ライフサイエンスコーパス: translationally

1 e cytoplasmic membrane of bacteria occurs co-translationally.

2 netic elements capable of self-splicing post-translationally.

3 is regulated both transcriptionally and post-translationally.

4 or more ADP-ribose units onto proteins post-translationally.

5 m folding post-translationally to folding co-translationally--a result consistent with previous exper

6 NatA co-translationally acetylates the N termini of a wide varie

7 o sapiens sequences reveals how co- and post-translationally acting chaperones differentially promote

8 downstream metabolic effects by TH can post-translationally activate other transcription factors.

9 Strikingly, genes that were translationally activated by IPF-derived ECM were enrich

10 e now report that YB-1 directly binds to and translationally activates the 5' untranslated region (UT

11 ial cells, that elevated expression of eIF4E translationally activates the transforming growth factor

12 The phylogenetic identity of translationally active cells can be determined by combin

13 tures and enrichments, and used to visualize translationally active cells within complex environmenta

14 Mss51 was enriched in a translationally active form that maintains full Cox1 syn

15 T(EC869) only cleaves tRNA in the context of translationally active GTP.EF-Tu.tRNA ternary complexes.

16 majority of the transcripts contain multiple translationally active ORFs, and also that most isoforms

17 nd functionally defective ribosomes into the translationally active pool, and the translational fidel

18 , switching them from a dormant state into a translationally active state.

19 Here, we show that translationally active tiRNAs assemble unique G-quadrupl

20 mmarize emerging evidence for distinct, post-translationally active, ubiquitin-dependent pathways cap

21 d contain messenger ribonucleic acid that is translationally active.

22 ility to associate with membranes via a post-translationally added lipid tail.

23 e promiscuous antigen binding potential post-translationally, after exposure to various redox-active

24 Together, these studies identify a translationally anchored anabolic circuit critical for c

25 CD47 protein localization occurs post-translationally and independently of RNA localization.

26 Golgi apparatus, most likely occurring post-translationally and specifically facilitating post-trans

27 In bacteria, SPase I is targeted co-translationally, and the catalytic domain remains unfold

28 wall and provide a clinically effective and translationally applicable therapeutic strategy that inv

29 artition into subpopulations that are either translationally arrested or that can continue translatin

30 curin associates with nascent separase to co-translationally assist proper folding, Cdk1-cyclin B1 ac

31 end a variety of signals, most often by post-translationally attaching ubiquitins to substrate protei

32 nal betaalpha1 superdomain of apoB, which co-translationally binds and remodels the luminal leaflet o

33 (Sirt1) regulates the production of CRH post-translationally by affecting PC2.

34 FOXP3 activity is regulated post-translationally by histone/protein acetyltransferases an

35 ional secretion signal and are modified post-translationally by O-linked glycosylation.

36 Furthermore, Wnt proteins are modified post-translationally by palmitoylation, which is essential fo

37 AIRE is modified post-translationally by phosphorylation and ubiquitylation.

38 in skeletal muscle is regulated in part post-translationally by the availability of the noncatalytic

39 l recognition particle (SRP) pathway or post-translationally by the mammalian transmembrane recogniti

40 plasmic reticulum has been shown to occur co-translationally by the signal recognition particle (SRP)

41 Ralpha protein levels can be controlled post-translationally by the ubiquitin-proteasome pathway thro

42 delling, oxidative phosphorylation, was post-translationally cleaved generating differential amounts

43 membrane-associated proteins, which are post-translationally cleaved into disulfide-linked polypeptid

44 Translationally co-regulated mRNA subsets share common u

45 the limitations in creating and maintaining translationally cold samples of trapped ions using neutr

46 different strategy that selectively targeted translationally competent host mRNAs for inhibition.

47 he incorporation of mt-tRNA(Phe) to generate translationally competent machinery.

48 some, uniting the two subunits to create the translationally competent monosome, and provide evidence

49 wn spliced HIV-RNA variants, they maintained translationally competent ORFs, involving elements of ga

50 disrupting the accumulation of grk mRNA in a translationally competent RNP complex that contains the

51 ated LARP1 scaffolds mTORC1 on the 3'UTRs of translationally-competent RP mRNAs to facilitate mTORC1-

52 al tool that can be used to rapidly and post-translationally control the activity of a given protein.

