p, an essential translation termination and mRNA turnover factor.

53 Here we review both translation termination and NMD, and our subsequent effo

54 cerevisiae orthologue that functions in both translation termination and NMD, has been the only facto

55 itional factors that play roles in premature translation termination and NMD.

56 Dlg4) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay

57 slated small ORFs (sORFs) by quantitation of translation termination and peptidic analysis identified

58 rveillance mechanism that monitors premature translation termination and promotes degradation of aber

59 hydrolysis by UPF1 is required for efficient translation termination and ribosome release at a premat

60 is an integral functional unit important for translation termination and that the presence of L11 in

61 ve hammerhead ribozyme structure between the translation termination and the polyadenylation signals

62 is conserved rRNA structure in UGA-dependent translation termination and, taken with previous in vitr

63 ithin the ribosomal exit tunnel, can inhibit translation termination and/or peptide elongation.

64 tive amino acid changes, potential premature translation terminations and potential altered splicing.

65 nascent peptide motif (which interferes with translation termination) and quantified the protein chai

66 the pioneer round of translation, premature translation termination, and proteins failing to fold pr

67 llance complex assembles onto the mRNA after translation termination, and scans the mRNA in a 3' to 5

68 The mechanisms underlying translation termination are key to the understanding of

69 Transcripts harboring premature signals for translation termination are recognized and rapidly degra

70 o acid 29 of the reading frame, resulting in translation termination at a nonsense codon 138 nucleoti

71 esults indicate that the Upf1p also enhances translation termination at a nonsense codon.

72 erapy utilizes small molecules that suppress translation termination at a PTC to restore synthesis of

73 RF1 was unable to increase the efficiency of translation termination at any termination signals.

74 represses downstream translation by blocking translation termination at its own stop codon and by cau

75 have been shown to affect the efficiency of translation termination at nonsense codons and/or the pr

76 rotein involved in modulating mRNA decay and translation termination at nonsense codons.

77 h as gentamicin have the ability to suppress translation termination at premature stop mutations, lea

78 TP hydrolysis also reduced the efficiency of translation termination at some termination signals but

79 t, the Euplotes hybrid facilitated efficient translation termination at UAA and UAG codons but not at

80 the mRNP can alter the rate of key steps in translation termination; (b) the discrimination between

81 (Psi), ref. 4) of nonsense codons suppresses translation termination both in vitro and in vivo.

82 is an epigenetic modifier of the fidelity of translation termination, but its impact on yeast biology

83 er RNA decay (NMD) is triggered by premature translation termination, but the features distinguishing

84 PABP increases the efficiency of translation termination by recruitment of eRF3a and eRF1

85 ribosome binding, polypeptide elongation, or translation termination, can influence the susceptibilit

86 n a nascent peptide and eRF1 to obstruct the translation termination cascade.

87 Defects in translation termination caused by this mutation have als

88 During translation termination, class II release factor RF3 bin

89 is activated by the presence of a premature translation termination codon (PTC) in an atypical seque

90 Premature translation termination codon (PTC)-mediated effects on

91 rameshift in exon 7 that created a premature translation termination codon (PTC).

92 AAA) was identified 191 bp downstream of the translation termination codon (TGA).

93 ormal open reading frame (ORF) and brought a translation termination codon 33 amino acids downstream.

94 A translation termination codon and a single polyadenylati

95 otide region immediately downstream from the translation termination codon and upstream of sequences

96 struction of a gammaHV68 mutant containing a translation termination codon in the LANA ORF (73.STOP).

97 n with a mutant virus containing a premature translation termination codon in the UL83 open reading f

98 ximately 180 bp, located 260 bases 3' to the translation termination codon of p21WAF1/CIP1 cDNA, was

99 on VIII that changes tyrosine codon 426 to a translation termination codon resulting in an EPOR prote

100 an RNA element downstream of the gag natural translation termination codon that prevents degradation

101 exon that replaces an arginine codon with a translation termination codon.

102 ng frame was disrupted by the insertion of a translation termination codon.

103 cated 30 to 70 nucleotides downstream of the translation termination codon.

104 loop, thereby changing the distance from the translation termination codon.

105 t are located at a similar distance from the translation termination codon.

106 That sequence contained a premature translation termination codon.

107 man genetic diseases are caused by premature translation-termination codon (PTC)-generating mutations

108 tron 3, and in the second allele a premature translation-termination codon in exon 1 was identified.

