ライフサイエンスコーパス: translational

1 insight into our knowledge of mRNA-specific translational activation and the function of the PABP-eI

2 lycolytic enzymes via ERK- and Akt-dependent translational activation of HIF-1alpha protein.

3 eneity directs distinct temporal patterns of translational activation or repression.

4 ws that, rather than sterically blocking 40S translational active sites, the associated assembly fact

5 Here, we report that the translational activity in the primordial germ cells (PGC

6 lippage of the viral RNA polymerase confer a translational advantage.

7 Transcriptional and translational analyses revealed endoplasmic reticulum st

8 sed systematic literature reviews, published translational and clinical studies, clinical practice gu

9 ates with many short transcripts involved in translational and mitochondrial regulation.

10 rs interested in stress responses as well as translational and posttranslational regulation in plants

11 ass stems from the distinct behaviour of the translational and rotational degrees of freedom under in

12 ergy in above-thermal collisions between the translational and rotational degrees of freedom.

13 Translational and rotational head movement, frequency, a

14 America and Europe with expertise in basic, translational, and clinical sciences in the field of ant

15 numerous mechanisms at the transcriptional, translational, and posttranslational level.

16 and failure to upregulate components of the translational apparatus in GATA1-mediated DBA.

17 Despite these advantages, its translational application in biomedical sciences has bee

18 biology and critical insights into the many translational applications for these small regulatory RN

19 ling and the exploration of Wnt agonists for translational applications in regenerative medicine.

20 reover, to move beyond proof-of-concept into translational applications, we discuss future prospects

21 As such, this translational approach provides sensitive and quantitati

22 Using a translational approach, we then demonstrate that human i

23 uces BMPR-II transcription and mediates post-translational BMPR-II cleavage via the sheddases, ADAM10

24 sequencing (WES) is widely utilized both in translational cancer genomics studies and in the setting

25 those of annotated isoforms and explore the translational capacity and quality of novel isoforms.

26 ral hydrophobic residues facilitate the post-translational cleavage of the CaValpha2delta1 subunit at

27 tly explain why the two cell lines differ in translational compensation.

28 We are just beginning to understand how translational control affects tumour initiation and mali

29 This translational control culminates in reprogramming of the

30 The degree and dynamics of translational control during mammalian development remai

31 cap-dependent initiation, a primary point of translational control in eukaryotic cells.

32 on for GCN2 phosphorylation of eIF2alpha and translational control in the formation of an intact huma

33 est that mitochondrial GCN5L1 modulates post-translational control of FoxO1, regulates gluconeogenesi

34 tion changes are part of a coordinated early translational control response shared across environment

35 entiation, little is known about the role of translational control.

36 nk of a SZ risk gene to neurodevelopment and translational control.

37 CARSs also catalyze co-translational cysteine polysulfidation and are involved

38 We additionally provide preliminary translational data regarding the brain disposition of [(

39 ainst M. abscessus infections with promising translational development possibilities for the treatmen

40 try, we found that as the conformational and translational dynamics of FN increased, the rate of bind

41 MICAL Redox enzymes are important post-translational effectors of actin that stereo-specificall

42 The translational efficiencies of mRNAs in cells progressing

43 cularly in the early stages, should increase translational efficiency and streamline resource utiliza

44 m by which mTORC2 activity stimulates Rictor translational efficiency via an AKT/HSF1/HuR signaling c

45 data support the use of gamma-band ASSR as a translational end point in pro-cognitive drug discovery

46 the eIF4E-binding Panicum mosaic virus-like translational enhancer (PTE) and ribosome-binding 3' T-s

47 Translational errors represent a major potential source

48 that are in concordance with replicative and translational errors.

49 steine biosynthesis) to prevent challenge of translational fidelity, and may reflect the mechanism th

50 and N6-methyladenosine (m6A) did not perturb translational fidelity, O6-methylguanosine (m6G) at the

51 oteins fold under mechanical force during co-translational folding at the ribosome.

52 specific codon identity-could coordinate co-translational folding of the encoded protein.

53 Here, using a translational gene fusion, we show that CrsR sequesters

54 tion of RGGT, an enzyme responsible for post-translational geranylgeranylation of Rab GTPases represe

55 It also remains unclear how translational heterogeneity originates.

56 d the temporal ordering and kinetics of post-translational histone and RNA polymerase II modification

57 cells in cancer immunotherapy and provide a translational humanized mouse model to test the lifespan

58 These studies have important translational implications as both EpCAM and ERK are cur

59 dentifying infant-directed timbre has direct translational implications for speech recognition techno

60 y and beta cell health, which may have broad translational implications for therapeutics aimed at imp

61 Ns from neoplastic nodules may have relevant translational implications in early diagnosis.

62 beta, mir200, ZEB1, OVOL2, p63 and p300) and translational implications of the Grainyhead proteins in

63 We will also discuss the translational implications of these new developments.

64 These principles have important clinical and translational implications, and they show striking paral

65 utation patterns, which could have important translational implications.

