ライフサイエンスコーパス: two

1 dian number of previous lines of therapy was two (2-5), 38 patients had high-risk cytogenetics, 17 we

2 hage 9 g DNA packaging (pac) site containing two 21-bp direct repeats and a major terminase cleavage

3 exia were the most common (each occurring in two [5%] of 37 patients).

4 Out of 11 adjuvants, only two, Abisco((R))-100 and CoVaccineHT(TM), enhanced vacci

5 In this manuscript, two additional assays have been developed.

6 Herein, we present two additional high-resolution crystal structures of the

7 riants are regulatory variants for which the two alleles confer different regulatory activities.

8 eased to 86% when individuals carried one or two alleles of epsilon4, and to 72% sensitivity and 77%

9 Studies of UL37 homologs from two alphaherpesviruses, herpes simplex virus 1 (HSV-1) a

10 ge <9% difference in predictions between the two analytical approaches across all samples analyzed, w

11 test a cocktail of three virulent phages in two animal models of cholera pathogenesis (infant mouse

12 patch CLC (central lateral color patch), and two anterior color patches ALC (anterior lateral color p

13 Unlike its predecessor, QFT-Plus utilizes two antigen tubes to elicit an immune response from CD4(

14 at 104 461 (19.0%) patients missed more than two appointments in the 3 year study period.

15 sulins can be found in fifteen bacterial and two archaeal phyla.

16 ipants report seeing a third flash when only two are presented (the "triple-flash" illusion) most oft

17 error detection, the dialogue between these two areas could play a role in the regulation of emotion

18 es a knowledge-based multibody potential and two atomic energy terms.

19 enzyme-based high-throughput screen yielded two attractive chemotypes capable of inhibiting S1P form

20 4,134 routine and HIV samples tested by the two automated assays, the percentage of agreement was ex

21 Two auxiliary negative feedback loops, from ERK to MEK a

22 robiota is unable to prevent colonization by two bacterial pathogens that cause mortality in neonates

23 A new control mechanism employing two-beam refraction and one solenoid valve was developed

24 racterized by a major capsid protein bearing two beta-barrels.

25 Two biophysical parameters, the diffusion coefficient an

26 ucture and the charge density profile of the two biopolymers.

27 adocus miersi, a brachiopod Liothyrella uva, two bivalve molluscs, Laternula elliptica, Aequiyoldia e

28 Two Borrelia burgdorferi interacting proteins, BB0238 an

29 es formation of free alkynylboronate and the two boryl substituents are not necessarily derived from

30 human attachment in providing a template for two-brain coordination.

31 Here, we describe two brothers with hematopoietic and immunologic symptoms

32 ctive reagent, resulting in the formation of two C-C bonds at a single carbon center bearing a C(sp(3

33 al hub (twofold axis of symmetry) flanked by two Cas1 lobes and two Cas3 lobes.

34 -lobed propeller-shaped structure, where the two Cas2 domains form a central hub (twofold axis of sym

35 s of symmetry) flanked by two Cas1 lobes and two Cas3 lobes.

36 Two case-control studies established a point-source outb

37 ectron-precise dianionic diboranes featuring two-center-two-electron bonds in the context of related

38 first doubly charmed baryon , which contains two charm quarks (c) and one up quark (u) and has a mass

39 binding energy of about 130 MeV between the two charm quarks.

40 We found that two chemokine receptors, CXCR3 and CCR10, are upregulate

41 ithiasis and primary sclerosing cholangitis, two cholangiopathies regarded as risk factors for CCA.

42 expression (ASE) - unequal expression of the two chromosomal gene copies.

43 the climate health profiles of 16 states and two cities participating in the U.S. Centers for Disease

44 Airways primarily secrete two closely related gel-forming mucins, MUC5B and MUC5AC

45 of three milk types, five fish species, and two coffee types were measured using electrospray ioniza

46 Two common polymorphisms, the c. 1298A > C, of the methy

47 RAllel FACtor (PARAFAC) analysis supported a two-component model of humic-like and nonhumic-like diss

48 pond to their environment through the use of two-component regulatory systems.