109 mRNAs containing premature translation termination codons (nonsense mRNAs) are targ

110 Eukaryotic mRNAs containing premature translation termination codons (PTCs) are rapidly degrad

111 essenger RNAs (mRNAs) that contain premature translation termination codons (PTCs) are targeted for r

112 How premature translation termination codons (PTCs) mediate effects on

113 d process that destroys mRNAs with premature translation termination codons (PTCs).

114 es aberrant transcripts containing premature translation termination codons and regulates the levels

115 ox translation initiation codons and partial translation termination codons are absent, the use of TG

116 Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidl

117 Recent results show that mRNAs without translation termination codons are unstable in eukaryoti

118 can suppress the accurate identification of translation termination codons in eukaryotic cells.

119 ative splicing switches introduces premature translation termination codons into selected transcripts

120 68 mutant virus (45STOP) by the insertion of translation termination codons into the portion of the g

121 D) eliminates transcripts carrying premature translation termination codons, but the role of NMD on y

122 .IX (hF.IX), or F.IX variants with premature translation termination codons, or missense mutations, u

123 All three translation termination codons, or nonsense codons, cont

124 pound that promotes readthrough of premature translation termination codons, suggesting that it may h

125 we investigated the efficiency of eukaryotic translation termination codons, to assess codon readthro

126 nd degrades transcripts containing premature translation termination codons.

127 bilization of transcripts carrying premature translation termination codons.

128 dation of yeast mRNAs that contain premature translation termination codons.

129 egrade aberrant mRNAs that contain premature translation termination codons.

130 ism that degrades mRNAs containing premature translation termination codons.

131 mRNAs and promotes readthrough of premature translation termination codons.

132 mechanism that degrades mRNAs with premature translation-termination codons.

133 izes and degrades transcripts with premature translation-termination codons.

134 suggests that they may regulate an aspect of translation termination common to all transcripts.

135 We report the crystal structure of a translation termination complex formed by the Thermus th

136 nstance and facilitating dissociation of the translation termination complex in the other.

137 eRF1 and eRF3 comprise the translation termination complex that recognizes stop cod

138 allographic refinement to a 70S ribosome-RF1 translation termination complex that was recently solved

139 g or looping out of some component(s) of the translation termination complex to the mark.

140 cerevisiae, Sup35p (eRF3), a subunit of the translation termination complex, can take up a prion-lik

141 ike [PSI(+)] variants, where the strength of translation termination corresponds to the level of solu

142 3' untranslated region of mRNAs that affects translation termination, deadenylation, and mRNA decay.

143 visiae Sup35/[PSI(+)] prion, which confers a translation termination defect and expression level-depe

144 re specifically impaired in establishing the translation termination defect that normally accompanies

145 ants recapitulate all of the mRNA export and translation termination defects found in mutants deplete

146 RF1 mutants are quantitatively unlinked with translation termination defects, suggesting that the evo

147 PABP's function in translation termination depends on its C-terminal domain

148 on-prion state that correlate with different translation termination efficiencies.

149 to describe the prion-mediated regulation of translation termination efficiency and discuss its impli

150 -like determinant [PSI+] is able to regulate translation termination efficiency in response to enviro

151 termination and polyadenylation) influences translation termination efficiency, mRNA poly(A) tail le

152 [PSI+] strains exhibit a marked decrease in translation termination efficiency, which permits decodi

153 After translation termination, ER-bound ribosomes are thought

154 ants have previously been shown to exhibit a translation termination error phenotype and the sup44+ a

155 Recognition of translation termination events as premature requires a s

156 ling activities are shared by the homologous translation termination factor complex eRF1:eRF3, sugges

157 cent studies have shown that domain 1 of the translation termination factor eRF1 mediates stop codon

158 Downregulating the translation termination factor eRF1 produces defective v

159 enzyme methylates Gln(185) of the eukaryotic translation termination factor eRF1.

160 e misfolded and self-propagating form of the translation termination factor eRF3 (Sup35), can be cure

161 Translation termination factor eRF3 enhances the activit

162 ics and the prion state of the S. cerevisiae translation termination factor eRF3, Rps23p hydroxylatio

163 PSI+] state is caused by a prion form of the translation termination factor eRF3.

164 e translation elongation factor EF1A and the translation termination factor eRF3.

165 endent ubiquitination and degradation of the translation termination factor GSPT1.

166 3), casein kinase 1alpha (CK1alpha), and the translation termination factor GSPT1] whose ubiquitylati

167 ite effects on [PSI(+)], a prion form of the translation termination factor Sup35 (eRF3).