66 nergic signaling-mediated suppression of the translational inhibitor 4E-BP1.

67 resistance, resulting in hypersensitivity to translational inhibitors.

68 (TRanslational Initiative on Unique and novel strategies

69 In the TRIUMPH (Translational Initiative on Unique and novel strategies

70 direct simulation of trajectories for the co-translational insertion of arbitrary polypeptide sequenc

71 e being tested, which hopefully will provide translational insights to stop the growing incidence of

72 imulation for the mechanistic analysis of co-translational integration and for the engineering of mem

73 or tunes this signaling in vivo by producing translational isoforms differing only in the length of t

74 ith two different functional groups for post-translational labeling at the specific amino acid positi

75 ng of TIs and revealed unanticipated complex translational landscapes in metazoans.

76 utic neovascularization via rAAV.Tbeta4 in a translational large animal model of hibernating myocardi

77 his helicase regulates p21 expression at the translational level independent of the transcriptional a

78 1 (Keap1), but how Nrf2 is regulated at the translational level is less clear.

79 chanism that acts at the transcriptional and translational level to repress NDC80 expression.

80 otein synthesis rates are determined, at the translational level, by properties of the transcript's s

81 aneuploidy can be further compensated at the translational level.

82 ot altered neither at transcriptional nor at translational levels, but its function was impacted sinc

83 Post-translational lipid modification of Ras proteins plays a

84 We find that binding of TDP-43 to the translational machinery is mediated by an interaction wi

85 Axonal translational machinery is thus a feature of adult CNS n

86 n initiation resulting from mutations in the translational machinery or inappropriate activation of t

87 that the egg cell is primed to activate the translational machinery, and that hormones likely play a

88 ctions between RNA polymerase (RNAP) and the translational machinery.

89 sitivity, yet little is known as to the post-translational mechanism behind its somatosensitization.

90 rden of unfolded ER proteins suggests a post-translational mechanism for adjusting BiP's activity to

91 the plant and, hence, finely repressed by a translational mechanism.

92 riptional program works in concert with post-translational mechanisms to regulate heme metabolism dur

93 RAS-mediated degradation of FOXOs, via post-translational mechanisms, blocks these important tumour

94 spite the importance of such experiments for translational medicine, there have been relatively few e

95 ages a recently demonstrated link between co-translational membrane integration efficiency and protei

96 man health, and we suggest steps for scaling translational microbiome research to high-throughput tar

97 Translational Mobilisation Theory (TMT) is a generic soc

98 This paper introduces Translational Mobilisation Theory, outlines its core com

99 The mechanism and regulation of this post-translational mode of targeting by cpSRP remain unclear.

100 Using this translational model, we showed that bromodomain inhibito

101 nt of atherogenesis, however, reliable human translational models aimed at characterizing these mecha

102 In mechanistic and translational models of T-ALL, we demonstrate NOTCH1 inh

103 tion has recently emerged as a dominant post-translational modification (PTM) in Alzheimer's disease

104 try for simultaneous quantification and post-translational modification (PTM) profiling of targeted p

105 tyrylation (Khib) is a newly identified post-translational modification found in animal and yeast cel

106 on is an essential and highly conserved post-translational modification in eukaryotes.

107 iring in disulfide linkages is a common post-translational modification in proteins entering the secr

108 cNAcylation is a ubiquitous and dynamic post-translational modification involving the O-linkage of be

109 rgets in Arabidopsis and show that this post-translational modification is central to the rewiring of

110 phagy protein, on Tyr-233 and that this post-translational modification limits Beclin1 association wi

111 gradation, and we hypothesize that this post-translational modification may act as a signal for the s

112 Hence, post-translational modification may be a mechanism by which c

113 yrosine phosphorylation is a widespread post-translational modification mechanism underlying cell phy

114 rotein S-palmitoylation is a reversible post-translational modification mediated by palmitoyl acyltra

115 latter function involves reversing the post-translational modification of cellular proteins conjugat