53 ion of integrin beta1 mRNA, which drives the translationally controlled assembly of a TGF-beta recept

54 ns involved in the translation machinery and translationally controlled by mTORC1 signaling), and (ii

55 Translationally Controlled Tumor Protein (TCTP) is anti-

56 The transcript encoding translationally controlled tumor protein (Tctp), a molec

57 One of these proteins, translationally controlled tumor protein (TCTP), was sel

58 Translationally controlled tumor protein(TCTP) has been

59 components of Tor signalling in Drosophila, translationally controlled tumour protein (Tctp) and Rhe

60 mportantly, we also identified a novel, post-translationally controlled, component of the heat shock

61 ing a mechanism by which lens development is translationally controlled.

62 It promotes GSC progeny differentiation by translationally controlling the expression of differenti

63 ng DNA-damage-induced Chk2 activation and by translationally controlling the expression of self-renew

64 at a sizable fraction of nascent GFP is post-translationally converted into a 20-kDa Triton X-100-ins

65 Formylglycine-generating enzyme (FGE) post-translationally converts a specific cysteine in newly sy

66 used broadband trapping to collect ions and translationally cool along the transmission axis before

67 Here, we show that mRNAs are, in fact, co-translationally degraded.

68 nserved signal recognition particle (SRP) co-translationally delivers newly synthesized membrane and

69 cine (FGly) active-site residue that is post-translationally derived from either cysteine or serine.

70 le, as evidenced by an increased fraction of translationally diffusing water molecules, a higher diff

71 TR features distinguish two functionally and translationally distinct subsets of MTOR-sensitive mRNAs

72 which monomeric Orb2 keeps target mRNA in a translationally dormant state and experience-dependent c

73 genes in the lipid metabolism pathways were translationally down-regulated in the rpl4d mutant.

74 Plasmodium berghei gametocytes, is activated translationally during ookinete formation, where the pro

75 ELF1 protein, which itself is regulated post-translationally during the EMT program.

76 g that their activity could be restored post-translationally (e.g. by reducing the temperature or by

77 se group from NAD(+) to target proteins post-translationally, either attached singly as mono(ADP-ribo

78 itutively active and can be rapidly and post-translationally enhanced by several stimuli, yet little

79 etermining whether a nascent protein will co-translationally fold and function or misfold and malfunc

80 ressing H(+)-ATPase isoform 2 (AHA2) that is translationally fused with a fluorescent protein and exa

81 Each group is post-translationally generated through the action of a specif

82 reactions may occur, such as those between a translationally hot H atom and an ambient acetylene (HCC

83 Sec is inserted co-translationally in a small fraction of proteins called s

84 Disulfide bonds are introduced co- and post-translationally in endoplasmic reticulum (ER) cargo in a

85 cell stress and are frequently targeted post-translationally in infected or transformed cells to avoi

86 regulated post-transcriptionally and/or post-translationally in primary neurons.

87 Dimerization occurs co-translationally in the endoplasmic reticulum and is regu

88 ion and PER-TIM repression is regulated post-translationally, in part through rhythmic phosphorylatio

89 ent to dimerize 2.5-MDa 70S ribosomes into a translationally inactive 100S complex.

90 nslated, whereas other cellular mRNAs become translationally inactive and are either targeted for sta

91 eIF4F bound the BTE and a translationally inactive mutant with high affinity, thus

92 dimerization, forming a 100S complex that is translationally inactive.

93 Selenocysteine (Sec) is naturally co-translationally incorporated into proteins by recoding t

94 he genetic code expansion strategy, which co-translationally incorporates ncAAs into specific sites o

95 Among those mRNAs translationally increased by equol was the oncogene and

96 several key antibiotic regulatory genes are translationally induced at transition growth phase.

