ライフサイエンスコーパス: zygotic

1 e same maternal origin, which differ only in zygotic ABA.

2 udies have been conducted to understand post-zygotic accumulation of mutations in cells of the health

3 t Dorsal target genes before Dorsal-mediated zygotic activation.

4 but inhibition dissipates upon synthesis of zygotic Ago proteins after MBT.

5 ed signals: maternal and ubiquitous Vg1, and zygotic and localized Nodal.

6 we investigated the phenotype resulting from zygotic and maternal/zygotic inactivation of Fgf4.

7 separate chromosomes, are each linked with a zygotic antidote able to rescue maternal-effect lethalit

8 nge will have a larger effect on eroding pre-zygotic barriers (eco-geographical isolation and phenolo

9 seen in naturally produced hybrids where pre-zygotic barriers are the largest contributors to reprodu

10 The pre-zygotic barriers between red- and green-fruited species

11 graphical isolation and phenology) than post-zygotic barriers, shifting the relative importance of th

12 ited effects on environment-independent post-zygotic barriers.

13 tide family is required for formation of the zygotic basal cell lineage and proembryo patterning in A

14 ifically impaired pre-mRNA splicing of early zygotic but not maternally encoded transcripts.

15 as BMP ligand expression in the zebrafish is zygotic, but regulated by maternal factors.

16 ales with sperm, to providing exclusive post-zygotic care.

17 rrors in meiosis, mitotic errors during post-zygotic cell division contribute to pervasive aneuploidy

18 of mouse PGC specification and suggest that zygotic cell signaling may direct PGC specification in G

19 Unlike the zygotic, central spindle-localized RhoGEF (Pebble), RhoG

20 chibana-Konwalski shows that a Chk1-mediated zygotic checkpoint monitors the cohesin-dependent repair

21 An understanding of this zygotic chromatin 'ground state' could potentially provi

22 s thought to result mostly from pre- or post-zygotic chromosome missegregation.

23 ifferent cell lineages during the first post-zygotic cleavage division.

24 ylated, but the loci are demethylated during zygotic cleavage stages to precisely the state observed

25 isabling pancreatogenesis in pig embryos via zygotic co-delivery of Cas9 mRNA and dual sgRNAs targeti

26 Zygotic coinjection of TALEN mRNAs directed to the Agout

27 requires the concomitant development of two zygotic compartments, the embryo and the endosperm.

28 henotype of zebrafish that lack maternal and zygotic contributions of the Hh signaling transducer Smo

29 ent insights into the balance of gametic and zygotic contributions to imprint specification should he

30 To determine the maternal, paternal and zygotic contributions to the early embryonic transcripto

31 The handover from maternal to zygotic control has to be carefully orchestrated.

32 evolves over the transition from maternal to zygotic control of development.

33 s, early plant embryogenesis is mostly under zygotic control.

34 Mouse embryos lacking intact maternal/zygotic CTNNB1 from two knockout strains were examined i

35 The effects of maternal and zygotic CTNNB1 on embryogenesis have each been separatel

36 indicate the events leading to noncanonical zygotic cytokinesis, segregating the parental genomes in

37 Recent evidence suggests that zygotic cytoplasm, if maintained at metaphase, can also

38 m-egg incompatibility typically resulting in zygotic death.

39 s essential for proper interpretation of the zygotic Decapentaplegic (Dpp) morphogen gradient that pa

40 Embryos with zygotic deletion of Cdx2 develop normally until the late

41 Maternal-zygotic deletion of ZFP57 in mice presents a highly pene

42 between maternal reproductive fitness, early zygotic development and genomic imprinting.

43 Mammalian zygotic development is initiated by sperm-mediated intra

44 However, proof that PAWP initiates mammalian zygotic development relies on demonstration that it acts

45 gulatory genes appear to function similar to zygotic development, making somatic embryogenesis a valu

46 ant of mammalian oocyte competence and early zygotic development.

47 and mouse fertilization, required to trigger zygotic development.

48 oocytes that are competent to sustain early zygotic development.

49 velopment during oocyte maturation and early zygotic development.

