ライフサイエンスコーパス: utricle

1 ents associated with establishing PCP in the utricle.

2 caudal ends that fuse to form the prostatic utricle.

3 supporting cell proliferation in the mature utricle.

4 on spontaneous hair cell death in the chick utricle.

5 II beta-tubulin and beta-actin from the same utricle.

6 al canal and ampulla, as well as part of the utricle.

7 myosin Ibeta in hair bundles of the bullfrog utricle.

8 om hair cells in the epithelium of the mouse utricle.

9 evelopment of a murine vestibular organ, the utricle.

10 -Seq) of hair cell regeneration in the chick utricle.

11 liferation in a murine vestibular organ, the utricle.

12 nd Pcdh15 and were not detected in the chick utricle.

13 ifferentiation, and PCP establishment in the utricle.

14 en supporting cells in the gravity-sensitive utricle.

15 mechanoelectrical transduction in the turtle utricle.

16 the vestibular dark cells in the ampulla and utricle.

17 he dissection and culture of the adult mouse utricle.

18 d recovery in saccules comparable to that in utricles.

19 eat-shocked utricles and the nonheat-shocked utricles.

20 g cells into hair cells in cisplatin-treated utricles.

21 epithelium of embryonic and 2-week-old mouse utricles.

22 ecipitated from purified hair bundles of rat utricle, 2w was the only site A variant detected; moreov

23 munolocalization of HCN protein in the mouse utricle, a mechanosensitive organ that contributes to th

24 l phenotype during regeneration in the avian utricle, a vestibular organ that detects linear accelera

25 hic evidence that, in cultured postnatal rat utricles, a substantial number of hair cells can survive

26 Taller and more compact bundles of the mouse utricle account for this difference.

27 ere we show that HC damage in neonatal mouse utricle activates the Wnt target gene Lgr5 in striolar s

28 We asked whether hair cells of the mouse utricle adapt, and if so, whether the adaptation was sim

29 contribute to hair cell regeneration in rat utricles after injury, it is very limited.

30 t-shocked utricles protected nonheat-shocked utricles against hair cell death.

31 Asynchrony within utricles allows reconstruction of the temporal progressi

32 lts indicated that hair cell survival in the utricle and ampulae does not require Cx30.

33 in both hair cells and support cells in the utricle and basilar papilla, and its expression does not

34 d in areas of cell proliferation in both the utricle and basilar papilla.

35 zed within sensory epithelia of the saccule, utricle and cochlea throughout development and into adul

36 ells and surrounding cells, from cochlea and utricle and from E16 to P7, we performed a comprehensive

37 lar canal crista, as well as a fusion of the utricle and saccule endolymphatic spaces into a common u

38 Only the utricle and saccule have an extremely dense matrix, the

39 ion and head position is the function of the utricle and saccule in mammals.

40 Otoconia are biominerals within the utricle and saccule of the inner ear that are critical f

41 ect in tlt homozygous mice is limited to the utricle and saccule of the inner ear, which completely l

42 The defect in het mutants is limited to the utricle and saccule of the inner ear, which completely l

43 nuclei and cerebellum similar to that of the utricle and saccule suggest that the primary role of the

44 Afferents innervating the utricle and saccule terminated generally in the lateral

45 In the utricle and saccule the hair cells are arranged in an or

46 a from experimental preparations of ampulla, utricle and saccule were found to be significantly highe

47 rcular canals and reduced innervation to the utricle and saccule were observed.

48 In addition, the maculae of the utricle and saccule were partially fused.

49 hatic duct and sac, in distinct areas of the utricle and saccule, and in the external sulcus region w

50 e striolar and extra-striolar regions of the utricle and saccule.

51 splatin-induced hair cell death in the mouse utricle and suggest that treatment with EGCG may be a us

52 find that only a subset of hair cells in the utricle and the crista ampullaris express BK channels.

53 Comparisons of cell types from utricles and cochleae demonstrate divergence between aud

54 onditional hair cell ablation in adult mouse utricles and demonstrates that hair cells are spontaneou

55 d STAT1 phosphorylation in cisplatin-treated utricles and resulted in concentration-dependent increas

56 ibular hair cell renewal in ototoxin-damaged utricles and the maturation of stereociliary bundle morp

57 ction was abolished in both the heat-shocked utricles and the nonheat-shocked utricles.