97 -associated protein (AIRAP) transcript to be translationally induced during arsenite stress condition

98 on regulators eIF4A and Pabp, which are also translationally-induced despite general translational in

99 CSE also down-regulated and post-translationally inhibited the glucocorticoid receptor (G

100 tain the amino acid selenocysteine (Sec), co-translationally inserted at a predefined UGA opal codon

101 Tail-anchored (TA) proteins are post-translationally inserted into membranes.

102 y of multi-spanning membrane proteins are co-translationally inserted into the bilayer by the Sec pat

103 Most membrane proteins are co-translationally inserted into the lipid bilayer via the

104 in animal bodies, owes its stability to post-translationally installed hydroxyl groups at position 4

105 acid, selenocysteine (Sec), is incorporated translationally into proteins and is synthesized on its

106 nvolved in vesicle fusion, are inserted post-translationally into the endoplasmic reticulum membrane

107 One implication is that this translationally invariant lattice of strongly correlated

108 We prove that for infinite (translationally invariant) systems the Chern number is c

109 such an approach gives completely misleading translationally invariant, local Hamiltonians on a squar

110 in systems on a two-dimensional lattice with translationally invariant, nearest-neighbour interaction

111 rconductor was originally conceived as being translationally invariant.

112 d and polarization in charged systems is not translationally invariant.

113 oscillations, although the quantum liquid is translationally invariant.

114 Post-translationally, K48-linked poly-ubiquitination of NUMBL

115 mall ubiquitin-like modifier' (SUMO) is post-translationally linked to target proteins at the varepsi

116 Proteome-wide studies of post-translationally methylated species using mass spectromet

117 The displacement of this translationally mobile water is energetically less costl

118 the hydrolysis of an acetyl group from post-translationally modified acetyl-lysine residues in a wid

119 inclusions consisting of aggregated and post-translationally modified alpha-synuclein (alpha-syn).

120 ptides possess a high percentage of post-/co-translationally modified amino acids, particularly gamma

121 s/specificities for peptides containing post-translationally modified amino acids.

122 trate that the prosthetic heme group is post-translationally modified and cross-linked with the prote

123 Lantibiotics are a group of highly post-translationally modified bacterial antimicrobial peptide

124 ytheonamides represent the most heavily post-translationally modified biomolecules that are derived f

125 In this study, we find that PRCD is post-translationally modified by a palmitoyl lipid group at t

126 We further found that AR is post-translationally modified by H(2)S through S-sulfhydratio

127 Here we show that BRI1 is post-translationally modified by K63 polyubiquitin chains in

128 Collagen is post-translationally modified by prolyl and lysyl hydroxylati

129 r insoluble organic matrix proteins are post-translationally modified by short polyamine groups, whic

130 Furthermore, fibulin 2 is post-translationally modified by tyrosine sulfation, and the

131 y (mAb) drugs and their degraded and/or post-translationally modified counterparts, drug-product-rela

132 A post-translationally modified form of annexin A1 (AnnA1) is s

133 n as Lewy bodies that consist mainly of post-translationally modified forms of alpha-synuclein.

134 and beta-tubulin, and between different post-translationally modified forms of alpha-tubulin.

135 matin-regulatory proteins and different post-translationally modified histone peptides.

136 e phenomena affect the accessibility of post-translationally modified histone residues that serve as

137 ytokeratins, topoisomerase-2-alpha, and post-translationally modified histones, which correlate with

138 ues responsible for coordination of the post-translationally modified histones.

139 Native and post-translationally modified HMGB1 were detected in humans a

140 tion, proteins in actinobacteria can be post-translationally modified in a process referred to as pup

141 ow that in airway basal cells, SPRY2 is post-translationally modified in response to FGFR1 signaling.

142 This is the first description of a post-translationally modified Mtb-derived protein antigen pre

143 growing family of ribosomally produced, post-translationally modified natural products.

