ライフサイエンスコーパス: translational efficiency

1 expression by influencing mRNA stability and translational efficiency.

2 known about the effects of radiation on gene translational efficiency.

3 heses that invoke constraints on function or translational efficiency.

4 broblasts that also binds mRNA and regulates translational efficiency.

5 is important in messenger RNA stability and translational efficiency.

6 considerably weaker than the enhancement of translational efficiency.

7 stem-loop structure drastically reduced the translational efficiency.

8 m messages by influencing mRNA stability and translational efficiency.

9 binding to ribosomes, and their influence on translational efficiency.

10 in exponential phase and increased rpoS mRNA translational efficiency.

11 nd provide evidence that avoidance increases translational efficiency.

12 nduction by regulating message stability and translational efficiency.

13 binding to alpha-MHC mRNA and attenuate its translational efficiency.

14 ic extracts revealed striking differences in translational efficiency.

15 egulation of MMP-9 synthesis at the level of translational efficiency.

16 let-7 miRNA biogenesis or modulation of mRNA translational efficiency.

17 tory roles in modulating mRNA degradation or translational efficiency.

18 at the loss of activity was due to decreased translational efficiency.

19 suggesting that polyadenylation may enhance translational efficiency.

20 rodent genes with a selective advantage for translational efficiency.

21 nes have higher codon usage bias to maximize translational efficiency.

22 criptional control of mRNA stability or mRNA translational efficiency.

23 poly(A) tail to increase synergistically the translational efficiency.

24 ated in the regulation of mRNA stability and translational efficiency.

25 s likely due to factors other than increased translational efficiency.

26 region and exhibit a significantly enhanced translational efficiency.

27 a protein kinase involved in the control of translational efficiency.

28 dance, fatality rates, codon adaptation, and translational efficiency.

29 ermine GRN expression via mRNA stability and translational efficiency.

30 coding sequences have been shown to increase translational efficiency.

31 actors that control transcript longevity and translational efficiency.

32 bias of the kaiBC genes is not optimized for translational efficiency.

33 phenotypes and the idea that i6A37 promotes translational efficiency.

34 ly codon bias, has a key role in determining translational efficiency.

35 eved through control of both mRNA levels and translational efficiency.

36 nges in mRNA expression than with changes in translational efficiency.

37 region of the Rictor transcript and enhance translational efficiency.

38 ase reporter assays significantly alter mRNA translational efficiency.

39 atory signals determining mRNA stability and translational efficiency.

40 critical determinant of their stability and translational efficiency.

41 t RNA dimerization, also strongly influenced translational efficiency.

42 llular processes, regulate mRNA stability or translational efficiency.

43 tein (PABP) to achieve maximal IRES-mediated translational efficiency.

44 ream open reading frames, suggesting varying translational efficiencies.

45 that are responsible for modulation of mRNA translational efficiencies.

46 same cell can exhibit dramatically different translational efficiencies.

47 is was used to generate mutants with altered translational efficiencies.

48 f transcript-specific ribosome densities and translational efficiencies.

49 A significant difference in translational efficiency among these 5'-UTRs variants wa

50 better understand this control, we profiled translational efficiencies and poly(A)-tail lengths thro

51 of isoaccepting tRNA, resulting in increased translational efficiency and accuracy.

52 s indicating the dual selection pressures of translational efficiency and accuracy.

53 ces, and Drosophila indicates that it favors translational efficiency and accuracy.

54 of isoaccepting tRNAs, results in increased translational efficiency and accuracy.

55 al deficits in anabolic hormones and blunted translational efficiency and capacity.

56 atural amino acid was incorporated with high translational efficiency and fidelity into the dimeric p

57 ins in vivo at TAG nonsense codons with high translational efficiency and fidelity.

58 imilar to a poly(A) tail in that it enhances translational efficiency and is co-dependent on a cap in

59 es in these cell types are the regulation of translational efficiency and let-7 miRNA maturation.

60 ation by miR-125 involves reductions in both translational efficiency and mRNA abundance.

61 For poly(A)+ mRNA, the translational efficiency and mRNA half-life increased on

62 cluding effects on subcellular localization, translational efficiency and mRNA half-life.

63 The poly(A) tail not only regulates translational efficiency and mRNA stability but is requi

64 To examine the effect of length on translational efficiency and mRNA stability, a 20-base s

65 ern of polymorphism, including selection for translational efficiency and positive selection.

66 ene and point to a strong connection between translational efficiency and RNA accumulation in mammali

67 and tissue-specific manner and regulate the translational efficiency and stability of partial or ful

68 o control gene expression by attenuating the translational efficiency and stability of transcripts.