49 modulated by MisRS (NGO0177 and NGO0176), a two-component system that is a homolog of CpxRA.

50 rticularly promising target is the bacterial two-component system.

51 lation in Bacillus subtilis and in bacterial two-component systems.

52 us, their tissue burden differentiates these two compounds while other mammals contain PFOS from both

53 ots to facilitate the transition between the two configurations, which may give rise to disease-assoc

54 laucoma (two ischemic optic neuropathies and two congenital optic disc anomalies).

55 tain electron microscopy, demonstrating that two copies of VirD4 dimers locate on both sides of the a

56 itical coupling at both or at any one of the two coupling regions.

57 2-3 mL of blood to accurately quantify these two cross-linked adducts simultaneously.

58 In this study, two CWT plants 10 and 19 km upstream of a reservoir left

59 Contacts were predicted with two DCA methods (gplmDCA and PSICOV).

60 idney injury associated with diarrhoea), and two deaths in the combination group (diarrhoea and urina

61 Among the competitive athletes, two deaths were attributed to hypertrophic cardiomyopath

62 al monitoring data reported during the first two decades of transgenic crops, with each case represen

63 ld be detectable with 12 subjects in each of two defined groups.

64 resonators results in their ability to host two degenerate resonant modes.

65 ng is a collective result of the coupling at two different coupling regions, and does not require cri

66 Two different formats of an enzyme-based high-throughput

67 synthesis (CFPS) that provides proteins with two different functional groups for post-translational l

68 oms on two U.S. college campuses adhering to two different furniture flammability standards: Technica

69 sitive IR spectroelectrochemical techniques, two different intermediates were identified as responsib

70 Participants were drawn from two different localities in England, one North, the othe

71 This shows that two different pathways of activation, immunogenic and to

72 After pretreatment with two different sample preparation steps assisted by ultra

73 ted with the reflectivity difference between two different substrates can be tracked and controlled.

74 pendent observers (A, B, C) measured PVRs at two different time points during the first and the last

75 unique structures and multifunctionalities, two-dimensional (2D) nanomaterials have aroused increasi

76 ESI) sequence, which is capable of obtaining two-dimensional (2D) spectra from three spatial dimensio

77 Twisted two-dimensional aromatic frameworks have been prepared b

78 High-quality two-dimensional atomic layered p-n heterostructures are

79 Ab-OPN (0.826) was significantly higher than two-dimensional combination of PGI/II-HpAb (0.786, P < 0

80 s in gated graphene structures at low doping.Two-dimensional Dirac semimetals are known to host fermi

81 Here, we demonstrate that comprehensive two-dimensional gas chromatography (GC x GC) retention t

82 n the freestanding and adhered states of the two-dimensional materials.

83 odified Langmuir-Blodgett method to organize two-dimensional molecular charge transfer crystals into

84 iffusion process to a spatially constrained, two-dimensional one.

85 The combination of two-dimensional radiation hydrodynamic and three-dimensi

86 Two-dimensional transition metal dichalcogenides (2D TMD

87 In this magnetically soft, two-dimensional van der Waals ferromagnet, we achieve un

88 lar momentum by a gas of ultracold bosons in two dimensions using a standard rotation procedure.

89 ed on information based on data collected in two dimensions: either histological sections imaged by l

90 opose improvements to SeqKernel that follows two directions.

91 ble switching of the DNA conductance between two discrete levels.

92 s has revealed major differences between the two diseases, which preferentially involve the PrP(Sc) c

93 outcome-specific conditioned inhibitors for two distinct appetitive outcomes.