50 ou5f1 and SoxB1 are required to initiate the zygotic developmental program and induce clearance of th

51 roducts may continue to act within incipient zygotic developmental programs.

52 at Etv2 protein levels persisted in maternal-zygotic dicer1 mutant embryos, suggesting that microRNAs

53 ttle is known about the control of the first zygotic division that gives rise to the proembryo.

54 We propose that during the first zygotic division, PLK-1-dependent chromosome congression

55 Before the first zygotic division, the nuclear envelopes of the maternal

56 usly, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains DNA methylation ge

57 In Arabidopsis thaliana, zygotic embryo divisions are highly regular, but it is n

58 ore-derived embryos and Arabidopsis thaliana zygotic embryos, and demonstrate that AUX1, LAX1 and LAX

59 ut the body, including in germline cells and zygotic embryos.

60 At four loci tests indicated that pre-zygotic events, such as meiotic drive in F1 parents or g

61 ish tp53(M214K)(w/m) line and the ewsa(w/m), zygotic ewsa(m/m), and Maternal-Zygotic (MZ) ewsa(m/m) l

62 Overall, zygotic exposure to venlafaxine disrupts early developme

63 Zygotic expression begins during embryonic morphogenesis

64 We show that zygotic expression of gdf3 is dispensable for embryonic

65 and are actively suppressed by parental and zygotic factors such as the conserved exonuclease ERI-1.

66 ecular "hand-off" between maternal Foxh1 and zygotic Foxa at these CRMs to maintain enhancer activati

67 Furthermore, in maternal-zygotic frv mutants, both myocardial and endocardial cel

68 layer specification is tightly coupled with zygotic gene activation and, in most metazoans, is depen

69 nal transcript turnover and failure in early zygotic gene activation appeared to associate with the a

70 of aneuploidy, but does not appear to affect zygotic gene activation at the two-cell stage or lineage

71 histone locus body (HLB) assembles prior to zygotic gene activation early during development and con

72 Pou5f1 (also called Oct4) and SoxB1 regulate zygotic gene activation in zebrafish.

73 e revised rates permit substantial levels of zygotic gene activity prior to the mid-blastula transiti

74 ility is counteracted by PI(3,4,5)P3 and the zygotic gene bottleneck, which acts by limiting myosin r

75 embryos, haploids exhibited a delay in both zygotic gene expression and cell cycle lengthening, whil

76 ited an intermediate effect on the timing of zygotic gene expression and cell cycle lengthening.

77 Cascades of zygotic gene expression pattern the anterior-posterior (

78 nce sex determination in C. elegans requires zygotic gene expression to read the sex chromosome karyo

79 for activation, beginning with the onset of zygotic gene expression.

80 These findings suggest that zygotic gene product(s) are required, either directly or

81 MBT embryos leads to premature activation of zygotic gene transcription and early onset of longer cel

82 N/C volume ratios showed early expression of zygotic genes and premature lengthening of cell cycles.

83 At mitotic cycle 8, when few zygotic genes are being transcribed, embryonic chromatin

84 idance a possible explanation why most early zygotic genes are intronless.

85 yos depend on maternally deposited RNA until zygotic genes become transcriptionally active.

86 very efficient at generating phenotypes for zygotic genes expressed during mid-embryogenesis.

87 Most zygotic genes remain transcriptionally silent in Drosoph

88 on and in doing so have identified the first zygotic genes to be expressed in the embryo.

89 is not required for the activation of early zygotic genes, but is essential to implement nodal activ

90 strulation and a failure to activate >75% of zygotic genes, including miR-430.

91 d direct recruitment, regulated by different zygotic genes.

92 sions limit transcription unit size of early zygotic genes.

93 effective at generating phenotypes for early zygotic genes.

94 cycle lengthening and the expression of some zygotic genes.

95 latory program centered on the expression of zygotic genes.

96 example of the interweaving of maternal and zygotic genetic functions during the egg-to-embryo trans

97 action and applied the system to investigate zygotic genome activation (ZGA) and RNA localization in

98 bryo, global epigenetic changes occur during zygotic genome activation (ZGA) at the 2-cell stage.