116 Covalent, reversible, post-translational modification of cellular proteins with the

117 While chromatin remodeling mediated by post-translational modification of histone is extensively stu

118 riant histone sequences, in addition to post-translational modification of histones, serves to modula

119 t it is unclear how mutations affecting post-translational modification of molecular clock proteins i

120 Post-translational modification of proteins with carbohydrate

121 lmethyltransferase (ICMT) catalyzes the post-translational modification of RAB GTPases that contain C

122 Rtr1, and Fcp1), which act through the post-translational modification of the C-terminal domain (CTD

123 atalyzing protein S-acylation, a common post-translational modification on proteins frequently affect

124 fier (SUMO) conjugation is a reversible post-translational modification process implicated in the reg

125 Protein prenylation is a post-translational modification that has been most commonly a

126 lation is a recently identified protein post-translational modification that is known to affect the a

127 on of histone proteins is a fundamental post-translational modification that regulates chromatin stru

128 RMTs) introduce arginine methylation, a post-translational modification with the increasingly eminent

129 iptional RNA editing, splice variation, post-translational modification, and subunit composition.

130 tively, these data demonstrate that the post-translational modification, O-GlcNAcylation, is a novel

131 cover new aspects of regulation by this post-translational modification, we undertook an analysis of

132 ion, a previously under-studied protein post-translational modification.

133 D8 onto protein targets is an important post-translational modification.

134 ifying enzymes and proteins involved in post-translational modification.

135 rane, protein-protein interactions, and post-translational modification.

136 Post-translational modifications (PTMs) affect protein functi

137 Post-translational modifications (PTMs) allot versatility to

138 tions in protein expression and histone post-translational modifications (PTMs) in bladder carcinoma

139 ciently translate upstream signals into post-translational modifications (PTMs) on histones and coreg

140 alternative splice variants (ASVs) and post-translational modifications (PTMs) reportedly tied to ce

141 sensors is sophisticatedly regulated by post-translational modifications (PTMs) resulting in a robust

142 es in epigenetic markers, i.e., histone post-translational modifications (PTMs), in the layers of the

143 that arise from genetic variations and post-translational modifications (PTMs).

144 their regulation is complex, involving post-translational modifications and allosteric regulation wi

145 sstalk as a critical regulator of MyD88 post-translational modifications and IL-1-driven inflammation

146 neuron activity is enhanced and drives post translational modifications at the dopamine transporter

147 While multiple post-translational modifications have been reported to regula

148 nd biophysical tools to investigate how post-translational modifications impact the aggregated prion

149 ide novel insight into the role of Nt17 post-translational modifications in regulating the structure

150 ision, signal peptide removal, and some post-translational modifications including oxidation and acet

151 in ligation simplifies incorporation of post-translational modifications into the protein scaffold.

152 modify specific signaling pathways via post-translational modifications of Cys residues in key regul

153 Post-translational modifications of histone proteins regulate

154 Post-translational modifications of histones have been shown

155 re, we discuss recent insights into the post-translational modifications of junctional proteins and s

156 Neoepitopes derived from post-translational modifications of native antigens are emerg

157 ukaryotic genes are marked by conserved post-translational modifications on the RNA pol II C-terminal

158 tailoring enzymes introduce additional post-translational modifications that are unique to each lant

159 ization in combination with rigidifying post-translational modifications to achieve high-potency bind

160 We examined important post-translational modifications to the DNA packaging histone

161 sequences of amino acids and localized post-translational modifications, are identified using precur

162 ic and protein interactions, and 38 559 post-translational modifications, as manually annotated from

163 ogen from healthy controls displayed no post-translational modifications, fibrinogen from patients on

164 of MCR (McrA) contains several unusual post-translational modifications, including a rare thioamidat

165 to the presence of antagonistic histone post-translational modifications, including acetylation and m

166 We conclude that post-translational modifications, specifically the degree and

167 lular N-terminus, which is a target for post-translational modifications, typically is ignored.

168 ination of tubulin isotypes and tubulin post-translational modifications-can generate microtubule div

169 s for regulation of AQP2 trafficking by post-translational modifications.

170 dy of the behavior of peptides carrying post-translational modifications.

171 TFAM tail may enable its regulation by post-translational modifications.

172 arity-determining regions and potential post-translational modifications.

173 or quantifying the abundance of histone post-translational modifications.

174 native splicing and post transcriptional and translational modifications.

175 multidomain enzymes may be modulated by post-translational modifications/mechanisms, allowing them to

176 ased on widely used protein domains and post-translational modifications; therefore, many membrane-as

177 self-administration model was used to obtain translational molecular and behavioral insights.