94 tanding in wound healing and regeneration as two distinct aspects of cellular self-repair by examinin

95 The Axl crystal structure revealed two distinct conformational states of the enzyme, provid

96 ic properties of KaiB, a protein that adopts two distinct folds, and the post-adenosine triphosphate

97 tida reveals that the protein is a fusion of two distinct modules: an N-terminal sugar phosphate isom

98 he DivIVA-like protein Cdv3, indicating that two distinct pools of MinC are coordinated in S. elongat

99 Thus two distinct proteotoxic stress responses control phosph

100 Bifunctionality is associated with two distinct sets of loop conformations, each essential

101 nalling to account for the separation of the two domains starting from a homogeneous array of cells,

102 The structure shows that POT1C contains two domains, a third OB fold and a Holliday junction res

103 Effective target sites fall within two domains, which are conserved in sequence/structure i

104 d Demographic Surveillance System to include two doses of HRV with the standard infant vaccines at 6

105 , the current increased 12-fold, showing the two effects are due to independent mechanisms that tune

106 ise dianionic diboranes featuring two-center-two-electron bonds in the context of related compounds f

107 Two emerging contaminants commonly found in aquatic envi

108 Thus, two enhancers integrate combinatorial transcription fact

109 Two EspP mutants were also gradually degraded by DegP bu

110 In two evolution experiments with the facultatively sexual

111 f the NMDA-DeltaCa(2+) responses between the two experimental groups.

112 ibition of HDAC6 improved established PAH in two experimental models and can be safely given in combi

113 e we found the surprising effect that linear two filament connections act as transistor-like, angle d

114 ormation about the molecular interactions in two filament states, we successfully predict point mutat

115 ry postsynaptic currents (sEPSCs) three- and two-fold higher, respectively, than those of adapting ne

116 xilla preserving part of the nasal floor and two fragmentary molars.

117 e the capability to resolve the responses of two genetically encoded Zn(2+) sensors at a range of tim

118 Two glaucoma-associated mutants of OPTN, E50K and M98K,

119 anti-gp120 MAbs in screening against one of two gp120s and against DS-SOSIP, which mimics the native

120 sive oddball paradigm was adopted to examine two groups (16 in the autism group and 15 in the control

121 s 0.1 [1.1], p=0.010) difference between the two groups in change from baseline in total cholesterol

122 The cost difference between the two groups was $648 ($87,476 in the gold-standard monito

123 xing, rather than an association between the two groups, although more work is required to show this

124 nch) was significantly different between the two groups.

125 r species investigated were categorized into two groups: species with the ability to harbour large nu

126 ingly, the patients could be classified into two groups: those who were infected and those who were n

127 Here we investigate the role of two gtr operons that we identified in the S Typhi genome

128 and treatment of hyponatremia, comparing the two guidelines and highlighting recent developments.

129 ster (BC half) forms a propenone bearing the two halves (a hydrobilin analogue).

130 lls the viral and cell membranes together as two heptad-repeat regions refold to form a six-helix bun

131 The amino acid substitutions lie in two highly conserved loop regions of uS12 with known rol

132 Two highly significant CAD loci were identified on chrom

133 Our study identifies a potential "two-hit" mechanism in which tau acetylation disengages t

134 Two hundred forty-seven of these proteins were validated

135 Two hundred ninety-seven eyes with a median follow-up of

136 Two hundred seventy-eight women from 25 to 76 years of a

137 genase was involved in the production of the two hydroxy intermediates.

138 et O2, relative to the unpaired electrons in two hydroxyl radicals, amounts to 100 kcal/mol.

139 Mean values for PD and CAL in the two hypertriglyceridemic groups were significantly highe

140 onth outcome was also comparable between the two ICH groups.

141 In the model, competition between two images in rivalry is driven by both attentional modu

142 In two independent cohorts of melanoma patients treated wit

143 st, persisted across age, as observed within two independent PGC-SCZ2 subsamples, and showed an incre

144 Their sheet-like structure derives from two independent polymeric networks - one of laminin and

145 autoinhibited at a single site by either of two inhibitory regions, CBD and LAVP, which block substr

146 Two Intensive Care Units in a large Academic Medical Cen

147 In the presence of ubiquitin, two interhelical loops of the C-terminal four-helix bund

148 Two investigators independently conducted abstract and f

149 studied proteins, the assembly of the other two is irreversible and enhanced at higher temperatures,

150 25% of these were misdiagnosed as glaucoma (two ischemic optic neuropathies and two congenital optic

151 ng 'respectful modeling' framework which has two key aims: (i) respecting the models themselves and f

152 The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cy

153 f the electronic structural effects of these two key principal amine compounds imposed by hydrogen bo

154 by smoking status among 1,037 patients from two large US prospective cohort studies diagnosed from 1

155 The other two laws, valid for reciprocal and nonreciprocal objects

156 Furthermore, the distinction of two lineages in the snapping shrimp Alpheus lottini comp

157 conditions where they exhibit coexistence of two liquid phases.