99 ernal factors direct development and trigger zygotic genome activation (ZGA) at the maternal-to-zygot

100 Zygotic genome activation (ZGA) is a major genome progra

101 Zygotic genome activation (ZGA) is mechanistically coord

102 Zygotic genome activation (ZGA) is thought to occur grad

103 , when maternal regulators are destroyed and zygotic genome activation (ZGA) occurs.

104 of cellular genes normally restricted to the zygotic genome activation (ZGA) period also become up-re

105 We hypothesise that following zygotic genome activation (ZGA), the combination of geno

106 oint to coordinate cell-cycle remodeling and zygotic genome activation (ZGA).

107 yos must achieve totipotency and prepare for zygotic genome activation (ZGA).

108 epend upon maternally provided factors until zygotic genome activation (ZGA).

109 riptional regulation of maternal mRNAs until zygotic genome activation (ZGA).

110 is likely reflects its preparation for early zygotic genome activation and comparatively accelerated

111 hat transcription factor Nfya contributes to zygotic genome activation and DHS formation at the 2-cel

112 lases KDM5A and KDM5B is required for normal zygotic genome activation and is essential for early emb

113 gulated by inherited maternal gene products: zygotic genome activation commences at the tenth cell cy

114 g model does not fully explain the nature of zygotic genome activation in plants.

115 promoters are differentially used during the zygotic genome activation, presumably because they have

116 of m(6)A-modified maternal mRNAs and impedes zygotic genome activation.

117 embryos, concomitant with the onset of major zygotic genome activation.

118 t program that accelerated degradation after zygotic genome activation.

119 osome 4, is expressed in a sharp peak during zygotic genome activation.

120 dBigH1 prevents premature activation of the zygotic genome during early embryogenesis.

121 se knockout embryos, we demonstrate that the zygotic genome folds into loops and domains that critica

122 will utilize this mechanism to activate the zygotic genome in a robust and precise manner.

123 Delayed transcriptional activation of the zygotic genome is a nearly universal phenomenon in metaz

124 During this developmental transition, the zygotic genome is largely transcriptionally quiescent an

125 However, in the nematode Ascaris the zygotic genome is never silent, and the maternal product

126 stigated whether TDCPP altered the status of zygotic genome methylation during early zebrafish embryo

127 ter stages that widespread activation of the zygotic genome occurs.

128 most part, been negative in vivo and because zygotic genome remethylation is a key biological event d

129 Using these zygotes, we found that when the zygotic genome was replaced with that of a somatic cell,

130 TDCPP-induced delays in remethylation of the zygotic genome, a mechanism that may be associated with

131 cell-specific differential activation of the zygotic genome, and identify genes that were previously

132 some transcripts must derive from the early zygotic genome, implying that the prevailing model does

133 Before activation of the zygotic genome, the maternal genome provides all transcr

134 on and for transcriptional activation of the zygotic genome.

135 that controls the initial activation of the zygotic genome.

136 ne expression comes under the control of the zygotic genome.

137 bryonic development before activation of the zygotic genome.

138 elda, a recently discovered activator of the zygotic genome.

139 , and subsequent steps being governed by the zygotic genome.

140 on of a hesx1 morpholino into a 'sensitised' zygotic headless (tcf3) mutant background leads to sever

141 hat are fully suppressed by maternal but not zygotic hrg-3 expression.

142 tabacum, supporting PELPIII function in pre-zygotic II.

143 henotype resulting from zygotic and maternal/zygotic inactivation of Fgf4.

144 t animals, including mice, appear to utilize zygotic inductive cell signals to specify germ cells dur

145 other early metazoan species that allow for zygotic injection.

146 Pre-zygotic interspecific incompatibility (II) involves an a

147 haracterize the genetic architecture of post-zygotic isolation.

148 h element of Tribolium that spreads via post-zygotic killing.

149 Combined maternal and zygotic knockout further revealed Aire's critical functi

150 Patterns of gametic and zygotic LDs indicate the absence of epistasis among CNV

151 homozygous cpl4 mutant, probably due to the zygotic lethality of this mutation.