178 e to monitor the conformational changes of a translational molecular machine during its operation.

179 cells.Distinguishing rotational motions from translational motions in the z-axis has been a long-stan

180 ge in distinguishing rotational motions from translational motions in the z-axis in differential inte

181 tasets confirmed PCSK9 hypomethylation and a translational mouse model of AUD showed that alcohol exp

182 ent hippocampal local field potential during translational movement, suggesting that theta encodes se

183 rownian motion due to diffusion but also the translational movement.

184 protein translocation channel to catalyze co-translational N-linked glycosylation of proteins in the

185 Advances in translational neuroimmunology over the last two decades

186 To contribute to MR translational neuroscience research, a brain template an

187 y agent by modifying transcriptional and non-translational neutrophil responses, which might permit a

188 sign, and implementation of N-of-1 trials in translational nutrition research that are meant to asses

189 ate animal models, and it provides important translational opportunities.

190 ucing a potentially rapid and cost-effective translational opportunity.

191 Surprisingly, overall translational output remains robust under eIF4F inhibiti

192 odeled collagen with Eulerian rotational and translational parameters of adjacent rungs in the triple

193 s such as rRNA, exhibiting the most dramatic translational perturbations.

194 Deletion mutants exhibited a range of translational phenotypes, with enzymes known to modify a

195 Using this translational platform, we demonstrated that amyloid-bet

196 Its performance and translational potential are demonstrated by in vivo imag

197 r (DAT) inhibitor, CTDP-32476, that may have translational potential for treating cocaine addiction.

198 nical properties at microscale level and its translational potential into clinical practice.

199 precludes their clinical use and limits the translational potential of MPIO-based contrast agents.

200 Thus, the translational potential of preclinical BE studies is par

201 To investigate the translational potential of the SEAM, cells within it tha

202 To verify the translational potential of these findings, we used a pha

203 iting features of painful neuropathy and the translational potential of this marker of spinal inhibit

204 ied Runx1 as a novel therapeutic target with translational potential to counteract the effects of adv

205 c imaging of bacterial infection with strong translational potential.

206 ed across independent datasets and that have translational potential.

207 with all 13 eIF3 subunits and several other translational preinitiation factors.

208 e cholesterol biosynthetic pathway, the post-translational prenylation of small GTP-binding proteins

209 FPP plays a crucial role in the post-translational prenylation of small GTPases that perform

210 ectivity of VTA dopamine neurons, their mRNA translational profile, and basic electrophysiological ch

211 Such translational prospects were further supported by the su

212 During co-translational protein targeting, the signal recognition

213 Post-translational protein translocation in yeast requires bo

214 cluster of down regulated genes that encode translational proteins, especially those with ribosome b

215 RPE cells were subsequently treated with two translational readthrough inducing drugs (G418 & PTC124)

216 Early translational recovery and SG disassembly induced by tre

217 Post-translational redox modification of methionine residues

218 gies that seek to address the alterations in translational regulation and energy metabolism that char

219 demonstrates that nutrient availability and translational regulation controls protein and small pept

220 a critical process in protein synthesis, but translational regulation in antigen-specific T cells in

221 This identified unexpected and pervasive translational regulation of most of the core signalling

222 ve found that PDHK4 plays a role in the post-translational regulation of mutant KRAS activity.

223 Here the authors report that the post-translational regulation of PRC1 components CBX4 and CBX

224 Together, these findings suggest that post-translational regulation of the Thr(567) in the MT1-MMP

225 Our results link genome evolution and translational regulation to the long-term persistence of

226 are found in nature, and their role in post-translational regulation.

227 , we investigated the axonal localization of translational regulators and associated mRNAs in five pa

228 An in vivo RNA interference screen of translational regulators revealed that depletion of conv

229 s and establish a hitherto unidentified post-translational regulatory mechanism of carotenogenic enzy

230 to propose putative transcriptional and post-translational regulatory mechanisms of metabolic process

231 NA-binding proteins, which implies extensive translational regulatory networks.

232 the expected phosphorylation of MAP kinases, translational regulatory proteins, and subunits of APC/C

233 tablished as a widely used animal model with translational relevance for neurodevelopmental psychiatr

234 driven HCC in mice, a finding which may have translational relevance in HCC pathogenesis.

235 Given the translational relevance of LAG3 and the heightened inter

236 The translational relevance of these findings is highlighted

237 for Gc action directly on the podocyte, with translational relevance to designing new selective synth

238 erging concepts and scientific insights with translational relevance.