158 uency of repeated choices between bundles of two liquids.

159 1 overlap in axillary buds, and TB1 binds to two locations in the tru1 gene as shown by chromatin imm

160 nd B2 (FB2) during industrial dry-milling in two lots from 2014 (n=120) and 2015 (n=120) of non-trans

161 oach to RNA-ligand kinetics, we overcome the two main difficulties by applying a gradient-based coars

162 Until very recently, there were two main evolutionary narratives for this rather puzzlin

163 We then elaborate the two main future directions that are centralized around t

164 Two main groups of strains were extracted from this anal

165 CNS function, but the relative roles for the two main sources of ATP production, glycolysis and oxida

166 tests that evaluate the sense of smell face two major challenges.

167 We defined two major genomic subtypes of primary stage Ta tumors.

168 ed from nine sites at varying distances from two major municipal wastewater treatment plants (MWWTPs)

169 that Drosophila centrosomin (cnn) expresses two major protein variants: the centrosomal form (CnnC)

170 ere, we investigated the causal influence of two major stress neuromodulators, cortisol and noradrena

171 centration and load in NT and CT systems via two major transport pathways: runoff and leaching.

172 Two male and three female patients were recruited in thi

173 fy the independent and joint associations of two measures of chronic kidney disease (estimated glomer

174 We now show that the loss of S100A4 produces two mechanistically distinct phenotypes with regard to m

175 In this paper, we compare these two methods, while also using a primitive method without

176 nts dissolved in water and whether/how these two modalities converge in the same neurons.

177 We demonstrate the loading of two model drugs: the chemotherapeutic doxorubicin and th

178 t cell type, the root hair cell, and between two model plants: Arabidopsis (Arabidopsis thaliana) and

179 s, and protected mice from MRSA infection in two model systems.

180 chemical and structural methods to show that two molecules of Cas2/3 assemble with four molecules of

181 The antibody extensively anchors two monomers together at the base of the trimer, and bio

182 Two murine models of synucleinopathy (a Gaucher-related

183 was shown to be spatially regulated through two myosin-signaling pathways, myosin light chain kinase

184 culations conducted for the reactions of the two N-oxyl radicals with toluene, which indicate that th

185 Two natural history cohorts were studied including 168 l

186 Mouse liver contains two natural killer (NK) cell populations, one of which r

187 l mechanism that uses cross-talk between the two NDK monomers to accelerate phosphorylation-related a

188 We describe two new complementary approaches - stable isotope probin

189 eces regenerate within about a week, forming two new worms.

190 algorithm (called constrained projection) to two non-constrained approaches including CIBERSORT and a

191 Two notable common variants were identified: rs10791286,

192 w that H. pylori deregulates mitochondria by two novel mechanisms, both rather associated with host c

193 ondrial DNA (mtDNA) survey and sequencing of two nuclear markers (AME and RAG-1) from P. theobaldi, f

194 reasonably resolve the tension between these two objectives as well as evaluate disparate racial impa

195 reater (13) C transfer to recipient roots in two of four Douglas-fir families, representing three- an

196 Two of the cis sequence motifs enriched in the PREs are

197 Two of the three events are contemporaneous with large-m

198 ents, 101 (4.9%) had diagnoses that involved two or more disease loci.

199 Across 94 countries with two or more survey datapoints, the population-weighted m

200 Each year, two or three species that had been considered to be exti

201 rbations in the past year: none, few (one to two), or exacerbation prone (>/=3).