144 In Escherichia coli, EF-P is post-translationally modified on a conserved lysine residue.

145 roduct of a ribosomally synthesized and post-translationally modified pathway consisting of five cons

146 ynthesis of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products

147 Most ribosomally synthesized and post-translationally modified peptide (RiPP) natural products

148 ally unique ribosomally synthesized and post-translationally modified peptide (RiPP) that possesses p

149 y revealed that FlaP is specific to the post-translationally modified peptide and can discriminate be

150 owing family of ribosomally encoded and post-translationally modified peptide natural products (RiPPs

151 dified microcins (TOMMs) are a class of post-translationally modified peptide natural products bearin

152 Lanthipeptides are a class of post-translationally modified peptide natural products.

153 n mode, except for the analysis of some post-translationally modified peptides (e.g., phosphorylation

154 Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a novel cl

155 a group of ribosomally synthesized and post-translationally modified peptides (RiPPs) exhibiting ant

156 eptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) that display a

157 that act on ribosomally synthesized and post-translationally modified peptides (RiPPs), known as a Ri

158 f bioactive ribosomally synthesized and post-translationally modified peptides (RiPPs), with a thread

159 ucts called ribosomally synthesized and post-translationally modified peptides (RiPPs).

160 e family of ribosomally synthesized and post-translationally modified peptides (RiPPs).

161 nt group of ribosomally synthesized and post-translationally modified peptides (RiPPs).

162 ides called ribosomally synthesized and post-translationally modified peptides (RiPPs).

163 d azoles in ribosomally synthesized and post-translationally modified peptides (RiPPs).

164 ew class of ribosomally synthesized and post-translationally modified peptides and thus far are only

165 tion time normalization and handling of post-translationally modified peptides are detailed.

166 om a family of ribosomally produced and post-translationally modified peptides called the cyanobactin

167 terpene and ribosomally synthesized and post-translationally modified peptides cluster products, repo

168 is a virulence factor consisting of two post-translationally modified peptides that synergistically k

169 a family of ribosomally synthesized and post-translationally modified peptides with a highly unusual

170 erived from ribosomally synthesized and post-translationally modified peptides.

171 of studied native islet antigens and to post-translationally modified peptides.

172 variety of ribosomally synthesized and post-translationally modified peptides.

173 s labeling of proteins and synthesis of post-translationally modified proteins and their analogues.

174 functions for quantitative analysis of post-translationally modified proteins and their modification

175 Antibodies that specifically recognize post-translationally modified proteins have a number of uses

176 scent polypeptides being translated and post-translationally modified proteins.

177 s that target 128 total proteins and 53 post-translationally modified proteins.

178 robisporicin, which contains two unique post-translationally modified residues (5-chlorotryptophan an

179 RING E3 ubiquitin ligases (CRLs) target post-translationally modified substrates for ubiquitination a

180 13 exhibited much lower activity toward post-translationally modified substrates.

181 gnificant support to proposals that the post-translationally modified sulfenato group serves as the n

182 rge number of proline residues that are post-translationally modified to 3-hydroxyproline or 4-hydrox

183 the canonical pathway, proteins must be post-translationally modified to expose an N-degron.

184 ific mRNA, the protein it encodes and a post-translationally modified version of the protein), a netw

185 Furthermore, B. subtilis EF-P is post-translationally modified with a 5-aminopentanol group bu

186 ic genome typically contain nucleosomes post-translationally modified with a trimethyl mark on histon

187 els, bound to fly microtubules and were post-translationally modified, hence displaying physiological

188 hat the microtubule cytoskeleton can be post-translationally modified, only recently have the enzymes

189 The lysines modified by DOB are often post-translationally modified.

190 aled low abundance proteoforms that are post-translationally modified.

191 native environment that have been fully post-translationally modified.

192 his superfamily shows the presence of a post-translationally-modified heme with one single covalent e

193 pled receptor kinase-2 (GRK2) that also post-translationally modifies eNOS.

194 onents physically interact with BRM and post-translationally modify BRM by phosphorylation/dephosphor

195 AGA and NuA4 stimulate transcription by post-translationally modifying chromatin.

196 ansferase activity, which is capable of post-translationally modifying lysine residues of the ICDH pr

197 gnaling systems transmit information by post-translationally modifying signaling proteins, often via

198 ail a displacement of the repressor from the translationally mute Smt1-ATP8/ATP6 complex by F1, there

199 ndem mass spectrometry, the chains were post-translationally overmodified.