239 glioblastoma model, which may have important translational relevance.

240 et mRNAs and silence gene expression through translational repression and deadenylation but not cleav

241 Here we describe the importance of mRNA translational repression and mRNA subcellular location f

242 tardation protein, proteins that function in translational repression and stress granule regulation.

243 g cold shock proteins escape cooling-induced translational repression are unknown.

244 3'UTR of a miRNA-targeted reporter modulates translational repression by affecting the translation ef

245 RNA sensors, demonstrated that miRNAs induce translational repression depending on their complementar

246 rticle that has been linked to pathogenesis, translational repression, starvation responses, and ribo

247 In Drosophila, the translational repressor Bgcn is required for spermatogon

248 es by signalling the degradation of GLD-1, a translational repressor that blocks V-ATPase synthesis.

249 translation rates, and also by mRNA-specific translational repressors.

250 immune system represent a promising tool for translational research as they may allow modeling and th

251 we review the most current basic science and translational research findings on several of the most c

252 scuss gaps and opportunities in clinical and translational research in metastatic breast cancer.

253 ering strategies, increasing the options for translational research in the vector control field.

254 Translational research in trials combining Vitamin D and

255 The TRIUMPH study (Translational Research Investigating Underlying Disparit

256 huge public health gains, while support for translational research is leading to the development of

257 echnique is now widely employed in basic and translational research, and increasingly is also used pr

258 nvened of world experts in immunology, human translational research, and positron emission tomographi

259 aming patient waveform data for clinical and translational research, and will advance the study and m

260 overy in developmental biology as well as in translational research, but whether organoids can truly

261 Part One includes the sections: Basic & Translational Research, Cardiac Failure, Cardiomyopathie

262 ith animal models would be of great value in translational research.

263 as well as integration of clinical data into translational research.

264 ard tests jeopardizes accurate diagnosis and translational research.

265 trong potential to accelerate both basic and translational research.

266 n culture and open new avenues for basic and translational research.

267 This coordinated transcriptional-translational response to DNA damage was not impaired by

268 We examined several aspects of the translational response, including density of ribosomal f

269 attention has been paid to the role of post-translational responses to pathogen-associated molecular

270 , thalamus, and hypothalamus) of BAC aldh1l1-translational ribosome affinity purification (TRAP) mice

271 By using translational ribosome affinity purification followed by

272 ent that we assume the mantle of the leading translational science journal in the world and the flags

273 Advances in preclinical translational science point to potential targets across

274 domains requiring the dual action of the co-translational Sec and post-translational Tat pathways fo

275 activation is through its ability to reverse translational shutoff and sustain the expression of othe

276 We here detail the mechanism by which co-translational signal-peptide cleavage is prevented.

277 Finally, we describe findings of high translational significance by demonstrating that Abl/Arg

278 Observed changes are of translational significance, as bromodomain and extra-ter

279 These elements drive the translational silencing of a group of chemokine (CC/CXC)

280 nonucleotide repeat that is placed between a translational start codon and a membrane-bound fluoresce

281 ogenesis is necessary for the development of translational strategies to harness this process for neu

282 T cells is mounting in animal models and in translational studies involving subjects with active HSV

283 pecies will facilitate the implementation of translational studies that better predict clinical outco

284 ector has greatly facilitated both basic and translational studies that require co-expression of mult

285 These results suggest the need for translational studies to evaluate the potential use of h

286 Further translational studies using induced pluripotent stem (iP

287 of personal regulomes in tissue context and translational studies.

288 This translational study thus aimed to investigate whether IL

289 n, a G4 ligand, specifically potentiated the translational suppressing effect of P1-HNF4A-5' UTR.

290 That translational suppression was more pronounced in termina

291 nalogy of crystals in space, the breaking of translational symmetry in time and the emergence of a 't

292 onucleoprotein particle that mediates the co-translational targeting of newly synthesized proteins to

293 action of the co-translational Sec and post-translational Tat pathways for integration.

294 cted to result in read through of the normal translational termination codon.

295 stem cells (MSCs) are regularly utilized for translational therapeutic strategies including cell ther

296 Lastly, we discuss translational therapies stemming from research on host-m

297 rases (TPSTs) are enzymes that catalyze post-translational tyrosine sulfation of proteins.

298 ntains plasticity-enhancing proteins of high translational value for targeting ageing- or disease-ass

299 ly defined boundary conditions, limiting the translational value of basic research.

300 s are discussed for extending the predictive translational value of mouse research, with an emphasis