202 nations of neutral compounds containing one, two, or three aromatic rings.

203 nts that differ from the original along one, two, or three environmental dimensions.

204 A two-order improvement in LOD is obtained as compared to

205 ection limit for dopamine can be improved by two orders of magnitude [from 10microM to 50nM] in compa

206 bon materials permit Terahertz operation and two orders of magnitude decrease in power-delay product

207 rstand the genetic architecture of how these two organs covary during developmental ontogeny, we cond

208 ervais & Fessler's analysis collapses across two orthogonal dimensions of social value to explain con

209 een 20 ant conspecifics in 10 genera between two paired forests (10 pairs of 20 forests) that consist

210 The two paralogs expressed in mammals, Cks1 and Cks2, share

211 Two participants withdrew from the AQ-13 group after par

212 Sequencing and comparing the genomes of two pathogenic species of Batrachochytrium to those of c

213 Subsequently, the two pathways diverge to produce distinct thermodynamical

214 ental micronutrients is compared in seeds of two pearl millet genotypes.

215 enerated using intracortical recordings from two people with tetraplegia.

216 equatorial reflections, suggesting that the two peptides adopt distinct lateral packing of the diffr

217 mplex with the HLA-E molecule presenting the two peptides.

218 e of the spatial and temporal instability of two-phase flow in fractured media at the macroscopic sca

219 ow that the history of the species comprises two phases, and conclude that the currently circulating

220 This study consisted of two phases.

221 sorption bands that are assigned to one- and two-phonon and impurity-related absorption processes.

222 ational simulations with analysis of in vivo two-photon Ca(2+) imaging data from somatosensory cortex

223 Here, we used two-photon Ca(2+) imaging to study visual processing in

224 sensors for monitoring kinase activity under two-photon fluorescence lifetime imaging microscopy (2pF

225 Using two-photon imaging of large groups of neurons, we show t

226 One solution to this problem is to use two-photon microscopy to target fluorescently labeled ne

227 quency of the transition, which is driven by two photons from a laser at 243 nanometres, is consisten

228 ve had more resources available to cope with two physiological challenges (ovarian development after

229 We investigated thalamic inputs to the two populations of striatal neuropeptide Y (NPY) interne

230 exposed embryos of 10 families from each of two populations to variable and constant thermal regimes

231 Two porous, chiral metal-organic frameworks (MOFs), Ca14

232 Three genes were identified, two possibly involved in biogenesis of the membrane-boun

233 It comprises a novel combination of two powerful technologies: deep convolutional neural net

234 radation of a permanently misfolded protein, two previously defined roles for Sse1.

235 e met the clinical response criteria for the two primary end points than did those who received place

236 Brown, Enquist (WBE) model argues that these two principles (space-filling and energy minimization) a

237 Using two probes, more than 700 well-isolated single neurons w

238 ied between 0.3 and 1.5, suggesting that the two processes are in balance and that in situ production

239 ation to the development of PTSD symptoms in two prospective military cohorts (one discovery and one

240 Proteomic analysis reveals that two proteases belonging to the calpain family (SmCalp1 a

241 EAVOR trial was a head-to-head comparison of two proteasome inhibitors in patients with relapsed or r

242 Two questions that presented the risk of AK as not progr

243 h-frequency streamwater samples taken during two rainfall and one snowmelt event in two watersheds wi

244 field-friendly test conditions, we evaluated two rapid lateral flow assays (LFA) for detection of Myc

245 The wavelength-dependent conversion of two rapid photoinduced ligation reactions, i.e., the lig

246 We then constructed two RBDs mutated in multiple key residues in the recepto

247 right knees of eight-week old male mice from two recombinant inbred lines (LGXSM-6 and LGXSM-33) were

248 Critical coupling in two-region coupling is a collective result of the coupli

249 Linkage to these two registers and to the National Crime Register enabled

250 the Rag GTPases, an obligate heterodimer of two related GTPases.

251 Two researchers independently screened 945 studies from

252 of (89)Zr-deferoxamine (Df)-pembrolizumab in two rodent models (mice and rats).