58 epletion of sensory cells in the saccule and utricle, and a complete loss of the horizontal semicircu

59 on patterns of Cx26 and Cx30 in the saccule, utricle, and ampulla by immunolabeling.

60 maining sensory epithelia (posterior crista, utricle, and cochlea) that closely corresponds to the de

61 and ventral projections from the saccule and utricle, and medial and dorsal projections from the lage

62 troma of the cristae ampullaris, the maculae utricle, and saccule in the human and mouse.

63 rnible IE substructures such as the cochlea, utricle, and saccule.

64 ing the auditory ganglion, cochlea, saccule, utricle, and semicircular canals.

65 ncluding three semicircular canals, saccule, utricle, and their associated sensory organs, detects an

66 sed within the striolar reversal zone of the utricle, and we show here that this regionalized express

67 ELISA in the media surrounding heat-shocked utricles, and depletion of HSP70 from the media abolishe

68 Similarly, inputs from the utricle are also segregated to distal regions, synapsing

69 semicircular canals, endolymphatic duct and utricle, are malformed or absent.

70 In GSI-treated utricles as old as P12, differentiated striolar SCs conv

71 nd medial extrastriolar (MES) regions of the utricle at embryonic day 11.5 (E11.5), while cells in th

72 related with morphological changes, we fixed utricles at different times between P0 and P28.

73 elow 5 Hz, within the frequency range of the utricle, but because it was incomplete, substantial resp

74 e/Cwe animals had very few hair cells in the utricle, but their ampullae and cochlea were devoid of a

75 iled to induce proliferation in neonatal rat utricles, but brief (</=1 hr) exposures to forskolin or

76 ve ablation of hair cells in the adult mouse utricle by inserting the human diphtheria toxin receptor

77 Lesions in embryonic utricles closed in <24 h via localized expansion of supp

78 ated for their ability to reduce the size of utricles (comedolytic activity) in a rhino mouse model o

79 ratio was significantly elevated in rda/rda utricles compared with controls, and the level of ARF6-G

80 this we used neomycin to kill hair cells in utricles cultured from mice of different ages and found

81 close proximity between the saccules and the utricles, deeply grooved sulci on the saccular otoliths,

82 In the utricle, deletion at E14.5 or E16.5 did not cause cell d

83 Closer analysis of adult mouse utricles demonstrated that the basolateral processes of

84 ngential nucleus, that are essential for the utricle-dependent VOR.

85 induced a local, dose-dependent reduction in utricle diameter after seven daily dermal doses.

86 In mature utricles, exogenous stimulation with lysophosphatidic ac

87 uting the BLB in the human vestibular macula utricle from normal and Meniere's disease.

88 In contrast, lesions in utricles from 2-week-old and older mice remained open ev

89 When heat-shocked utricles from Hsp70-/- mice were used in cocultures, pro

90 We used cultured utricles from mature Swiss Webster mice to investigate t

91 ter photobleaching (FRAP) of SC junctions in utricles from mice that express a gamma-actin-GFP fusion

92 In utricles from neonatal mice, time-lapse recordings in th

93 pha were assayed in organo-typic cultures of utricles from the mature, undamaged (normal) chicken inn

94 t proliferation increased tenfold in damaged utricles from the youngest neonates.

95 When we cultured utricles from young mice with gamma-secretase inhibitors

96 In the toadfish utricle, glutamatergic hair cells are present throughout

97 15 using mass spectrometry of purified chick utricle hair bundles, we did not detect USH1G.

98 w that HES7 is specifically expressed during utricle hair cell regeneration and closely parallels the

99 In rda/rda mice, cuticular plates of utricle hair cells initially formed normally, then degen

100 stereocilia actin dynamics in more than 500 utricle hair cells.

101 The utricle has a structure and hair cell orientation patter

102 th widely expressed in the cochlear duct and utricle in an overlapping pattern, suggesting coexpressi

103 bundles in the extrastriolar regions of the utricle in Ptprq(-/-) mice become significantly longer t

104 ia also occurs in the striolar region of the utricle in Ptprq(-/-) mice, but is not accompanied by ha

105 tivated in the hair cells of the adult mouse utricle in response to neomycin exposure in vitro.