152 ryo fate and auxin markers, we show that the zygotic-like pathway requires polar auxin transport for

153 spore embryos are formed via two pathways: a zygotic-like pathway, characterized by initial suspensor

154 entify missing sequences, and then allow the zygotic macronucleus to reproduce the same deletions.

155 loops, but not compartments, are present in zygotic maternal chromatin, suggesting that these are ge

156 We show that post-zygotic maternal provisioning by means of a placenta is

157 Moreover, we demonstrate that post-zygotic maternal provisioning correlates with superfetat

158 choice to polyandry in conjunction with post-zygotic mechanisms of sexual selection.

159 common ancestor may have specified PGCs via zygotic mechanisms.

160 ocked down have normal activation of several zygotic mesoderm, endoderm and ectoderm patterning genes

161 Zygotic microRNAs coordinate the clearance of maternal m

162 S-derived BWMs can be restored by preventing zygotic MOM-2 expression, which removes the inhibitory s

163 require precise spatiotemporal expression of zygotic MOM-2, which is dependent upon two distinct Notc

164 CL has been hypothesized to be due to a post-zygotic, mosaic mutation.

165 These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why mal

166 Furthermore, accumulation of translatable zygotic mRNAs is minimal in 1-cell embryos because of in

167 We show that sphk2 maternal-zygotic mutant zebrafish embryos (sphk2(MZ)) display ear

168 Elimination of Gdf3 in oocytes of maternal-zygotic mutants results in embryonic lethality that can

169 nos 3' UTR led to the generation of maternal-zygotic mutants, as well as increased viability and decr

170 Genomic mosaicism arising from post-zygotic mutation has recently been demonstrated to occur

171 gives insight into the contribution of post-zygotic mutations and population-specific mutational pro

172 parent-offspring trios, suggesting that post-zygotic mutations contribute little to the human germ-li

173 ructural mosaic abnormalities are large post-zygotic mutations present in a subset of cells and have

174 also result from multigenic effects or post-zygotic mutations.

175 Unexpectedly, maternal zygotic (MZ) dchs1b mutants show defects in the earliest

176 e ewsa(w/m), zygotic ewsa(m/m), and Maternal-Zygotic (MZ) ewsa(m/m) lines all displayed zero to low i

177 man SMN in motoneurons in zebrafish maternal-zygotic (mz) smn mutants.

178 les rapid signaling at low concentrations of zygotic Nodal.

179 The macronucleus develops from the zygotic nucleus through a series of chromosomal rearrang

180 The developmental failure of Cdx2 maternal-zygotic null embryos is associated with cell death and f

181 rlier lethal phenotype than observed in Cdx2 zygotic null embryos that develop until the late blastoc

182 ssessment of a large cohort of Cdx2 maternal-zygotic null embryos, all individually filmed, examined

183 dges meet, closely resemble defects in canoe zygotic null mutants and in embryos lacking the actin re

184 Here, we show that neither maternal nor zygotic Oct4 is required for the formation of EPI cells

185 ouse embryos deficient for both maternal and zygotic Oct4 suggest that it is dispensable for zygote f

186 Zygotic oep mutants (Zoep(-/-)) exhibited defects in mid

187 of the information dynamics in the maternal-zygotic one-eyed pinhead mutant, which is defective in m

188 ster embryo, mRNAs have a maternal origin, a zygotic origin, or both.

189 ctor responsible for initiating the earliest zygotic patterns along the dorsal-ventral axis, have rev

190 ula stage onwards and that both maternal and zygotic pools of Cdx2 are required for correct pre-impla

191 Ectopic maternal expression of an early zygotic pre-mRNA was sufficient to suppress its splicing

192 Similarly, loss of maternal-zygotic PRMT5 also leads to IAP upregulation.

193 ryogenesis a valuable model for the study of zygotic processes.

194 Zygotic production of CaMKII mRNA with a long 3'-untrans

195 However, the factors that activate the zygotic program in vertebrates are unknown.

196 Microinjection of recombinant DNA into zygotic pronuclei has been widely used for producing tra

197 Here we describe zygotic ptk7 (Zptk7) mutant zebrafish, deficient in a cr

198 embryonic loss-of-gene function in maternal-zygotic ptk7 mutants (MZptk7) leads to vertebral anomali

199 Although the zygotic regulation of these cell migration processes is

200 one responsible for the maternal storage and zygotic release of histones H2A/H2B.