253 Two rotavirus vaccines, Rotarix (RV1) and RotaTeq (RV5),

254 nts with major depressive disorder completed two rtfMRI-nf sessions (18 received amygdalar rtfMRI-nf,

255 ee different models of this system how these two seemingly conflicting criteria are met.

256 rgeon in the Detroit and St. Clair represent two semi-independent populations that could require sepa

257 We experimentally validated candidates from two sets of plant-associated genes: one involved in plan

258 with and without diarrhea were obtained from two shelter facilities and determined to shed atypical E

259 Two sources of 3T3-L1 preadipocytes as well as OP9 pread

260 tor cortices (PMd and PMv, respectively) are two specialized areas involved in the control of hand mo

261 ion, we predict that within rosemary extract two specific constituent components; gallic acid and car

262 leate more astral microtubules on one of the two spindle poles than the other.

263 imicking turn-on RNA aptamer, Broccoli, into two split fragments that could tandemly bind to target m

264 The paper presents a novel two-stage particle swarm optimization (PSO) for the maxi

265 ndocytic-site maturation can be divided into two stages corresponding to the arrival of the early and

266 enzyme and we analyse the data in terms of a two-state equilibrium between compact and extended confo

267 ons that shift the equilibrium between those two states.

268 UO2(2+) cation occurs readily in a one-pot, two-step stoichiometric reaction at room temperature to

269 erlie intelligence in nonhumans has followed two strategies: one that concerns observing differences

270 or asynchronous activity allows formation of two streams of information processing.

271 Regression analysis revealed the two strongest independent radiological predictors for IP

272 Here we report the experimental discovery of two structure types by computational identification of t

273 Two structures of this segment determined by the cryo-el

274 We extended our analysis to two studies containing transcriptomics, phosphoproteomic

275 ct cell types and that each tissue contained two subgroups.

276 ce of transgene-specific T-cell responses in two subjects that were part of the phase II trial.

277 Two subsets of blood monocytes are commonly described in

278 ate here that the synergistic application of two such principles in the design of peptoid foldamers y

279 protection corresponded to the higher of the two symbionts present.

280 yses reveal a huge chemical diversity in the two taxa.

281 We explored the functionality of two terminal PKS modules that produce the 16-membered ty

282 The cohort was randomly divided into a two thirds set (Nd = 10 083) for model development and a

283 terized classes, nearly all of the remaining two-thirds of mEC cells can be categorized as spatially

284 govitecan once weekly at 8 and 10 mg/kg, or two times per week at 4 and 6 mg/km on weeks 1 and 2 of

285 imidines with affinity for AChBP showed only two to be agonists on the alpha7-nAChR below 10 muM conc

286 nuation of risperidone was associated with a two- to fourfold increased risk of relapse over 16-32 we

287 Two trained evaluators located in the same laboratory ev

288 When the two treatments were combined, the current increased 12-f

289 er ear, cochlear hair cells display at least two types of mechanically gated ion channel: normal mech

290 to the similarity in data structure of these two types of researches.

291 dormitory common areas and student rooms on two U.S. college campuses adhering to two different furn

292 find that the resonance stabilization of the two unpaired electrons in triplet O2, relative to the un

293 h the vacuolar cation channel SlTPC1 and the two vacuolar H(+)-pumps, SlAVP1 and SlVHA-A1, which in t

294 uring two rainfall and one snowmelt event in two watersheds with contrasting levels of urbanization.

295 Two weeks later, computed tomographic angiography (CTA)

296 constitutively accumulate greater amounts of two well-characterized defensive compounds, the volatile

297 ential therapeutic effects of cortistatin in two well-established preclinical models of atheroscleros

298 crude polysaccharides (CPS), extracted from two widely cultivated pomegranate varieties, Laffan and

299 Two women died by asphyxiation due to a tongue swelling.

300 Two zeolitic imidazolate frameworks, ZIF-67 and ZIF-8, w

301 ping in the anomalous dispersion region with two Zero Dispersion Wavelengths (ZDWs) and the process o