106 contrast to adults, HC ablation in neonatal utricles in vivo recruits Lgr5+ cells to regenerate stri

107 at high levels in stereocilia of the chicken utricle, in an approximate 1:1 molar ratio with radixin.

108 Genes up-regulated in the utricle included SMAD2, KIT, beta-AMYLOID, LOC51637, HMG

109 in different regions of the lagena, saccule, utricle, macula neglecta, and cristae was characterized

110 n other annexin genes are expressed in mouse utricles, mass spectrometry showed that none were presen

111 st that gravity-sensing hair cells in murine utricles may increase in number during neonatal developm

112 cluded hypospadias, opacification of a small utricle (not in the patient with hypospadias), ejaculato

113 ulin, along with that for beta-actin, in the utricle of chicks after hair cell damage both in vitro a

114 supernumerary hair cells in the cochlea and utricle of the inner ear.

115 Both the epidermis and utricles of the VDR-null animals overexpress elements of

116 higher than that of sensory epithelium from utricle or saccule.

117 ked specific structures such as the cochlea, utricle, or saccule throughout late IE development.

118 Ventral to the mid-level of the presumptive utricle, Otx1 and Otx2 were co-expressed, in regions suc

119 the number of BK-positive hair cells in the utricle peaks in juvenile rats and declines in early adu

120 Coculture with heat-shocked utricles protected nonheat-shocked utricles against hair

121 After damage, non-mammalian utricles regenerate HCs via both proliferation and direc

122 Supporting cells in those utricles remained compact and columnar and had significa

123 The inner ear utricle requires mechanosensory hair cells (HCs) to dete

124 periods, total RNA was extracted from single utricles, reverse transcribed to cDNA and the cDNA ampli

125 hich triggers proliferation and restores the utricle's growth; interfering with Yap's activity revers

126 ave a misshapen and smaller ear with a fused utricle, saccule, and cochlea and absent horizontal cana

127 ular attention was focused on the developing utricle, saccule, and cochlea.

128 e numbers of hair cells differentiate in the utricle, saccule, and cochlear base but sensory epitheli

129 ferents from the three otolithic organs (the utricle, saccule, and lagena) project to the intermediat

130 t, including the mature semicircular canals, utricle, saccule, cochlear duct, endolymphatic duct and

131 lia of the three mechanoreceptor organs, the utricle/saccule, cristae, and cochlea, with distinct typ

132 munoreactive sensory epithelia of the macula utricle, sacule, and crista ampullaris, and the membrano

133 Sensory hair cells in the avian utricle SE are in a constant state of turnover, where dy

134 uished from that resulting in a reduction in utricle size.

135 We used this difference to enrich for utricle-specific genes, using reiterative cDNA subtracti

136 A subtraction and demonstrate enrichment for utricle-specific sequences.

137 cells of the sensory epithelium of the chick utricle subjected to aminoglycoside-induced damage under

138 nner ear endorgans (the saccule, lagena, and utricle) synapse directly on the ipsilateral M-cell, the

139 d into a morphologically distinct structure (utricle) that maintains epidermal function.

140 agena as two separate pouches ventral to the utricle, the lungfish has a single large ventral pouch t

141 the anterior crista, the lateral crista, the utricle, the saccule, and both the basilar papilla and l

142 We report that in mouse utricles this electrophysiological differentiation occur

143 Although sparse, the projections of the utricle to the flocculus/ventral paraflocculus suggest a

144 ir cells and support cells after exposure of utricles to cisplatin.

145 and organ cultures of the chick cochlea and utricle, we found that cisplatin treatment caused apopto

146 In the utricle, we observed high levels of alpha9 AChR expressi

147 pieces of sensory epithelia from the chicken utricle were cultured in glass microwells.

148 Chick utricles were cultured in media supplemented with the ot

149 Utricles were removed from 1-day-old chicks and incubate

150 he number of otoconia in the saccule and the utricle, were consistently observed in the Raldh3 mutant

151 mainly in the medial striolar region of the utricle, where they constitute at most 12% of hair cells

152 abundant in a subpopulation of cells in the utricle, which undergoes continual postembryonic hair ce

153 three semicircular canals extending from the utricle, with the typical hair cell orientations, but th