69 cularly in the early stages, should increase translational efficiency and streamline resource utiliza

70 t the Fed-1 iLRE mediates a rapid decline in translational efficiency and that iLRE-containing mRNAs

71 The WOR1 5' UTR reduces translational efficiency and the association of the tran

72 ys an important role in determining both the translational efficiency and the stability of an mRNA.

73 at codon usage is the key factor determining translational efficiency and, surprisingly, also mRNA st

74 these regulatory targets leads to decreased translational efficiency and/or decreased mRNA levels, b

75 her factors, natural selection for increased translational efficiency and/or fidelity may shape nucle

76 ongly correlated with its protein stability, translational efficiency, and abundance.

77 ar dsRNA structures within 3'-UTRs decreases translational efficiency, and although the structures un

78 Ps generally exhibit high protein stability, translational efficiency, and protein abundance but thei

79 o study the roles of translational accuracy, translational efficiency, and the Hill-Robertson effect

80 tory mechanisms involving RNA processing and translational efficiency are discussed.

81 As in the regulation of mRNA turnover and/or translational efficiency are discussed.

82 e site selection on transcript stability and translational efficiency are discussed.

83 of most eukaryotic mRNAs and influences its translational efficiency as well as its stability.

84 th translational machinery and modulates the translational efficiency as well as the mTOR pathway.

85 on assays demonstrated that the TE augmented translational efficiency, as well as RNA levels.

86 ocalization of the mRNA or variations in the translational efficiency at different sites along the de

87 enomes to identify those that exhibit strong translational efficiency bias (389 out of 1,700 sequence

88 ruct resulted in a corresponding increase in translational efficiency, but the most pronounced effect

89 TG for GTG as the initiation codon increased translational efficiency by 50%.

90 Re-ordering the segments reduced mRNA translational efficiency by 50%.

91 e GTG codon by one to four bases reduced the translational efficiency by 50-75%.

92 g on the context, this can strongly modulate translational efficiency by a variety of mechanisms.

93 tures are major determinants of the observed translational efficiency changes.

94 The correspondence between translational-efficiency changes and tail-length changes

95 t leaders lacking the 5'UTR intron increased translational efficiency compared to that of the unsplic

96 ol of cyclin D1 and c-myc mRNA stability and translational efficiency constitutes a coordinate respon

97 ablished in which global and individual mRNA translational efficiencies could be examined.

98 255 transcripts that manifest an increase in translational efficiency during eIF4E-mediated escape fr

99 ta suggest that PABP may exert its effect on translational efficiency either by increasing the format

100 inity and isoform preference correlates with translational efficiency, fluorescence spectroscopy was

101 determinant of ribosome binding strength and translational efficiency for mRNA with or without the 5'

102 ream in-frame ATG also resulted in increased translational efficiency from the downstream gp64-cat OR

103 In the absence of a functional minicistron, translational efficiency from the downstream gp64-cat re

104 5'-UUUU-3' results in a 15-fold reduction in translational efficiency; however, removing the leader a

105 ds attenuate mRNA translation at two levels: translational efficiency, i.e. translation initiation, a

106 A high-throughput screening for translational efficiency identified several antiapoptoti

107 As expected, tail lengths were coupled to translational efficiencies in early zebrafish and frog e

108 on, the different transcripts showed varying translational efficiencies in several cell lines, indica

109 Genes with up-regulated translational efficiencies in the caf20Delta mutant have

110 criminate among synonymous codons to enhance translational efficiency in a wide range of prokaryotes

111 ive secondary structure selectively regulate translational efficiency in adult cardiocytes.

112 the pseudoknot structure and correlates with translational efficiency in both the PTV-1 and HCV IRES.

113 ciated with lymphoid replication and altered translational efficiency in cell culture, were found in

114 For poly(A)- reporter mRNA, translational efficiency in CHO cells increased 38-fold

115 eading frames that show greater than average translational efficiency in diverse eukaryotes.

116 nterruptions have no detectable influence on translational efficiency in either a cell-free system or

117 >A and G(243)-->A mutations showed preserved translational efficiency in HuH7 cells but reduced effic

118 he Mek1 kinase pathways all fail to increase translational efficiency in MDA468 cells.

119 how that MMP-9 levels are also controlled by translational efficiency in murine prostate carcinoma ce

120 in may play an important role in determining translational efficiency in plants.

121 Translational efficiency in the presence and absence of

122 characteristics that are known to influence translational efficiency in their free-living relative.

123 te NRF-1 expression by interfering with mRNA translational efficiency in transfected cells and in an

124 these codons to more common codons increases translational efficiency in vitro and increases mRNA abu

125 These data suggest that translational efficiency is a key mechanism for regulati

126 Our data demonstrate that change in translational efficiency is a major contributor to early

127 Translational efficiency is controlled by tRNAs and othe

128 It has been hypothesized that translational efficiency is determined by the amount of

129 en our findings and the channeling theory of translational efficiency is discussed.