200 Translationally, pregnant women with low or high ACEs we

201 ity of bioreactors and their ability to post-translationally process recombinant factor IX (rFIX) lim

202 elongated precursor peptides, which are post-translationally processed by proteases to yield the acti

203 The MnSOD is post-translationally processed to 27 and 24 kDa forms in the

204 We propose mitomiRs can translationally regulate mitochondrially encoded protein

205 e that MbtA activity can be reversibly, post-translationally regulated by acetylation.

206 These findings indicate that MetAP2 is post-translationally regulated by an allosteric disulfide bon

207 tochondrially encoded ATP6 and ATP8 genes is translationally regulated by F1 ATPase.

208 These data show that ERalpha protein is post-translationally regulated by Pin1 in a proportion of bre

209 In order to dissect the gene network that is translationally regulated by SRSF1, we performed a high-

210 Here, we have discovered that moesin is translationally regulated by TGF-beta and is also requir

211 by polysome profiling that inhibin betaA is translationally regulated by TGFbeta via hnRNP E1.

212 We identify a group of ten translationally regulated drivers of EMT sharing a commo

213 Cellular enzymes interact in a post-translationally regulated fashion to govern individual c

214 Translationally regulated genes are predominantly associ

215 e that the methods are able to identify post-translationally regulated genes with high statistical co

216 A subset of Orb2 targets is translationally regulated in cultured S2 cells and fly h

217 hip analysis, we have identified a cohort of translationally regulated mRNAs that are induced during

218 perturbations, and identify many additional translationally regulated mRNAs throughout the yeast gen

219 Of the translationally regulated mRNAs, 30% had one or more ups

220 With post-translationally regulated proteins, one expects their co

221 However, how this protease is post-translationally regulated remains unclear.

222 knockdown on tumor growth, reduction of the translationally regulated survivin profoundly inhibited

223 enome-wide association studies are primarily translationally regulated.

224 at least one-quarter of the transcriptome is translationally regulated.

225 nophosphate (c-di-GMP) binding activity post-translationally regulates alginate secretion.

226 We find that LEP-2 post-translationally regulates LIN-28 by promoting LIN-28 pro

227 We found that CK2alpha post-translationally regulates the ERK-specific phosphatase d

228 This study reveals a novel pathway that post-translationally regulates the general stress response si

229 These findings establish that PRL post-translationally regulates ZnT2-mediated zinc secretion i

230 Our work provides strong evidence that translationally regulating riboswitches also regulate mR

231 In addition, promoter methylation of two translationally relevant genes, Schlafen 11 (SLFN11) and

232 lidate the effect of Pim1-modified CSCs in a translationally relevant large animal preclinical model

233 evelopment of targeted therapeutics required translationally relevant preclinical models with well-ch

234 in functioning at a systems level, to elicit translationally relevant symptomatology and behavioral d

235 rough which acute ketamine treatment induces translationally relevant symptomatology may differ from

236 this protein splicing activity arose to post-translationally repair proteins that had been inactivate

237 nding protein with a predicted prion domain, translationally repress cyclin CLB3 in meiosis I, thereb

238 As a result, target mRNAs are translationally repressed and subsequently deadenylated

239 VAR2CSA is translationally repressed by an upstream open reading fr

240 DHHC10, translationally repressed in female Plasmodium berghei g

241 storage, degradation, and quality control of translationally repressed messenger RNAs in eukaryotic c

242 Translationally repressed mRNAs accumulate in cytoplasmi

243 ced by similar stress conditions and contain translationally repressed mRNAs and a partially overlapp

244 s) are conserved cytoplasmic aggregations of translationally repressed mRNAs assembled with mRNA deca

245 in, in dynamic and reversible aggregation of translationally repressed mRNAs during hypoxia.

246 ng bodies and stress granules, which contain translationally repressed mRNAs.

247 porter that includes only the mom-2 3'UTR is translationally repressed properly in oocytes and early

248 rong association between transcripts acutely translationally repressed under oxidative stress and tho

249 ire Ssp2, a meiosis-specific protein that is translationally repressed until anaphase of MII.

250 ergo gene-specific regulation in mitosis are translationally repressed, rather than activated.

251 gly, many mRNAs localized to protrusions are translationally repressed.