201 We then test for post-zygotic reproductive barriers using experimental crosses

202 d with habitat, dietary preferences and post-zygotic reproductive isolation.

203 rm band elongation, and is likely to require zygotic reprogramming rather than alternative deployment

204 These results reveal that zygotic rest is unable to compensate for deficits in mat

205 oci could not be attributed entirely to post-zygotic selective loss of F2 individuals that failed to

206 ed to the sex-determining region because the zygotic sex ratio is determined by the relative number a

207 A potential complication is that zygotic sex-ratios become biased when haploid selected l

208 Despite causing biased zygotic sex-ratios, we find that a period of sex-specifi

209 (2) maternally loaded Gal4 protein to drive zygotic shRNA expression.

210 nnot be inactivated, resulting in multipolar zygotic spindles.

211 Focussing on the liver and eye, we show that zygotic Ssrp1a is essential for proliferation and differ

212 f the maternal genome, and by the end of the zygotic stage the genome-wide methylation level in male

213 he methylome of human early embryos from the zygotic stage through to post-implantation by reduced re

214 we focus on hermaphrodites that nourish post-zygotic stages, e.g. flowering plants and internally fer

215 development of organisms starting from their zygotic state involves a tight integration of the myriad

216 ) compositions of the oils stored in the two zygotic tissues.

217 Maternal-zygotic tmem2 mutants (MZtmem2) exhibit muscle fiber det

218 Animals lacking zygotic Top2 function can survive to pupation and displa

219 Reprogramming is essential for zygotic totipotency and to prevent transgenerational inh

220 Furthermore, a small early zygotic transcript with multiple introns was poorly spli

221 distinct mechanisms regulating the onset of zygotic transcription and changes to the cell cycle duri

222 s gambiae Yob, activated at the beginning of zygotic transcription and expressed throughout a male's

223 ryos can partially proceed in the absence of zygotic transcription and is a multi-level hierarchical

224 sely, decreasing the N/C volume ratio delays zygotic transcription and leads to additional rapid cell

225 e-associated positioning at promoters before zygotic transcription and subsequent transcription-indep

226 rrently experiences a receding first wave of zygotic transcription and the surge of a massive second

227 ry for the establishment of proper levels of zygotic transcription at the MBT, and that genes activat

228 smic ratio and depended on the activation of zygotic transcription at the MBT, including expression o

229 on is the midblastula transition (MBT), when zygotic transcription begins and cell cycles elongate.

230 Massive zygotic transcription begins in many organisms during th

231 wing this period of transcriptional silence, zygotic transcription begins, the maternal influence on

232 ), during which the cell cycle elongates and zygotic transcription begins.

233 m embryos up to the mid-blastula stage, when zygotic transcription begins.

234 n (MZT) when maternal mRNAs are degraded and zygotic transcription begins.

235 deposited messenger RNAs are degraded while zygotic transcription begins.

236 ion of maternal transcripts; a broad wave of zygotic transcription detectable as early as the seventh

237 de CENP-A incorporation in progeny, and that zygotic transcription during early embryogenesis remodel

238 ic founder cells have been ablated, or where zygotic transcription has been inhibited.

239 Initiation of zygotic transcription in mammals is poorly understood.

240 e of alternate cell divisions we manipulated zygotic transcription induced by beta-catenin or downreg

241 embryo titrate out these factors, leading to zygotic transcription initiation, presumably in response

242 al mRNAs are required for different modes of zygotic transcription initiation, which is not simply de

243 RNA post-transcriptional regulation prior to zygotic transcription initiation.

244 In mice, zygotic transcription is first detected shortly after pr

245 How the onset of zygotic transcription is regulated remains unclear.

246 The results also suggest that the first zygotic transcription itself is an active component of c

247 m of CaMKII mRNA and a process that requires zygotic transcription of CaMKII mRNA.