130 ffect of the S209L mutation on mitochondrial translational efficiency is due to reduced activity of t

131 s in the case of hereditary thrombocythemia: translational efficiency is increased by mutations that

132 ary pool of localized RNA undergoes enhanced translational efficiency is not clear.

133 nzyme identical to constitutive GGT cDNA but translational efficiency is reduced 2-fold.

134 port that of these two parameters, increased translational efficiency is the predominant source of in

135 eased Fmr1 mRNA production but impaired FMRP translational efficiency, leading to a modest reduction

136 Identification of genes with altered translational efficiency leads to the discovery of novel

137 ndicating that processes determining overall translational efficiency may vary between these two cate

138 Overall, our findings suggest that translational efficiency mechanisms, known to regulate d

139 s carrying one of these constructs show that translational efficiency mirrors gene transcription; gen

140 hat the eIF4G or eIFiso4G subunits influence translational efficiency more than the cap-binding subun

141 ) tail of an mRNA plays an important role in translational efficiency, mRNA stability and mRNA degrad

142 these types of changes were shown to affect translational efficiency, not transcript stability.

143 ore caused no significant differences in the translational efficiencies of GR transcripts.

144 As measured by polysome profiling, the translational efficiencies of individual NF subunit mRNA

145 that eliminating eIF4B reduces the relative translational efficiencies of many more genes than does

146 The translational efficiencies of mRNAs in cells progressing

147 The translational efficiencies of the brain-derived IRES seq

148 We determined the in vivo translational efficiency of 'unleadered' lacZ compared w

149 that receptor-mediated cell death has on the translational efficiency of a large number of mRNAs, tra

150 MDA receptor activity through the control of translational efficiency of a single subunit.

151 Translational efficiency of an AUG, CUG, GUG, or UUG ini

152 The translational efficiency of an mRNA engineered to form a

153 ucture, a feature previously shown to reduce translational efficiency of an mRNA.

154 The inhibitory effect of 2-PMAP on translational efficiency of APP mRNA into protein was di

155 Furthermore, IL-1beta increased the translational efficiency of ATF5 mRNA via the 5' UTRalph

156 initiation factor (elF) 4E (eIF4E) regulates translational efficiency of c-jun mRNA as measured by fl

157 Thus, translational efficiency of c-jun mRNA was not affected

158 Translational efficiency of c-jun/betaGal mRNA increased

159 ell-surface CD36 secondary to an increase in translational efficiency of CD36 mRNA.

160 o test this hypothesis, we have measured the translational efficiency of CGG-repeat mRNAs with 0-2 AG

161 and DEN 3' UTR were the main sources of the translational efficiency of DCLD RNA, and they acted syn

162 tein 1 (AUF1) regulates the stability and/or translational efficiency of diverse mRNA targets, includ

163 (A) tail act synergistically to increase the translational efficiency of eukaryotic mRNAs, which sugg

164 etaxolol is likely to reflect an increase in translational efficiency of existing mRNA and/or stabili

165 Differences in translational efficiency of full-length and deletion-mut

166 isoacceptor over-expression may increase the translational efficiency of genes relevant to cancer dev

167 formation but it regulates the stability and translational efficiency of histone mRNAs.

168 erefore allows analysis of variations in the translational efficiency of individual mRNAs by accounti

169 Most importantly, we show that the translational efficiency of injected mRNAs containing ca

170 hers; the addition of caffeine increased the translational efficiency of most SRSF2 transcripts.

171 A in the nucleus have a direct effect on the translational efficiency of mRNA in the cytoplasm.

172 ction in Drosophila to increase the apparent translational efficiency of mRNAs by as much as 20-fold.

173 teins (ARE-BP) regulate the stability and/or translational efficiency of mRNAs containing cognate bin

174 Polysome profiles confirmed the decreased translational efficiency of mRNAs in tit1-Delta cells.

175 gies to alter the stability, solubility, and translational efficiency of nascent lacritin, and discov

176 nal upstream initiation sites, enhancing the translational efficiency of oncogenic mRNAs.

177 s in the L1 RNA could explain differences in translational efficiency of ORF1 and ORF2.

178 lovastatin or C3 exoenzyme, can increase the translational efficiency of p27 mRNA.

179 xpression was the direct result of decreased translational efficiency of p53 mRNA.

180 We have also determined the translational efficiency of PDE subunits and the role of

181 in vitro transcribed mRNAs, we examined the translational efficiency of reporter genes that simulate

182 de non-coding RNA molecule, acts to increase translational efficiency of RpoS mRNA under some growth

183 In order to investigate translational efficiency of RpoS mRNA, we examined both

184 TLR-TRIF is at least partially via promoting translational efficiency of RTA mRNA.

185 overshadowed by differential effects on the translational efficiency of specific existing mRNA speci

186 er, eIF4F deregulation results in changes in translational efficiency of specific mRNA classes.