252 One of the most pronounced translationally-repressed genes is Emi1, an inhibitor of

253 hich determines female physiognomy, but also translationally represses male-specific lethal 2 (msl-2)

254 egies to prepare for transmission, including translationally repressing and protecting mRNAs needed t

255 od, including whether Plasmodium changes its translationally repressive complexes and mRNA targets in

256 myloid-like form of Rim4 that is the active, translationally repressive form of the protein.

257 st, SPases I in eukaryotes are targeted post-translationally, requiring an alternative strategy to pr

258 The dimensions of the translationally serviceable locale around synapses have

259 cterium Shewanella oneidensis regulates post-translationally sigma(S) (also called RpoS), the general

260 Genes that are translationally silenced by hnRNP E1 and expressed by it

261 Gs) are cytoplasmic storage sites containing translationally silenced mRNPs that can be released to r

262 F) homodimerizes the 70S ribosomes to form a translationally silent 100S complex.

263 acteria dimerize pairs of 70S ribosomes into translationally silent 100S particles in a process calle

264 nown as stress granules (SGs), which contain translationally silent mRNAs, preinitiation factors, and

265 Remarkably, these granules are not translationally silent.

266 This series post-translationally stabilizes the SMN protein, unrelated to

267 Stress granules (SGs) harbour translationally stalled messenger ribonucleoproteins and

268 ing the tested model ER-targeted nonstop and translationally stalled proteins for degradation.

269 and how soluble or transmembrane nonstop and translationally stalled proteins targeted to the endopla

270 le and transmembrane ER-targeted nonstop and translationally stalled proteins.

271 degradation of soluble cytosolic nonstop and translationally stalled proteins.

272 c analysis of Nedd8-conjugated proteins from translationally stalled ribosomal fractions identified r

273 not all, proteins encoded by mRNAs that are translationally stimulated by equol treatment.

274 Herein, we report that PRL post-translationally stimulated ZnT2 ubiquitination, which al

275 Chemokine receptors are commonly post-translationally sulfated on tyrosine residues in their N

276 ads to snatching of these targets, which are translationally suppressed during infection.

277 membrane helix at their C terminus, are post-translationally targeted to the endoplasmic reticulum me

278 synthesized on cytosolic ribosomes and post-translationally targeted to the organelle by PEX5, the p

279 ants, where the chloroplast SRP (cpSRP) post-translationally targets light-harvesting chlorophyll a/b

280 In addition, NCOA3 stabilized mucins post translationally through fucosylation by FUT8, as the kno

281 Unlike PRC, which was induced post-translationally through increased protein half-life, c-M

282 uited to the Sec71-Sec72 complex either post-translationally through Ssa1 or co-translationally throu

283 ther post-translationally through Ssa1 or co-translationally through Ssb1.

284 expression in higher eukaryotes is regulated translationally through the 5'TOP sequence.

285 osperm Arabidopsis thaliana and respond post-translationally to ethylene when expressed in plant cell

286 witch some protein domains from folding post-translationally to folding co-translationally--a result

287 Thus, de novo folding is translationally tuned by an integrated cellular response

288 ) regulates many biological pathways by post-translationally ubiquitylating proteins for degradation.

289 The 4.2-A structure of post-translationally unmodified human alpha1A/betaIII microtu

290 mRNAs specifically translationally up-regulated with tamoxifen resistance i

291 brown adipose tissue (BAT) and iWAT, and is translationally upregulated by beta3-adrenergic signalin

292 and RNA sequencing, we identified the mRNAs translationally upregulated during mGluR-LTD.

293 ed that oxidative phosphorylation mRNAs were translationally upregulated during vaccinia virus-induce

294 gene expression; however, specific mRNAs are translationally upregulated in quiescent (G0) mammalian

295 to-oncogene that drives colon oncogenesis by translationally upregulating COX-2 and activating the be

296 s review aims to provide information that is translationally useful and complementary to pathogenic h

297 ome makes miRNA-based therapeutic strategies translationally valuable.

298 in modifications in eukaryotes and occurs co-translationally when the N-terminus of the nascent polyp

299 gh N-terminal myristoylation is catalyzed co-translationally within the cytoplasm of the parasite, pa

300 ) in the thylakoid membrane is targeted post-translationally without a ribosome.