248 e nucleocytoplasmic ratio-dependent onset of zygotic transcription of tribbles and other unknown gene

249 Zygotic transcription was primarily from the maternal ge

250 the slowing of the cell cycle, the onset of zygotic transcription, and the developmental activation

251 nsition (MBT) marks the onset of large-scale zygotic transcription, as well as an increase in cell cy

252 In the absence of zygotic transcription, ingression movements proceed norm

253 arge mRNAs emerge shortly after the onset of zygotic transcription, with several of these genes acqui

254 ns are specified prior to the broad onset of zygotic transcription, yet when transcription initiates

255 of time immediately after the activation of zygotic transcription.

256 rnal factors, constituting the first wave of zygotic transcription.

257 sperm and egg indicate early and widespread zygotic transcription.

258 s present that predicted the initial wave of zygotic transcription.

259 The subsequent zygotic transcriptional activation further elevated over

260 This switch complements an earlier switch to zygotic transcriptional control and explains why the pre

261 hich presumptively derive from divergent pre-zygotic transcriptional states established in the gamete

262 how that the transition from the maternal to zygotic transcriptome is characterized by a switch betwe

263 tant to distinguish between the maternal and zygotic transcriptomes during this period.

264 f: (1) maternally loaded shRNAs to knockdown zygotic transcripts and (2) maternally loaded Gal4 prote

265 Maternal-to-zygotic transition (MZT) is essential for the formation

266 The maternal-to-zygotic transition (MZT) is one of the most profound and

267 Drosophila development, when the maternal-to-zygotic transition (MZT) takes place.

268 plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental proces

269 ion in vertebrate embryos is the maternal-to-zygotic transition (MZT) when maternal mRNAs are degrade

270 ogenesis is characterized by the maternal to zygotic transition (MZT), in which maternally deposited

271 During the maternal-to-zygotic transition (MZT), transcriptionally silent embry

272 l microRNAs are regulated during maternal-to-zygotic transition (MZT).

273 c genome activation (ZGA) at the maternal-to-zygotic transition (MZT).

274 ain regulator at the time of the maternal to zygotic transition (MZT).

275 in a process referred to as the maternal-to-zygotic transition (MZT).

276 pufferfish and zebrafish during maternal to zygotic transition and annotated 1120 long non-coding RN

277 rk that is shedding light on the maternal to zygotic transition and the interrelated but distinct mec

278 e clearance of maternal mRNA during maternal zygotic transition in embryonic development.

279 one modifications throughout the maternal-to-zygotic transition in embryos of Drosophila melanogaster

280 ternal mRNA clearance during the maternal-to-zygotic transition in zebrafish, Xenopus, mouse, and Dro

281 The maternal-to-zygotic transition is a conserved developmental progress

282 sequencing during key stages of maternal to zygotic transition of Tetraodon nigroviridis and report

283 Maternal to zygotic transition represents the most marked change of

284 murine zygotes prior to the maternal to the zygotic transition yet absent in oocytes, consistent wit

285 The zygotic transition, from a fertilized egg to an embryo,

286 ular mechanisms controlling this maternal to zygotic transition, it is important to distinguish betwe

287 Before this maternal-to-zygotic transition, many species execute rapid and synch

288 During the maternal-to-zygotic transition, maternal mRNAs are cleared by multip

289 During the maternal-zygotic transition, maternal products are degraded and g

290 trolling gene expression during the maternal-zygotic transition.

291 g transcription at the embryonic maternal-to-zygotic transition.

292 scriptionally inactive until the maternal-to-zygotic transition.

293 ome system (UPS) accompanies the maternal-to-zygotic transition.

294 d embryos failing to undergo the maternal-to-zygotic transition.

295 n A/T-rich (W-box) motif, is replaced with a zygotic TSS selection grammar characterized by broader p

296 ment to the final position downstream of the zygotic TSS.

297 Maternal or zygotic vpr-1 expression is sufficient to induce gonadog

298 rcupine inhibitor C59, which interferes with zygotic Wnt ligand secretion.

299 Remarkably, zygotic Wnt-signaling inputs are required for only three

300 Zygotic XND-1 turns on shortly thereafter, at the approx