168 When the translation termination factor Sup35 adopts the prion st

169 otein Lsb2 (Pin3) promotes conversion of the translation termination factor Sup35 into its prion form

170 es derived from the prion domain NM of yeast translation termination factor Sup35 persistently propag

171 pic prion strains, weak and strong, of yeast translation termination factor Sup35 with respect to ang

172 of the yeast prion [PSI (+)], formed by the translation termination factor Sup35.

173 elf-propagating amyloidogenic isoform of the translation termination factor Sup35.

174 self-perpetuating amyloid conformers of the translation termination factor Sup35.

175 y defective self-perpetuating isoform of the translation termination factor Sup35.

176 [PSI(+)] is a prion isoform of the translation termination factor Sup35.

177 The prion [PSI+] forms when the translation termination factor Sup35p adopts a self-prop

178 rpetuating change in the conformation of the translation termination factor Sup35p is the basis for t

179 is a nonfunctional, ordered aggregate of the translation termination factor Sup35p that influences ne

180 ange in the conformation and function of the translation termination factor Sup35p, and is transmitte

181 [PSI(+)] is a prion of the essential translation termination factor Sup35p.

182 The yeast Sup35 protein is a subunit of the translation termination factor, and its conversion to th

183 the Sup35 protein, normally a subunit of the translation termination factor, but impaired in this vit

184 When Sup35, a yeast translation termination factor, is aggregated in its [PS

185 ] prion is a self-propagating amyloid of the translation termination factor, Sup35p, of Saccharomyces

186 sure as a result of aggregation of the Sup35 translation termination factor, which increases stop cod

187 The yeast prion protein Sup35 is a translation termination factor, whose activity is modula

188 ing amyloid form of Sup35p, a subunit of the translation termination factor.

189 p, a subunit of the Saccharomyces cerevisiae translation termination factor.

190 , which is the prion form of the yeast Sup35 translation termination factor.

191 ich is the altered conformation of the Sup35 translation termination factor.

192 ional change in the prion domain of Sup35, a translation-termination factor.

193 Dom34p and Hbs1p are similar to the translation termination factors eRF1 and eRF3, indicatin

194 ssays revealed that Tpa1p interacts with the translation termination factors eRF1 and eRF3.

195 s of the Upf1p interact with both eukaryotic translation termination factors eRF1 and eRF3.

196 tamine residue in the GGQ motif of ribosomal translation termination factors.

197 st [PSI+] prion is an epigenetic modifier of translation termination fidelity that causes nonsense su

198 ation and targets mRNAs undergoing premature translation termination for rapid degradation.

199 d Pyl insertion can effectively compete with translation termination for UAG codons obviating the nee

200 e initiation ternary complex after premature translation termination has occurred nor the elongation

201 (NMD) pathway functions by checking whether translation termination has occurred prematurely and sub

202 ontaining that structure was found to affect translation termination in a codon-specific manner.

203 al ADAR2 protein expression due to premature translation termination in an alternate reading frame.

204 of rluD was recently shown to interfere with translation termination in Escherichia coli.

205 Translation termination in eukaryotes is mediated by two

206 Translation termination in eukaryotes typically requires

207 se results support a direct role for eRF3 in translation termination in higher eukaryotes and also hi

208 th Gle1 and IP(6) are required for efficient translation termination in Saccharomyces cerevisiae and

209 Recent studies on translation termination in the yeast Saccharomyces cerev

210 ary target of IP(6) for both mRNA export and translation termination in vivo.

211 ribosome positioning and find that premature translation termination in yeast extracts is indeed aber

212 ne (Sup45p or eRF1) is a factor required for translation termination in yeast.

213 of eRF1 are important for ensuring efficient translation termination in yeast.

214 Our results show that eukaryotic translation termination involves a network of interactio

215 w level of readthrough that is enhanced when translation termination is disrupted.

216 Sup35p forms aggregates and its activity in translation termination is downregulated.

217 The results presented here suggest that translation termination is important for assembly of the

218 The role of eRF3 in eukarytotic translation termination is less well understood as its o

219 In Saccharomyces cerevisiae, translation termination is mediated by a complex of two

220 Eukaryotic translation termination is mediated by two release facto

221 In eukaryotes, translation termination is performed by eRF1, which reco

222 Eukaryotic translation termination is triggered by peptide release

223 Bacterial translation termination is triggered when a stop codon a

224 t to reflect a direct role of NMD factors in translation termination, its mechanism is unknown.