187 hat the 5'-UTR functions as a determinant of translational efficiency of specific mRNAs, such as c-ju

188 molecules that regulate the stability or the translational efficiency of target messenger RNAs (mRNAs

189 RNA molecules that regulate the stability or translational efficiency of target messenger RNAs.

190 RNAs) in bacteria modulate the stability and translational efficiency of target mRNAs through limited

191 upstream open reading frame, which restored translational efficiency of the 92-nt 5'-UTR AS mRNA.

192 of a nonsense codon led to a decrease in the translational efficiency of the mRNA.

193 Increased translational efficiency of the parasite requires a high

194 nd ndhA are absent in ppr53 mutants, and the translational efficiency of the residual ndhA mRNAs is r

195 al operator sequence that serves to regulate translational efficiency of the s4 mRNA.

196 Elimination of these two uORFs raises the translational efficiency of the transcript by over 10-fo

197 These mutations dramatically enhance the translational efficiency of the v4 5'-UTR, leading to el

198 tein-protein interactions, and some modulate translational efficiency of their host genes.

199 , which express endogenous let-7a miRNA, the translational efficiency of these IRES-containing report

200 on of cyclin E was associated with increased translational efficiency of this mRNA, suggesting that c

201 rnate codon usage significantly enhanced the translational efficiency of this tightly regulated gene

202 The stability and translational efficiency of TNF transcript are regulated

203 tone stem-loop did not function to influence translational efficiency or mRNA stability in plant prot

204 gest that mechanisms such as mRNA transport, translational efficiency or mRNA turnover may be implica

205 ion of caveolin-1 does not affect caveolin-1 translational efficiency, phosphorylation, or proteasome

206 n (UTR) and regulates its expression through translational efficiency rather than RNA stability.

207 antitatively examined the effects of several translational-efficiency-related sequence features on mR

208 in receptor mRNA stability and ferritin mRNA translational efficiency, respectively.

209 riptome-proteome datasets for estimating the translational efficiencies, resulting in an increased co

210 abnormally short poly(A) tail and a reduced translational efficiency, resulting in an approximately

211 mportant determinant of RNA quality control, translational efficiency, RNA-protein interactions and s

212 - 2 fold change; O: +1.9 +/- 1 fold change), translational efficiency (S6K1 phosphorylation, Y: +10 +

213 at the suppressors do not generally increase translational efficiency, since some alleles that strong

214 hich newly created 5'-UTR Alu exons modulate translational efficiency, such as the creation or elonga

215 quadruplex lead to a 15-fold enhancement of translational efficiency, suggesting that a possible bio

216 Translational efficiency (TE) was used as a metric for t

217 ects of mutations in Ded1 or eIF4A on global translational efficiencies (TEs) in budding yeast Saccha

218 gnificantly lower mRNA stability and greater translational efficiency than proximal isoforms on avera

219 A synthetases (UaaRS) are evaluated on their translational efficiency (the extent to which they allow

220 While each is known to regulate translational efficiency, the mechanism by which they co

221 A cargo shifting and resultant regulation of translational efficiency upon the initiation of differen

222 Our analysis suggests that translational efficiencies vary over a broad range durin

223 m by which mTORC2 activity stimulates Rictor translational efficiency via an AKT/HSF1/HuR signaling c

224 RNAs and because tRNA competition determines translational efficiency vs. fidelity and production of

225 Optimal translational efficiency was achieved when mRNAs contain

226 Translational efficiency was calculated by measuring pro

227 s was performed to identify genes whose mRNA translational efficiency was differentially affected fol

228 yribosomes by 2.3-fold, which indicates that translational efficiency was enhanced by mobilization.

229 While global translational efficiency was reduced in mitotic cells, a

230 Translational efficiency was restored by mutations that

231 onal capacity, in E-UN offspring (P < 0.05); translational efficiency was similar across dietary trea

232 that the mRNA level of the AS form with high translational efficiency was specifically reduced in mor

233 oncogenic Ras and Akt signaling pathways on translational efficiencies, we compared the gene express

234 ader sequences of transcripts with increased translational efficiency, we find a highly enriched mess

235 it was once thought that mRNA stability and translational efficiency were directly linked, the inter

236 ive changes in poly(A)-tail length, and thus translational efficiency, were largely retained in the a

237 erived variants showed altered IRES-mediated translational efficiency, which might favor CNS infectio

238 ed protein synthesis resulted from decreased translational efficiency with impaired initiation of tra

239 f recombinant protein through extremely high translational efficiency without the need for viral repl