225 Although a UAG codon typically directs translation termination, its presence in Methanosarcina

226 Premature translation termination leads to a reduced mRNA level in

227 Moreover, a translation termination linker (TTL) mutant of mtrII tha

228 genomes, as well as genomes containing an E6 translation termination linker, an E6 frameshift mutatio

229 istic view of how MoMLV manipulates the host translation termination machinery for the synthesis of i

230 interact with each other, the ribosome, the translation termination machinery, and multiple mRNA dec

231 This system illustrates that translation termination may be a critical step controlli

232 somal arrest at termination and suggest that translation termination may be a regulatory step in expr

233 putative surveillance complex that enhances translation termination, monitors whether termination ha

234 e genes (Ofd1, Schizosaccharomyces pombe) to translation termination/mRNA polyadenylation (Tpa1p, Sac

235 ntaining mutant HPV 31 E7 genes, including a translation termination mutant, two Rb-binding site muta

236 HPV type 11 (HPV-11) genomes that contained translation termination mutations in E6 or E7 were const

237 eudouridylation at the PTC can suppress this translation termination (nonsense suppression).

238 Eukaryotic mRNAs where translation termination occurs too soon (nonsense-mediat

239 wnstream sequence information influences how translation termination occurs.

240 -containing reporters results from premature translation termination on out of frame stop codons foll

241 gation of [PSI(+)] but are not necessary for translation termination or cell viability.

242 heir release into bulk lipid is triggered by translation termination or, in some cases, by the arriva

243 Additional structural snapshots of the translation termination pathway reveal the conformationa

244 We identify general translation termination pauses in both normal and stress

245 el in which the nascent uORF2 peptide blocks translation termination prior to hydrolysis of the pepti

246 ingle small-molecule drug that modulates the translation termination process at a premature nonsense

247 eRF3 is a GTPase that stimulates the translation termination process by a poorly characterize

248 sitive to the PSI state, indicating either a translation termination process independent of eRF3 or a

249 y pathway, which occurs during the premature translation termination process.

250 h) activity releases tRNA from the premature translation termination product peptidyl-tRNA.

251 a, where it releases tRNA from the premature translation termination product peptidyl-tRNA.

252 he yeast Saccharomyces cerevisiae, premature translation termination promotes rapid degradation of mR

253 ted in order to function, and that premature translation termination promotes rapid mRNA decay indica

254 d in a general decrease in the efficiency of translation termination rather than a decrease at a subs

255 By modulating the efficiency of translation termination, recognition of long 3'UTRs by U

256 d expression occurred as a result of a novel translation termination/reinitiation event between the n

257 th several ribosomal proteins and eukaryotic translation termination release factor 1.

258 During translation termination, release factor (RF) protein cat

259 n's normal function, nitrogen regulation, or translation termination, respectively.

260 sequence-dependent manner to inhibit its own translation termination, resulting in persistence of the

261 Eukaryotic translation termination results from the complex functio

262 Eukaryotic translation termination results from the complex functio

263 Translation termination results in hydrolysis of the fin

264 In contrast to inefficient translation termination, ribosome recycling from truncat

265 coding exons, leading to a frameshift and a translation termination signal 20 codons after the AUG.

266 ight neurofilament (NF-L) mRNA, spanning the translation termination signal, participates in regulati

267 68 nt segment of the transcript spanning the translation termination signal.

268 nation efficiency, which permits decoding of translation termination signals and, presumably, the pro

269 RF3 is required to couple the recognition of translation termination signals by eRF1 to efficient pol

270 One region is just beyond the translation termination site in the 3' region, and the o

271 17 was the largest exon and included the UAG translation termination site, AUUAAA polyadenylation sig

272 he cytoplasm when recognized downstream of a translation termination site.

273 of UPF3B during the early and late phases of translation termination suggest that UPF3B is involved i

274 that NMD factors appear to dictate efficient translation termination, suggests that NMD factors do no

275 ng a tetrapeptide and to propose a model for translation termination that accounts for the cooperativ

276 th important roles in ribosome recycling and translation termination that are conserved in eukaryotes

277 This mutation, P70, leads to premature translation termination that deletes a large portion of

278 e nascent polypeptide can affect the rate of translation termination, thereby influencing ribosome pa

279 ons were isolated that resulted in premature translation termination though retained partial activity

280 HCV 3'UTR retains ribosome complexes during translation termination to facilitate efficient initiati

281 A codon is transformed from one that signals translation termination to one specific for Sec.

282 gnal-dependent decrease in the efficiency of translation termination was due to a defect in either eR

283 at the contribution of products of premature translation termination was minimal.

284 he basis of these results and the process of translation termination, we suggest a multistep model fo

285 codon (TGG) at amino acid position 34 into a translation termination (X) codon (TGA).